Gene

KWMTBOMO09414

Pre Gene Modal

BGIBMGA012771

Annotation

PREDICTED:_nucleoredoxin-like_[Bombyx_mori]

Location

Bomo_Chr16(+):887637-930648      View in EpiBrowser

Full name

Nucleoredoxin      

Location in the cell

Cytoplasmic   Reliability : 1.714

CDS

ATGGATTGGCGCGAAAAACTTTTCGGTAAAGTGCTCGTGAAATGCGAATCAGTGTCACAGGGTGGCCAATATGACAACGTGCCGACAGTAGAAGCTTTGAATGATTGTGTGGAGGCAGGCGAAGGTGCTGTGTGCGGTATTTACTTTTCTTTCGCGAACATTAGCGATAATAGTGACGATTTTGGTCTGCGTTTAGAGGAGATTCATAGACGAGTACACCCGCGGCTGCAAGTTGTTCAAGTTGTGTTGTGGGCTCATGTCGGTACACCTGAAGGTCCGGTGGAGAGAGAGGCTGGTTTCTACAAGAGTCTGATGGGAAAGCCGTGGTTTGCTGTGCCCTATCATGATGTGGACATAAAGCGCCGTCTGACCCAAAAATACAGCATAGCAGTAGGAGTACCCACTCTAGTCATACGCGGGAGACCAGTAAGAGACGCTCTGTTGGAAGATCCGCTGGGCGAAAGGTTTCCATGGCCTGCTCCACCTTTAACGGAAGTCCTCAGAGGAATTCAGCTTCAAGGTGAAGGGGAAACGAAGCTGTATGAGGATCTGCCTGGAGATGCCTTGAGAGTATTCTATTTTGCTGCTCATTGGTGTCCCCCATGTCGGACGTTCGCTCCGAGCCTCTGCGCGGCGCTGTCAGCAGTACGCAAGCGGCGTGCGAAATACGCCAACACGCAGCTCATAATCGTATCCAGTGACAGAAGCGAGCAGTCGTATAATCGCACCGTGCAGTCTGTTGCCGCGGCCAACGCTTTGGCTGTCCCGTGGAGCGCTGCCGAGGCGCGGGGAGCCTTGCCCACAGCCCTGGGAGTCGCCGGTATACCCGCCCTGGTCATAGCAAACGGTGATGGTACCGTGCTCACCACGAACGGCAGGCAAAAACTTGCTGCCGATCCCACTGGCTTGAACTTTCCGTGGTCCCAGAGACCTCTTTCAGTGTTGACTGAACAAGCTCTCCTAAAGATGGCCAGACACCCGGCCATAGTTTTGTTTGTGGATGACGAAGATTCCGAAATAGAATTCGCCGAATCGGTACTAACGCCGGCCGCGGAGTCGTACTACGAGGAATGCAGCATCCAATACCCTGGATTCTGCCCGCACCAGAGCTCTTCGGACGACGAGACCCTTGACTTCGACTACCCGCCCAGGAAATCCAAGAAGCGACCGTTCAAACACGTCATGTTCTACGTCGGCGTGGACGGCACAGACACCGCGGACATGCTGAGAGAGCACATCTGCTTAGATGACGCGGTGCCACTGCTCACAGCCATCGACTTCCCGAAGCAACGGATGTTCACCATGAAGTACGGCGATGAGATAACCACGCACTCGGTACAGAACTTCCTCGACGCTTATCTGAGCGGCAATGCAGACTTCAAGCCGCTGAAGCCTTACAGTGACAAATGTTAA

Protein

MDWREKLFGKVLVKCESVSQGGQYDNVPTVEALNDCVEAGEGAVCGIYFSFANISDNSDDFGLRLEEIHRRVHPRLQVVQVVLWAHVGTPEGPVEREAGFYKSLMGKPWFAVPYHDVDIKRRLTQKYSIAVGVPTLVIRGRPVRDALLEDPLGERFPWPAPPLTEVLRGIQLQGEGETKLYEDLPGDALRVFYFAAHWCPPCRTFAPSLCAALSAVRKRRAKYANTQLIIVSSDRSEQSYNRTVQSVAAANALAVPWSAAEARGALPTALGVAGIPALVIANGDGTVLTTNGRQKLAADPTGLNFPWSQRPLSVLTEQALLKMARHPAIVLFVDDEDSEIEFAESVLTPAAESYYEECSIQYPGFCPHQSSSDDETLDFDYPPRKSKKRPFKHVMFYVGVDGTDTADMLREHICLDDAVPLLTAIDFPKQRMFTMKYGDEITTHSVQNFLDAYLSGNADFKPLKPYSDKC

Description

Functions as a redox-dependent negative regulator of the Wnt signaling pathway.

Catalytic Activity

[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH
[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH

Similarity

Belongs to the nucleoredoxin family.

Keywords

Cytoplasm   Developmental protein   Differentiation   NAD   Nucleus   Oxidoreductase   Wnt signaling pathway  

Feature

chain  Nucleoredoxin

Uniprot

A0A2A4K6A7   A0A194Q0V5   A0A212FMC2   D2A4C5   U4TW14   N6SVJ1   + More
F4WKV7   A0A151J8S5   A0A0J7L4B1   E2BK23   A0A026VYL6   A0A3L8DQE2   A0A195CQ01   A0A195BJG7   A0A151JVE9   A0A0L7QLL0   A0A0M9A9J1   A0A2A3E3N0   K7IRX3   A0A310S6V0   E2AUD0   E0VHQ2   A0A151WVU9   A0A087ZR58   E9J1N0   A0A1B6BWY6   A0A0P4W3J9   A0A2H8TFI6   A7S2B8   A0A1S3IYS8   A0A2B4S5L1   A0A2C9LLN5   A0A1B6LMS3   A0A2P6K849   A0A3M6TIK7   C3YDC0   T1J2S8   H3A932   A0A0B7AXF3   A0A401SLG9   V4AWI9   S4S061   A0A1A7WD35   B5DEA3   M3ZP45   A0A0S7JSN5   A0A3P9NYQ2   A0A3B3VVP0   A0A146MUD7   A0A3B4XCL2   A0A3B4UAR4   A0A087XXA3   A0A1W4YCQ3   A0A3B3Z243   A0A146ZVL7   A0A437CRD1   A0A3Q2DB49   A0A146VRQ6   G3PA84   A0A0P7UD15   A0A1X7VIF4   A0A3Q1F1C3   A0A1L8HG37   A0A3P8W9F5   A0A3Q3G951   A0A3B3BE72   H2RSX2   A0A1A8BGU0   A0A1A7Z9Y2   A0A3P8SL63   A0A3B5B976   A0A3Q3MI52   A0A1L8H859   Q6GM16   A0A151NAK0   A0A2U9B4B3   A0A1A8PD06   A0A1A8KHB7   A0A1A8PQK3   A0A1A8G0N1   A0A1W4ZTC5   R7UT05   A0A3B4GH21   A0A3Q3CV04   I3K5Z6  

EC Number

1.8.1.8

Pubmed

26354079    22118469    18362917    19820115    23537049    21719571    + More
20798317    24508170    30249741    20075255    20566863    21282665    17615350    15562597    30382153    18563158    9215903    30297745    23254933    20431018    23542700    27762356    24487278    29451363    21551351    16604061    22293439    25186727   

EMBL

NWSH01000086    PCG79767.1    KQ459582    KPI98943.1    AGBW02007654    OWR54829.1    + More
KQ971348    EFA04807.1    KB631749    ERL85769.1    APGK01054977    KB741256    ENN71764.1    GL888206    EGI65199.1    KQ979480    KYN21257.1    LBMM01000854    KMQ97378.1    GL448740    EFN83931.1    KK107570    EZA48862.1    QOIP01000005    RLU22660.1    KQ977513    KYN02189.1    KQ976453    KYM85318.1    KQ981701    KYN37472.1    KQ414924    KOC59401.1    KQ435709    KOX80005.1    KZ288442    PBC25701.1    KQ777667    OAD52066.1    GL442815    EFN62987.1    DS235171    EEB12938.1    KQ982708    KYQ51811.1    GL767674    EFZ13297.1    GEDC01031505    JAS05793.1    GDRN01090617    GDRN01090615    JAI60450.1    GFXV01000677    MBW12482.1    DS469568    EDO42086.1    LSMT01000193    PFX23887.1    GEBQ01014945    JAT25032.1    MWRG01021199    PRD22509.1    RCHS01003525    RMX41149.1    GG666503    EEN61731.1    JH431808    AFYH01189891    AFYH01189892    AFYH01189893    AFYH01189894    AFYH01189895    HACG01038568    CEK85433.1    BEZZ01000350    GCC31221.1    KB201304    ESO97881.1    HADW01002041    HADX01014401    SBP03441.1    AAMC01032361    AAMC01032362    AAMC01032363    AAMC01032364    AAMC01032365    BC168589    AAI68589.1    GBYX01230807    JAO68193.1    GCES01163487    JAQ22835.1    AYCK01011882    AYCK01011883    AYCK01011884    GCES01016381    JAR69942.1    CM012449    RVE65034.1    GCES01066159    JAR20164.1    JARO02014205    KPP58318.1    CM004468    OCT95056.1    HADZ01002483    HAEA01002256    SBP66424.1    HADY01001122    HAEJ01002829    SBP39607.1    CM004469    OCT92294.1    BC074275    AKHW03003672    KYO33767.1    CP026245    AWO98804.1    HAEH01006392    HAEI01008958    SBR79108.1    HAED01000251    HAEE01011526    SBR31576.1    HAEF01007693    HAEG01009140    SBR83715.1    HAEB01018064    HAEC01000402    SBQ64591.1    AMQN01006428    KB298315    ELU09340.1    AERX01004936    AERX01004937    AERX01004938    AERX01004939   

Proteomes

UP000218220    UP000053268    UP000007151    UP000007266    UP000030742    UP000019118    + More
UP000007755    UP000078492    UP000036403    UP000008237    UP000053097    UP000279307    UP000078542    UP000078540    UP000078541    UP000053825    UP000053105    UP000242457    UP000002358    UP000000311    UP000009046    UP000075809    UP000005203    UP000001593    UP000085678    UP000225706    UP000076420    UP000275408    UP000001554    UP000008672    UP000287033    UP000030746    UP000245300    UP000008143    UP000002852    UP000242638    UP000261500    UP000261360    UP000261420    UP000028760    UP000192224    UP000261480    UP000265020    UP000007635    UP000034805    UP000007879    UP000257200    UP000186698    UP000265120    UP000261660    UP000261560    UP000005226    UP000265080    UP000261400    UP000261640    UP000050525    UP000246464    UP000014760    UP000261460    UP000264840    UP000005207   

PRIDE

Q6GM16   

Pfam

PF13905   Thioredoxin_8        + More
PF11761   CbiG_mid
PF00271   Helicase_C
PF00176   SNF2_N

Interpro

IPR036249   Thioredoxin-like_sf        + More
IPR012336   Thioredoxin-like_fold       
IPR013766   Thioredoxin_domain       
IPR021745   CbiG_mid       
IPR000330   SNF2_N       
IPR027417   P-loop_NTPase       
IPR038718   SNF2-like_sf       
IPR014001   Helicase_ATP-bd       
IPR001650   Helicase_C       
IPR041861   NRX_PDI_b'       

SUPFAM

SSF52833   SSF52833        + More
SSF52540   SSF52540       

Gene 3D

3.40.50.10810    

CDD

cd00079  HELICc
cd03071  PDI_b'_NRX

ProteinModelPortal

A0A2A4K6A7   A0A194Q0V5   A0A212FMC2   D2A4C5   U4TW14   N6SVJ1   + More
F4WKV7   A0A151J8S5   A0A0J7L4B1   E2BK23   A0A026VYL6   A0A3L8DQE2   A0A195CQ01   A0A195BJG7   A0A151JVE9   A0A0L7QLL0   A0A0M9A9J1   A0A2A3E3N0   K7IRX3   A0A310S6V0   E2AUD0   E0VHQ2   A0A151WVU9   A0A087ZR58   E9J1N0   A0A1B6BWY6   A0A0P4W3J9   A0A2H8TFI6   A7S2B8   A0A1S3IYS8   A0A2B4S5L1   A0A2C9LLN5   A0A1B6LMS3   A0A2P6K849   A0A3M6TIK7   C3YDC0   T1J2S8   H3A932   A0A0B7AXF3   A0A401SLG9   V4AWI9   S4S061   A0A1A7WD35   B5DEA3   M3ZP45   A0A0S7JSN5   A0A3P9NYQ2   A0A3B3VVP0   A0A146MUD7   A0A3B4XCL2   A0A3B4UAR4   A0A087XXA3   A0A1W4YCQ3   A0A3B3Z243   A0A146ZVL7   A0A437CRD1   A0A3Q2DB49   A0A146VRQ6   G3PA84   A0A0P7UD15   A0A1X7VIF4   A0A3Q1F1C3   A0A1L8HG37   A0A3P8W9F5   A0A3Q3G951   A0A3B3BE72   H2RSX2   A0A1A8BGU0   A0A1A7Z9Y2   A0A3P8SL63   A0A3B5B976   A0A3Q3MI52   A0A1L8H859   Q6GM16   A0A151NAK0   A0A2U9B4B3   A0A1A8PD06   A0A1A8KHB7   A0A1A8PQK3   A0A1A8G0N1   A0A1W4ZTC5   R7UT05   A0A3B4GH21   A0A3Q3CV04   I3K5Z6  

PDB

2LUS     E-value=1.84359e-15,     Score=202

KEGG

101746437    K17609 nucleoredoxin [EC:1.8.1.8] | (RefSeq) nucleoredoxin-like

GO

GO:0005623   GO:0045454   GO:0005524   GO:0005829   GO:0047134   GO:0030178   GO:0005634   GO:0016055   GO:0072358   GO:0031397   GO:0030154   GO:0008270   GO:0006508   GO:0015074   GO:0004672   GO:0006468   GO:0006418   GO:0000049   GO:0016876  

Subcellular location

Cytoplasm  
Cytosol  
Nucleus  

Length:

470

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10692

Exp number, first 60 AAs:

0.00074

Total prob of N-in:

0.00480

outside

1  -  470

 

 

Pi

220.498943

Theta

163.6143

Tajima's D

1.465533

CLR

0.26664

CSRT

0.778561071946403

Interpretation

Uncertain