Gene

KWMTBOMO09386

Annotation

PREDICTED:_peroxisome_assembly_protein_12_[Bombyx_mori]

Location

Bomo_Chr16(+):316296-320620      View in EpiBrowser

Full name

Peroxisome assembly protein 12      

Alternative Name

Peroxin-12
Peroxisome assembly factor 3

Location in the cell

PlasmaMembrane   Reliability : 2.21

CDS

ATGGCGGTATACGCGGCTCATTTAACACGCAGCTTCCAAGGGACTCCATCGGTTTTTCAAGTGACAGCACAGGAGGCCCTTGGAACTACTTTAAAACCTGCTCTCAGGAAGGTTATTGAATATTTATCAGTGCTGTACCCTAACAAATGCAGCTGGTGCACTCATTGGTACGATGAACTGTATTTGCTGTTTGATTGTATAGTGCAGTACAATTACCTTAAATATTATGCTGCATCTTTTTCTGAAAGTTTCTATGGTCTACTCCGGGTGCCCATATCGTACAGTAGTGAGTTCAGCATTGGACAACGTCTCCCAATAGACTTAGAGCGAGGATCTCTTGCACTTCTAGTATTGTTGCCATACGTTAAGGACAAAGTCGGTGCTATTATTGATAAATGGAGGGAAGACAATGAAGATGGGAAACTTGGTAAGGACACGCGGGGCCGGCTTCGTTCGGCAGCGATAAAAGTGTACGCGATCCTCCACCTCGTGTACGAGGGTCTACAGCTGGTGCAGCTGGCGCGCTACCTGAGGGGCGGCTCCCCGTCGCACTCGCTGCCCATGGCGGCGCTGGGGCTCACACTGAGGAACGCGCCCCCCCAGGAACTGCCCGAGGACGAATACACCTGGAGTGATTTATTCAAGAATTTGTCGTCTGGGCAAATCGGGAGCGCAGCCCTGACGTTCCCCATGGTGGGCGGAGCGGTGGTCCGCGGCGCAGAGTACGGCGCCTTCGTGGTGCAGCTGCTGCGCTGGTGGCGCGACCGCGGCGCCCCCCCGCCCTCCCTGCCCGCGCCGCCCCCGCCCGCAGTAAGCAACACCCTGCAGTCCACACACAGATCTATGTCGCTGACCATAAACGAGGCTAAGGTCCTGCTCCGGCGACCGGAGGCCGCGGCGACTGCTGCGGCGTCACGTTACGTAGACGCGACATTGCTTTAA

Protein

MAVYAAHLTRSFQGTPSVFQVTAQEALGTTLKPALRKVIEYLSVLYPNKCSWCTHWYDELYLLFDCIVQYNYLKYYAASFSESFYGLLRVPISYSSEFSIGQRLPIDLERGSLALLVLLPYVKDKVGAIIDKWREDNEDGKLGKDTRGRLRSAAIKVYAILHLVYEGLQLVQLARYLRGGSPSHSLPMAALGLTLRNAPPQELPEDEYTWSDLFKNLSSGQIGSAALTFPMVGGAVVRGAEYGAFVVQLLRWWRDRGAPPPSLPAPPPPAVSNTLQSTHRSMSLTINEAKVLLRRPEAAATAAASRYVDATLL

Description

Required for protein import into peroxisomes.

Subunit

Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain (By similarity).
Interacts with PEX5 and PEX10. Interacts with PEX19 via its cytoplasmic domain.

Similarity

Belongs to the pex2/pex10/pex12 family.
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

Keywords

Complete proteome   Membrane   Metal-binding   Peroxisome   Reference proteome   Transmembrane   Transmembrane helix   Zinc   Zinc-finger   Disease mutation   Peroxisome biogenesis disorder   Polymorphism   Zellweger syndrome  

Feature

chain  Peroxisome assembly protein 12
sequence variant  In PBD-CG3; dbSNP:rs147530802.

Uniprot

A0A3S2N6Z7   A0A2W1BP34   A0A2A4K7P6   A0A212FM69   A0A2H1WRF5   A0A194Q1U9   + More
A0A0N0PCE0   A0A182GHU1   A0A067R5N8   Q176A8   A0A1Q3F7G2   A0A210PYN0   A0A1B6C605   A0A182YF98   D2A427   A0A2P8Y1F9   B0WP05   A0A182U3B0   A0A182WUW9   A0NDZ1   A0A182VC09   A0A182HYG3   W5JRU7   A0A182FTG6   A0A182RIU7   A0A182LPW6   A0A182GIY1   A0A182VT54   A0A3L8D9H9   A0A0P4WRZ0   A0A1J1HRV8   W4Z282   A0A1B0CY49   A0A195DQN0   V4B9Q0   A0A1W4WG14   J9JW34   A0A096P3X3   A0A2S2QJP9   A0A1S3HCG2   A0A2F0BIN6   A0A087ZNZ8   A0A384AS98   A0A1B0D811   A0A182PUG6   A0A154PBN1   A0A182JT71   A0A0D9R1R9   A4FUD4   A0A340WC38   L8IDC3   A0A2K5NG80   A0A2K6QZH3   A0A2K6JV27   A0A2K5Y0E5   H9EV34   A0A2D4NFY7   F6WC25   G3T896   A0A2K6JV34   A0A2K5X4M1   W5P982   K7IVW9   A0A2K6CDD2   A0A2J8RCS9   A0A452G3U6   M3WD63   A0A2K5IWF5   A0A2J8RCT6   A0A232F441   I3N2U0   A0A341DDC4   G1RUI6   A0A212DB81   A0PJ54   H2QCP9   A0A2J8LJC8   G3QLC4   A0A444SW57   A0A2R9BAF6   U6CR09   S9XL90   A0A1Y1L2Z8   I7G2Z0   F6UYN6   A0A075B773   O00623   A0A1B6K936   A0A2K5BWR3   M3YTY7   A0A2Y9K039   A0A3Q7NV46   G7PU39   A0A2U3WYT9   F7DEK1   J9NYE4   A0A3Q7S7N5  

Pubmed

28756777    22118469    26354079    26483478    24845553    17510324    + More
28812685    25244985    18362917    19820115    29403074    12364791    14747013    17210077    20920257    23761445    20966253    30249741    23254933    22751099    25362486    25319552    17431167    20809919    20075255    17975172    28648823    15489334    16136131    22398555    22722832    23149746    28004739    17194215    19892987    16625196    9090384    9632816    14702039    10704444    11390669    10562279    19105186    22002653    25243066    16341006   

EMBL

RSAL01000280    RVE43055.1    KZ149997    PZC75394.1    NWSH01000045    PCG80251.1    + More
AGBW02007654    OWR54848.1    ODYU01010503    SOQ55655.1    KQ459582    KPI98969.1    KQ460635    KPJ13419.1    JXUM01064751    KQ562313    KXJ76168.1    KK852685    KDR18500.1    CH477391    EAT41950.1    GFDL01011553    JAV23492.1    NEDP02005380    OWF41591.1    GEDC01028569    JAS08729.1    KQ971348    EFA04853.2    PYGN01001050    PSN38097.1    DS232018    EDS32032.1    AAAB01008933    EAU76750.2    APCN01005906    ADMH02000540    ETN66013.1    JXUM01067137    JXUM01067138    JXUM01067139    JXUM01067140    KQ562435    KXJ75922.1    QOIP01000011    RLU17165.1    GDRN01037800    JAI67278.1    CVRI01000020    CRK90816.1    AAGJ04089348    AAGJ04089349    AAGJ04089350    AJWK01035466    KQ980612    KYN15173.1    KB199861    ESP04191.1    ABLF02028177    AHZZ02010048    GGMS01008754    MBY77957.1    NTJE010224278    MBW02868.1    AJVK01027193    KQ434857    KZC08814.1    AQIB01146976    BC114718    JH881560    ELR53559.1    JU322487    AFE66243.1    IACM01181318    LAB44622.1    JSUE03016484    AQIA01027261    AMGL01017574    ABGA01275056    NDHI03003710    PNJ06323.1    LWLT01000022    AANG04004035    PNJ06324.1    NNAY01001060    OXU25299.1    AGTP01022353    MKHE01000005    OWK15489.1    BC015751    AAH15751.1    AC161478    GABC01007381    GABF01010454    GABD01005293    GABE01004108    NBAG03000289    JAA03957.1    JAA11691.1    JAA27807.1    JAA40631.1    PNI47374.1    PNI47376.1    CABD030038287    SAUD01021097    RXG57621.1    AJFE02061521    HAAF01000933    CCP72759.1    KB016468    EPY88424.1    GEZM01068147    GEZM01068146    JAV67141.1    AB170778    BAE87841.1    AC015911    U91521    U91522    AB004546    AK312635    CH471147    BC031085    GEBQ01032027    JAT07950.1    AEYP01021497    CM001291    EHH57888.1    GAMT01003565    GAMS01006804    GAMR01005810    GAMQ01004193    GAMP01007521    JAB08296.1    JAB16332.1    JAB28122.1    JAB37658.1    JAB45234.1    AAEX03006623   

Proteomes

UP000283053    UP000218220    UP000007151    UP000053268    UP000053240    UP000069940    + More
UP000249989    UP000027135    UP000008820    UP000242188    UP000076408    UP000007266    UP000245037    UP000002320    UP000075902    UP000076407    UP000007062    UP000075903    UP000075840    UP000000673    UP000069272    UP000075900    UP000075882    UP000075920    UP000279307    UP000183832    UP000007110    UP000092461    UP000078492    UP000030746    UP000192223    UP000007819    UP000028761    UP000085678    UP000005203    UP000261681    UP000092462    UP000075885    UP000076502    UP000075881    UP000029965    UP000009136    UP000265300    UP000233060    UP000233200    UP000233180    UP000233140    UP000006718    UP000007646    UP000233100    UP000002356    UP000002358    UP000233120    UP000001595    UP000291000    UP000011712    UP000233080    UP000215335    UP000005215    UP000252040    UP000001073    UP000002277    UP000001519    UP000288706    UP000240080    UP000002281    UP000005640    UP000233020    UP000000715    UP000248482    UP000286641    UP000009130    UP000245340    UP000008225    UP000002254    UP000286640   

PRIDE

A4FUD4    A0PJ54    O00623   

Pfam

PF04757   Pex2_Pex12        + More
PF05189   RTC_insert
PF01137   RTC
PF00076   RRM_1
PF10613   Lig_chan-Glu_bd
PF01094   ANF_receptor
PF00107   ADH_zinc_N
PF08240   ADH_N
PF13639   zf-RING_2
PF00097   zf-C3HC4
PF00096   zf-C2H2

Interpro

IPR017375   PEX12        + More
IPR006845   Pex_N       
IPR013083   Znf_RING/FYVE/PHD       
IPR001841   Znf_RING       
IPR003613   Ubox_domain       
IPR016443   RNA3'_term_phos_cyc_type_2       
IPR013791   RNA3'-term_phos_cycl_insert       
IPR020719   RNA3'_term_phos_cycl-like_CS       
IPR023797   RNA3'_phos_cyclase_dom       
IPR000228   RNA3'_term_phos_cyc       
IPR036553   RPTC_insert       
IPR037136   RNA3'_phos_cyclase_dom_sf       
IPR013792   RNA3'P_cycl/enolpyr_Trfase_a/b       
IPR035979   RBD_domain_sf       
IPR034520   SRSF1_RRM1       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       
IPR001828   ANF_lig-bd_rcpt       
IPR028082   Peripla_BP_I       
IPR001320   Iontro_rcpt       
IPR019594   Glu/Gly-bd       
IPR002328   ADH_Zn_CS       
IPR013154   ADH_N       
IPR020843   PKS_ER       
IPR014183   ADH_3       
IPR036291   NAD(P)-bd_dom_sf       
IPR011032   GroES-like_sf       
IPR013149   ADH_C       
IPR018957   Znf_C3HC4_RING-type       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF55205   SSF55205        + More
SSF54928   SSF54928       
SSF53822   SSF53822       
SSF50129   SSF50129       
SSF51735   SSF51735       
SSF57667   SSF57667       

Gene 3D

3.30.40.10     3.30.360.20     3.65.10.20     3.30.70.330    

CDD

cd00875  RNA_Cyclase_Class_I
cd12597  RRM1_SRSF1
cd08300  alcohol_DH_class_III

ProteinModelPortal

A0A3S2N6Z7   A0A2W1BP34   A0A2A4K7P6   A0A212FM69   A0A2H1WRF5   A0A194Q1U9   + More
A0A0N0PCE0   A0A182GHU1   A0A067R5N8   Q176A8   A0A1Q3F7G2   A0A210PYN0   A0A1B6C605   A0A182YF98   D2A427   A0A2P8Y1F9   B0WP05   A0A182U3B0   A0A182WUW9   A0NDZ1   A0A182VC09   A0A182HYG3   W5JRU7   A0A182FTG6   A0A182RIU7   A0A182LPW6   A0A182GIY1   A0A182VT54   A0A3L8D9H9   A0A0P4WRZ0   A0A1J1HRV8   W4Z282   A0A1B0CY49   A0A195DQN0   V4B9Q0   A0A1W4WG14   J9JW34   A0A096P3X3   A0A2S2QJP9   A0A1S3HCG2   A0A2F0BIN6   A0A087ZNZ8   A0A384AS98   A0A1B0D811   A0A182PUG6   A0A154PBN1   A0A182JT71   A0A0D9R1R9   A4FUD4   A0A340WC38   L8IDC3   A0A2K5NG80   A0A2K6QZH3   A0A2K6JV27   A0A2K5Y0E5   H9EV34   A0A2D4NFY7   F6WC25   G3T896   A0A2K6JV34   A0A2K5X4M1   W5P982   K7IVW9   A0A2K6CDD2   A0A2J8RCS9   A0A452G3U6   M3WD63   A0A2K5IWF5   A0A2J8RCT6   A0A232F441   I3N2U0   A0A341DDC4   G1RUI6   A0A212DB81   A0PJ54   H2QCP9   A0A2J8LJC8   G3QLC4   A0A444SW57   A0A2R9BAF6   U6CR09   S9XL90   A0A1Y1L2Z8   I7G2Z0   F6UYN6   A0A075B773   O00623   A0A1B6K936   A0A2K5BWR3   M3YTY7   A0A2Y9K039   A0A3Q7NV46   G7PU39   A0A2U3WYT9   F7DEK1   J9NYE4   A0A3Q7S7N5  

KEGG

101735612    K13345 peroxin-12 | (RefSeq) peroxisome assembly protein 12

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0005778   GO:0006625   GO:0008270   GO:0005779   GO:0008022   GO:0004842   GO:0016874   GO:0003824   GO:0005730   GO:0006396   GO:0042254   GO:0016558   GO:1990429   GO:0006513   GO:0003723   GO:0016021   GO:0030054   GO:0045211   GO:0004970   GO:0051903   GO:0006069   GO:0003676   GO:0007031   GO:0005777   GO:0016567  

PANTHER

PTHR12888   PTHR11096:SF1   PTHR11096  

Subcellular location

Peroxisome membrane  
  

Length:

313

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.52873

Exp number, first 60 AAs:

0.00288

Total prob of N-in:

0.08480

outside

1  -  313

 

 

Pi

17.719366

Theta

14.781982

Tajima's D

0.70461

CLR

0.059375

CSRT

0.588620568971551

Interpretation

Uncertain