Pre Gene Modal
BGIBMGA012778
Annotation
PREDICTED:_LIM_domain_kinase_1_[Bombyx_mori]
Full name
LIM domain kinase 1
Alternative Name
dLIMK
Location in the cell
Nuclear Reliability : 3.072
Sequence
CDS
ATGTGCGCACCGAGGGACACGGAGAAACCCTGCAAGGTAACGGAGGGGGTCATGGACAAGGGGACCTATGAAGGCAAGAAAGAGAGGCTGTTCAAGAGAAAGGGAGAGGATGGGGGCAAGCCGAGGATGATGAAGCGGAGACAGACGCCGTCCAGTCCGCTGCTCGGCGACAAAGAGAAGAGCAGCAGTATGTCCAAGCTGTTGGACGTCGTGGACGGCGAGGAGTCGAACGGCGTGCAGGGCGACCTGAGCCGGGCGCGATCCTTCCGCGCCGACACCAGCTCCGCCGGGCAGAAGGTGTTCCGCGCCTGCGACCTGCTGCAGGGCGAGTTGCTAGGCTCCGGATTCTTCGGCGAGGTGTACAAGGTGACCCACCAGGACACCGGTGAGGTCATGGTGCTCAAGCAGCTGTACAGGGTTGACGAGGAAGCGCAGAGGAACTTCCTCAAAGAGGTAACCAGACTGTTTGACTCTTGTAGGGCACATTGTCGATGGTAG
Protein
MCAPRDTEKPCKVTEGVMDKGTYEGKKERLFKRKGEDGGKPRMMKRRQTPSSPLLGDKEKSSSMSKLLDVVDGEESNGVQGDLSRARSFRADTSSAGQKVFRACDLLQGELLGSGFFGEVYKVTHQDTGEVMVLKQLYRVDEEAQRNFLKEVTRLFDSCRAHCRW
Summary
Description
Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor tsr/cofilin, thereby stabilizing the actin cytoskeleton. Modulation of actin cytoskeleton dynamics may be essential for imaginal disk morphogenesis and axon guidance.
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Subunit
Interacts with LATS1, and this interaction inhibits phosphorylation of tsr/cofilin.
Similarity
Belongs to the peptidase S1 family.
Belongs to the phospholipase A2 family.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Belongs to the phospholipase A2 family.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Keywords
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Kinase
LIM domain
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Repeat
Transferase
Zinc
Feature
chain LIM domain kinase 1
splice variant In isoform 3.
splice variant In isoform 3.
Uniprot
H9JTB6
A0A194R2A4
A0A2A4K1Y5
A0A2A4K0W2
A0A194Q6H6
A0A2H1VPW9
+ More
A0A437BFL2 A0A212FMY9 A0A067QT21 A0A2J7Q788 E2AJQ1 A0A0M8ZTC7 A0A088AE00 A0A2A3E9C7 A0A232FKK2 A0A154PNC8 A0A0L7R2Z4 A0A195CMV4 A0A2P8ZJ94 A0A151XER9 E9ISV3 A0A0J7L734 A0A3L8DWG7 A0A026WJ13 F4WI79 A0A158NZS3 A0A195BDE3 A0A151IXT7 E2BR47 A0A195F2J5 A0A0K8TB59 A0A1S4EV79 Q17PY5 A0A2M4A206 A0A2M4BA58 A0A2M4A243 W5JR92 A0A2M4CNF0 A0A182FPN1 A0A2M3YZ07 B0W0P8 A0A0K8TB73 A0A2P6KEH0 D2A3V3 A0A087TGI2 A0A0T6BH66 A0A182YJF6 A0A182L4F9 A0A182WEF6 A0A0A9VYG1 A0A0A9WSK4 A0A0P4WG81 A0A1Y1N295 A0A1Y1MZC7 A0A182IL97 A0A182K9C1 A0A1Y1MZE1 A0A182HH14 A0A182PC59 A0A182Q8M8 A0A453YZN9 A0A182R4B5 A0A182MXV1 A0A0P4WKM1 A0A0P4WIY5 A0A182M4A3 A0A182XKQ8 A0A1W4WSX5 A0A1B6MQF5 U4UR90 N6TU05 A0A1B6J824 A0A1B6HK26 E0VK24 A0A336LBI2 A0A1B0G724 A0A023EZJ9 A0A1Z5LDF4 A0A2R5LFZ2 A0A1B0AG95 A0A1A9V1T4 A0A293LE34 E1JJM8 C7LAB4 Q8IR79-3 H5V8E7 B3NXB5 Q8IR79-2 E1JJM7 A0A0Q5TKT9 Q8IR79 A0A444TPA7 A0A1J1HKS8
A0A437BFL2 A0A212FMY9 A0A067QT21 A0A2J7Q788 E2AJQ1 A0A0M8ZTC7 A0A088AE00 A0A2A3E9C7 A0A232FKK2 A0A154PNC8 A0A0L7R2Z4 A0A195CMV4 A0A2P8ZJ94 A0A151XER9 E9ISV3 A0A0J7L734 A0A3L8DWG7 A0A026WJ13 F4WI79 A0A158NZS3 A0A195BDE3 A0A151IXT7 E2BR47 A0A195F2J5 A0A0K8TB59 A0A1S4EV79 Q17PY5 A0A2M4A206 A0A2M4BA58 A0A2M4A243 W5JR92 A0A2M4CNF0 A0A182FPN1 A0A2M3YZ07 B0W0P8 A0A0K8TB73 A0A2P6KEH0 D2A3V3 A0A087TGI2 A0A0T6BH66 A0A182YJF6 A0A182L4F9 A0A182WEF6 A0A0A9VYG1 A0A0A9WSK4 A0A0P4WG81 A0A1Y1N295 A0A1Y1MZC7 A0A182IL97 A0A182K9C1 A0A1Y1MZE1 A0A182HH14 A0A182PC59 A0A182Q8M8 A0A453YZN9 A0A182R4B5 A0A182MXV1 A0A0P4WKM1 A0A0P4WIY5 A0A182M4A3 A0A182XKQ8 A0A1W4WSX5 A0A1B6MQF5 U4UR90 N6TU05 A0A1B6J824 A0A1B6HK26 E0VK24 A0A336LBI2 A0A1B0G724 A0A023EZJ9 A0A1Z5LDF4 A0A2R5LFZ2 A0A1B0AG95 A0A1A9V1T4 A0A293LE34 E1JJM8 C7LAB4 Q8IR79-3 H5V8E7 B3NXB5 Q8IR79-2 E1JJM7 A0A0Q5TKT9 Q8IR79 A0A444TPA7 A0A1J1HKS8
EC Number
2.7.11.1
Pubmed
19121390
26354079
22118469
24845553
20798317
28648823
+ More
29403074 21282665 30249741 24508170 21719571 21347285 17510324 20920257 23761445 18362917 19820115 25244985 20966253 25401762 26823975 28004739 12364791 23537049 20566863 25474469 28528879 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 11027607 12537569 14972681 15220930 15572110 15657426 17372656 17994087
29403074 21282665 30249741 24508170 21719571 21347285 17510324 20920257 23761445 18362917 19820115 25244985 20966253 25401762 26823975 28004739 12364791 23537049 20566863 25474469 28528879 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 11027607 12537569 14972681 15220930 15572110 15657426 17372656 17994087
EMBL
BABH01004170
BABH01004171
KQ460878
KPJ11649.1
NWSH01000261
PCG77914.1
+ More
PCG77915.1 KQ459582 KPI99005.1 ODYU01003737 SOQ42891.1 RSAL01000071 RVE49105.1 AGBW02007651 OWR55111.1 KK853054 KDR12013.1 NEVH01017447 PNF24439.1 GL440062 EFN66335.1 KQ435885 KOX69576.1 KZ288315 PBC28328.1 NNAY01000078 OXU31192.1 KQ434999 KZC13375.1 KQ414663 KOC65250.1 KQ977580 KYN01797.1 PYGN01000038 PSN56576.1 KQ982251 KYQ58825.1 GL765434 EFZ16326.1 LBMM01000393 KMQ98489.1 QOIP01000003 RLU24706.1 KK107182 EZA56015.1 GL888175 EGI66010.1 ADTU01004934 ADTU01004935 KQ976511 KYM82591.1 KQ980791 KYN13115.1 GL449898 EFN81853.1 KQ981856 KYN34683.1 GBRD01003024 JAG62797.1 CH477188 EAT48809.1 GGFK01001357 MBW34678.1 GGFJ01000759 MBW49900.1 GGFK01001397 MBW34718.1 ADMH02000706 ETN65274.1 GGFL01002627 MBW66805.1 GGFM01000751 MBW21502.1 DS231818 EDS41350.1 GBRD01003023 JAG62798.1 MWRG01014204 PRD24726.1 KQ971348 EFA05574.2 KK115121 KFM64221.1 LJIG01000709 KRT86231.1 GBHO01043383 GDHC01003345 JAG00221.1 JAQ15284.1 GBHO01032167 GDHC01003976 JAG11437.1 JAQ14653.1 GDRN01025352 GDRN01025350 JAI67723.1 GEZM01016960 GEZM01016959 JAV91010.1 GEZM01016958 JAV91013.1 GEZM01016956 JAV91014.1 APCN01002372 AXCN02002115 AAAB01008986 GDRN01025351 JAI67724.1 GDRN01025353 JAI67722.1 AXCM01003695 GEBQ01001862 JAT38115.1 KB632404 ERL95023.1 APGK01054674 KB741251 ENN71871.1 GECU01012375 JAS95331.1 GECU01032715 JAS74991.1 DS235237 EEB13730.1 UFQS01002480 UFQT01002480 SSX14137.1 SSX33553.1 CCAG010003762 GBBI01004035 JAC14677.1 GFJQ02001906 JAW05064.1 GGLE01004263 MBY08389.1 GFWV01001576 MAA26306.1 AE014298 ACZ95269.1 BT099664 ACV31092.1 AB042816 AB042818 AY119587 BT133248 AFB40593.1 CH954180 EDV47287.1 ACZ95268.1 KQS30438.1 SAUD01001261 RXG71852.1 CVRI01000009 CRK88664.1
PCG77915.1 KQ459582 KPI99005.1 ODYU01003737 SOQ42891.1 RSAL01000071 RVE49105.1 AGBW02007651 OWR55111.1 KK853054 KDR12013.1 NEVH01017447 PNF24439.1 GL440062 EFN66335.1 KQ435885 KOX69576.1 KZ288315 PBC28328.1 NNAY01000078 OXU31192.1 KQ434999 KZC13375.1 KQ414663 KOC65250.1 KQ977580 KYN01797.1 PYGN01000038 PSN56576.1 KQ982251 KYQ58825.1 GL765434 EFZ16326.1 LBMM01000393 KMQ98489.1 QOIP01000003 RLU24706.1 KK107182 EZA56015.1 GL888175 EGI66010.1 ADTU01004934 ADTU01004935 KQ976511 KYM82591.1 KQ980791 KYN13115.1 GL449898 EFN81853.1 KQ981856 KYN34683.1 GBRD01003024 JAG62797.1 CH477188 EAT48809.1 GGFK01001357 MBW34678.1 GGFJ01000759 MBW49900.1 GGFK01001397 MBW34718.1 ADMH02000706 ETN65274.1 GGFL01002627 MBW66805.1 GGFM01000751 MBW21502.1 DS231818 EDS41350.1 GBRD01003023 JAG62798.1 MWRG01014204 PRD24726.1 KQ971348 EFA05574.2 KK115121 KFM64221.1 LJIG01000709 KRT86231.1 GBHO01043383 GDHC01003345 JAG00221.1 JAQ15284.1 GBHO01032167 GDHC01003976 JAG11437.1 JAQ14653.1 GDRN01025352 GDRN01025350 JAI67723.1 GEZM01016960 GEZM01016959 JAV91010.1 GEZM01016958 JAV91013.1 GEZM01016956 JAV91014.1 APCN01002372 AXCN02002115 AAAB01008986 GDRN01025351 JAI67724.1 GDRN01025353 JAI67722.1 AXCM01003695 GEBQ01001862 JAT38115.1 KB632404 ERL95023.1 APGK01054674 KB741251 ENN71871.1 GECU01012375 JAS95331.1 GECU01032715 JAS74991.1 DS235237 EEB13730.1 UFQS01002480 UFQT01002480 SSX14137.1 SSX33553.1 CCAG010003762 GBBI01004035 JAC14677.1 GFJQ02001906 JAW05064.1 GGLE01004263 MBY08389.1 GFWV01001576 MAA26306.1 AE014298 ACZ95269.1 BT099664 ACV31092.1 AB042816 AB042818 AY119587 BT133248 AFB40593.1 CH954180 EDV47287.1 ACZ95268.1 KQS30438.1 SAUD01001261 RXG71852.1 CVRI01000009 CRK88664.1
Proteomes
UP000005204
UP000053240
UP000218220
UP000053268
UP000283053
UP000007151
+ More
UP000027135 UP000235965 UP000000311 UP000053105 UP000005203 UP000242457 UP000215335 UP000076502 UP000053825 UP000078542 UP000245037 UP000075809 UP000036403 UP000279307 UP000053097 UP000007755 UP000005205 UP000078540 UP000078492 UP000008237 UP000078541 UP000008820 UP000000673 UP000069272 UP000002320 UP000007266 UP000054359 UP000076408 UP000075882 UP000075920 UP000075880 UP000075881 UP000075840 UP000075885 UP000075886 UP000075900 UP000075884 UP000075883 UP000076407 UP000192223 UP000030742 UP000019118 UP000009046 UP000092444 UP000092445 UP000078200 UP000000803 UP000008711 UP000288706 UP000183832
UP000027135 UP000235965 UP000000311 UP000053105 UP000005203 UP000242457 UP000215335 UP000076502 UP000053825 UP000078542 UP000245037 UP000075809 UP000036403 UP000279307 UP000053097 UP000007755 UP000005205 UP000078540 UP000078492 UP000008237 UP000078541 UP000008820 UP000000673 UP000069272 UP000002320 UP000007266 UP000054359 UP000076408 UP000075882 UP000075920 UP000075880 UP000075881 UP000075840 UP000075885 UP000075886 UP000075900 UP000075884 UP000075883 UP000076407 UP000192223 UP000030742 UP000019118 UP000009046 UP000092444 UP000092445 UP000078200 UP000000803 UP000008711 UP000288706 UP000183832
Pfam
Interpro
IPR001781
Znf_LIM
+ More
IPR036034 PDZ_sf
IPR017441 Protein_kinase_ATP_BS
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001478 PDZ
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR018114 TRYPSIN_HIS
IPR001254 Trypsin_dom
IPR001314 Peptidase_S1A
IPR009003 Peptidase_S1_PA
IPR033116 TRYPSIN_SER
IPR041489 PDZ_6
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
IPR036034 PDZ_sf
IPR017441 Protein_kinase_ATP_BS
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001478 PDZ
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR018114 TRYPSIN_HIS
IPR001254 Trypsin_dom
IPR001314 Peptidase_S1A
IPR009003 Peptidase_S1_PA
IPR033116 TRYPSIN_SER
IPR041489 PDZ_6
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
Gene 3D
CDD
ProteinModelPortal
H9JTB6
A0A194R2A4
A0A2A4K1Y5
A0A2A4K0W2
A0A194Q6H6
A0A2H1VPW9
+ More
A0A437BFL2 A0A212FMY9 A0A067QT21 A0A2J7Q788 E2AJQ1 A0A0M8ZTC7 A0A088AE00 A0A2A3E9C7 A0A232FKK2 A0A154PNC8 A0A0L7R2Z4 A0A195CMV4 A0A2P8ZJ94 A0A151XER9 E9ISV3 A0A0J7L734 A0A3L8DWG7 A0A026WJ13 F4WI79 A0A158NZS3 A0A195BDE3 A0A151IXT7 E2BR47 A0A195F2J5 A0A0K8TB59 A0A1S4EV79 Q17PY5 A0A2M4A206 A0A2M4BA58 A0A2M4A243 W5JR92 A0A2M4CNF0 A0A182FPN1 A0A2M3YZ07 B0W0P8 A0A0K8TB73 A0A2P6KEH0 D2A3V3 A0A087TGI2 A0A0T6BH66 A0A182YJF6 A0A182L4F9 A0A182WEF6 A0A0A9VYG1 A0A0A9WSK4 A0A0P4WG81 A0A1Y1N295 A0A1Y1MZC7 A0A182IL97 A0A182K9C1 A0A1Y1MZE1 A0A182HH14 A0A182PC59 A0A182Q8M8 A0A453YZN9 A0A182R4B5 A0A182MXV1 A0A0P4WKM1 A0A0P4WIY5 A0A182M4A3 A0A182XKQ8 A0A1W4WSX5 A0A1B6MQF5 U4UR90 N6TU05 A0A1B6J824 A0A1B6HK26 E0VK24 A0A336LBI2 A0A1B0G724 A0A023EZJ9 A0A1Z5LDF4 A0A2R5LFZ2 A0A1B0AG95 A0A1A9V1T4 A0A293LE34 E1JJM8 C7LAB4 Q8IR79-3 H5V8E7 B3NXB5 Q8IR79-2 E1JJM7 A0A0Q5TKT9 Q8IR79 A0A444TPA7 A0A1J1HKS8
A0A437BFL2 A0A212FMY9 A0A067QT21 A0A2J7Q788 E2AJQ1 A0A0M8ZTC7 A0A088AE00 A0A2A3E9C7 A0A232FKK2 A0A154PNC8 A0A0L7R2Z4 A0A195CMV4 A0A2P8ZJ94 A0A151XER9 E9ISV3 A0A0J7L734 A0A3L8DWG7 A0A026WJ13 F4WI79 A0A158NZS3 A0A195BDE3 A0A151IXT7 E2BR47 A0A195F2J5 A0A0K8TB59 A0A1S4EV79 Q17PY5 A0A2M4A206 A0A2M4BA58 A0A2M4A243 W5JR92 A0A2M4CNF0 A0A182FPN1 A0A2M3YZ07 B0W0P8 A0A0K8TB73 A0A2P6KEH0 D2A3V3 A0A087TGI2 A0A0T6BH66 A0A182YJF6 A0A182L4F9 A0A182WEF6 A0A0A9VYG1 A0A0A9WSK4 A0A0P4WG81 A0A1Y1N295 A0A1Y1MZC7 A0A182IL97 A0A182K9C1 A0A1Y1MZE1 A0A182HH14 A0A182PC59 A0A182Q8M8 A0A453YZN9 A0A182R4B5 A0A182MXV1 A0A0P4WKM1 A0A0P4WIY5 A0A182M4A3 A0A182XKQ8 A0A1W4WSX5 A0A1B6MQF5 U4UR90 N6TU05 A0A1B6J824 A0A1B6HK26 E0VK24 A0A336LBI2 A0A1B0G724 A0A023EZJ9 A0A1Z5LDF4 A0A2R5LFZ2 A0A1B0AG95 A0A1A9V1T4 A0A293LE34 E1JJM8 C7LAB4 Q8IR79-3 H5V8E7 B3NXB5 Q8IR79-2 E1JJM7 A0A0Q5TKT9 Q8IR79 A0A444TPA7 A0A1J1HKS8
PDB
5NXC
E-value=1.40527e-14,
Score=188
Ontologies
GO
GO:0046872
GO:0004672
GO:0005524
GO:0004252
GO:0006644
GO:0005576
GO:0050482
GO:0004623
GO:0005737
GO:0030036
GO:0005634
GO:0004674
GO:0016021
GO:0004715
GO:0004709
GO:0001736
GO:0051124
GO:0048749
GO:0006468
GO:0050770
GO:0048477
GO:0007416
GO:0001737
GO:0032154
GO:0030496
GO:0007560
GO:0015074
GO:0006418
GO:0000049
GO:0016876
Topology
Subcellular location
Secreted
Cytoplasm
Cleavage furrow
Midbody
Cytoplasm
Cleavage furrow
Midbody
Length:
165
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00075
Exp number, first 60 AAs:
0
Total prob of N-in:
0.24894
outside
1 - 165
Population Genetic Test Statistics
Pi
191.98436
Theta
144.594727
Tajima's D
1.194375
CLR
0.002826
CSRT
0.709364531773411
Interpretation
Uncertain
