Gene

KWMTBOMO09321  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003296

Annotation

beta-tubulin_[Operophtera_brumata]

Location

Bomo_Chr15(-):15974551-15975814      View in EpiBrowser

Full name

Tubulin beta chain      

Alternative Name

Beta-tubulin

Location in the cell

Cytoplasmic   Reliability : 1.602 Nuclear   Reliability : 1.485

CDS

ATGGATTCAATCCGAGGCGGACCCTACGGCTCTATCTACCGTCCAGATAACGTAGTCTGCGGTGCCTCAGGCGCAGGCAATAACTGGGCTAAAGGACATTACACCGAAGGGGCAGATTTACTTGAAACAGTCCTCGATGTGGTCAGAAAGGAAGCGGAAGGCTGCGATTGCTTGCAAGGCTTCCAATTAGTCCATTCTCTTGGAGGAGGTACAGGATCAGGCATGGGCACTTTGCTGCTCGCTAACTTAACCGAAGAATACCCAGATCGAATTACGGCCACATACTCAGTGGTTCCAAGTCCAACAGTTTCAGACACAGTCGTTGAACCATACAATGCCACTTTATCCGTGAATCAATTAATAGAGAATTCAATCCAGTCTTACTGCATCGATAACGAAGCTTTGTATTACATATGCCACAGAACGTTGAAGCTCATGACGCCTACGTACGGGGATCTGAACCATCTGGTGTCTTTAACGATGTCTGGCGTGACAACGTGTCTGCGGTTTCCAGGGCAACTTAACGCGGATCTACGAAAGTTAGCGGTCAATATGATACCCTTTCCGAGGCTGCACTTCTTTATGCCCGGCTTTGCACCGCTGACGTCAAGAAATAGTCAGCAGTACCGCGCTCTCACGGTACCAGAATTAACACAACAAATGTTCGACGCAAAGAATATGATGGCGGCTTGTGATCCTCACCGCGGTCGCTATCTCACTGTAGCCACCGTCTTCCGGGGAAGAATGTCAATGAAGGAAATAGACGAGCAAATCCTTAACGTGCAGAAAAAGAATAAGGACTTTTTCGTCGAATGGATCCCAAATAACGTGCAGACTGCGGTTTGTGACATCCCGCCCAGAGGAATGAAAATGTCCGCGACATTCATTGGGAATACAACCGCGATCCAGGAAATTTTCAAGAGGATTTCAGAGCAGTTTGCAGCAATGTTTAGTAGAAAAGCTTTCCTACATTGGTACACAGGCGAGGGTATGGAGGAGGGAGATTTTGCAGAAGCTGATAACAATGTCAGTGATCTGTTATCGGAGTACCAGCAGTATCAGGATGCGACCATTGACCAGGAGTTCGAAGACGAAGAAACAGTAGAAGAGCAAAACGACGACAGTGATGAACAATAA

Protein

MDSIRGGPYGSIYRPDNVVCGASGAGNNWAKGHYTEGADLLETVLDVVRKEAEGCDCLQGFQLVHSLGGGTGSGMGTLLLANLTEEYPDRITATYSVVPSPTVSDTVVEPYNATLSVNQLIENSIQSYCIDNEALYYICHRTLKLMTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMIPFPRLHFFMPGFAPLTSRNSQQYRALTVPELTQQMFDAKNMMAACDPHRGRYLTVATVFRGRMSMKEIDEQILNVQKKNKDFFVEWIPNNVQTAVCDIPPRGMKMSATFIGNTTAIQEIFKRISEQFAAMFSRKAFLHWYTGEGMEEGDFAEADNNVSDLLSEYQQYQDATIDQEFEDEETVEEQNDDSDEQ

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Similarity

Belongs to the tubulin family.

Keywords

Complete proteome   Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Reference proteome  

Feature

chain  Tubulin beta chain

Uniprot

H9J1A9   P41385   A0A0L7LNC9   A0A2H1WFD2   A0A2A4K2J6   A0A3S2NIS9   + More
A0A212FFP2   A0A2W1B4J9   A0A0N1IGQ0   A0A194Q0N8   A0A2W1BC24   A0A2A4K3I5   A3EXM9   A0A2H1WFD3   A0A212FFP1   Q8T8B0   A0A0P5DMN5   A0A023F9R5   A0A0P6GW27   A0A182M5U0   A0A3S2M5W1   A0A194Q6V3   A0A1B6EWG6   A0A0P4YFZ6   A0A0P5GVC0   A0A0N7ZJZ4   A0A0P5FPY0   A0A091VG74   A0A091G2G3   A0A087VCK3   A0A091L3N6   A0A0A0A9V4   A0A091TRJ4   A0A094L232   A0A224XK43   A0A224XCJ7   Q0PHP0   A0A0P4W3J2   A0A0V0G3G1   A0A170XZV4   O18342   A0A162PE16   A0A0P6FPN7   A0A0P5CQN5   E9HEX5   A0A069DTP4   R4G4U5   A0A0P5BEA9   A0A091VM17   A0A093BR76   A0A2B4SV07   A0A023ESD5   A0A2C9JVG7   A0A1S3DFH4   T1DI49   A0A1Q3EUF9   U5EUT8   A0A0A9Z1S4   A0A0A9Z399   A0A0A9Z018   A0A0V0G2I5   W5JQL0   A0A182KDY0   A0A087V0D8   A0A0P5PM08   A0A0P5IGT4   A0A182TD76   A0A069DZ10   R4G8S6   A0A0P6G935   B0W7E7   A0A336M9C0   Q17GX9   A0A182H8F4   A0A401RR89   Q7ZY50   A0A1L8E5M5   A0A0L7K471   A0A2W1BD95   A0A2A4JTH9   T1JL27   A0A0N0PBJ8   A2I3X7   A0A3S2TRY0   T1DF12   D6WSV2   A0A0A9Z013   A0A0A9X553   A0A0J7KI69   A0A2H1VRL4   A0A182YD80   A0A067R568   H9J513   A0A2M3ZFE2   A0A2M4A0W5   A0A212ETB0   A0A182PTT4   A0A182Q4Z1   N6U8U9   A0A182UM44  

Pubmed

19121390    7557453    26227816    22118469    28756777    26354079    + More
12459208    25474469    17257209    27129103    9303342    21292972    26334808    24945155    15562597    24330624    25401762    20920257    17510324    26483478    30297745    27762356    18362917    19820115    25244985    24845553    23537049   

EMBL

BABH01024033    X74951    JTDY01000486    KOB76957.1    ODYU01008310    SOQ51789.1    + More
NWSH01000200    PCG78467.1    RSAL01000026    RVE52090.1    AGBW02008792    OWR52549.1    KZ150438    PZC70868.1    KQ460419    KPJ14856.1    KQ459581    KPI99121.1    PZC70867.1    PCG78468.1    EF091947    ABN11939.1    SOQ51788.1    OWR52548.1    AB072310    BAB86855.1    GDIP01155093    JAJ68309.1    GBBI01000490    JAC18222.1    GDIQ01028664    JAN66073.1    AXCM01001793    RVE52091.1    KPI99120.1    GECZ01027490    JAS42279.1    GDIP01229135    JAI94266.1    GDIQ01235200    JAK16525.1    GDIP01237985    JAI85416.1    GDIP01145349    GDIQ01187717    JAJ78053.1    JAK64008.1    KK429396    KFQ88618.1    KL447753    KFO76740.1    KL488290    KFO10345.1    KL292087    KFP49755.1    KL871146    KGL90836.1    KK464399    KFQ80979.1    KL272888    KFZ64905.1    GFTR01006238    JAW10188.1    GFTR01006309    JAW10117.1    DQ833529    ABH03477.1    GDKW01000582    JAI56013.1    GECL01003605    JAP02519.1    GEMB01003850    JAR99404.1    D89793    BAA22381.1    LRGB01000512    KZS18769.1    GDIQ01046063    JAN48674.1    GDIP01168131    JAJ55271.1    GL732632    EFX69673.1    GBGD01001446    JAC87443.1    ACPB03021733    GAHY01000456    JAA77054.1    GDIP01185588    GDIQ01190371    GDIP01050713    JAJ37814.1    JAK61354.1    KL409630    KFQ90738.1    KL229451    KFV04688.1    LSMT01000025    PFX32245.1    GAPW01001430    JAC12168.1    GALA01001146    JAA93706.1    GFDL01016207    JAV18838.1    GANO01001316    JAB58555.1    GBHO01005778    JAG37826.1    GBHO01005781    JAG37823.1    GBHO01005775    JAG37829.1    GECL01003768    JAP02356.1    ADMH02000621    ETN65588.1    KK122591    KFM83077.1    GDIQ01126492    JAL25234.1    GDIQ01221501    JAK30224.1    GBGD01001455    JAC87434.1    ACPB03005525    GAHY01000457    JAA77053.1    GDIQ01047153    GDIQ01002074    JAN47584.1    DS231853    EDS37862.1    UFQT01000630    UFQT01000929    SSX25891.1    SSX28043.1    CH477254    EAT45945.1    JXUM01029037    KQ560840    KXJ80657.1    BEZZ01001697    GCC20190.1    BC043974    CM004481    AAH43974.1    OCT65195.1    GFDF01000155    JAV13929.1    JTDY01010939    KOB57867.1    KZ150419    PZC70936.1    NWSH01000668    PCG74924.1    JH431796    KQ460891    KPJ10834.1    EF070480    ABM55546.1    RSAL01000012    RVE53489.1    GAMD01003291    JAA98299.1    KQ971352    EFA06663.1    GBHO01005780    JAG37824.1    GBHO01028818    JAG14786.1    LBMM01007242    KMQ89916.1    ODYU01004017    SOQ43460.1    KK852686    KDR18435.1    BABH01025836    GGFM01006525    MBW27276.1    GGFK01000957    MBW34278.1    AGBW02012621    OWR44709.1    AXCN02002037    AXCN02002038    APGK01034942    KB740923    ENN78090.1   

Proteomes

UP000005204    UP000037510    UP000218220    UP000283053    UP000007151    UP000053240    + More
UP000053268    UP000075883    UP000053760    UP000053858    UP000076858    UP000000305    UP000015103    UP000053283    UP000225706    UP000076420    UP000079169    UP000000673    UP000075881    UP000054359    UP000075902    UP000002320    UP000008820    UP000069940    UP000249989    UP000287033    UP000186698    UP000007266    UP000036403    UP000076408    UP000027135    UP000075885    UP000075886    UP000019118    UP000075903   

PRIDE

H9J1A9    P41385    Q8T8B0    H9J513   

Pfam

PF00091   Tubulin        + More
PF03953   Tubulin_C

Interpro

IPR036525   Tubulin/FtsZ_GTPase_sf        + More
IPR023123   Tubulin_C       
IPR037103   Tubulin/FtsZ_C_sf       
IPR002453   Beta_tubulin       
IPR017975   Tubulin_CS       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR000217   Tubulin       
IPR013838   Beta-tubulin_BS       
IPR008280   Tub_FtsZ_C       
IPR003008   Tubulin_FtsZ_GTPase       

SUPFAM

SSF52490   SSF52490        + More
SSF55307   SSF55307       

Gene 3D

1.10.287.600     3.30.1330.20     3.40.50.1440    

ProteinModelPortal

H9J1A9   P41385   A0A0L7LNC9   A0A2H1WFD2   A0A2A4K2J6   A0A3S2NIS9   + More
A0A212FFP2   A0A2W1B4J9   A0A0N1IGQ0   A0A194Q0N8   A0A2W1BC24   A0A2A4K3I5   A3EXM9   A0A2H1WFD3   A0A212FFP1   Q8T8B0   A0A0P5DMN5   A0A023F9R5   A0A0P6GW27   A0A182M5U0   A0A3S2M5W1   A0A194Q6V3   A0A1B6EWG6   A0A0P4YFZ6   A0A0P5GVC0   A0A0N7ZJZ4   A0A0P5FPY0   A0A091VG74   A0A091G2G3   A0A087VCK3   A0A091L3N6   A0A0A0A9V4   A0A091TRJ4   A0A094L232   A0A224XK43   A0A224XCJ7   Q0PHP0   A0A0P4W3J2   A0A0V0G3G1   A0A170XZV4   O18342   A0A162PE16   A0A0P6FPN7   A0A0P5CQN5   E9HEX5   A0A069DTP4   R4G4U5   A0A0P5BEA9   A0A091VM17   A0A093BR76   A0A2B4SV07   A0A023ESD5   A0A2C9JVG7   A0A1S3DFH4   T1DI49   A0A1Q3EUF9   U5EUT8   A0A0A9Z1S4   A0A0A9Z399   A0A0A9Z018   A0A0V0G2I5   W5JQL0   A0A182KDY0   A0A087V0D8   A0A0P5PM08   A0A0P5IGT4   A0A182TD76   A0A069DZ10   R4G8S6   A0A0P6G935   B0W7E7   A0A336M9C0   Q17GX9   A0A182H8F4   A0A401RR89   Q7ZY50   A0A1L8E5M5   A0A0L7K471   A0A2W1BD95   A0A2A4JTH9   T1JL27   A0A0N0PBJ8   A2I3X7   A0A3S2TRY0   T1DF12   D6WSV2   A0A0A9Z013   A0A0A9X553   A0A0J7KI69   A0A2H1VRL4   A0A182YD80   A0A067R568   H9J513   A0A2M3ZFE2   A0A2M4A0W5   A0A212ETB0   A0A182PTT4   A0A182Q4Z1   N6U8U9   A0A182UM44  

PDB

5HNW     E-value=1.46964e-164,     Score=1487

KEGG

693049    K07375 tubulin beta | (RefSeq) beta-tubulin

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0007017   GO:0003924   GO:0005737   GO:0005200   GO:0005874   GO:0005525   GO:0000226   GO:0000278   GO:0003676   GO:0004812   GO:0006418   GO:0000049   GO:0016876  

PANTHER

PTHR11588  

Subcellular location

  

Length:

378

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0365

Exp number, first 60 AAs:

0.00038

Total prob of N-in:

0.00546

outside

1  -  378

 

 

Pi

57.614425

Theta

48.115225

Tajima's D

1.872448

CLR

1.472201

CSRT

0.861156942152892

Interpretation

Uncertain