Gene

KWMTBOMO09389

Pre Gene Modal

BGIBMGA012761

Annotation

PREDICTED:_2-methoxy-6-polyprenyl-1?4-benzoquinol_methylase?_mitochondrial_[Plutella_xylostella]

Location

Bomo_Chr16(+):339327-344326      View in EpiBrowser

Full name

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial      

Alternative Name

Ubiquinone biosynthesis methyltransferase COQ5

Location in the cell

Cytoplasmic   Reliability : 2.055 Mitochondrial   Reliability : 1.544

CDS

ATGGCTCTGAAGAGAGGATTATTTCGTTTAGCTGAAACGTACAGGCCTTCGCGGCCCCACATCAGGGCGCGATTACTGGCCACACAGTCCGCTGCCAACAATGAAGAGAGACAAAGCAAAAACCAAACTCATTTTGGATTTCAAACTGTTGACGAAAATGAAAAAACTAAGAAAGTTCACGAAGTATTCGAAACGGTAGCAGGCAAGTATGATCTAATGAATGATGTAATGTCCTTTGGAATACATAGAGTATGGAAAGACATATTCATGGCTCGCTTGGCACCAATGCCGGAAACCAATTTACTGGATATGGCTGGAGGGACAGGGGACATTACATTTAGGTACATAAAATATCTTCAAAATCTTCGTTCAAAACCTACAGAAGGAGCTCGCAGCTCTGTCACAGTGTGTGACATAAACCAGGCCATGCTGGATGTAGGAAAAGTCAGAGCAGAAAGGTTAGGTTACACAAAGGAATCCAGTGGTGTGGACATAGATTGGTTGTGTGCTGATGCTGAACAGCTTCCAGTAGCGGACGACACCTACACAGCATATACTATTGCTTTTGGCATCAGAAACTGTACCCATATTGATAAGGTTTTAGAAGAGGCATACAGAGTGCTAAAGCCGGGCGGACGCTTTATGTGTTTGGAGTTCAGTCAAATACCTAACGAGGCTTTACAGTGGGCATACGACCAGTACTCGTTCCAAGTGATCCCGGTGTTGGGTCAGCTGGTGGCCGGCCAGTGGAAGCCGTACCAGTACCTCGTCGAGAGCATCAGGCAGTTTCCTAATCAGGAGAAATTCAAGATGATGATAGAAGACGCAGGATTCAGACAGGTGGCCTACGAAAACCTCACGTTCGGAACCGTGGCCATCCACTCCGGCTTCAAGATCTAA

Protein

MALKRGLFRLAETYRPSRPHIRARLLATQSAANNEERQSKNQTHFGFQTVDENEKTKKVHEVFETVAGKYDLMNDVMSFGIHRVWKDIFMARLAPMPETNLLDMAGGTGDITFRYIKYLQNLRSKPTEGARSSVTVCDINQAMLDVGKVRAERLGYTKESSGVDIDWLCADAEQLPVADDTYTAYTIAFGIRNCTHIDKVLEEAYRVLKPGGRFMCLEFSQIPNEALQWAYDQYSFQVIPVLGQLVAGQWKPYQYLVESIRQFPNQEKFKMMIEDAGFRQVAYENLTFGTVAIHSGFKI

Description

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

Catalytic Activity

a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine

Subunit

Component of a multi-subunit COQ enzyme complex.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

Keywords

Complete proteome   Membrane   Methyltransferase   Mitochondrion   Mitochondrion inner membrane   Reference proteome   S-adenosyl-L-methionine   Transferase   Transit peptide   Ubiquinone biosynthesis  

Feature

chain  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Uniprot

H9JT99   A0A2A4K7M1   A0A2W1BM77   A0A194Q6D0   A0A212FM75   A0A0N1I7D4   + More
A0A2H1WPB5   A0A2J7R8A1   A0A067REL2   A0A0L0BMK1   A0A1B6G3G9   A0A2P8Y1N3   A0A1B6L345   T1PGX5   A0A182FTF9   A0A2M4AUI9   A0A1W4VKU5   B4Q225   W5JPH4   B3NWR3   X2JES4   Q9VYF8   B4IGP1   A0A0K8TTX6   A0A182YFA7   A0A182VT48   A0A182NDE1   B4N2H1   B4JNM4   A0A1B6CR76   B4M849   A0A1B0A9Y5   A0A1B3PD93   A0A0M4EI60   A0A437AY15   A0A1A9VB07   B3MRP4   Q29GG8   A0A1W4XF56   A0A0R3P6K3   A0A1B0G400   A0A1B3PDL0   B4H0V9   A0A182JA32   A0A151X2G0   A0A182V8I7   A0A1B0BGJ8   A0A195CV83   A0A0A1XSM1   A0A182TWH0   B4L6H3   A0A088AQJ5   A0A1Q3FFM1   A0A1A9W190   A0A2A3EKW0   A0A034W7P3   A0A3L8DF52   A0A3B0KR24   A0A1I8Q4D8   A0A1A9XC21   A0A0N0BHG2   B0W0M4   A0A0K8U5Z0   A0A195BXU3   A0A026W0A9   A0A195DQD7   E9IE59   Q17PW7   W8AXW3   F4WZJ0   A0A1S4H4Z7   A0A232F3M6   Q7QKJ2   A0A158NH80   K7IN47   J3JVK2   A0A154P3Q4   A0A195ESZ7   A0A1J1J080   A0A139WH00   A0A1B6IHU1   E2AQ39   A0A2C9JGT9   A0A2S2NXE0   A0A2S2QTE6   E2BWU7   A0A2R7VXP1   A0A1L8DZF3   A0A0L8GHR3   A0A1L8DZK1   A0A2H8TJ75   A0A1B0D8D6   A0A336LZF1   C4WS56   A0A1S3JV24   V4ANT6   A0A0L7RHB1   A0A0T6B8V6   A0A1Y1L7C2   A0A182KFK3  

EC Number

2.1.1.201

Pubmed

19121390    28756777    26354079    22118469    24845553    26108605    + More
29403074    25315136    17994087    17550304    20920257    23761445    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    12537569    26369729    25244985    15632085    25830018    25348373    30249741    24508170    21282665    17510324    24495485    21719571    12364791    28648823    21347285    20075255    22516182    18362917    19820115    20798317    15562597    23254933    28004739   

EMBL

BABH01004246    NWSH01000045    PCG80275.1    KZ149997    PZC75391.1    KQ459582    + More
KPI98965.1    AGBW02007654    OWR54845.1    KQ460635    KPJ13415.1    ODYU01010068    SOQ54910.1    NEVH01006723    PNF37064.1    KK852685    KDR18513.1    JRES01001651    KNC21158.1    GECZ01012783    JAS56986.1    PYGN01001050    PSN38104.1    GEBQ01021869    JAT18108.1    KA648011    AFP62640.1    GGFK01010937    MBW44258.1    CM000162    EDX01546.1    ADMH02000540    ETN66021.1    CH954180    EDV47225.1    AE014298    AHN59663.1    AY122141    CH480836    EDW48991.1    GDAI01000198    JAI17405.1    CH963925    EDW78560.1    CH916371    EDV92317.1    GEDC01021232    JAS16066.1    CH940653    EDW62325.1    KU659899    AOG17698.1    CP012528    ALC48491.1    RSAL01000280    RVE43052.1    CH902622    EDV34449.1    CH379064    EAL32141.1    KRT06992.1    CCAG010005647    KU660025    AOG17823.1    CH479201    EDW29875.1    KQ982585    KYQ54384.1    JXJN01013884    KQ977259    KYN04540.1    GBXI01000744    JAD13548.1    CH933812    EDW05969.1    GFDL01008698    JAV26347.1    KZ288227    PBC31816.1    GAKP01009164    JAC49788.1    QOIP01000009    RLU19077.1    OUUW01000011    SPP86348.1    KQ435756    KOX75964.1    DS231818    EDS41326.1    GDHF01030237    JAI22077.1    KQ976398    KYM92763.1    KK107519    EZA49355.1    KQ980612    KYN15071.1    GL762556    EFZ21159.1    CH477188    EAT48827.1    GAMC01016902    JAB89653.1    GL888479    EGI60434.1    AAAB01008795    NNAY01001024    OXU25446.1    EAA03586.4    ADTU01001633    BT127270    AEE62232.1    KQ434809    KZC06546.1    KQ981979    KYN31375.1    CVRI01000066    CRL05861.1    KQ971344    KYB27131.1    GECU01021212    JAS86494.1    GL441688    EFN64448.1    GGMR01009264    MBY21883.1    GGMS01011720    MBY80923.1    GL451188    EFN79811.1    KK854072    PTY10695.1    GFDF01002224    JAV11860.1    KQ421758    KOF76498.1    GFDF01002225    JAV11859.1    GFXV01002360    MBW14165.1    AJVK01027353    AJVK01027354    UFQT01000251    SSX22401.1    ABLF02021936    AK340053    BAH70726.1    KB201656    ESO95311.1    KQ414592    KOC70209.1    LJIG01009334    KRT83287.1    GEZM01066505    JAV67845.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000235965    + More
UP000027135    UP000037069    UP000245037    UP000095301    UP000069272    UP000192221    UP000002282    UP000000673    UP000008711    UP000000803    UP000001292    UP000076408    UP000075920    UP000075884    UP000007798    UP000001070    UP000008792    UP000092445    UP000092553    UP000283053    UP000078200    UP000007801    UP000001819    UP000192223    UP000092444    UP000008744    UP000075880    UP000075809    UP000075903    UP000092460    UP000078542    UP000075902    UP000009192    UP000005203    UP000091820    UP000242457    UP000279307    UP000268350    UP000095300    UP000092443    UP000053105    UP000002320    UP000078540    UP000053097    UP000078492    UP000008820    UP000007755    UP000215335    UP000007062    UP000005205    UP000002358    UP000076502    UP000078541    UP000183832    UP000007266    UP000000311    UP000076420    UP000008237    UP000053454    UP000092462    UP000007819    UP000085678    UP000030746    UP000053825    UP000075881   

PRIDE

H9JT99    X2JES4    Q9VYF8   

Pfam

PF01209   Ubie_methyltran

Interpro

IPR004033   UbiE/COQ5_MeTrFase        + More
IPR023576   UbiE/COQ5_MeTrFase_CS       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF53335   SSF53335       

ProteinModelPortal

H9JT99   A0A2A4K7M1   A0A2W1BM77   A0A194Q6D0   A0A212FM75   A0A0N1I7D4   + More
A0A2H1WPB5   A0A2J7R8A1   A0A067REL2   A0A0L0BMK1   A0A1B6G3G9   A0A2P8Y1N3   A0A1B6L345   T1PGX5   A0A182FTF9   A0A2M4AUI9   A0A1W4VKU5   B4Q225   W5JPH4   B3NWR3   X2JES4   Q9VYF8   B4IGP1   A0A0K8TTX6   A0A182YFA7   A0A182VT48   A0A182NDE1   B4N2H1   B4JNM4   A0A1B6CR76   B4M849   A0A1B0A9Y5   A0A1B3PD93   A0A0M4EI60   A0A437AY15   A0A1A9VB07   B3MRP4   Q29GG8   A0A1W4XF56   A0A0R3P6K3   A0A1B0G400   A0A1B3PDL0   B4H0V9   A0A182JA32   A0A151X2G0   A0A182V8I7   A0A1B0BGJ8   A0A195CV83   A0A0A1XSM1   A0A182TWH0   B4L6H3   A0A088AQJ5   A0A1Q3FFM1   A0A1A9W190   A0A2A3EKW0   A0A034W7P3   A0A3L8DF52   A0A3B0KR24   A0A1I8Q4D8   A0A1A9XC21   A0A0N0BHG2   B0W0M4   A0A0K8U5Z0   A0A195BXU3   A0A026W0A9   A0A195DQD7   E9IE59   Q17PW7   W8AXW3   F4WZJ0   A0A1S4H4Z7   A0A232F3M6   Q7QKJ2   A0A158NH80   K7IN47   J3JVK2   A0A154P3Q4   A0A195ESZ7   A0A1J1J080   A0A139WH00   A0A1B6IHU1   E2AQ39   A0A2C9JGT9   A0A2S2NXE0   A0A2S2QTE6   E2BWU7   A0A2R7VXP1   A0A1L8DZF3   A0A0L8GHR3   A0A1L8DZK1   A0A2H8TJ75   A0A1B0D8D6   A0A336LZF1   C4WS56   A0A1S3JV24   V4ANT6   A0A0L7RHB1   A0A0T6B8V6   A0A1Y1L7C2   A0A182KFK3  

PDB

4OBX     E-value=1.18148e-56,     Score=555

KEGG

101743462    K06127 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.201] | (RefSeq) 2-methoxy-6-polypr

PATHWAY

00130    Ubiquinone and other terpenoid-quinone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0031314   GO:0006744   GO:0043333   GO:0008168   GO:0005739   GO:0043334   GO:0016021   GO:0003676   GO:0008289   GO:0016849   GO:0004672   GO:0005524   GO:0006468   GO:0006418   GO:0000049   GO:0016876  

Subcellular location

Mitochondrion inner membrane  

Length:

299

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04349

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01172

outside

1  -  299

 

 

Pi

26.823279

Theta

22.210878

Tajima's D

0.755962

CLR

0.402227

CSRT

0.6027198640068

Interpretation

Uncertain