Gene

KWMTBOMO09319  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004603

Annotation

beta-tubulin_[Bombyx_mori]

Location

Bomo_Chr15(+):15956575-15958595      View in EpiBrowser

Full name

Tubulin beta chain       + More
Tubulin beta-4 chain      

Alternative Name

Beta-tubulin

Location in the cell

Cytoplasmic   Reliability : 2.781

CDS

ATGAGGGAAATTATCAATCTCCAGGTCGGTTCTTGTGGAAACCAAATCGGCGGAAAGTTCTGGGAGGTGATATCTGACGAGCACGGCATCGATCCAAGCGGATGCTACCACGGCGACTCCGACCTGCAACTCGAAAGGATCAACGTGTACTACAACGAGGCATCGGCTGGGAAATATGTTCCTCGCACGGTTCTTATCGACTTGAAGCCGGCCACGATGGACGCGGTGAGGTCGGGACCCTTCGGATGCCTATTCAGACCGGACAATTTCGTCTACGGACAAAACTGTGCGGCCAACAACTGGGCGAAGGGACACTACACTGAAGGAGTAGAGATTCTGGAGTCTGCTTTAGATGTCATTCGAAGGGAAGCTGAGGGCTGCGATTGCCTGCAAGGTTTTCAGATGTCACACTCGCTAGGTGGCGGTACCGGTTCCGGATTAGGTACGCTACTCGTGAACAGGATACGCGAAGAGTATCCCGACAGAATTATACTGACCTTTTCAGTCTTTCCAAGTCCCCGAGTGTCGGATTGTGTGGTGGAGCCATATAACACAACGCTGGCGGTCAATCAGTTGGTCGAGAATACTGATCACACGTTCTGTCTCGATAACGAAGCATTGTACGACATTTGCTTCAGAACGCTGAAGCTAACCACACCGACATACGGGGACTTGAACCACTTGGTCTGCGCCACGATGTCCGGCATTACGACGTGTTTGCGGTTTCCTGGACAGCTGAACGCTGATCTGAGGAAGTTGGCTGTGAACATGGTGCCGTTTCCGCGCCTGCATTTCTACACCCCTGGCTTTGCGCCGCTGACGTCGCGAGGAGCTCAACAGTATCGAGCTTTAACTGTACCCGAGCTGACGCTGCAAATGTTCGACGCCAAAAACATGATGGTCGCGTGTGATCCTCGACACGGGAGGTATTTGACCGTTGCGACGATATTCAGGGGGCGAATGTCTATGAAAGAAGTTGACGAGCAACTGGCGAATATTCAGAACAAAAACAGCACGTATTTTGTCGAGTGGATACCCAATAACTGCAAGATTGCCGTGTGTGACATACCTCCGAGGGGTCTTAAAATGGCTTCGACCTTCATTGGTAACACGACGGCCATACAGACCATATTCAAGAGGGTGTCTGAGCAGTTCGTGGCTATGTTTAGGCGGAAAGCCTTCTTGCACTGGTACACTGGTGAGGGTATGGATGAAATGGAGTTCACGGAGGCAGAGTCCAACATGAATGATTTAATATCTGAATACCAACAGTATCAGGACGCTACGGCTGATGACGAAGGGGAGTTCGACGAGGAAGCGGAAGAGGGCTTAGAGGAATAG

Protein

MREIINLQVGSCGNQIGGKFWEVISDEHGIDPSGCYHGDSDLQLERINVYYNEASAGKYVPRTVLIDLKPATMDAVRSGPFGCLFRPDNFVYGQNCAANNWAKGHYTEGVEILESALDVIRREAEGCDCLQGFQMSHSLGGGTGSGLGTLLVNRIREEYPDRIILTFSVFPSPRVSDCVVEPYNTTLAVNQLVENTDHTFCLDNEALYDICFRTLKLTTPTYGDLNHLVCATMSGITTCLRFPGQLNADLRKLAVNMVPFPRLHFYTPGFAPLTSRGAQQYRALTVPELTLQMFDAKNMMVACDPRHGRYLTVATIFRGRMSMKEVDEQLANIQNKNSTYFVEWIPNNCKIAVCDIPPRGLKMASTFIGNTTAIQTIFKRVSEQFVAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQDATADDEGEFDEEAEEGLEE

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Similarity

Belongs to the tubulin family.

Keywords

Cytoplasm   Cytoskeleton   GTP-binding   Isopeptide bond   Microtubule   Nucleotide-binding  

Feature

chain  Tubulin beta-4 chain

Uniprot

Q2F628   A0A2W1BTK3   A0A2A4K354   A0A2H1V2K2   Q94586   A0A3S2TQ55   + More
A0A212FFP0   A0A0N1IPL9   A0A194Q295   A0A0L7LP10   A0A2U9BBA2   A0A1V9X5G4   A0A1W0WVF7   A0A1I8FZR8   A0A3B3Y6L7   A0A3B3WK42   A0A087XWY3   A0A3B3VK42   A0A0K8RBZ1   A0A267E855   W5M3A6   A0A1D1VB95   W5M384   A0A401PJC9   A0A3Q3A5D0   W4XVG9   A0A3B4YS84   A0A0F8CDM5   A0A3Q1IB31   A0A3B4V1S7   A0A023GK59   G3MKF8   A0A224YT70   A0A023FK66   A0A131XPI7   A0A2D0QLI6   G1KQV3   A0A433STR6   A0A3B3WSX9   A0A087XQ91   A0A3B3U1B1   A0A3Q3G5W8   A0A1W7RC46   A0A1S3STF6   T1DKD8   J3SFJ0   A0A3Q2EK48   A0A2G8KRX3   A0A1B6FQ04   A0A1E1XCR6   A0A1B6HUR5   A0A146ML95   A0A060X6Y9   A0A3B1JNB6   A0A1S3M440   V9KI87   O18343   A0A267EPP9   A0A1I8G0E9   A0A1L8F5P2   A0A147AZX8   A0A3Q2DLW7   A0A3Q1G5K7   A0A3B4ZGE5   A0A3B3R037   U3EQ63   A0A2D0Q4T1   A0A3N0XHU7   A0A1W4YKF2   A0A3Q1BQV1   A0A0B8RT61   D6R713   Q6IQJ2   A0A2C9JVG7   A0A1E1XN09   W4XHC0   L7MAS7   A0A267H8Q4   A0A087UDA5   A0A131XMB9   B7PA95   F6SYL0   P30883   A0A3Q2T780   A0A2D0QG95   A0A060XV78   A0A3P8ZBQ8   W5UL31   C0H808   A0A2B4SV07   A0A1X7VM44   A0A0B7B670   W4X9L8   A0A1E1XAB0   P11833   A0A147A9R5   A0A3Q2DJM2   A0A151NL66   A0A3Q2VSP0   A0A1W4ZDV0  

Pubmed

28756777    8974394    22118469    26354079    26227816    28327890    + More
26392545    27649274    30297745    25835551    22216098    28797301    28049606    26358130    23758969    23025625    29023486    28503490    24755649    25329095    24402279    9303342    27762356    29240929    23915248    25476704    23594743    15562597    29209593    25576852    12481130    15114417    1379202    25069045    23127152    20433749    2762163    22293439   

EMBL

DQ311244    ABD36189.1    KZ149923    PZC77681.1    NWSH01000200    PCG78469.1    + More
ODYU01000381    SOQ35070.1    U75868    AAC47425.1    RSAL01000026    RVE52085.1    AGBW02008792    OWR52547.1    KQ460419    KPJ14854.1    KQ459581    KPI99119.1    JTDY01000486    KOB76961.1    CP026247    AWP01106.1    MNPL01023288    OQR68825.1    MTYJ01000042    OQV19199.1    AYCK01006022    AYCK01009716    GADI01005146    JAA68662.1    NIVC01002550    PAA56989.1    AHAT01021582    BDGG01000005    GAU98894.1    AHAT01021583    BFAA01002293    GCB73215.1    AAGJ04150948    KQ042255    KKF16960.1    GBBM01001101    JAC34317.1    JO842359    AEO33976.1    GFPF01006317    MAA17463.1    GBBK01002480    JAC22002.1    GEFH01000319    JAP68262.1    RQTK01001031    RUS72686.1    AYCK01016331    GDAY02002750    JAV48717.1    GAAZ01002747    JAA95196.1    JU176338    GBEX01003742    AFJ51861.1    JAI10818.1    MRZV01000406    PIK50738.1    GECZ01017535    JAS52234.1    GFAC01002138    JAT97050.1    GECU01029297    GECU01024300    JAS78409.1    JAS83406.1    GCES01166490    JAQ19832.1    FR904845    CDQ72615.1    JW865185    AFO97702.1    D89794    BAA22382.1    NIVC01001887    PAA62944.1    NIVC01001153    NIVC01000679    PAA71604.1    PAA78557.1    CM004480    OCT66897.1    GCES01002180    JAR84143.1    GAEP01001763    JAB53058.1    RJVU01073043    ROI27855.1    GBSH01002951    JAG66076.1    HM124750    ADF97612.1    AL929549    CR855258    BC071414    AAH71414.1    GFAA01002831    JAU00604.1    AAGJ04065213    GACK01004800    JAA60234.1    NIVC01000004    PAA94656.1    KK119310    KFM75344.1    GEFH01001236    JAP67345.1    ABJB010239130    ABJB010594595    ABJB010954908    DS670557    EEC03517.1    EAAA01002946    L06232    BC054297    FR906120    CDQ83152.1    JT418604    AHH42782.1    BT058464    BT058720    BT060171    ACN10177.1    ACN10433.1    LSMT01000025    PFX32245.1    HACG01041507    CEK88372.1    AAGJ04132828    GFAC01003041    JAT96147.1    X15389    GCES01011053    JAR75270.1    AKHW03002666    KYO37551.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000246464    UP000192247    UP000095280    UP000261480    UP000028760    UP000261500    UP000215902    UP000018468    UP000186922    UP000288216    UP000264800    UP000007110    UP000261360    UP000265040    UP000261420    UP000221080    UP000001646    UP000271974    UP000261660    UP000087266    UP000265020    UP000230750    UP000193380    UP000018467    UP000186698    UP000257200    UP000261400    UP000261540    UP000192224    UP000257160    UP000000437    UP000076420    UP000054359    UP000001555    UP000008144    UP000265000    UP000265140    UP000225706    UP000007879    UP000050525    UP000264840   

PRIDE

Q2F628    L7MAS7    P30883    P11833   

Pfam

PF03953   Tubulin_C        + More
PF00091   Tubulin
PF00612   IQ
PF00307   CH
PF03836   RasGAP_C
PF00616   RasGAP

Interpro

IPR036525   Tubulin/FtsZ_GTPase_sf        + More
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR000217   Tubulin       
IPR023123   Tubulin_C       
IPR037103   Tubulin/FtsZ_C_sf       
IPR002453   Beta_tubulin       
IPR013838   Beta-tubulin_BS       
IPR008280   Tub_FtsZ_C       
IPR003008   Tubulin_FtsZ_GTPase       
IPR017975   Tubulin_CS       
IPR036872   CH_dom_sf       
IPR001715   CH-domain       
IPR000048   IQ_motif_EF-hand-BS       
IPR008936   Rho_GTPase_activation_prot       
IPR023152   RasGAP_CS       
IPR027417   P-loop_NTPase       
IPR000593   RasGAP_C       
IPR001202   WW_dom       
IPR001936   RasGAP_dom       

SUPFAM

SSF52490   SSF52490        + More
SSF55307   SSF55307       
SSF52540   SSF52540       
SSF47576   SSF47576       
SSF48350   SSF48350       

Gene 3D

1.10.287.600     3.30.1330.20     3.40.50.1440     1.10.418.10    

CDD

cd00201  WW
cd00014  CH

ProteinModelPortal

Q2F628   A0A2W1BTK3   A0A2A4K354   A0A2H1V2K2   Q94586   A0A3S2TQ55   + More
A0A212FFP0   A0A0N1IPL9   A0A194Q295   A0A0L7LP10   A0A2U9BBA2   A0A1V9X5G4   A0A1W0WVF7   A0A1I8FZR8   A0A3B3Y6L7   A0A3B3WK42   A0A087XWY3   A0A3B3VK42   A0A0K8RBZ1   A0A267E855   W5M3A6   A0A1D1VB95   W5M384   A0A401PJC9   A0A3Q3A5D0   W4XVG9   A0A3B4YS84   A0A0F8CDM5   A0A3Q1IB31   A0A3B4V1S7   A0A023GK59   G3MKF8   A0A224YT70   A0A023FK66   A0A131XPI7   A0A2D0QLI6   G1KQV3   A0A433STR6   A0A3B3WSX9   A0A087XQ91   A0A3B3U1B1   A0A3Q3G5W8   A0A1W7RC46   A0A1S3STF6   T1DKD8   J3SFJ0   A0A3Q2EK48   A0A2G8KRX3   A0A1B6FQ04   A0A1E1XCR6   A0A1B6HUR5   A0A146ML95   A0A060X6Y9   A0A3B1JNB6   A0A1S3M440   V9KI87   O18343   A0A267EPP9   A0A1I8G0E9   A0A1L8F5P2   A0A147AZX8   A0A3Q2DLW7   A0A3Q1G5K7   A0A3B4ZGE5   A0A3B3R037   U3EQ63   A0A2D0Q4T1   A0A3N0XHU7   A0A1W4YKF2   A0A3Q1BQV1   A0A0B8RT61   D6R713   Q6IQJ2   A0A2C9JVG7   A0A1E1XN09   W4XHC0   L7MAS7   A0A267H8Q4   A0A087UDA5   A0A131XMB9   B7PA95   F6SYL0   P30883   A0A3Q2T780   A0A2D0QG95   A0A060XV78   A0A3P8ZBQ8   W5UL31   C0H808   A0A2B4SV07   A0A1X7VM44   A0A0B7B670   W4X9L8   A0A1E1XAB0   P11833   A0A147A9R5   A0A3Q2DJM2   A0A151NL66   A0A3Q2VSP0   A0A1W4ZDV0  

PDB

6H9B     E-value=0,     Score=1984

KEGG

100101153    K07375 tubulin beta | (RefSeq) beta-tubulin

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0005874   GO:0007017   GO:0005525   GO:0005737   GO:0003924   GO:0005200   GO:0043087   GO:0007165   GO:0000226   GO:0000278   GO:0003676   GO:0004812   GO:0006418   GO:0000049   GO:0016876  

PANTHER

PTHR11588  

Subcellular location

  

Length:

446

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01655

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.00397

outside

1  -  446

 

 

Pi

142.441157

Theta

135.028551

Tajima's D

-0.237383

CLR

1.019428

CSRT

0.307084645767712

Interpretation

Uncertain