Gene

KWMTBOMO09415  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012772

Annotation

PREDICTED:_ATP-dependent_RNA_helicase_WM6_[Amyelois_transitella]

Location

Bomo_Chr16(+):937827-939320      View in EpiBrowser

Full name

ATP-dependent RNA helicase WM6      

Alternative Name

HEL/UAP56

Location in the cell

Nuclear   Reliability : 2.74

CDS

ATGGCTGACAACGACGATCTTCTCGACTACGAAGATGAAGAACAAGCAGATCAACAGACTGCTGACGGGTCTACCGAAGTGGCGCCAAAGAAGGAGGTTAAAGGATCCTACGTATCCATCCACAGTTCTGGTTTTAGAGACTTCTTACTTAAGCCAGAGATACTCCGCGCTATTGTTGATTGCGGTTTTGAGCATCCTTCCGAAGTTCAACACGAATGCATTCCGCAAGCCGTCCTCGGTATGGACATACTTTGCCAAGCCAAGTCCGGTATGGGTAAGACAGCCGTGTTTGTTTTGGCAACATTGCAGCAGCTGGAACCCTCCGAGAGCCACGTTTACGTGCTTGTAATGTGCCACACCAGAGAGTTGGCTTTCCAAATAAGTAAGGAGTACGAGCGTTTCTCGAAATATATGTCAGGAGTCAGAGTATCAGTATTCTTTGGTGGTATGCCAATTCAGAAAGACGAGGAAGTCCTTAAGACAGCATGTCCTCACATTGTAGTGGGAACTCCCGGTAGAATTTTGGCATTAGTAAACAGTAAGAAACTTAATTTGAAACATTTAAAACACTTCATCCTTGATGAGTGTGATAAGATGCTGGAATCTCTAGACATGAGGCGAGATGTGCAGGAGATATTCCGGAACACTCCTCACGGGAAACAGGTGATGATGTTCTCAGCCACATTGAGTAAAGAAATCAGACCTGTGTGTAAGAAATTTATGCAAGACCCAATGGAAGTTTATGTAGATGATGAAGCCAAACTCAAGCTACATGGACTGCAGCAACATTATGTGAAACTAAAAGAAAATGAGAAGAATAAAAAACTCTTCGAACTACTTGATGTATTGGAGTTCAATCAGGTGGTTATTTTTGTGAAATCAGTACAGCGCTGCATAGCTCTGGCACAACTGCTCACCGACCAAAACTTCCCTGCCATTGGTATCCACAGAAATATGACCCAGGATGAGCGTCTCTCCCGCTATCAACAGTTCAAGGACTTCCAAAAAAGGATCCTGGTTGCAACAAATTTGTTTGGCCGGGGAATGGACATTGAAAGGGTAAATATTGTCTTCAACTATGACATGCCTGAAGATTCAGATACATATCTACATCGTGTCGCCCGCGCAGGAAGGTTTGGTACCAAAGGTCTGGCCATTACTATGATATCTGATGAAAATGATGCCAAGATCTTAAACCAAGTACAAGATCGTTTCGATGTGAACATTACAGAGCTGCCTGAAGAAATTGAGCTCTCTACCTACATCGAAGGACGATAG

Protein

MADNDDLLDYEDEEQADQQTADGSTEVAPKKEVKGSYVSIHSSGFRDFLLKPEILRAIVDCGFEHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSESHVYVLVMCHTRELAFQISKEYERFSKYMSGVRVSVFFGGMPIQKDEEVLKTACPHIVVGTPGRILALVNSKKLNLKHLKHFILDECDKMLESLDMRRDVQEIFRNTPHGKQVMMFSATLSKEIRPVCKKFMQDPMEVYVDDEAKLKLHGLQQHYVKLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCIALAQLLTDQNFPAIGIHRNMTQDERLSRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITMISDENDAKILNQVQDRFDVNITELPEEIELSTYIEGR

Description

Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Component of the spliceosome (Probable). Interacts with the exon junction complex.

Similarity

Belongs to the DEAD box helicase family. DECD subfamily.
Belongs to the glycosyl hydrolase 18 family.

Keywords

ATP-binding   Complete proteome   Helicase   Hydrolase   mRNA processing   mRNA splicing   Nucleotide-binding   Nucleus   Reference proteome   RNA-binding   Spliceosome  

Feature

chain  ATP-dependent RNA helicase WM6

Uniprot

H9JTB0   S4NNL7   A0A2A4K6S1   A0A2H1VKS8   A0A194RSI8   I4DJM2   + More
A0A212FM47   A0A1L8DRS1   K7J0K7   A0A2J7RMJ1   A0A067RV07   V9IIX6   A0A411G6H1   T1PBI2   B4LU13   B4KF36   A0A0M5J9L8   Q1HR75   B4P055   A0A158NA44   B3N4X2   A0A026VV72   A0A1Q3EYG3   U5EWP6   A0A1I8PD82   B0X3U8   W8BPM9   A0A0K8TZP5   A0A034WST2   Q8MYL5   A0A0A1XR85   A0A336M0V1   A0A1W4UXM1   T1EA73   A0A1J1IN60   A0A1Y1M1K1   A0A182MDS0   A0A182R6H4   B4I1H2   B4NRX8   Q27268   D6WLU7   A0A182WH84   E2AH52   A0A0P6IZC8   A0A2M3Z1P2   A0A2M4BPB1   W5JTU8   A0A154PNY9   A0A1A9X652   A0A1A9VTL9   A0A1B0AS58   B3MMZ5   B4JAF3   A0A1B0A5V8   J3JZ95   A0A1W4WKZ6   A0A1A9X0P8   A0A182V770   A0A182YFG3   A0A1S4H010   B4MWD1   A0A182I4W6   A0A182PDF8   A0A182JUC4   A0A182UA76   A0A182X2Y9   A0A182R9S6   V5I9W2   A0A0N0BED2   A0A0L0C8Z1   K7J0K9   A0A182M9L9   A0A182QFS2   A0A182NF91   A0A084VY69   Q29NU1   A0A195CV96   E9IXM7   A2I858   A0A195DLS0   F4X1F1   A0A3B0KAV0   A0A195BKD3   A0A336LYS3   A0A2D1QUG1   A0A182KUT1   A0A1B6CLH7   A0A1D2MQE0   A0A1B6HLK6   A0A0A9YR59   A0A1B0FEQ7   A0A0L7RFR5   D3PGA2   A0A384DT24   A0A423TBN8   A0A452TBZ9   G1M447   A0A384A4F9   G1PDC3  

EC Number

3.6.4.13

Pubmed

19121390    23622113    26354079    22651552    22118469    20075255    + More
24845553    25315136    17994087    17204158    17510324    17550304    21347285    24508170    30249741    24495485    25348373    12015125    25830018    28004739    22936249    7808417    9215899    10731132    12537572    12537569    11696332    12743041    18362917    19820115    20798317    20920257    23761445    22516182    23537049    25244985    12364791    26108605    24438588    15632085    21282665    17519023    21719571    20966253    27289101    25401762    24813606    20010809    21993624   

EMBL

BABH01004187    GAIX01013881    JAA78679.1    NWSH01000086    PCG79769.1    ODYU01003090    + More
SOQ41406.1    KQ459700    KPJ20359.1    AK401490    KQ459582    BAM18112.1    KPI98942.1    AGBW02007654    OWR54828.1    GFDF01004908    JAV09176.1    NEVH01002553    PNF42055.1    KK852451    KDR23694.1    JR047589    AEY60451.1    MH365681    QBB01490.1    KA646126    AFP60755.1    CH940649    EDW65066.1    CH933807    EDW13019.1    CP012523    ALC40118.1    DQ440219    CH477210    ABF18252.1    EAT47701.1    CM000157    EDW88920.1    ADTU01009963    CH954177    EDV57874.1    KK107796    QOIP01000013    EZA47627.1    RLU15501.1    GFDL01014702    JAV20343.1    GANO01001323    JAB58548.1    DS232322    EDS40025.1    GAMC01003400    JAC03156.1    GDHF01032350    JAI19964.1    GAKP01001732    JAC57220.1    AJ428513    CAD21558.1    GBXI01000902    JAD13390.1    UFQT01000295    SSX22951.1    GAMD01000687    JAB00904.1    CVRI01000055    CRL01600.1    GEZM01044472    JAV78195.1    AXCM01003231    CH480820    EDW54379.1    CH981625    CM002910    EDX15356.1    KMY88313.1    X79802    L06018    AE014134    AY118921    KQ971343    EFA04166.1    GL439483    EFN67169.1    GDIQ01002134    JAN92603.1    GGFM01001701    MBW22452.1    GGFJ01005640    MBW54781.1    ADMH02000504    ETN66174.1    KQ435007    KZC13579.1    JXJN01002673    CH902620    EDV31020.1    CH916368    EDW03824.1    APGK01051866    BT128576    KB741207    KB632327    AEE63533.1    ENN72901.1    ERL92518.1    AAAB01008984    CH963857    EDW76001.1    APCN01003737    GALX01002240    JAB66226.1    KQ435830    KOX71742.1    JRES01000736    KNC28883.1    AXCM01001875    AXCN02000824    ATLV01018323    KE525231    KFB42913.1    CH379058    EAL34553.2    KQ977276    KYN04462.1    GL766762    EFZ14680.1    EF173367    ABM68586.1    KQ980734    KYN13791.1    GL888529    EGI59746.1    OUUW01000006    SPP82171.1    KQ976455    KYM85108.1    SSX22950.1    KY285064    ATP16167.1    GEDC01022971    GEDC01003436    JAS14327.1    JAS33862.1    LJIJ01000685    ODM95320.1    GECU01032251    JAS75455.1    GBHO01008920    GBRD01011920    JAG34684.1    JAG53904.1    CCAG010014746    KQ414598    KOC69827.1    BT120658    BT121851    HACA01004213    ADD24298.1    ADD38781.1    CDW21574.1    QCYY01001978    ROT73866.1    ACTA01049948    AAPE02040635   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000002358    + More
UP000235965    UP000027135    UP000095301    UP000008792    UP000009192    UP000092553    UP000008820    UP000002282    UP000005205    UP000008711    UP000053097    UP000279307    UP000095300    UP000002320    UP000192221    UP000183832    UP000075883    UP000075900    UP000001292    UP000000304    UP000000803    UP000007266    UP000075920    UP000000311    UP000000673    UP000076502    UP000092443    UP000078200    UP000092460    UP000007801    UP000001070    UP000092445    UP000019118    UP000030742    UP000192223    UP000091820    UP000075903    UP000076408    UP000007798    UP000075840    UP000075885    UP000075881    UP000075902    UP000076407    UP000053105    UP000037069    UP000075886    UP000075884    UP000030765    UP000001819    UP000078542    UP000078492    UP000007755    UP000268350    UP000078540    UP000075882    UP000094527    UP000092444    UP000053825    UP000261680    UP000291021    UP000283509    UP000008912    UP000261681    UP000001074   

PRIDE

H9JTB0    Q27268   

Pfam

PF00270   DEAD        + More
PF00271   Helicase_C
PF00704   Glyco_hydro_18

Interpro

IPR014014   RNA_helicase_DEAD_Q_motif        + More
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR001650   Helicase_C       
IPR014001   Helicase_ATP-bd       
IPR027417   P-loop_NTPase       
IPR017853   Glycoside_hydrolase_SF       
IPR011583   Chitinase_II       
IPR029070   Chitinase_insertion_sf       
IPR001223   Glyco_hydro18_cat       

SUPFAM

SSF52540   SSF52540        + More
SSF51445   SSF51445       

Gene 3D

3.10.50.10    

CDD

cd00079  HELICc

ProteinModelPortal

H9JTB0   S4NNL7   A0A2A4K6S1   A0A2H1VKS8   A0A194RSI8   I4DJM2   + More
A0A212FM47   A0A1L8DRS1   K7J0K7   A0A2J7RMJ1   A0A067RV07   V9IIX6   A0A411G6H1   T1PBI2   B4LU13   B4KF36   A0A0M5J9L8   Q1HR75   B4P055   A0A158NA44   B3N4X2   A0A026VV72   A0A1Q3EYG3   U5EWP6   A0A1I8PD82   B0X3U8   W8BPM9   A0A0K8TZP5   A0A034WST2   Q8MYL5   A0A0A1XR85   A0A336M0V1   A0A1W4UXM1   T1EA73   A0A1J1IN60   A0A1Y1M1K1   A0A182MDS0   A0A182R6H4   B4I1H2   B4NRX8   Q27268   D6WLU7   A0A182WH84   E2AH52   A0A0P6IZC8   A0A2M3Z1P2   A0A2M4BPB1   W5JTU8   A0A154PNY9   A0A1A9X652   A0A1A9VTL9   A0A1B0AS58   B3MMZ5   B4JAF3   A0A1B0A5V8   J3JZ95   A0A1W4WKZ6   A0A1A9X0P8   A0A182V770   A0A182YFG3   A0A1S4H010   B4MWD1   A0A182I4W6   A0A182PDF8   A0A182JUC4   A0A182UA76   A0A182X2Y9   A0A182R9S6   V5I9W2   A0A0N0BED2   A0A0L0C8Z1   K7J0K9   A0A182M9L9   A0A182QFS2   A0A182NF91   A0A084VY69   Q29NU1   A0A195CV96   E9IXM7   A2I858   A0A195DLS0   F4X1F1   A0A3B0KAV0   A0A195BKD3   A0A336LYS3   A0A2D1QUG1   A0A182KUT1   A0A1B6CLH7   A0A1D2MQE0   A0A1B6HLK6   A0A0A9YR59   A0A1B0FEQ7   A0A0L7RFR5   D3PGA2   A0A384DT24   A0A423TBN8   A0A452TBZ9   G1M447   A0A384A4F9   G1PDC3  

PDB

1XTI     E-value=5.6586e-180,     Score=1620

KEGG

101741115    K12812 ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13] | (RefSeq) ATP-dependent RNA helicase WM6

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)
03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)
03040    Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0003676   GO:0004386   GO:0000381   GO:0005634   GO:0006406   GO:0005700   GO:0006338   GO:0004004   GO:0003723   GO:0016607   GO:0000346   GO:0000398   GO:0005681   GO:0008061   GO:0005975   GO:0042802   GO:0005737   GO:0006508   GO:0015074   GO:0004672   GO:0006468   GO:0006418   GO:0000049   GO:0016876  

Subcellular location

Nucleus speckle  

Length:

425

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00249

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00492

outside

1  -  425

 

 

Pi

146.851338

Theta

130.412303

Tajima's D

-0.651738

CLR

1.301359

CSRT

0.205689715514224

Interpretation

Uncertain