Gene

KWMTBOMO09410

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr16(+):841927-847381      View in EpiBrowser

Full name

RNA-directed DNA polymerase from mobile element jockey       + More
Probable RNA-directed DNA polymerase from transposon BS      

Alternative Name

Reverse transcriptase

Location in the cell

Nuclear   Reliability : 2.538

CDS

ATGGAGGAAAAACTTTTCATCGACTTCATTCGGGAAAAATATCCGACAATCGCGCCCGAATTCGAAGCCTATAGGGCTTCATTTGGTAAATATTCTCCCCCCGCATCTAACGCCGCCGTCGCCAAACATGCCTCGCAGGCATGCCTCGCGTGCCCCGCCGCCGGTCCGTGTTCAAGCGCACGTACGCACGCCGCCGCCGTAGCGTCTAACGCCCCCGCCCCCGCTACCCCCGCGCCCGCGTCAATCACGTCAGTTTCGTCCGTCGCGACCTCAATAGCGTCTAGTTCAGGCTCCGATACCGAATCGGAGATGGACTTCGAGTCCGCGACTAGCCCTCAACCCGGAACCTCGGATGGGTTCCAAACTGTAACGCGCGGTAAAAAGCGTACTCGCGTCGTGGAGTCCCGGAGCTCCATGACGAAGCAAACCAAGTCCGCGACCGCCTCCCGACCGCAGGTAGTCGTGACGCCGGAGTCGGACTCCGCCCGCCGCGTAACCCCACCGCCGCGCCCAAAAACCGCGCCCGCGCCTAAAACAGTTGTCCCGCCCCCGCTGATACTCCAAGAGAAGTCAGCGTGGAATCGCGTATCCCAGGCCCTTCAGGCCAACAAAATTAATTATACCCATGCGCGTAACGTCGCGCATGGGATTCAGATTAAGGTCGCAACTCCGGGCGACCATAGGGCCCTCTCTGCTTACCTCCGAAAGGAGAACATAGGTTATCACACCTATGCTCTTCAGGAGGACCGCGAACTCCGCGTAGTGATACGCGGAGTCCCCAAGGAACTCGACATAGACTACGTAAAGGAGGATCTGATCGGTCAGTCCCTCCCAATAGTTAGTGTGCACCGGATGCACAGCGGACGCGGCAGACAGCCGTACAATATGATTCTCGTCGCGCTAGAATCAACCCCGGAGGCAAAGAAAAGAATCTCATGTCTCAAAACGATATGCGGCCTCTCCGGGGTCACCATCGAAGCCCCCCATAAACGTGGTACTCCCGGGCAGTGCCACAGGTGCCAGCTCTATGGCCACTCAGCGCCATTCTACAATGCTAACGGACTCGCGCGGCAACGCGATCAAATTTTCGAATTCCTCCGCGACAATCTTGTAGATATTTTGTTAGTGCAGGAGACCTGTCTGAAGCCCTCGCGTCGTGACCCGAAAGTCGCGAATTACGTCATGGTTAGGAATGACAGACTCACCGCCTCCAAAGGCGGGACTGCCATTTACTATAGGCGGGCCCTGCACGTTGTCCCTCTCGATACTCCCTCGCTCTTACATATCGAGGCGTCAGTGTGCCGTATCTCGCTGACGGGACACCAGCCGATCGTCATCGCATCCGTTTATCTCCCCCCGGACAAGCCCCTCCTAAGCAGTGACATCGAGTCACTGTTCGGCATGGGAGACTCCGTCATCCTGGCAGGCGATTTAAATTGCCACCACACTAGGTGGAACTGCCATCGTACTAACGTTAACGGTAGGCGTCTCGACGCGTTTATAGACGACCTCACTTTTGAAGTAGTCGGTCCCCCAACTCCAACATGTTATCCGTATAACATCGCGCTCCGTCCGAGCACTATAGACCTGGCATTGCTTAGGAACGTAACTCTGTGCTTACGTTCCATCGAAGCACTGTCAGAGCTCGACTCAGACCACCGACCTGTCCTTATGCAGCTCGGTCGCCCTCACAACCCAGTCACTGTTACGAGGACCATGGTGGATTGGAATAAGCTGGGCACGTGCCTACTCGAAGCCGCTCCGCCAATCCTCCCTTACGGCCCGGATTCGAATCTATCCCCCGAGGACACCGTCGAATCCATAAACATCATTACCGATCACATCTCTTCCGCGATCATTAGATCTTCAAAAGAAGTCGATGTGGAGGACAGCTTCCACCGCATCAGACTATCCTCCGAACTTAGGAATCTCTTAAGAGTTAGGAACGCGGCAATCCGGGCCTACGATCGTCTTCCCACGCATTCAAACCGGATTCGGATGCGTCGTCTACAACGCGAAGTCCACTCCCGCCTAAGCGACGCGCGTAACGATAATTGGCATAGTTATTTAGAACAACTCGCGCCCTCCCACCAAGCATACTGGCGACTAGCTAGGACTCTCAAATCCGAAACTACCGCTACTATGCCTCCCCTCGTACGCCCTTCAGGCCAACCACCGGCATTCGATGACGATGACAAGGCTGAGCTGCTGGCCGATGCACTGCAAGAGCAGTGCACCACCAGCACTCAACACGCGGACCCCGAACACACCGAGTTAGTCGACAGGGAGGTCGAGCGCAGAGCTGCCCTGCCGCCCTCGGACGCGTTACCCCCCATTACCACTGACGAAGTTAGAGACGCGATCCACAATCTCCAACCTAGAAAGGCATCCGGCTCCGACGGCATCCGCAACCGCGCGCTAAAACTCTTGCCAGTCCAACTGATAGCAATGTTGGCTACAATTTTAAATGCCGCTATGACGCACTGCATCTTTCCCGCGGTGTGGAAAGAAGCGGACGTTATCGGTATACATAAGCCGGGCAAACCGACAAACGAAACATCTAGTTACCGTCCGATTAGTCTCCTCCCGACGATAGGAAAAATTTACGAACGGCTCCTTAGGAAACGCCTCTGGGATTTTGTTACCGCGAACAAAATTCTCATAGACGAACAGTTCGGATTCCGCTCTAAACACTCGTGCGTACAACAAGTGCACCGCCTCACGGAGCACATCCTGATAGGACTAAATAGGCGTAAACAAATCCCGACCGGCGCCCTCTTCTTCGACATCGCGAAGGCGTTCGACAAAGTCTGGCACAACGGTTTAATTTACAAACTGTACAACATGGGAGTGCCAGACAGACTCGTGCTCATCATACGAGACTTCTTGTCGAACCGTTCGTTTCGATATCGAGTAGAGGGAACTCGTTCTCGTCCCCGTCAACTGACTGCCGGAGTCCCGCAAGGCTCCGCGCTCTCCCCGTTATTATTTAGTTTGTATATCAATGATATACCCCGGTCTCCGGAGACCCATCTAGCGCTCTTCGCCGATGACACGGCTATCTACTACTCGTGTAGGAAGATGTCGTTGCTGCATCGGCGACTCCAGATCGCAGTAGCCACCATGGGACAGTGGTTCCGGAAGTGGCGCATCGACATCAACCCCACGAAAAGCACAGCGGTGCTCTTCAAAAGGGGTCGCCCTCCAAATACTACTTCGAGCATCCCACTCCCTAATAGGCGCGCAAACACCTCCGCCGTTAGCCCCGTCACTCTCTTTGGCCAGCCCATACCGTGGGCCTCGCAGGTCAAATACCTAGGCGTCACCCTCGACAGAGGGATGACATTCCGTCCCCATATTAAGACGGTACGCGACCGTGCCGCCTTCATATTAGGACGTCTCTACCCTATGCTTTGCAAGCGAAGCAAACTGTCCCTCCGTAATAAGGTAACTCTCTACAAAACTTGCATACGCCCCATTATGACGTATGCAAGCGTAGTGTTCGCTCACGCAGCCCGCACCAACTTGAAGCCCCTTCAGGTTATTCAATCCCGATTCTGCAGGATAGCCGTCGGAGCACCATGGTTCCTGAGGAACGTGGATCTCCACGATGACCTGGAGCTCGACTCTGTCAGTAAGTATCTTCAGTCGGCATCATTGCGCCATTTCGAGAAGGCGGCACGACATGAGAACCCTCTTGTCGTGGCGGCTGGAAACTACATACCCGATCCTGTAGACCGAATGACCGCTATCAATTTAGTTACCGAAGTAAACTTCACATTGTATAATTAA

Protein

MEEKLFIDFIREKYPTIAPEFEAYRASFGKYSPPASNAAVAKHASQACLACPAAGPCSSARTHAAAVASNAPAPATPAPASITSVSSVATSIASSSGSDTESEMDFESATSPQPGTSDGFQTVTRGKKRTRVVESRSSMTKQTKSATASRPQVVVTPESDSARRVTPPPRPKTAPAPKTVVPPPLILQEKSAWNRVSQALQANKINYTHARNVAHGIQIKVATPGDHRALSAYLRKENIGYHTYALQEDRELRVVIRGVPKELDIDYVKEDLIGQSLPIVSVHRMHSGRGRQPYNMILVALESTPEAKKRISCLKTICGLSGVTIEAPHKRGTPGQCHRCQLYGHSAPFYNANGLARQRDQIFEFLRDNLVDILLVQETCLKPSRRDPKVANYVMVRNDRLTASKGGTAIYYRRALHVVPLDTPSLLHIEASVCRISLTGHQPIVIASVYLPPDKPLLSSDIESLFGMGDSVILAGDLNCHHTRWNCHRTNVNGRRLDAFIDDLTFEVVGPPTPTCYPYNIALRPSTIDLALLRNVTLCLRSIEALSELDSDHRPVLMQLGRPHNPVTVTRTMVDWNKLGTCLLEAAPPILPYGPDSNLSPEDTVESINIITDHISSAIIRSSKEVDVEDSFHRIRLSSELRNLLRVRNAAIRAYDRLPTHSNRIRMRRLQREVHSRLSDARNDNWHSYLEQLAPSHQAYWRLARTLKSETTATMPPLVRPSGQPPAFDDDDKAELLADALQEQCTTSTQHADPEHTELVDREVERRAALPPSDALPPITTDEVRDAIHNLQPRKASGSDGIRNRALKLLPVQLIAMLATILNAAMTHCIFPAVWKEADVIGIHKPGKPTNETSSYRPISLLPTIGKIYERLLRKRLWDFVTANKILIDEQFGFRSKHSCVQQVHRLTEHILIGLNRRKQIPTGALFFDIAKAFDKVWHNGLIYKLYNMGVPDRLVLIIRDFLSNRSFRYRVEGTRSRPRQLTAGVPQGSALSPLLFSLYINDIPRSPETHLALFADDTAIYYSCRKMSLLHRRLQIAVATMGQWFRKWRIDINPTKSTAVLFKRGRPPNTTSSIPLPNRRANTSAVSPVTLFGQPIPWASQVKYLGVTLDRGMTFRPHIKTVRDRAAFILGRLYPMLCKRSKLSLRNKVTLYKTCIRPIMTYASVVFAHAARTNLKPLQVIQSRFCRIAVGAPWFLRNVDLHDDLELDSVSKYLQSASLRHFEKAARHENPLVVAAGNYIPDPVDRMTAINLVTEVNFTLYN

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  RNA-directed DNA polymerase from mobile element jockey

Uniprot

Q93137   Q9XXW0   Q9BPQ0   O96546   A0A1Y1NA23   A0A139WA11   + More
V5GNJ2   X1WLB2   V5GNF3   A0A023EYS8   A0A2S2Q383   A0A023EZE6   A0A3N5Z7I3   Q07995   J9M522   A0A087UCW3   A0A224X6Q4   A0A087UGF5   X1WNI2   A0A2M4BD66   A0A2M4CV42   A0A2M4BDA5   A0A2S2QEE0   A0A2J7QR37   A0A2M4BD62   A0A2J7R7D0   A0A2M4CV52   A0A2J7PBY3   A0A2J7QY69   A0A2J7PU96   A0A2M4BD67   A0A2S2NGV8   A0A2M4BDV6   A0A224XB44   A0A224X6T4   A0A224X6S1   A0A2J7Q6J2   X1WZH0   A0A2H8TF37   A0A2S2N814   A0A224X6U5   A0A224XI99   A0A2S2P698   A0A069DZL8   A0A224X6R6   A0A2J7PVX3   A0A2J7QB68   A0A0A9YU04   A0A1Y1KFR3   A0A0A9YJ00   A0A2S2R9D4   P21328   A0A224XHW8   A0A1B6EGD8   A0A069DX78   A0A142LX26   A0A2A4IUM2   A0A2S2PJG2   A0A2S2NPG3   A0A224XJI0   A0A2M4CVF1   A0A2M4CVK2   A0A224X6W2   A0A0V0G5B6   A0A2S2N6Q7   Q95SX7   A0A2S2PHL7   A0A2H8TKI9   P21329   A0A352X8G4   A0A2J7Q0S7   A0A2S2P6C4  

EC Number

2.7.7.49

Pubmed

10333566    10380107    28004739    18362917    19820115    25474469    + More
30086797    8387152    26334808    25401762    2463954    3040362    1714378    25527032    7753626    12537569    1701254    30148503   

EMBL

U07847    AAA17752.1    AB018558    BAA76304.1    AB055391    BAB21761.1    + More
AF081103    AAC72921.1    GEZM01008457    JAV94772.1    KQ971729    KYB24751.1    GALX01005299    JAB63167.1    ABLF02042518    ABLF02057746    GALX01005359    JAB63107.1    GBBI01004395    JAC14317.1    GGMS01002992    MBY72195.1    GBBI01004571    JAC14141.1    RPOV01000134    RPJ78669.1    S59870    AAB26437.2    ABLF02024246    KK119261    KFM75202.1    GFTR01008279    JAW08147.1    KK119692    KFM76444.1    ABLF02008153    ABLF02008462    ABLF02008464    GGFJ01001844    MBW50985.1    GGFL01005012    MBW69190.1    GGFJ01001842    MBW50983.1    GGMS01006359    MBY75562.1    NEVH01011985    PNF31054.1    GGFJ01001843    MBW50984.1    NEVH01006736    PNF36716.1    GGFL01004957    MBW69135.1    NEVH01027074    PNF13841.1    NEVH01009134    PNF33528.1    NEVH01021205    PNF19912.1    GGFJ01001858    MBW50999.1    GGMR01003407    MBY16026.1    GGFJ01001857    MBW50998.1    GFTR01008262    JAW08164.1    GFTR01008261    JAW08165.1    GFTR01008271    JAW08155.1    NEVH01017470    PNF24199.1    ABLF02034467    GFXV01000908    MBW12713.1    GGMR01000676    MBY13295.1    GFTR01008251    JAW08175.1    GFTR01008256    JAW08170.1    GGMR01012305    MBY24924.1    GBGD01000415    JAC88474.1    GFTR01008269    JAW08157.1    NEVH01020940    PNF20481.1    NEVH01016302    PNF25823.1    GBHO01021814    GBHO01010549    JAG21790.1    JAG33055.1    GEZM01084969    JAV60363.1    GBHO01010547    GBHO01010546    JAG33057.1    JAG33058.1    GGMS01017365    MBY86568.1    M22874    M38643    GFTR01008254    JAW08172.1    GEDC01000337    JAS36961.1    GBGD01000389    JAC88500.1    KU543673    AMS38352.1    NWSH01007753    PCG62823.1    GGMR01016905    MBY29524.1    GGMR01006408    MBY19027.1    GFTR01008257    JAW08169.1    GGFL01005122    MBW69300.1    GGFL01005121    MBW69299.1    GFTR01008260    JAW08166.1    GECL01003538    JAP02586.1    GGMR01000226    MBY12845.1    AY060438    AAL25477.1    GGMR01016296    MBY28915.1    GFXV01002840    MBW14645.1    M38437    DNOY01000259    HBE18313.1    NEVH01019963    PNF22185.1    GGMR01012283    MBY24902.1   

Proteomes

UP000007266    UP000007819    UP000054359    UP000235965    UP000218220   

PRIDE

Q93137    Q9XXW0    Q9BPQ0    P21328    Q95SX7    P21329    + More

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF07530   PRE_C2HC
PF03372   Exo_endo_phos
PF07727   RVT_2

Interpro

IPR036691   Endo/exonu/phosph_ase_sf        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR000477   RT_dom       
IPR006579   Pre_C2HC_dom       
IPR013103   RVT_2       

SUPFAM

SSF56219   SSF56219       

Gene 3D

3.60.10.10    

ProteinModelPortal

Q93137   Q9XXW0   Q9BPQ0   O96546   A0A1Y1NA23   A0A139WA11   + More
V5GNJ2   X1WLB2   V5GNF3   A0A023EYS8   A0A2S2Q383   A0A023EZE6   A0A3N5Z7I3   Q07995   J9M522   A0A087UCW3   A0A224X6Q4   A0A087UGF5   X1WNI2   A0A2M4BD66   A0A2M4CV42   A0A2M4BDA5   A0A2S2QEE0   A0A2J7QR37   A0A2M4BD62   A0A2J7R7D0   A0A2M4CV52   A0A2J7PBY3   A0A2J7QY69   A0A2J7PU96   A0A2M4BD67   A0A2S2NGV8   A0A2M4BDV6   A0A224XB44   A0A224X6T4   A0A224X6S1   A0A2J7Q6J2   X1WZH0   A0A2H8TF37   A0A2S2N814   A0A224X6U5   A0A224XI99   A0A2S2P698   A0A069DZL8   A0A224X6R6   A0A2J7PVX3   A0A2J7QB68   A0A0A9YU04   A0A1Y1KFR3   A0A0A9YJ00   A0A2S2R9D4   P21328   A0A224XHW8   A0A1B6EGD8   A0A069DX78   A0A142LX26   A0A2A4IUM2   A0A2S2PJG2   A0A2S2NPG3   A0A224XJI0   A0A2M4CVF1   A0A2M4CVK2   A0A224X6W2   A0A0V0G5B6   A0A2S2N6Q7   Q95SX7   A0A2S2PHL7   A0A2H8TKI9   P21329   A0A352X8G4   A0A2J7Q0S7   A0A2S2P6C4  

PDB

6AR3     E-value=0.00575609,     Score=98

KEGG

105842112    no KO assigned | (RefSeq) actin cytoskeleton-regulatory complex protein pan1-like

GO

GO:0003964   GO:0004519   GO:0006313  

Length:

1263

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.331930000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00002

outside

1  -  1263

 

 

Pi

136.697909

Theta

133.99049

Tajima's D

0

CLR

162.789969

CSRT

0.364081795910205

Interpretation

Uncertain