Gene

KWMTBOMO09393  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012764

Annotation

prophenoloxidase-1_[Bombyx_mori]

Location

Bomo_Chr16(+):376827-398740      View in EpiBrowser

Full name

Phenoloxidase subunit 1       + More
Phenoloxidase 2      

Alternative Name

PO 1
Tyrosinase 1
proPO-P1
Phenoloxidase subunit A3
Processed phenoloxidase A3

Location in the cell

Cytoplasmic   Reliability : 1.377 Nuclear   Reliability : 1.406

CDS

ATGTCTGACGCCAAGAAAAACCTGTTACTGTTCTTCGACCGTCCCTCAGAGCCATGCTTCATGCAAAAGGGAGAAGACAAGGCAGTATTCGATATTCCTGACAATTACTACCCGGAGAAGTACCAGCGTGTGTCAAATGCTATAAGCAACAGGTTCGGTAGCGACGCGGGCCGCATGATACCCATCAGGAACATTGCCCTGCCCAATCTGGACCTGCCCATGGAACTGCCCTACAACGAGCAGTTCTCCTTGTTCGTCCCTAAACACAGGCAAATGGCAGGAAAGCTGATTGATATCTTCATGGGAATGCGTGACGTAGAAGATCTCCAGAGTATCTGTGCGTACTGCCAACTGCGGATCAATCCCTATATGTTCAATTATTGCCTCTCCGTCGCCATCTTGCATAGATCAGACACGAAAGGTTTGCAAATCCCAACCTTTGCTGAGTGCTTTCCCGATAAGTTCATGGACCCGAAGGTGTTCCGCAAAGCCAGAGAAGTGACCAGCGTTGTACCGACTGGAGCCAGGATGCCAATAGTGATTCCGTCGAACTACACCGCGTCGGACGCGGAGCCGGAGCAGCGCGTGGCGTACTTCCGCGAGGACATCGGCACCAACCTGCACCACTGGCACTGGCACCTCGTGTACCCCTTCGACGCCGCAGACCGCGCCCTCGTCAACAAGGACCGCCGCGGGGAGCTCTTCTACTACATGCACCAGCAGATGATCGCCAGATTCAACATCGAACGATTCTGCAACGACCTGAGGAAAGTGGAAACCTACAGTGACTTCAGGGGTCCCATTAAAGAGGGCTACTTCCCTAAGATGGACTCGCAAGTTGCCAGCAGAGCCTGGCCTCCTAGATTTGCTGGTTCGTTTCTCCGTGACTTAGACAGACCGATAGACCAGATCAGAATCGATATCTCTGAGCTGGAGATCTGGAGGGACAGGTTTCTGAAGGCGATCGAGGATATGGCAGTGATCCTGCCCAATGGGCGTCAAATGCCTCTGGACGAAGAGACTGGTATTGACGTGCTGGGTAACCTGATGGAATCGTCCACCATCAGTATAAACCGCCCATACTACGGTGACCTCCACAACATGGGGCACGTCTTTATCGGGTACTGCCACGACCCTGATCATCGTCATCTGGAACCGTTCGGCGTGATGGGAGACCTGGCAACGACCATGCGTGACCCATTGTTCTTTCGCTGGCATGGATACATAGATTCTGTTTTCCACCTCTACAAGTACAAACTTACACCTTATAGCGATGATAGGCTGATCTTCCCCGACATCAGGGTTCGGTCCATTAGTCTCGATGGTAAAGGAGCTCCCAACATGCTGAATACTTTCTGGGAGCAGAGTACTGTGGACTTGGCTCGTGGCTTGGACTTTAGTCCCCGTGGCAGTGTTCTGGCCAGGTTCACTCATCTACAGCATGAAGACTACAGTTATGTGATCGAAGTGAATAACACGGGCCGCAGTAGTGTCATGGGCATGTTTAGGATATTCATCGCCCCAACACTTGACGAGAATAAGCGGCCTCTGAACTTCGACGAGCAACGGAAACTCATGATCGAACTCGACAAGTTCTCACAGGGCTTGAAGCCCGGCAACAATACAGTACGTCGTCGCAGTGTGGACTCCTCAGTGACCGTTCCGTTCGAGAGGACATTCAGCAACCAGGCTGACAGGCCAGGTAATCCGGGATCTCCCGAGTCCGCCGAGTTTGACTTCTGCGGCTGCGGGTGGCCTCAGCACATGCTGATACCCAAGGGAACCACTGAAGGATATCCTATGGTGCTGTTTGTCATGGTGTCCAACTGGAACGATGACCGGGTGGAGCAAGACCTGGTGGGGTCGTGCAATGATGCGGCGTCGTACTGCGGCATCCGCGACCGCAAGTACCCGGACCGGCGCGCCATGGGCTTCCCGTTCGACCGGCCCGCGCCCGCCGCCACCACGCTGTCCGACTTCCTGCGCCCCAACATGGCCGTGCGCGACTGCATCGTACGCTTCACCGACAGGACCCGCCAGCGCGGCCAGCAGGAGTAG

Protein

MSDAKKNLLLFFDRPSEPCFMQKGEDKAVFDIPDNYYPEKYQRVSNAISNRFGSDAGRMIPIRNIALPNLDLPMELPYNEQFSLFVPKHRQMAGKLIDIFMGMRDVEDLQSICAYCQLRINPYMFNYCLSVAILHRSDTKGLQIPTFAECFPDKFMDPKVFRKAREVTSVVPTGARMPIVIPSNYTASDAEPEQRVAYFREDIGTNLHHWHWHLVYPFDAADRALVNKDRRGELFYYMHQQMIARFNIERFCNDLRKVETYSDFRGPIKEGYFPKMDSQVASRAWPPRFAGSFLRDLDRPIDQIRIDISELEIWRDRFLKAIEDMAVILPNGRQMPLDEETGIDVLGNLMESSTISINRPYYGDLHNMGHVFIGYCHDPDHRHLEPFGVMGDLATTMRDPLFFRWHGYIDSVFHLYKYKLTPYSDDRLIFPDIRVRSISLDGKGAPNMLNTFWEQSTVDLARGLDFSPRGSVLARFTHLQHEDYSYVIEVNNTGRSSVMGMFRIFIAPTLDENKRPLNFDEQRKLMIELDKFSQGLKPGNNTVRRRSVDSSVTVPFERTFSNQADRPGNPGSPESAEFDFCGCGWPQHMLIPKGTTEGYPMVLFVMVSNWNDDRVEQDLVGSCNDAASYCGIRDRKYPDRRAMGFPFDRPAPAATTLSDFLRPNMAVRDCIVRFTDRTRQRGQQE

Description

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone. Binds to the surface of hemocytes and is involved in hemocyte melanization.
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinonee (By similarity).

Catalytic Activity

2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone
L-tyrosine + O2 = H2O + L-dopaquinone

Cofactor

Cu(2+)

Subunit

Heterodimer.
Heterodimer. Forms a complex with an interleukin 1-like protein as a consequence of a host defense response.

Similarity

Belongs to the tyrosinase family.

Keywords

Complete proteome   Copper   Direct protein sequencing   Disulfide bond   Glycoprotein   Melanin biosynthesis   Metal-binding   Monooxygenase   Oxidoreductase   Reference proteome   Secreted   Zymogen   3D-structure  

Feature

chain  Phenoloxidase subunit 1

Uniprot

H9JTA2   Q9GU89   H9JTA1   Q27451   B2YKU4   R4WAL7   + More
A0S6A0   Q0MVN6   A0A290U614   A0A0M4MZ77   Q64H43   O44249   A0A212FM73   B4XID9   A0A194Q050   A0A173GPE3   D2KBI1   D2KI01   G3ESX4   A0A0N1I987   E0AEY7   A0A076FU33   D6QZJ9   Q964D5   A0A1Q1MKI5   A0A1Q1MKI0   A0A194Q055   A0A194Q1T9   O77002   A0A0L7KR86   A0A194Q0W8   A0A0N0PCP2   A0A1I8ND44   Q6RSJ0   A0A1I8Q7Q8   A0A0A1WDY9   A0A1J1J6I1   J7GXB2   A0A1I8QBX9   W8BTJ6   A0A0K8VQL9   A0A0L0C2T8   Q9Y0B4   A0A0L0C2W4   A0A1I8NVC5   A0A0K8UHE0   A0A034V716   Q16G28   A0A1I8PHG1   A0A182JDP3   B0WJT1   A0A0L0C587   A0A1I8NBL4   A0A1B0BSF2   B3N821   A0A1Y9IUV5   A0A0L0C2Z2   A0A1A9XS96   A0A1Y9HDP1   A0A1A9XS95   A0A1A9VT99   A0A1A9VT97   A0A182P263   B4P3V6   A0A0L0C2Q7   A0A139WGK2   A0A1A9WK14   A0A240SX07   A0A182VBQ8   A0A182LGH1   Q7QCV8   A0A182HTP1   A0A182N764   B4LLI3   Q49I38   A0A1B0AFL7   A0A182XW38   O76951   A0A182XHP7   A0A182F758   D2A424   Q9V521   W5J518   A0A1A9WK12   B4HSD9   A0A1W4UKH8   A0A1I8NH64   A0A182QZA2   A0A0J9R8I8   A0A3B0JMC7   B4N636   A0A240SX08   Q28ZC9   B4GHX8   A0A240SX01   L7US91   B4J5E9   L7UVJ1   B3MI87   A0A1A9VT98  

EC Number

1.14.18.1

Pubmed

19121390    7644494    7793973    18839417    28953952    15898113    + More
9474780    8626641    10436935    16291091    19805072    22118469    18348246    26354079    12110299    28078308    9537761    26227816    25315136    25830018    24495485    26108605    10899462    25348373    17510324    30735632    17994087    17550304    18362917    19820115    20966253    12364791    14747013    17210077    16076951    25244985    9459428    10611292    10731132    12537572    12537569    12834045    19141111    20920257    23761445    22936249    15632085   

EMBL

BABH01004242    BABH01004243    BABH01004244    AF178462    AAG09304.1    BABH01004245    + More
D49370    BAA08368.1    EU569724    ACC69184.1    AB778568    BAM76811.1    DQ289581    ABB92834.1    DQ841706    NWSH01000045    ABH10016.2    PCG80267.1    KY744277    ATD13326.1    KP974690    ALE19971.1    AY665397    AAU29555.1    AF003253    AAC05796.1    AGBW02007654    OWR54842.1    EU046570    EU046571    EU046572    ABW16859.1    ABW16861.1    KQ459582    KPI98957.1    KT006134    ANH58159.1    GU199189    ACZ97553.1    GU214206    ADA60206.1    JF342362    AEA92682.1    KQ460635    KPJ13408.1    HM776513    ADL14486.1    KJ803014    AII22868.1    HM026570    ADG65539.1    AF336289    AAK64363.1    KX452359    AQM36768.1    KX437622    AQM36767.1    KPI98962.1    KPI98959.1    U86875    AAC34251.1    JTDY01006889    KOB65615.1    KPI98958.1    KPJ13410.1    AY494738    AAR84669.1    GBXI01017411    JAC96880.1    CVRI01000070    CRL07388.1    JX110850    AFP81886.1    GAMC01009964    GAMC01009963    JAB96591.1    GDHF01011142    JAI41172.1    JRES01000975    KNC26576.1    AF161260    AAD45526.1    KNC26577.1    GDHF01026318    JAI25996.1    GAKP01021407    JAC37545.1    CH478340    MH810192    EAT33194.1    QBC65457.1    DS231964    EDS29448.1    KNC26609.1    JXJN01019700    CH954177    EDV59434.1    KNC26607.1    CM000157    EDW89439.1    KNC26610.1    KQ971348    KYB26937.1    CCAG010007845    AAAB01008859    EAA07521.2    APCN01000572    APCN01000573    CH940648    EDW59888.1    AY884064    AAX84205.1    L76038    AF031626    AAC27383.1    AAD01936.1    EFA05662.1    AE013599    AY060652    AB055857    ADMH02002195    ETN57874.1    CH480816    EDW47034.1    AXCN02000327    CM002911    KMY92407.1    OUUW01000001    SPP74446.1    CH964154    EDW79825.1    CM000071    EAL25684.2    CH479183    EDW36098.1    JX987235    AGC54940.1    CH916367    EDW01791.1    JX987234    AGC54939.1    CH902619    EDV35932.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000095301    UP000095300    UP000183832    UP000037069    UP000008820    UP000075880    UP000002320    UP000092460    UP000008711    UP000075920    UP000092443    UP000075900    UP000078200    UP000075885    UP000002282    UP000007266    UP000091820    UP000092444    UP000075903    UP000075882    UP000007062    UP000075840    UP000075884    UP000008792    UP000092445    UP000076408    UP000076407    UP000069272    UP000000803    UP000000673    UP000001292    UP000192221    UP000075886    UP000268350    UP000007798    UP000001819    UP000008744    UP000001070    UP000007801   

PRIDE

H9JTA2    Q9GU89    H9JTA1    Q27451    O44249    Q9V521    + More

Pfam

PF03722   Hemocyanin_N        + More
PF03723   Hemocyanin_C
PF00372   Hemocyanin_M
PF01401   Peptidase_M2

Interpro

IPR036697   Hemocyanin_N_sf        + More
IPR005203   Hemocyanin_C       
IPR000896   Hemocyanin/hexamerin_mid_dom       
IPR002227   Tyrosinase_Cu-bd       
IPR005204   Hemocyanin_N       
IPR014756   Ig_E-set       
IPR013788   Hemocyanin/hexamerin       
IPR037020   Hemocyanin_C_sf       
IPR008922   Unchr_di-copper_centre       
IPR001548   Peptidase_M2       

SUPFAM

SSF48056   SSF48056        + More
SSF48050   SSF48050       
SSF81296   SSF81296       

Gene 3D

1.10.1280.10     1.20.1370.10     2.60.40.1520    

ProteinModelPortal

H9JTA2   Q9GU89   H9JTA1   Q27451   B2YKU4   R4WAL7   + More
A0S6A0   Q0MVN6   A0A290U614   A0A0M4MZ77   Q64H43   O44249   A0A212FM73   B4XID9   A0A194Q050   A0A173GPE3   D2KBI1   D2KI01   G3ESX4   A0A0N1I987   E0AEY7   A0A076FU33   D6QZJ9   Q964D5   A0A1Q1MKI5   A0A1Q1MKI0   A0A194Q055   A0A194Q1T9   O77002   A0A0L7KR86   A0A194Q0W8   A0A0N0PCP2   A0A1I8ND44   Q6RSJ0   A0A1I8Q7Q8   A0A0A1WDY9   A0A1J1J6I1   J7GXB2   A0A1I8QBX9   W8BTJ6   A0A0K8VQL9   A0A0L0C2T8   Q9Y0B4   A0A0L0C2W4   A0A1I8NVC5   A0A0K8UHE0   A0A034V716   Q16G28   A0A1I8PHG1   A0A182JDP3   B0WJT1   A0A0L0C587   A0A1I8NBL4   A0A1B0BSF2   B3N821   A0A1Y9IUV5   A0A0L0C2Z2   A0A1A9XS96   A0A1Y9HDP1   A0A1A9XS95   A0A1A9VT99   A0A1A9VT97   A0A182P263   B4P3V6   A0A0L0C2Q7   A0A139WGK2   A0A1A9WK14   A0A240SX07   A0A182VBQ8   A0A182LGH1   Q7QCV8   A0A182HTP1   A0A182N764   B4LLI3   Q49I38   A0A1B0AFL7   A0A182XW38   O76951   A0A182XHP7   A0A182F758   D2A424   Q9V521   W5J518   A0A1A9WK12   B4HSD9   A0A1W4UKH8   A0A1I8NH64   A0A182QZA2   A0A0J9R8I8   A0A3B0JMC7   B4N636   A0A240SX08   Q28ZC9   B4GHX8   A0A240SX01   L7US91   B4J5E9   L7UVJ1   B3MI87   A0A1A9VT98  

PDB

3HHS     E-value=0,     Score=2796

KEGG

101742744    no KO assigned | (RefSeq) phenoloxidase subunit 1-like

GO

GO:0046872   GO:0016491   GO:0004503   GO:0005576   GO:0006952   GO:0006583   GO:0031404   GO:0005507   GO:0035008   GO:0016020   GO:0008237   GO:0008241   GO:0036264   GO:0050830   GO:0050832   GO:0035011   GO:0036263   GO:0005615   GO:0004097   GO:0042438   GO:0042417   GO:0035006   GO:0008152   GO:0005875   GO:0016849   GO:0004672   GO:0005524   GO:0006468   GO:0006418   GO:0000049   GO:0016876  

PANTHER

PTHR11511  

Subcellular location

Secreted  

Length:

685

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00904999999999998

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00049

outside

1  -  685

 

 

Pi

233.154432

Theta

178.527119

Tajima's D

0.937009

CLR

0.27623

CSRT

0.639018049097545

Interpretation

Uncertain