Gene

KWMTBOMO09285

Pre Gene Modal

BGIBMGA003315

Annotation

PREDICTED:_adenylate_cyclase_type_8_[Bombyx_mori]

Location

Bomo_Chr15(-):15089419-15133784      View in EpiBrowser

Full name

Adenylate cyclase      

Location in the cell

PlasmaMembrane   Reliability : 4.2

CDS

ATGGTTCACAAAATAGTCTGGAGTGTGGCCTTCGCGTGGCTGAACATCGGGGTCTGTCTGCTCGGATGCTGGCGGTGCTTCGCCAACAACTACCTGCACTGGGCAGCAGCGGCTACTTGGATACTGTTAATTGCTCAAGGTATAAGCGGACAGGGAATCGGCTTCCAGACTCCTCAAAACCAGGTCTGGTATATGCTGTTCGTGGTGTTCGTTCCCTATGCGATGCTTCCGCTCTCACTCGTGTGGTGCATCGTGATTGGAATTCTATCGTTTCTGTCTCACATCCTCGCGACGGCTGTGGACATAGAGAACCTGGAACAAAATAACATGATTCAGGCGGCCAGTTCCTGCAGTATCCGTCTACTAACCGGCAATGCGCTTCTATACATTGCTGTAAACTTTGCGGGTATGTACGCCAAATCACTAGCTGATTGGGGCCAGAGAAAGGCCTTTCTGGAGACTCATCGCTCGATGGTCACCAGACAACGAACTAAAACAGAGAGCGACAAGCAATGGAACTTATTTCAGAGCGTAATCCCAGACTTCTTAGCCAAGGAGATCTACAGCCATGTTTCAAAGGTGAAAGGGGATTTCCAAGAGCAGCAATTCAACAATCTTTACATACAGAGACATGAAAACGTGTCCATACTCTACGCAGACATAAAGGGTTTTACTGAGCTATCAAGTAAGTGCAACGCTCAAGAATTGGTCAAATTATTGAATGAATTGTTCGCTAGATTCGACAAATTGGCTTCGGAGAATCATTGTCTCCGAATCAAGTTGCTCGGTGATTGCTATTTCTGCGTGAGTGGTCTGACGGAGCAACGCGCCTCACATGCGTACGATTGCGTCAACATGGGCCTGCATATGATCCGGGCTATCCGTGACGTCCGTTACAATACACAGGTGGACCTGGATATGCGTATCGGCATCCATAGCGGCACGGTGCTGTGCGGGGTGCTAGGTCTGCTCAAGTGGCAGTTCGACCTTTGGTCCTATGACGTCACACTCGCCAACCACATGGAGAGCGGGGGCTTGCCCGGACGAGTGCACATTTCGTCAGCAACATATGAGTGCCTGTGCGGTGCTTTCGAGGTGGAACCTGGTGACGGAGCCTCCAGAGATCCTTACATCAAAGAACAGAACATCACCACTTACCTGATAAAAGCGACGGAGCAGCCTCGGAGAGCCAGGCACCCTTCTCGCAACGGTTTTCCCTTAAGCCAGCAGATCTGGACGACAATGACGCGTCGTCCAAGCGGCAGCATCGATGACGAAACCACGACCGACTGGACCCCGGAAATGCCGTTTCAGAACTATTTAACTGGTGGTACAACTACAAGGGCACGGTTGGACATGTTCCGAGTGGGTCAAGAAGCCGAGGTGGAGGAGGACGCCCCAGTCTCAGATGTTGAAGAAGGCGATATTATTAATCACTCGATAGAGGTGGAAAGCAATCGCCGGATGCGCGTGGACAACATGCGCGCGGTCTCGCTGCGGTTCAGACGGGCGTCCCTCGAACGAAGCTTTGGAGAGCTGGACGAGCGGACCTTCAAGTCTAACGTGCTCTGCTGCTTCGTACTCTGGCTCTTCAATGTAGCCGTCCAGGCGGTCATACATTACAATTGCTGGATCCTGATGATAATATTGGCGAACATGACAATCCCGCTGGTGATATCATTCGTGCTGGTGATGATGGAAGAATTCCCGAGACTGTCGCCGCGACTGGCAAAGTTTTCGGCTGCTCTAAGTGCGACCACGCTCAGGAGAAACATACATATTTGCTGTTTCATCATGATTATGTCTGTGTCCAGCACAATAAAACTGTACGTTTGTCCGTCATCTTTTCCGCCGACTTCGTACAATGGAAGCTACACGTTAAACACCACGTTCTGTGAGGATACAAACTCGACGATGTGCGCGGTCGAAGCCGGCGAATGCTATCGTCCGGAATACGTGGTTTACACGTGGGTCTTGTGCCTGGTCGCTCTGACGTCAGTACTGAAACTCCACTACCAGATCAAAACGTTACTGGCCATCATAGACGTTCTCATGTTCTGCGTTTTGCTCTTGAAGAACTACGACGTTTATTATTTCGTCACGAACGAGGGTGCTACAAATCAACTGCCAGCGTATGTCCAAATGTTAATACTAATGGCAATGTTCCTCGCCGTTGTCATTTACCACGGGCGGCTGGTGGAAGTGACGTCACGTCTCGACTTTCTCTGGAAACTTCAAGCGGAGACCGATCTCGGAGAAATGGAGGACACACAGAGAATCAACAGACATCTACTGAAGCACATATTACCTGACCATGTCGTAACACACTTCTTGAGTAAAGATCGGTGTCCTAATGAACTGTACTCGCAGTGGCGCGACGAGGTGGGAGTGATGTTCGCCGGCATCCCGAACTTCCACGAGTTCTACTCGGAGACGAAGGCCGTCGACTGCATGCGGTTGCTCAACGAGATAATTATTGATTTCGACAAGCTGTTGATGGAGGAGCGGTTCAAGAGCATCGAGAAGATCAAGACCATCGGAGCCACTTACATGGCCGCCAGTGGACTGGACCCCGATGTTAAGTCTGGTGCTGACGAGTGCGCGCACCTGTGTGCGCTCGTGGACTACGCGTTTGCGCTGCGCGAGGCTCTGGATGACGTCAACAAGCACAGCTTCAACAAATTTCGCCTCAGGGTCGGTATCAGCTGTGGACCTTTGGTGGGCGGCGTAATCGGTGCTCTGAAACCGGTCTACGACATCTGGGGGAACACTGTGAACGAAGCTTCGAGAATGGAGAGCACAGGCGCTATGGACAAGATACAAGTCACCAAATATACTAAACAGTTGTTAGAGGTTCGCGGATACGGCGTGGAGCGCCGTGGTTGCGTCGAGGTGAAGGGCAAGGGGCGCATGGAGACGTGGTGGGTGGTGTCGAGGCGGGGCGCCCCGCGTCCCCCGCGCCGCCCCGCGCCCCACCCCCGCTCCCTCGCCGCGCTCGTCTACACTATGCTGCAGGCGAGAAAGCGCATCTACACGCACCCTCTAGATGCCACGCATATCGTGAATCGAAGCGACAGCATGCGGCCGACCCGCGTGGACACTGCGCCCAGCGGCTCCAACCGGCGCCGCTCAGAGCTGCGGCGGGCGCGCACGCGGCACAACGACCGCCATGCGGACACGGAGCTGAGGGCGTTGGGTCGTCATTCCGCGTCGGCGCCGCACACTCCGACGGCGACGCACTGCCCGCCGCCCCCCGACCCCCCGCAACTGTCCACCATCACCAGGATAGCCCGGTTGAAAGCTAACAGCTTCACATTCCGGTCGCGGCCCAGAGATAAGTCTCCCAAGATCCGGGAGCAGCCTAACGAGGGATCCGGTACATCACTAGCGAACGGAACGCCTGGCTCGTTCCGCATCAGGTCGGTGACGACAGCGTCGTTCTTCAGAAGCCGAAACAAAGACAAGAGGAGCAAGGAGCAAATAGATACTGAAACCAGGAGTGAAGGAGTGGAAAACGGTGACGCCTACACCACCAAAATGTAA

Protein

MVHKIVWSVAFAWLNIGVCLLGCWRCFANNYLHWAAAATWILLIAQGISGQGIGFQTPQNQVWYMLFVVFVPYAMLPLSLVWCIVIGILSFLSHILATAVDIENLEQNNMIQAASSCSIRLLTGNALLYIAVNFAGMYAKSLADWGQRKAFLETHRSMVTRQRTKTESDKQWNLFQSVIPDFLAKEIYSHVSKVKGDFQEQQFNNLYIQRHENVSILYADIKGFTELSSKCNAQELVKLLNELFARFDKLASENHCLRIKLLGDCYFCVSGLTEQRASHAYDCVNMGLHMIRAIRDVRYNTQVDLDMRIGIHSGTVLCGVLGLLKWQFDLWSYDVTLANHMESGGLPGRVHISSATYECLCGAFEVEPGDGASRDPYIKEQNITTYLIKATEQPRRARHPSRNGFPLSQQIWTTMTRRPSGSIDDETTTDWTPEMPFQNYLTGGTTTRARLDMFRVGQEAEVEEDAPVSDVEEGDIINHSIEVESNRRMRVDNMRAVSLRFRRASLERSFGELDERTFKSNVLCCFVLWLFNVAVQAVIHYNCWILMIILANMTIPLVISFVLVMMEEFPRLSPRLAKFSAALSATTLRRNIHICCFIMIMSVSSTIKLYVCPSSFPPTSYNGSYTLNTTFCEDTNSTMCAVEAGECYRPEYVVYTWVLCLVALTSVLKLHYQIKTLLAIIDVLMFCVLLLKNYDVYYFVTNEGATNQLPAYVQMLILMAMFLAVVIYHGRLVEVTSRLDFLWKLQAETDLGEMEDTQRINRHLLKHILPDHVVTHFLSKDRCPNELYSQWRDEVGVMFAGIPNFHEFYSETKAVDCMRLLNEIIIDFDKLLMEERFKSIEKIKTIGATYMAASGLDPDVKSGADECAHLCALVDYAFALREALDDVNKHSFNKFRLRVGISCGPLVGGVIGALKPVYDIWGNTVNEASRMESTGAMDKIQVTKYTKQLLEVRGYGVERRGCVEVKGKGRMETWWVVSRRGAPRPPRRPAPHPRSLAALVYTMLQARKRIYTHPLDATHIVNRSDSMRPTRVDTAPSGSNRRRSELRRARTRHNDRHADTELRALGRHSASAPHTPTATHCPPPPDPPQLSTITRIARLKANSFTFRSRPRDKSPKIREQPNEGSGTSLANGTPGSFRIRSVTTASFFRSRNKDKRSKEQIDTETRSEGVENGDAYTTKM

Description

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic Activity

ATP = 3',5'-cyclic AMP + diphosphate

Cofactor

Mg(2+)

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Feature

chain  Adenylate cyclase

Uniprot

H9J1C8   A0A2H1VD99   A0A437BNT1   A0A212F546   A0A194RK59   A0A194PJK1   + More
A0A2W1BWS2   A0A2A4JYB9   A0A2A4J4W6   A0A2H1VNT2   A0A0L7KXB4   A0A2A4J4U7   A0A0N0BIT4   A0A154P206   J9JRH3   A0A2S2NEH7   A0A2S2Q9X8   A0A2H8TUF5   T1IKH0   A0A2R5L7Z5   A0A131XVB0   A0A1J1IIY5   A0A1L8FTY2   A0A1L8G048   A4IGT8   A0A151P8F6   A0A151P7X1   A0A2I0MW10   A0A1V4KVB2   A0A384BYD8   D2H7A3   U3JIS7   A0A1D5PNE8   A0A0Q3MQF7   A0A452VC85   W5N4M7   A0A3Q7VGE3   A0A452HUQ3   A0A1W5AC82   A0A2D4Q209   A0A0F7Z1G0   A0A2D4FAP3   A0A3B3CNM2   A0A1S2ZQ21   G1KKD9   F7BCI5   A0A3B4TKY1   I3K3B0   A0A3P8R1Q8   A0A226N9N4   A0A3B3S1H4   A0A098M1V3   A0A401RWJ0   A0A0B8RRT3   A0A139WI81   A0A452G620   A0A1W7RJN6   T1DP06   A0A452G691   E1BQ12   A0A0F7ZE02   A0A287AWF4   D6WK22   J3RYC9   L8IAT5   A0A2K5R7M0   A0A384ANN7   A0A287DAM6   E2RCX6   F6R859   A0A340WM11   A0A3Q7S0N3   A0A287DCD9   H0V9J2   A0A3Q7QGH2   A0A2K5EK24   A0A2U3WLQ4   U3DX42   A0A2D0T7E1   A0A3P9Q9A5   A0A1S3LVG8   G5B4Q6   U3DLD7   A0A3B5QDJ9   A0A3Q0GSN8   A0A2I2ZTJ4   G1R0Z0   A0A2U4B351   A0A096N068   A0A2K5M765   H9F9J8   A0A1D5Q874   G7PCU6   B7UCF8   A0A1S3FW47   A0A2K6DDC0   A0A2K5XPW5   A0A2Y9DED6   H2PR79  

EC Number

4.6.1.1

Pubmed

19121390    22118469    26354079    28756777    26227816    27762356    + More
22293439    23371554    20010809    15592404    24813606    28562605    29451363    17495919    25186727    29240929    30297745    25476704    18362917    19820115    26358130    23758969    25727380    19393038    30723633    23025625    22751099    16341006    19892987    21993624    25243066    21993625    23542700    22398555    25319552    17431167    22002653   

EMBL

BABH01023949    BABH01023950    BABH01023951    ODYU01001670    SOQ38214.1    RSAL01000026    + More
RVE52061.1    AGBW02010254    OWR48857.1    KQ460106    KPJ17814.1    KQ459602    KPI93601.1    KZ149923    PZC77647.1    NWSH01000401    PCG76668.1    NWSH01003368    PCG66442.1    ODYU01003556    SOQ42473.1    JTDY01004844    KOB67681.1    PCG66443.1    KQ435726    KOX78138.1    KQ434786    KZC05160.1    ABLF02010787    ABLF02010788    ABLF02033700    ABLF02033702    ABLF02033705    ABLF02033707    ABLF02033708    ABLF02049221    ABLF02057914    GGMR01002974    MBY15593.1    GGMS01005147    MBY74350.1    GFXV01005636    MBW17441.1    JH430530    GGLE01001497    MBY05623.1    GEFM01004563    JAP71233.1    CVRI01000051    CRK99500.1    CM004477    OCT75025.1    CM004476    OCT77174.1    BC135243    AAI35244.1    AKHW03000629    KYO45189.1    KYO45191.1    AKCR02000001    PKK33863.1    LSYS01001531    OPJ88376.1    ACTA01113176    ACTA01121176    ACTA01129176    ACTA01137176    ACTA01145175    ACTA01153174    GL192550    EFB24884.1    AGTO01000306    AADN05000663    LMAW01000991    KQK84735.1    AHAT01002480    AHAT01002481    AHAT01002482    IACN01108799    LAB64244.1    GBEW01000039    JAI10326.1    IACJ01068186    LAA44541.1    AERX01029748    AERX01029749    AERX01029750    AERX01029751    AERX01029752    AERX01029753    AERX01029754    AERX01029755    AERX01029756    MCFN01000128    OXB64197.1    GBSI01000169    JAC96326.1    BEZZ01000012    GCC22491.1    GBSH01000215    JAG68809.1    KQ971342    KYB27619.1    LWLT01000011    GDAY02000074    JAV51339.1    GAAZ01000082    GBKC01000119    JAA97861.1    JAG45951.1    GBEX01000113    JAI14447.1    AEMK02000022    DQIR01184664    HDB40141.1    EFA03629.2    JU173823    AFJ49349.1    JH881600    ELR53323.1    AGTP01001445    AGTP01001446    AGTP01001447    AGTP01001448    AGTP01001449    AAEX03008817    AAEX03008818    AAKN02041798    AAKN02041799    GAMS01008821    JAB14315.1    JH168480    EHB04267.1    GAMR01003168    GAMP01008056    JAB30764.1    JAB44699.1    CABD030061129    CABD030061130    CABD030061131    ADFV01168929    ADFV01168930    ADFV01168931    ADFV01168932    ADFV01168933    ADFV01168934    ADFV01168935    ADFV01168936    ADFV01168937    ADFV01168938    AHZZ02034445    AHZZ02034446    AHZZ02034447    AHZZ02034448    JU327551    AFE71307.1    JSUE03042472    JSUE03042473    JSUE03042474    AQIA01069298    AQIA01069299    AQIA01069300    AQIA01069301    CM001283    EHH64433.1    FJ472834    ACK57564.1    ABGA01133391    ABGA01133392    ABGA01133393    ABGA01133394    ABGA01160142    ABGA01160143    ABGA01160144    ABGA01293229    ABGA01293230    ABGA01293231   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053240    UP000053268    UP000218220    + More
UP000037510    UP000053105    UP000076502    UP000007819    UP000183832    UP000186698    UP000050525    UP000053872    UP000190648    UP000261680    UP000008912    UP000016665    UP000000539    UP000051836    UP000291021    UP000018468    UP000286642    UP000291020    UP000192224    UP000261560    UP000079721    UP000001646    UP000002280    UP000261420    UP000005207    UP000265100    UP000198323    UP000261540    UP000287033    UP000007266    UP000291000    UP000009136    UP000008227    UP000233040    UP000261681    UP000005215    UP000002254    UP000002281    UP000265300    UP000286640    UP000005447    UP000286641    UP000233020    UP000245340    UP000221080    UP000242638    UP000087266    UP000006813    UP000008225    UP000002852    UP000189705    UP000001519    UP000001073    UP000245320    UP000028761    UP000233060    UP000006718    UP000009130    UP000233100    UP000081671    UP000233120    UP000233140    UP000248480    UP000001595   

PRIDE

H9J1C8    A0A1D5PNE8   

Pfam

PF16214   AC_N        + More
PF06327   DUF1053
PF00211   Guanylate_cyc
PF00076   RRM_1
PF00002   7tm_2

Interpro

IPR032628   AC_N        + More
IPR029787   Nucleotide_cyclase       
IPR001054   A/G_cyclase       
IPR009398   Adcy_conserved_dom       
IPR018297   A/G_cyclase_CS       
IPR030672   Adcy       
IPR035979   RBD_domain_sf       
IPR000832   GPCR_2_secretin-like       
IPR017981   GPCR_2-like       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       

SUPFAM

SSF55073   SSF55073        + More
SSF54928   SSF54928       

Gene 3D

3.30.70.1230     3.30.70.330    

ProteinModelPortal

H9J1C8   A0A2H1VD99   A0A437BNT1   A0A212F546   A0A194RK59   A0A194PJK1   + More
A0A2W1BWS2   A0A2A4JYB9   A0A2A4J4W6   A0A2H1VNT2   A0A0L7KXB4   A0A2A4J4U7   A0A0N0BIT4   A0A154P206   J9JRH3   A0A2S2NEH7   A0A2S2Q9X8   A0A2H8TUF5   T1IKH0   A0A2R5L7Z5   A0A131XVB0   A0A1J1IIY5   A0A1L8FTY2   A0A1L8G048   A4IGT8   A0A151P8F6   A0A151P7X1   A0A2I0MW10   A0A1V4KVB2   A0A384BYD8   D2H7A3   U3JIS7   A0A1D5PNE8   A0A0Q3MQF7   A0A452VC85   W5N4M7   A0A3Q7VGE3   A0A452HUQ3   A0A1W5AC82   A0A2D4Q209   A0A0F7Z1G0   A0A2D4FAP3   A0A3B3CNM2   A0A1S2ZQ21   G1KKD9   F7BCI5   A0A3B4TKY1   I3K3B0   A0A3P8R1Q8   A0A226N9N4   A0A3B3S1H4   A0A098M1V3   A0A401RWJ0   A0A0B8RRT3   A0A139WI81   A0A452G620   A0A1W7RJN6   T1DP06   A0A452G691   E1BQ12   A0A0F7ZE02   A0A287AWF4   D6WK22   J3RYC9   L8IAT5   A0A2K5R7M0   A0A384ANN7   A0A287DAM6   E2RCX6   F6R859   A0A340WM11   A0A3Q7S0N3   A0A287DCD9   H0V9J2   A0A3Q7QGH2   A0A2K5EK24   A0A2U3WLQ4   U3DX42   A0A2D0T7E1   A0A3P9Q9A5   A0A1S3LVG8   G5B4Q6   U3DLD7   A0A3B5QDJ9   A0A3Q0GSN8   A0A2I2ZTJ4   G1R0Z0   A0A2U4B351   A0A096N068   A0A2K5M765   H9F9J8   A0A1D5Q874   G7PCU6   B7UCF8   A0A1S3FW47   A0A2K6DDC0   A0A2K5XPW5   A0A2Y9DED6   H2PR79  

PDB

3MAA     E-value=8.41548e-74,     Score=709

KEGG

101744252    K08048 adenylate cyclase 8 [EC:4.6.1.1] | (RefSeq) adenylate cyclase type 8

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0004016   GO:0000166   GO:0035556   GO:0006171   GO:0016021   GO:0005886   GO:0046872   GO:0005524   GO:0016849   GO:0009190   GO:0004930   GO:0007166   GO:0003723   GO:0071315   GO:0098685   GO:0007626   GO:0016323   GO:0051480   GO:0010255   GO:1900273   GO:1900454   GO:0008294   GO:0035774   GO:0098686   GO:0032793   GO:0031915   GO:0060076   GO:0150076   GO:0016324   GO:0014069   GO:0048786   GO:0030425   GO:0030424   GO:0080135   GO:0007616   GO:0098978   GO:0032809   GO:0099056   GO:0005887   GO:0007189   GO:0016199   GO:0031290   GO:0016829   GO:0016020   GO:0016876   GO:0043039  

Length:

1180

Number of predicted TMHs:

8

Exp number of AAs in TMHs:

215.365600000001

Exp number, first 60 AAs:

42.27683

Total prob of N-in:

0.20947

POSSIBLE N-term signal

sequence

outside

1  -  4

TMhelix

5  -  24

inside

25  -  30

TMhelix

31  -  53

outside

54  -  62

TMhelix

63  -  85

inside

86  -  521

TMhelix

522  -  539

outside

540  -  543

TMhelix

544  -  566

inside

567  -  651

TMhelix

652  -  674

outside

675  -  677

TMhelix

678  -  700

inside

701  -  708

TMhelix

709  -  731

outside

732  -  1180

 

 

Pi

241.949484

Theta

173.567221

Tajima's D

1.974035

CLR

0.314374

CSRT

0.875206239688016

Interpretation

Uncertain