Gene

KWMTBOMO09317

Annotation

PREDICTED:_diacylglycerol_kinase_eta_[Amyelois_transitella]

Location

Bomo_Chr15(-):15822385-15832194      View in EpiBrowser

Full name

Diacylglycerol kinase       + More
Diacylglycerol kinase eta      

Alternative Name

130 kDa diacylglycerol kinase
Diglyceride kinase eta

Location in the cell

Extracellular   Reliability : 2.088

CDS

ATGGTGATAACTGCGAGCCGTTGTCTGGTCCTCTGCGCCGACACTCGGAGCGAGATGGAGTCCTGGGCTGATGCAGTCCGTGGCGCTCTCCACCGGGGTGCTGACGTCGCTGACCTCGTCGCGAGGCTGTCCTCCGGAGACCATCACTGGTACGCAGCAACGCACGCGCGTCCTACGTTCTGCAACGTTTGCAGGGAGCCACTCGGCGCCCTGGGGACCGCTCACGCGCTCGCCTGCGAGCTTTGCAAGTTTAAAGCGCACAAGAGATGCGCTTCCAGAGCGCCGCCGTCCTGCAAGTGGAGCACGCTGGCGTCACTCGGCCCGCACCTCGTCGAAGACGCTGACGGGGAACCATAA

Protein

MVITASRCLVLCADTRSEMESWADAVRGALHRGADVADLVARLSSGDHHWYAATHARPTFCNVCREPLGALGTAHALACELCKFKAHKRCASRAPPSCKWSTLASLGPHLVEDADGEP

Description

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (By similarity).

Catalytic Activity

a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

Subunit

Forms homooligomers through the SAM domain. Able to form heterooligomers with SAM domain-containing isoforms of DGKD. Oligomerization inhibits its catalytic activity. Interacts with RAF1 and BRAF (By similarity).

Similarity

Belongs to the eukaryotic diacylglycerol kinase family.

Keywords

ATP-binding   Cell membrane   Complete proteome   Cytoplasm   Kinase   Membrane   Metal-binding   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   Transferase   Zinc   Zinc-finger  

Feature

chain  Diacylglycerol kinase eta

Uniprot

A0A0N1PI83   A0A3S2P4E8   A0A0M8ZP58   A0A1S3IF28   U6DNA1   A0A1S3IF57   + More
A0A1S3IHA5   A0A1S3IFE8   A0A452HID5   A0A060VQ41   A0A1S3A415   M1EKN5   A0A2T7NB80   L5KHP9   A0A2I3BQA6   A0A452HI48   R7TG47   A0A452HI54   A0A0S7JWP5   I3MES8   F1PFD9   A0A2Y9DM06   A0A0S7FYA1   A0A452HIA1   G3UF68   A0A3Q2VR01   A0A452UL58   A0A0S7FVT3   A0A401PI98   A0A3Q2GSY0   A0A0S7JWL1   A0A0S7JWW5   G1PVH3   A0A452UKQ3   T1IWF5   A0A452HII3   A0A3N0Z9C1   A0A452HIG2   A0A091ST16   A0A3B5M587   L5M2K9   A0A452HHF9   A0A2U3ZLR5   A0A337SST6   L5MI92   S7NG25   G3T434   A0A337RY15   A0A0S7JWN0   A0A226PJW8   A0A2I3FS69   A0A2R8ZX16   F1RJ94   A0A337SVN0   G3VD81   A0A287B002   H0V6Z8   A0A151MHN7   A0A091NDS3   A0A2U3ZKM1   A0A3Q2ZTE4   G1TAN5   A0A287AAL4   A0A1W4Y9F2   A0A093HC28   A0A3Q3EY53   U3IUH9   A0A2Y9HPG9   A0A287A664   D3ZSZ6   A0A2I4D2R7   K9J0B5   G1NQ24   Q64398   A0A3Q2P690   A0A091INS9   A0A0A0ALZ6   A0A452HIG4   A0A091FXM1   A0A091UYG9   A0A091XWF7   A0A3Q0CRJ4   A0A093LQQ6   R0L8C4   A0A2U3WAI6   A0A1U7Q6L5   A0A093R5G6   A0A1U7QF57   D3YXJ0   F6WIA3   M3XRP2   A0A452HII6   A0A3Q0CRJ8   A0A0S7FS44   D2H2S8   A0A452ULA5   A0A2I2ZVG5   G1LQH7   A0A2Y9JL45  

EC Number

2.7.1.107

Pubmed

26354079    26383154    28562605    24755649    23236062    23258410    + More
19468303    21183079    23254933    16341006    24813606    30297745    19892987    21993624    17975172    24621616    22722832    21709235    22293439    23749191    15057822    22673903    20838655    8702685    20431018    22398555    20010809   

EMBL

KQ460419    KPJ14853.1    RSAL01000026    RVE52084.1    KQ435955    KOX68067.1    + More
HAAF01012193    CCP84016.1    FR904278    CDQ56977.1    JP008577    AER97174.1    PZQS01000014    PVD18402.1    KB030771    ELK10028.1    AC124715    AC126251    AC161608    AMQN01002753    KB310004    ELT92758.1    GBYX01227391    JAO69592.1    AGTP01102563    AGTP01102564    AGTP01102565    AGTP01102566    AGTP01102567    AAEX03013165    AAEX03013166    AAEX03013167    AAEX03013168    AAEX03013169    GBYX01462124    GBYX01462122    GBYX01462118    JAO19459.1    GBYX01462127    JAO19454.1    BFAA01000537    GCB72831.1    GBYX01227428    JAO69558.1    GBYX01227402    JAO69583.1    AAPE02005440    AAPE02005441    JH431613    RJVU01004028    ROL54922.1    KK933502    KFQ46107.1    KB105166    ELK32611.1    AANG04001781    KB098985    ELK38379.1    KE164143    EPQ15395.1    GBYX01227412    JAO69574.1    AWGT02000062    OXB79812.1    ADFV01053116    ADFV01053117    ADFV01053118    ADFV01053119    ADFV01053120    ADFV01053121    ADFV01053122    ADFV01053123    ADFV01053124    ADFV01053125    AEMK02000076    AEFK01132305    AEFK01132306    AEFK01132307    AAKN02011068    AAKN02011069    AAKN02011070    AAKN02011071    AAKN02011072    AKHW03006155    KYO24035.1    KK845475    KFP87192.1    AAGW02019806    AAGW02019807    AAGW02019808    AAGW02019809    AAGW02019810    AAGW02019811    AAGW02019812    AAGW02019813    AAGW02019814    AAGW02019815    KL217395    KFV76965.1    ADON01068020    ADON01068021    ADON01068022    ADON01068023    ADON01068024    AABR07018479    AABR07018480    AABR07018481    GABZ01003834    JAA49691.1    U59429    KK500730    KFP09967.1    KL872371    KGL95474.1    KL447473    KFO73846.1    KL410280    KFQ95487.1    KK736086    KFR17216.1    KK576963    KFW11041.1    KB743032    EOB01849.1    KL224983    KFW66264.1    AAMC01076323    AAMC01076324    AAMC01076325    AAMC01076326    AAMC01076327    AAMC01076328    AEYP01048878    AEYP01048879    AEYP01048880    GBYX01462120    JAO19461.1    GL192447    EFB24686.1    CABD030088753    CABD030088754    CABD030088755    CABD030088756    CABD030088757    ACTA01145128    ACTA01153127    ACTA01161126    ACTA01169124    ACTA01177122    ACTA01185120    ACTA01193118   

Proteomes

UP000053240    UP000283053    UP000053105    UP000085678    UP000291020    UP000193380    + More
UP000079721    UP000245119    UP000010552    UP000000589    UP000014760    UP000005215    UP000002254    UP000248480    UP000007646    UP000264840    UP000291021    UP000288216    UP000002281    UP000001074    UP000261380    UP000245340    UP000011712    UP000198419    UP000001073    UP000240080    UP000008227    UP000007648    UP000005447    UP000050525    UP000264800    UP000001811    UP000192224    UP000053875    UP000016666    UP000248481    UP000002494    UP000192220    UP000001645    UP000189706    UP000265000    UP000053119    UP000053858    UP000053760    UP000053283    UP000053605    UP000054081    UP000008143    UP000000715    UP000001519    UP000008912    UP000248482   

PRIDE

F1RJ94    D3ZSZ6    D3YXJ0   

Pfam

PF00609   DAGK_acc        + More
PF00781   DAGK_cat
PF00536   SAM_1
PF00130   C1_1
PF07647   SAM_2
PF00169   PH

Interpro

IPR013761   SAM/pointed_sf        + More
IPR037607   DGK       
IPR002219   PE/DAG-bd       
IPR001660   SAM       
IPR016064   NAD/diacylglycerol_kinase_sf       
IPR017438   ATP-NAD_kinase_N       
IPR001206   Diacylglycerol_kinase_cat_dom       
IPR000756   Diacylglycerol_kin_accessory       
IPR001849   PH_domain       
IPR011993   PH-like_dom_sf       
IPR037606   DGK-delta_SAM       

SUPFAM

SSF111331   SSF111331        + More
SSF47769   SSF47769       

Gene 3D

1.10.150.50     3.40.50.10330     2.30.29.30    

CDD

cd00029  C1
cd09575  SAM_DGK-delta

ProteinModelPortal

A0A0N1PI83   A0A3S2P4E8   A0A0M8ZP58   A0A1S3IF28   U6DNA1   A0A1S3IF57   + More
A0A1S3IHA5   A0A1S3IFE8   A0A452HID5   A0A060VQ41   A0A1S3A415   M1EKN5   A0A2T7NB80   L5KHP9   A0A2I3BQA6   A0A452HI48   R7TG47   A0A452HI54   A0A0S7JWP5   I3MES8   F1PFD9   A0A2Y9DM06   A0A0S7FYA1   A0A452HIA1   G3UF68   A0A3Q2VR01   A0A452UL58   A0A0S7FVT3   A0A401PI98   A0A3Q2GSY0   A0A0S7JWL1   A0A0S7JWW5   G1PVH3   A0A452UKQ3   T1IWF5   A0A452HII3   A0A3N0Z9C1   A0A452HIG2   A0A091ST16   A0A3B5M587   L5M2K9   A0A452HHF9   A0A2U3ZLR5   A0A337SST6   L5MI92   S7NG25   G3T434   A0A337RY15   A0A0S7JWN0   A0A226PJW8   A0A2I3FS69   A0A2R8ZX16   F1RJ94   A0A337SVN0   G3VD81   A0A287B002   H0V6Z8   A0A151MHN7   A0A091NDS3   A0A2U3ZKM1   A0A3Q2ZTE4   G1TAN5   A0A287AAL4   A0A1W4Y9F2   A0A093HC28   A0A3Q3EY53   U3IUH9   A0A2Y9HPG9   A0A287A664   D3ZSZ6   A0A2I4D2R7   K9J0B5   G1NQ24   Q64398   A0A3Q2P690   A0A091INS9   A0A0A0ALZ6   A0A452HIG4   A0A091FXM1   A0A091UYG9   A0A091XWF7   A0A3Q0CRJ4   A0A093LQQ6   R0L8C4   A0A2U3WAI6   A0A1U7Q6L5   A0A093R5G6   A0A1U7QF57   D3YXJ0   F6WIA3   M3XRP2   A0A452HII6   A0A3Q0CRJ8   A0A0S7FS44   D2H2S8   A0A452ULA5   A0A2I2ZVG5   G1LQH7   A0A2Y9JL45  

PDB

3PFQ     E-value=0.00191412,     Score=91

KEGG

101745704    K00901 diacylglycerol kinase (ATP) [EC:2.7.1.107] | (RefSeq) diacylglycerol kinase eta-like

PATHWAY

00561    Glycerolipid metabolism - Bombyx mori (domestic silkworm)
00564    Glycerophospholipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)

GO

GO:0035556   GO:0005524   GO:0004143   GO:0007205   GO:0003951   GO:0046872   GO:0046473   GO:0042803   GO:0046339   GO:0046834   GO:0046486   GO:0005737   GO:0051259   GO:0005768   GO:0016301   GO:0016021   GO:0046982   GO:0005886  

PANTHER

PTHR11255  

Subcellular location

Cytoplasm   Translocated from the cytoplasm to endosomes in response to stress stimuli. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.   With evidence from 2 publications.
Cell membrane   Translocated from the cytoplasm to endosomes in response to stress stimuli. Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS.   With evidence from 2 publications.

Length:

118

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00131

Exp number, first 60 AAs:

2e-05

Total prob of N-in:

0.25592

outside

1  -  118

 

 

Pi

14.83294

Theta

168.756268

Tajima's D

0.350804

CLR

0.04852

CSRT

0.469176541172941

Interpretation

Uncertain