SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO09320  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA004603
Annotation
beta-tubulin_[Bombyx_mori]
Location
Bomo_Chr15(+):15971105-15973798      View in EpiBrowser
Full name
Tubulin beta chain       + More
Tubulin beta-4 chain      
Alternative Name
Beta-tubulin
Location in the cell
Cytoplasmic   Reliability : 3.392
 

Sequence

CDS
ATGAGGGAAATCGTCCACATCCAGGCGGGTCAATGCGGGAATCAGATCGGAGCAAAGTTCTGGGAAGTAATCTCGGACGAGCACGGCATTGACGCCACGGGTGCTTACAGCGGCGACTCCGACCTGCAGCTTGAACGCATCAATGTCTACTATAACGAAGCTTCAGGGGGCAAGTACGTCCCGCGAGCTGTGATGGTGGACCTTGAGCCTGGAACCATGGACTCCGTCCGTTCCGGGCCGTTTGGGCAAATCTTCCGACCGGACAACTTCGTCTTCGGACAGTCTGGGGCGGGGAATAACTGGGCGAAAGGACATTACACAGAGGGGGCTGAACTGGTTGATTCGGTACTGGATGTAGTTAGAAAAGAAGCAGAAGGCTGCGATTGTCTGCAGGGTTTTCAGCTAACTCATTCTCTGGGAGGAGGTACTGGATCTGGTATGGGGACTCTTTTGATTTCCAAAATCCGTGAAGAGTATCCAGATCGTATTATGAATACGTTTTCCGTGGTACCAAGTCCAAAGGTTTCCGATACTGTGGTAGAGCCATATAACGCAACGCTATCAGTCCACCAATTGGTAGAAAACACTGATGAGACGTATTGTATAGACAATGAGGCGCTTTACGATATCTGCTTCAGGACTTTGAAGCTAACAACCCCAACGTATGGGGACTTGAACCATTTGGTTTCAGCGACAATGTCTGGTGTGACCACGTGCTTGCGATTCCCAGGACAACTGAACGCCGATTTGCGGAAACTAGCGGTTAACATGGTTCCATTTCCGAGGTTACACTTCTTTATGCCGGGCTTTGCACCATTGACCTCTCGTGGGAGCCAACAGTATCGAGCTCTATCTGTGCCGGAGCTGACGCAGCAAATGTTTGATGCCAAGAACATGATGGCTGCCTGTGACCCTCGCCATGGTAGATATCTGACCGTCGCTGCCGTTTTCCGCGGACGGATGTCTATGAAGGAAGTGGACGAACAGATGCTCAACATACAGAACAAAAATAGCAGCTACTTCGTGGAATGGATTCCCAATAACGTCAAGACGGCCGTGTGCGACATTCCACCTCGTGGACTCAAAATGTCTGCCACCTTCATCGGAAACACCACAGCTATCCAAGAGCTGTTTAAAAGAATTTCTGAACAATTTACAGCCATGTTCAGACGAAAAGCTTTCTTGCACTGGTACACGGGGGAGGGTATGGATGAAATGGAGTTCACGGAGGCTGAATCGAACATGAACGATTTGGTTTCGGAGTACCAGCAGTATCAAGACGCCACGGCTGATGATGAAGGGGAATTTGATGAAGAGGTAGAGGAAGAGTGA
Protein
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDATGAYSGDSDLQLERINVYYNEASGGKYVPRAVMVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALSVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNTTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADDEGEFDEEVEEE

Summary

Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Subunit
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Similarity
Belongs to the tubulin family.
Keywords
Cytoplasm   Cytoskeleton   GTP-binding   Isopeptide bond   Microtubule   Nucleotide-binding  
Feature
chain  Tubulin beta-4 chain
Uniprot
Q8T8B0   A0A2W1BC24   A0A2A4K3I5   A0A2H1WFD3   A0A3S2M5W1   A0A0L7LP10   + More
A0A1L8F5P2   A0A023ESD5   T1DI49   A0A1Q3EUF9   U5EUT8   O18342   A0A0P6G935   A0A336M9C0   Q17GX9   P30883   A0A3B4EFT5   A0A1E1XAB0   A0A212FFP1   A0A3Q3BDZ6   A0A2G8KRV2   A0A1L8E5M5   A0A1I8FZR8   A0A146NTL8   Q7ZY50   G5BFZ1   K9J100   T1JL27   A0A1B6EWG6   Q0IIR4   A0A091CSX5   A0A0A9X553   A0A3B1JNB6   C0H8A6   A0A0A9Z013   A0A0A9Z399   T1FNQ3   A0A0P6IJV9   A0A060X6Y9   A0A1S3STF6   V9KI87   A0A452FM11   A0A1L8E5H8   A0A0N1IHX4   H2YR68   T1DF12   W4X9L8   A0A194Q6V3   A0A2M3ZFE2   A0A2M4A0W5   A0A182PTT4   A0A182Q4Z1   A0A182UM44   A0A182MY88   A0A087Z068   A0A182WG12   A0A084WAZ7   A0A182WUP7   A0A182J5N4   A0A182KKB6   Q7PSI4   A0A1W2WKR4   A0A182RQT8   A0A182HVT0   P11833   A0A3B4XR20   A0A3Q2EBE5   A0A3B3YXN2   A0A3Q1GAH3   A0A2I4C9U5   A0A3Q2VUY4   A0A3Q3M0J2   A0A3Q4I9I6   A0A087YKS8   A0A3B4TGS9   A0A1A8ET23   A0A1A8HE11   I3KHY4   A0A1S3M440   A0A3P9BF10   A0A1A8SP20   A0A1A8NCX4   A0A1A8IN77   A0A1A7XEX2   A0A1A8C457   A0A1A7ZLM6   A0A1W4VI24   B4LNW8   A0A2W1BD95   W8BUE6   A0A2C9JVG7   D3TR30   A0A2A4JTH9   B4KME5   A0A0N0PBJ8   A0A1A9YJQ2   A0A3S2TRY0   A0A0G4AL61   A0A1A9UYD7   A0A0K8V9H2  
Pubmed
12459208    28756777    26227816    27762356    24945155    24330624    + More
9303342    17510324    1379202    28503490    22118469    29023486    26392545    21993625    20431018    25401762    25329095    20433749    23254933    24755649    24402279    26354079    20920257    24438588    20966253    12364791    14747013    17210077    12481130    15114417    2762163    25186727    17994087    24495485    15562597    20353571    26252388   
EMBL
AB072310    BAB86855.1    KZ150438    PZC70867.1    NWSH01000200    PCG78468.1    + More
ODYU01008310    SOQ51788.1    RSAL01000026    RVE52091.1    JTDY01000486    KOB76961.1    CM004480    OCT66897.1    GAPW01001430    JAC12168.1    GALA01001146    JAA93706.1    GFDL01016207    JAV18838.1    GANO01001316    JAB58555.1    D89793    BAA22381.1    GDIQ01047153    GDIQ01002074    JAN47584.1    UFQT01000630    UFQT01000929    SSX25891.1    SSX28043.1    CH477254    EAT45945.1    L06232    BC054297    GFAC01003041    JAT96147.1    AGBW02008792    OWR52548.1    MRZV01000406    PIK50736.1    GFDF01000155    JAV13929.1    GCES01151223    JAQ35099.1    BC043974    CM004481    AAH43974.1    OCT65195.1    JH170063    EHB08202.1    GABZ01006096    JAA47429.1    JH431796    GECZ01027490    JAS42279.1    AAMC01107528    AAMC01107529    BC121707    BC135706    KV460631    AAI21708.1    AAI35707.1    OCA16315.1    KN124375    KFO21452.1    GBHO01028818    JAG14786.1    BT058562    BT059649    BT060271    ACN10275.1    ACN11362.1    GBHO01005780    JAG37824.1    GBHO01005781    JAG37823.1    AMQM01007627    KB097642    ESN92436.1    GDIQ01040660    GDIQ01003233    JAN91504.1    FR904845    CDQ72615.1    JW865185    AFO97702.1    LWLT01000009    GFDF01000126    JAV13958.1    KQ460419    KPJ14855.1    GAMD01003291    JAA98299.1    AAGJ04132828    KQ459581    KPI99120.1    GGFM01006525    MBW27276.1    GGFK01000957    MBW34278.1    AXCN02002037    AXCN02002038    GGFL01004205    MBW68383.1    ATLV01022298    KE525331    KFB47391.1    AXCP01003904    AXCP01003905    AAAB01008823    EAA05547.5    APCN01001414    X15389    AYCK01019193    HAEB01003171    SBQ49698.1    HAEC01013222    SBQ81439.1    AERX01023495    HAEH01011657    HAEI01016960    SBS19429.1    HAEF01000251    HAEG01002272    SBR66930.1    HAED01011648    HAEE01007281    SBQ98016.1    HADW01015212    HADX01013195    SBP16612.1    HADZ01009524    HAEA01015236    SBP73465.1    HADY01004445    HAEJ01016192    SBP42930.1    CH940648    EDW61137.1    KZ150419    PZC70936.1    GAMC01001610    JAC04946.1    EZ423882    ADD20158.1    NWSH01000668    PCG74924.1    CH933808    EDW09833.1    KQ460891    KPJ10834.1    RSAL01000012    RVE53489.1    KR133399    AKM70869.1    GDHF01016881    JAI35433.1   
Proteomes
UP000218220    UP000283053    UP000037510    UP000186698    UP000008820    UP000261440    + More
UP000007151    UP000264800    UP000230750    UP000095280    UP000006813    UP000008143    UP000028990    UP000018467    UP000087266    UP000015101    UP000193380    UP000291000    UP000053240    UP000007875    UP000007110    UP000053268    UP000075885    UP000075886    UP000075903    UP000075884    UP000075920    UP000030765    UP000076407    UP000075880    UP000075882    UP000007062    UP000008144    UP000075900    UP000075840    UP000261360    UP000265020    UP000261480    UP000257200    UP000192220    UP000264840    UP000261640    UP000261580    UP000028760    UP000261420    UP000005207    UP000265160    UP000192221    UP000008792    UP000076420    UP000009192    UP000092443    UP000078200   
PRIDE
Q8T8B0    P30883    P11833    I3KHY4   
Pfam
PF00091   Tubulin        + More
PF03953   Tubulin_C
Interpro
IPR036525   Tubulin/FtsZ_GTPase_sf        + More
IPR023123   Tubulin_C       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR000217   Tubulin       
IPR008280   Tub_FtsZ_C       
IPR003008   Tubulin_FtsZ_GTPase       
IPR002453   Beta_tubulin       
IPR037103   Tubulin/FtsZ_C_sf       
IPR013838   Beta-tubulin_BS       
IPR017975   Tubulin_CS       
SUPFAM
SSF52490   SSF52490        + More
SSF55307   SSF55307       
Gene 3D
1.10.287.600     3.30.1330.20     3.40.50.1440    
ProteinModelPortal
Q8T8B0   A0A2W1BC24   A0A2A4K3I5   A0A2H1WFD3   A0A3S2M5W1   A0A0L7LP10   + More
A0A1L8F5P2   A0A023ESD5   T1DI49   A0A1Q3EUF9   U5EUT8   O18342   A0A0P6G935   A0A336M9C0   Q17GX9   P30883   A0A3B4EFT5   A0A1E1XAB0   A0A212FFP1   A0A3Q3BDZ6   A0A2G8KRV2   A0A1L8E5M5   A0A1I8FZR8   A0A146NTL8   Q7ZY50   G5BFZ1   K9J100   T1JL27   A0A1B6EWG6   Q0IIR4   A0A091CSX5   A0A0A9X553   A0A3B1JNB6   C0H8A6   A0A0A9Z013   A0A0A9Z399   T1FNQ3   A0A0P6IJV9   A0A060X6Y9   A0A1S3STF6   V9KI87   A0A452FM11   A0A1L8E5H8   A0A0N1IHX4   H2YR68   T1DF12   W4X9L8   A0A194Q6V3   A0A2M3ZFE2   A0A2M4A0W5   A0A182PTT4   A0A182Q4Z1   A0A182UM44   A0A182MY88   A0A087Z068   A0A182WG12   A0A084WAZ7   A0A182WUP7   A0A182J5N4   A0A182KKB6   Q7PSI4   A0A1W2WKR4   A0A182RQT8   A0A182HVT0   P11833   A0A3B4XR20   A0A3Q2EBE5   A0A3B3YXN2   A0A3Q1GAH3   A0A2I4C9U5   A0A3Q2VUY4   A0A3Q3M0J2   A0A3Q4I9I6   A0A087YKS8   A0A3B4TGS9   A0A1A8ET23   A0A1A8HE11   I3KHY4   A0A1S3M440   A0A3P9BF10   A0A1A8SP20   A0A1A8NCX4   A0A1A8IN77   A0A1A7XEX2   A0A1A8C457   A0A1A7ZLM6   A0A1W4VI24   B4LNW8   A0A2W1BD95   W8BUE6   A0A2C9JVG7   D3TR30   A0A2A4JTH9   B4KME5   A0A0N0PBJ8   A0A1A9YJQ2   A0A3S2TRY0   A0A0G4AL61   A0A1A9UYD7   A0A0K8V9H2  
PDB
6O2T     E-value=0,     Score=2183

Ontologies

KEGG
692512    K07375 tubulin beta | (RefSeq) Tub4, bmtub4; beta-tubulin
PATHWAY
04145    Phagosome - Bombyx mori (domestic silkworm)
GO
GO:0005874   GO:0007017   GO:0005525   GO:0005737   GO:0003924   GO:0005200   GO:0003725   GO:0000226   GO:0000278   GO:0003676   GO:0004812   GO:0006418   GO:0000049   GO:0016876  
PANTHER
PTHR11588  

Topology

Subcellular location
  
Length:
443
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0094
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00593
outside
1  -  443
 
 

Population Genetic Test Statistics

Pi
261.95355
Theta
163.145042
Tajima's D
1.793184
CLR
0.008456
CSRT
0.851507424628769
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
26822097 TAVCDIPPR 100.00 7e-14
26280517 SGNIIVTTSVVDPK 100.00 7e-14
25044914 SGNDIIIR 100.00 7e-14
24402669 SGNIDFEGK 100.00 7e-14
27102218 GHYTEGAEIVDSVIDVVR 100.00 7e-14
28467696 SGNISVNYK 100.00 7e-14
21761556 LHFFMPGFAPLTSR 100.00 7e-14
28556443 SGPFGQIFRPDNFVFGQSGAGNNWAK 100.00 7e-14
28556443 SGPFGQIFRPDNFVFGQSGAGNNWAK 100.00 7e-14
28556443 SGPFGQIFRPDNF 100.00 7e-14
28556443 SGPFGQIFRPDNF 100.00 7e-14
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 7e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 7e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 7e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 7e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 7e-10
28556443 QIFRPDNFVFGQSGAGNNWAK 100.00 7e-10
28556443 NSSYFVEWIPNNVK 100.00 7e-10
28556443 NSSYFVEWIPNNVK 100.00 7e-10
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 2e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 2e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 2e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 2e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 2e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 2e-09
28556443 QLFRPDNFVFGQSGAGNNWAK 95.24 2e-09
28556443 NMMAACDPR 95.24 2e-09
28556443 LAVNMVPFP 100.00 3e-09
26822097 EIVHIQAGQCGNQIGAK 100.00 6e-08
26280517 IPSGDEMPVR 100.00 6e-08
27102218 EIVHIQAGQCGNQIGAK 100.00 6e-08
28467696 MREEGFMSGSDDVR 100.00 6e-08
26822097 MREIVHIQAGQCGNQIGAK 100.00 7e-07
28467696 PDIDNAVIVR 100.00 7e-07
28556443 LHFFMPGFAP 100.00 1e-06
31223520 NSSYFVEWIPNNVK 100.00 2e-06
26822097 AITVPEITQQMFDAK 100.00 2e-06
26280517 VYYESICPGCR 100.00 2e-06
25044914 EIVFPISSDWQVDYESYDWK 100.00 2e-06
24402669 EIVCHASAWDFFDGEDFR 100.00 2e-06
27102218 SGPFGQIFRPDNFVFGQSGAGNNWAK 100.00 2e-06
28467696 EIVEYCSNEEDKKK 100.00 2e-06
28556443 EIVHIQAGQCGNQIGAK 100.00 2e-06
28556443 EIVHIQAGQCGNQIGAK 100.00 2e-06
28556443 EIVHIQAGQCGN 100.00 2e-06
28556443 EAESCDCLQGFQLTH 100.00 2e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 GHYTEGAELVDSVLDVVR 100.00 3e-06
28556443 FWEIISDEHGIDPTGAYHGDSDLQLER 100.00 3e-06
28556443 FWEIISDEHGIDPTGAYHGDSDLQLER 100.00 3e-06
26280517 INTFIIK 100.00 2e-05
27102218 MSMKEVDEQMINIQNK 100.00 2e-05
28556443 VSDTVVEPY 100.00 2e-05
28556443 TAVCDIPPK 100.00 4e-05
28556443 TFIGNSTAIQEIFK 100.00 4e-05
28556443 INVYYNEASGGKYVPR 100.00 4e-05
31223520 LHFFMPGFAPLTSR 100.00 2e-04
31223520 AILVDLEPGTMDSVR 100.00 2e-04
21761556 ISEQFTAMFR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTS 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLTSR 100.00 2e-04
28556443 LHFFMPGFAPLT 100.00 2e-04
28556443 LAVNMVPFPR 100.00 2e-04
28556443 VSDTVVEPYNATLSVH 100.00 2e-04
28556443 TAVCDIPPR 100.00 2e-04
28556443 TAVCDIPPR 100.00 2e-04
31223520 ALTVPELTQQMFDAK 100.00 3e-04
26822097 GHYTEGAEIVDSVIDVVRK 100.00 3e-04
26280517 NQITTNPENTVFDAKR 100.00 3e-04
25044914 NSSIDPDIPIIIK 100.00 3e-04
27102218 INVYYNEASGGKYVPR 100.00 3e-04
28467696 NSSPQTISVEAYR 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NSSYFVEWIPNNVK 100.00 3e-04
28556443 NMMAACDPR 100.00 3e-04
28556443 MAATFIGNSTAIQELFK 100.00 3e-04
28556443 LHFFMPGFAPLT 100.00 0.001
28556443 VDLEPGTMDSVR 100.00 0.001
28556443 SGPFGQIFRPDNF 100.00 0.001
28556443 QLTHSLGGGTGSGMGTLLISK 100.00 0.001
28556443 QLTHSLGGGTGSGMGTLLISK 100.00 0.001
28556443 SLGGGTGSGMGTLLISK 100.00 0.001
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