Gene

KWMTBOMO09418

Pre Gene Modal

BGIBMGA013084

Annotation

PREDICTED:_cell_division_control_protein_45_homolog_[Papilio_machaon]

Location

Bomo_Chr16(-):953621-973306      View in EpiBrowser

Full name

Cell division control protein 45 homolog      

Alternative Name

PORC-PI-1

Location in the cell

Cytoplasmic   Reliability : 1.292 PlasmaMembrane   Reliability : 1.157

CDS

ATGTTTATAGAGGACCTCAGAAATGACTTTTACAATCTCCTTTTAGGCAATCGCGTGTTATTATTAGTGCATTATGATGTAGATGCAATATGTACATGTAAAATACTTCAAGGATTATTCAAGAGTGATAATATATCATATACGCTAGTGCCGGTGGGGGGTATTTCTGAATTGAAGACTGCTTACGAAGAAAACAATGAAGAAGTCAAGTACGTAGTGTTGGTGAACTGCGGAGGTACTATAGACCTGGTCGATATCTTACAGCCCGAGGAGGATGTGGTATTTTTTGTGCTGGACTCCCATAAACCGACTGATGTCTGCAATGTTTATAGCGATGGACAGGTGAGACTGGTGTACCGTGATGAAGAAGAGAACATTCCTAATTTTGATGATATATTCAGAGATGATGATGATGAGAACGAAGAAGAAATGCCAAGTGGTCGAGAAGACCTAGAAGCTTTTGTCGAGAGACGGCGTCAACGTAGAGAATGGGAAACAAAACGAAACGATCTTATGTTTAACTACACTCAATTCTCATATTATGGTAAACCGAGTGCTTGCATAGCAGTAGAGCTGGCCTGGCTGCTATGTCGCAGCGGAGTGGAGTACACGTGGGCCGGATGCATAGCTGTCAGTGCGTATGCTGCCACTCACACACGCTCCCCTGCACAAGCTCTGCTTGATGCACATGCGCTGCATCGACATCTCGCCGCGCAACTACCTTCACATGGTGCTTCAGTAAGCATGGAAAAGGATGCGTTCCTGCCACTCTACCGGACCTGGTCTTTGGAGAATGCGTTGAAGTATTCTCCAGTTGTGGCTCCTCATCTTCGTCTTCATTCACTGGCTGGTGCTGACAGATTGAGGCAGCTATTGGCAGATATGGGGATCCCGCTGCAGCAGGCCCGCCAGGCCTACCGCTCCATGGACGTGGAGCTGCGGCGCTCGCTGCTGGACGCGCTGGACGCCGCCGCCGACAAGCACCACCTGCCGCGCCTCACGCACGCCACCTACCTCCTGCGCCGCGACCACTGCGCGCCGCTCGCCGCACTCGACTGCGTCTACTGCGTCATGGCGCTGCTCGAGCTCGAAGGCCCCGGCGGGTTCCAGCTGGCGCTGGCGTCGGTGGACACGTCGAGCGCGGAGTGCGAGGCCCGGCAGCGCGGGCTGGGCGCGGCGCGGCGCGGGCTGGCGGCGGCGGCGGCGCTGGCGGGCGCCACGCTGGCGGCGCGCGCGCTGCACCACGCCGGGCCCTTCGCGCACTTCACCATCAGCGAGGGCGCGGCGGAGTGCGAGTGGGGTCCGTGGTGGCTGGCGGTGTGCGCGCGGTGGGTGGGCGCGGGCGCGGGGCGGGGGGCGGCCGCCGTGCTGGTGGCGGCGCCCCGGGGCCGCACCGTGCTGCTGTGCGGGGTGCCGCCGCCGCAGCGGACTGACACCAGGAATCTGTTCGGGGCGGCGTTCGAGCAGGCGGCGGCCAAGTGCGGCGCCTCCGTGTCGCTCGACCACTTCGACTCCGCCGTGGTGACGCTGCCCGCCGCGCAGCGCCCGCAGTTCCTGGACGCGCTCACCGCGCTGCTGGCCTGA

Protein

MFIEDLRNDFYNLLLGNRVLLLVHYDVDAICTCKILQGLFKSDNISYTLVPVGGISELKTAYEENNEEVKYVVLVNCGGTIDLVDILQPEEDVVFFVLDSHKPTDVCNVYSDGQVRLVYRDEEENIPNFDDIFRDDDDENEEEMPSGREDLEAFVERRRQRREWETKRNDLMFNYTQFSYYGKPSACIAVELAWLLCRSGVEYTWAGCIAVSAYAATHTRSPAQALLDAHALHRHLAAQLPSHGASVSMEKDAFLPLYRTWSLENALKYSPVVAPHLRLHSLAGADRLRQLLADMGIPLQQARQAYRSMDVELRRSLLDALDAAADKHHLPRLTHATYLLRRDHCAPLAALDCVYCVMALLELEGPGGFQLALASVDTSSAECEARQRGLGAARRGLAAAAALAGATLAARALHHAGPFAHFTISEGAAECEWGPWWLAVCARWVGAGAGRGAAAVLVAAPRGRTVLLCGVPPPQRTDTRNLFGAAFEQAAAKCGASVSLDHFDSAVVTLPAAQRPQFLDALTALLA

Subunit

Associated with ORC2. Interacts with HELB.
Associated with ORC2. Interacts with HELB (PubMed:25933514).

Similarity

Belongs to the CDC45 family.

Keywords

Cell cycle   Complete proteome   DNA replication   Nucleus   Phosphoprotein   Reference proteome   3D-structure   Alternative splicing   Cytoplasm   Disease mutation   Dwarfism   Polymorphism  

Feature

chain  Cell division control protein 45 homolog
splice variant  In isoform 2.
sequence variant  In MGORS7; decreased protein level; dbSNP:rs879255633.

Uniprot

H9JU72   A0A2H1VKQ4   A0A2A4K7M8   A0A194Q1R9   A0A194RVZ2   T1HHG2   + More
A0A023F0J3   A0A067R9J8   A0A2R7WKB3   A0A224XN74   A0A2J7RBG6   A0A1Y1LJK7   A0A2S2R8N5   A0A1W4X9Z5   A0A1B6K275   A0A2S2NN53   A0A182GR65   A0A2H8TQS0   A0A232FJQ4   A0A1Y1LES8   J9K5U7   Q16EN6   A0A026VYI2   A0A182Y9K9   A0A3L8DQJ9   A0A0M9AAS8   E2BK22   Q170F3   A0A0C9QZG8   A0A182M445   A0A1B0CPX3   J9K7X0   A0A195BKW3   A0A154PU39   A0A2S2PQW2   A0A158P3W2   A0A1B0D3Z1   F4WKV8   A0A310SCM5   A0A087ZR06   D2A4C4   A0A151WV55   A0A336L5R6   A0A1A9WVN8   A0A1B0BDI7   A0A1A9ZKR9   A0A2H8TX98   A0A0L7QLB8   A0A182Q3S6   A0A2A3E1X5   A0A1A9YME8   A0A3R7M7E1   E1BYS7   A0A2U4ALI7   R7VUU8   A0A3Q2UBE9   H0ZDT9   A0A182FV47   A0A087V099   A0A341CYT0   A4FV47   A0A2Y9FDE4   A0A384BAJ1   A0A3Q7VW59   H9GZX0   Q3UI99   Q9Z1X9   A0A0A9YQW4   K7GSB7   F1MQQ0   Q5E9W1   A0A1U7TNB8   A0A3Q7U1N8   A0A061I7M6   Q4U3P7   G3QNC9   A0A2R9A6H4   A0A2Y9LBD2   A0A2Y9H4H2   A0A2U3YXH3   O75419   A0A3P4LWF5   A0A2I2Y746   A0A2R9A140   L8I6K2   A0A3Q7MZ45   K7A671   A0A2K5IJU4   B4GTR9   A0A2K6SB67   F7IIN6   A0A2Y9J0S9   A0A2K6P4W2  

Pubmed

19121390    26354079    25474469    24845553    28004739    26483478    + More
28648823    17510324    24508170    25244985    30249741    20798317    21347285    21719571    18362917    19820115    15592404    23371554    20360741    19393038    19892987    10349636    11042159    11076861    11217851    12466851    12040188    16141073    21183079    9724329    10051334    15489334    25401762    26823975    30723633    11282978    16305752    23929341    15753125    22398555    22722832    9755170    9660782    12975309    14702039    15461802    10591208    18669648    21269460    22814378    25933514    27374770    22751099    17994087    25362486   

EMBL

BABH01004178    BABH01004179    BABH01004180    BABH01004181    BABH01004182    BABH01004183    + More
BABH01004184    BABH01004185    BABH01004186    ODYU01003090    SOQ41403.1    NWSH01000086    PCG79773.1    KQ459582    KPI98939.1    KQ459700    KPJ20356.1    ACPB03009329    GBBI01003715    JAC14997.1    KK852802    KDR16293.1    KK854801    PTY18855.1    GFTR01006955    JAW09471.1    NEVH01005904    PNF38168.1    GEZM01057716    JAV72125.1    GGMS01017183    MBY86386.1    GECU01002162    JAT05545.1    GGMR01005577    MBY18196.1    JXUM01081860    KQ563273    KXJ74145.1    GFXV01004157    MBW15962.1    NNAY01000122    OXU30770.1    GEZM01057717    JAV72124.1    ABLF02024971    CH478641    EAT32693.1    KK107570    EZA48863.1    QOIP01000005    RLU22661.1    KQ435709    KOX80006.1    GL448740    EFN83930.1    CH477475    EAT40319.1    GBYB01006107    JAG75874.1    AXCM01007581    AJWK01022752    AJWK01022753    ABLF02039328    KQ976453    KYM85317.1    KQ435134    KZC14878.1    GGMR01019176    MBY31795.1    ADTU01008602    AJVK01023820    AJVK01023821    GL888206    EGI65200.1    KQ777667    OAD52067.1    KQ971348    EFA05648.1    KQ982708    KYQ51812.1    UFQS01001695    UFQT01001695    SSX11889.1    SSX31451.1    JXJN01012503    GFXV01007061    MBW18866.1    KQ414924    KOC59400.1    AXCN02001081    KZ288442    PBC25700.1    QCYY01001827    ROT74957.1    AADN05000505    KB376592    AKCR02000030    EMC88936.1    PKK25989.1    ABQF01029280    KK122584    KFM83038.1    BC123732    AAI23733.1    AK147013    CH466521    BAE27607.1    EDK97534.1    AF098068    AJ223729    AF081536    AF081537    AF081538    AF081539    BC028635    GBHO01011684    GDHC01021402    JAG31920.1    JAP97226.1    AEMK02000096    DQIR01245662    DQIR01259016    HDC01140.1    HDC14494.1    BT020809    AAX08826.1    KE674677    ERE76198.1    DQ016322    AAY41172.1    CABD030119964    CABD030119965    CABD030119966    CABD030119967    AJFE02045136    AJFE02045137    AF062495    AF053074    AJ223728    AF081535    AY358971    AK293123    AK293338    BT006792    AY572790    CT841513    AC000082    AC000087    AC000088    CH471176    BC006232    BC010022    CYRY02003558    VCW68172.1    JH882094    ELR50902.1    GABC01007453    GABF01008944    GABD01005361    GABE01003596    NBAG03000088    JAA03885.1    JAA13201.1    JAA27739.1    JAA41143.1    PNI90392.1    PNI90396.1    CH479190    EDW25939.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000015103    UP000027135    + More
UP000235965    UP000192223    UP000069940    UP000249989    UP000215335    UP000007819    UP000008820    UP000053097    UP000076408    UP000279307    UP000053105    UP000008237    UP000075883    UP000092461    UP000078540    UP000076502    UP000005205    UP000092462    UP000007755    UP000005203    UP000007266    UP000075809    UP000091820    UP000092460    UP000092445    UP000053825    UP000075886    UP000242457    UP000092443    UP000283509    UP000000539    UP000245320    UP000053872    UP000007754    UP000069272    UP000054359    UP000252040    UP000009136    UP000248484    UP000261681    UP000286642    UP000002281    UP000000589    UP000008227    UP000189704    UP000030759    UP000001519    UP000240080    UP000248483    UP000248481    UP000245341    UP000005640    UP000286641    UP000233080    UP000008744    UP000233220    UP000008225    UP000248482    UP000233200   

PRIDE

H9JU72    Q16EN6    Q9Z1X9    Q4U3P7    O75419   

Pfam

PF02724   CDC45        + More
PF01612   DNA_pol_A_exo1
PF01712   dNK

Interpro

IPR038763   DHH_sf        + More
IPR003874   CDC45       
IPR036397   RNaseH_sf       
IPR031314   DNK_dom       
IPR027417   P-loop_NTPase       
IPR012337   RNaseH-like_sf       
IPR002562   3'-5'_exonuclease_dom       

SUPFAM

SSF64182   SSF64182        + More
SSF52540   SSF52540       
SSF53098   SSF53098       

Gene 3D

3.30.420.10    

ProteinModelPortal

H9JU72   A0A2H1VKQ4   A0A2A4K7M8   A0A194Q1R9   A0A194RVZ2   T1HHG2   + More
A0A023F0J3   A0A067R9J8   A0A2R7WKB3   A0A224XN74   A0A2J7RBG6   A0A1Y1LJK7   A0A2S2R8N5   A0A1W4X9Z5   A0A1B6K275   A0A2S2NN53   A0A182GR65   A0A2H8TQS0   A0A232FJQ4   A0A1Y1LES8   J9K5U7   Q16EN6   A0A026VYI2   A0A182Y9K9   A0A3L8DQJ9   A0A0M9AAS8   E2BK22   Q170F3   A0A0C9QZG8   A0A182M445   A0A1B0CPX3   J9K7X0   A0A195BKW3   A0A154PU39   A0A2S2PQW2   A0A158P3W2   A0A1B0D3Z1   F4WKV8   A0A310SCM5   A0A087ZR06   D2A4C4   A0A151WV55   A0A336L5R6   A0A1A9WVN8   A0A1B0BDI7   A0A1A9ZKR9   A0A2H8TX98   A0A0L7QLB8   A0A182Q3S6   A0A2A3E1X5   A0A1A9YME8   A0A3R7M7E1   E1BYS7   A0A2U4ALI7   R7VUU8   A0A3Q2UBE9   H0ZDT9   A0A182FV47   A0A087V099   A0A341CYT0   A4FV47   A0A2Y9FDE4   A0A384BAJ1   A0A3Q7VW59   H9GZX0   Q3UI99   Q9Z1X9   A0A0A9YQW4   K7GSB7   F1MQQ0   Q5E9W1   A0A1U7TNB8   A0A3Q7U1N8   A0A061I7M6   Q4U3P7   G3QNC9   A0A2R9A6H4   A0A2Y9LBD2   A0A2Y9H4H2   A0A2U3YXH3   O75419   A0A3P4LWF5   A0A2I2Y746   A0A2R9A140   L8I6K2   A0A3Q7MZ45   K7A671   A0A2K5IJU4   B4GTR9   A0A2K6SB67   F7IIN6   A0A2Y9J0S9   A0A2K6P4W2  

PDB

5DGO     E-value=6.57939e-46,     Score=465

KEGG

101746151    K06628 cell division control protein 45 | (RefSeq) cell division control protein 45 homolog

GO

GO:0006270   GO:0051301   GO:0016021   GO:0003676   GO:0008408   GO:0005656   GO:0000727   GO:0003688   GO:0003682   GO:0031938   GO:1900087   GO:0003697   GO:0043138   GO:1902977   GO:0031261   GO:0031298   GO:0005813   GO:0005634   GO:0005654   GO:0000076   GO:0005737   GO:0006260   GO:0000082   GO:0000083   GO:0006277   GO:0030261   GO:0006508   GO:0015074   GO:0004672   GO:0005524   GO:0006468   GO:0006418   GO:0000049   GO:0016876  

PANTHER

PTHR10507  

Subcellular location

Nucleus  
Cytoplasm  

Length:

527

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13329

Exp number, first 60 AAs:

0.0199

Total prob of N-in:

0.00328

outside

1  -  527

 

 

Pi

168.502424

Theta

146.5509

Tajima's D

0.978797

CLR

1.14748

CSRT

0.647667616619169

Interpretation

Uncertain