Gene

KWMTBOMO09273  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003421

Annotation

PREDICTED:_periodic_tryptophan_protein_1_homolog_[Amyelois_transitella]

Location

Bomo_Chr15(+):14920425-14928646      View in EpiBrowser

Full name

Periodic tryptophan protein 1 homolog      

Alternative Name

Protein no child left behind

Location in the cell

Cytoplasmic   Reliability : 3.532

CDS

ATGGAGGAAGAAAATACACCTAATGTTAGCCTTATATCGTGCATGCACTTTGTGCAAAGAGGCGTGGCGAAAGCAGTTCCTGAAAAAATTGAATTAACCCAAGGGGAACTAGAGAACATAATCAGACAGACAGCTAATGACCTGAGGATTGCAGAGCAAGGAGATGACGAGACTGATGATGAAGGTACAGGCTCAGCCCCAGAGATACCAGCCAATCCGAATGATGAATTCAACTTTGATAACTATGATAATGAAGACCTAAATTTGAATCCAGTTGGTATAGGAACAGTAGCAACAATACCTAATCTGGGGGATTTAAGTGAGAATGTGCAAATAAGAACTGAAGGGCCAGACAGTGATGAGGAGGATGATATAATTAAGCCCGAGGACAATTTGCTGCTTGTGGGACACGTAGAGAGTGATGCCAGCGTGTTAGAAGTTCACATATTTAATAAGGAGGAAGGCTCTTTCTACGTGCATCATGATATAATACTGCCGTGGTTCCCTCTGTGCATCGAGTGGCTCAGCCATGATCCAACAGATCCAAACCCTGGTAATCTGTGCGCTCTCGGTGGTATGGACCCGGTGATTCAAGTTTGGGACCTGGATATTGAAAATTGCCTCGAACCAGCATTTAAATTGGGAAAGAAACCGAATAAAAAGAAGAAAACAAAACGCATAGGCCACAAGGAAGCTGTACTGGATCTCTCTTGGAATAGGAATTTTACGCATGTATTGGCGAGTGGTTCAGCTGACAACACAGTTCTACTCTGGGACATGGATCAGGGCACTCCTCACACTAAACTGGACTATTTTGCTGATAAGGTCCAGAGTGTCAGCTTCCACCCGCTGGAGGCGCAGACGCTGGCGGCGGGCGCGTGCGACGGCGGCGTGCGCGTGGCGGACTGCCGCACGCCCGCCGCGCACCGCGCCTGGCACCTGCCGCCGGAGATAGAGCGAGTCGCCTGGGACCAGCTCAACCCCTTCTGCTTTGCTATGAGCAACAATGAAGGAAAAGTAGCCTATGTTGATTGCAGACAAGATGAACCGCTCTGGACCGTACAAGCTCATGAAAAAGAAGTCACAGGTTTAATACTGAGCAATAAAGTGCCTGGTTTGATGATCACAGTCAGCACAGATGGTTTCATGAAGACCTGGGATATTACAAGGTCCGGGGCGGTGACAGCCAGCGGCCGCGCCGTCCGTGTGGGTCAGGCCCTTTGCGCCGCGCTGTGTCCCGACGCGCCTTACAGCGTGGCGGTGGGCGGAGACAACAAGGAAAACTATCTGGAGATGGTCGATCTCTCCCTTAGCGATGACTTTTTAAACCGTTTTGGGTCACGGCCGCTTGTGTCAGCGAGAACAGAAGAGAGTAGTGCCAGTATGGAAACTTAG

Protein

MEEENTPNVSLISCMHFVQRGVAKAVPEKIELTQGELENIIRQTANDLRIAEQGDDETDDEGTGSAPEIPANPNDEFNFDNYDNEDLNLNPVGIGTVATIPNLGDLSENVQIRTEGPDSDEEDDIIKPEDNLLLVGHVESDASVLEVHIFNKEEGSFYVHHDIILPWFPLCIEWLSHDPTDPNPGNLCALGGMDPVIQVWDLDIENCLEPAFKLGKKPNKKKKTKRIGHKEAVLDLSWNRNFTHVLASGSADNTVLLWDMDQGTPHTKLDYFADKVQSVSFHPLEAQTLAAGACDGGVRVADCRTPAAHRAWHLPPEIERVAWDQLNPFCFAMSNNEGKVAYVDCRQDEPLWTVQAHEKEVTGLILSNKVPGLMITVSTDGFMKTWDITRSGAVTASGRAVRVGQALCAALCPDAPYSVAVGGDNKENYLEMVDLSLSDDFLNRFGSRPLVSARTEESSASMET

Description

Chromatin-associated factor that regulates transcription (PubMed:21752937). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the localization to the nucleolus of Cdk7, a regulator of the Pol I-elongation factor TFIIH (PubMed:29065309). Acts as regulator of cell proliferation and tissue growth as part of the TORC1 and Myc signaling pathway in response to nutrients (PubMed:29065309). Required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts (PubMed:21752937). Not required for female germline stem cell (GSC) maintenance, but necessary to regulate germ cell differentiation and egg chamber development (PubMed:21752937). In female somatic cells, required for follicle stem cell survival and maintenance (PubMed:21752937).

Subunit

Interacts with Mybbp1A.

Similarity

Belongs to the WD repeat PWP1 family.

Keywords

Chromosome   Complete proteome   Nucleus   Phosphoprotein   Reference proteome   Repeat   Ribosome biogenesis   Transcription   Transcription regulation   WD repeat  

Feature

chain  Periodic tryptophan protein 1 homolog

Uniprot

H9J1N4   A0A2H1X2Z1   A0A3S2TQ38   S4NVK0   A0A2A4JTT9   A0A2H1WEN6   + More
A0A1E1WJJ6   A0A212ENF4   A0A194PJU5   D2A2W9   A0A1W4WLB0   A0A067RBE6   A0A154PK80   A0A182NND2   Q16KW1   A0A182G5J3   A0A182JUR4   A0A2J7RI32   A0A1S4FXN6   A0A182P8D5   A0A182M3T8   A0A182RXF8   A0A182WCM1   A0A0M8ZXK5   A0A336LNU4   A0A182QJ92   A0A1L8DNE1   A0A182LI61   Q7PMW1   A0A182HXJ0   A0A182WYK3   A0A182VCZ0   W5JWM1   A0A2M3Z2D4   A0A2M3Z2E3   A0A182JIM5   A0A182YI22   A0A182UKI4   A0A0L7R0A1   U5EIW8   A0A310SBE1   A0A2M4BLG7   A0A0J7L7X5   A0A195EIQ7   A0A2M4BLV1   A0A2M4ACN0   A0A2M4ACQ3   A0A158NK95   A0A151I7K3   A0A1B0D6I7   A0A084VZR4   J3JTQ3   A0A1Q3F3W9   B0XGX9   A0A0C9QWZ0   A0A2A3EKL7   A0A182FLR3   A0A2P8XRC7   A0A088AKJ4   E2AU07   A0A034VJF1   A0A151WJ65   A0A1B0CEK8   F4W8J5   A0A0K8W8T9   C1BVG9   W8B554   A0A026WL90   A0A0A1WER5   E9JAR8   A0A195FBB5   A0A195B9Y3   A0A0K2TCV2   U4U694   A0A1Y1LJ22   A0A0P4WA21   A0A3B0J787   B4LMS5   A0A0P5G8Q0   A0A164VH10   A0A0N8DHL3   B4MKC1   Q28YL5   B4H8G8   A0A0M4EM32   A0A1W4VDE4   A0A0K8TQM8   W5NDU3   A0A3P8ZBG9   B3NN37   B4HN16   B4KNA3   A1Z8D0  

Pubmed

19121390    23622113    22118469    26354079    18362917    19820115    + More
24845553    17510324    26483478    20966253    12364791    14747013    17210077    20920257    23761445    25244985    21347285    24438588    22516182    29403074    20798317    25348373    21719571    24495485    24508170    30249741    25830018    21282665    23537049    28004739    17994087    15632085    26369729    25069045    10731132    12537572    12537569    21752937    29065309   

EMBL

BABH01023932    ODYU01013059    SOQ59720.1    RSAL01000026    RVE52054.1    GAIX01011506    + More
JAA81054.1    NWSH01000596    PCG75447.1    ODYU01008160    SOQ51529.1    GDQN01003864    JAT87190.1    AGBW02013658    OWR43035.1    KQ459602    KPI93592.1    KQ971338    EFA02231.2    KK852809    KDR15987.1    KQ434943    KZC12252.1    CH477936    EAT34945.1    JXUM01043644    KQ561370    KXJ78820.1    NEVH01003505    PNF40490.1    AXCM01013720    KQ435808    KOX72977.1    UFQT01000092    SSX19600.1    AXCN02001907    GFDF01006153    JAV07931.1    AAAB01008968    EAA13134.5    EDO63504.1    APCN01005313    ADMH02000132    ETN67655.1    GGFM01001912    MBW22663.1    GGFM01001951    MBW22702.1    KQ414672    KOC64226.1    GANO01002467    JAB57404.1    KQ764772    OAD54395.1    GGFJ01004779    MBW53920.1    LBMM01000337    KMR00425.1    KQ978881    KYN27782.1    GGFJ01004780    MBW53921.1    GGFK01005189    MBW38510.1    GGFK01005181    MBW38502.1    ADTU01018747    ADTU01018748    KQ978406    KYM94155.1    AJVK01003620    ATLV01018946    KE525256    KFB43458.1    BT126610    AEE61574.1    GFDL01012783    JAV22262.1    DS233076    EDS27898.1    GBYB01005192    JAG74959.1    KZ288217    PBC32363.1    PYGN01001485    PSN34545.1    GL442764    EFN63083.1    GAKP01015526    JAC43426.1    KQ983082    KYQ47735.1    AJWK01008964    AJWK01008965    AJWK01008966    AJWK01008967    GL887908    EGI69486.1    GDHF01004691    JAI47623.1    BT078598    ACO13022.1    GAMC01012838    JAB93717.1    KK107183    QOIP01000011    EZA55869.1    RLU16660.1    GBXI01017389    JAC96902.1    GL770679    EFZ10046.1    KQ981693    KYN37671.1    KQ976537    KYM81343.1    HACA01006503    CDW23864.1    KB632168    ERL89394.1    GEZM01058967    JAV71596.1    GDRN01075511    JAI63043.1    OUUW01000001    SPP75752.1    CH940648    EDW61016.1    GDIQ01245057    JAK06668.1    LRGB01001361    KZS12314.1    GDIP01032943    JAM70772.1    CH963846    EDW72560.1    CM000071    EAL25950.2    CH479223    EDW35003.1    CP012524    ALC42755.1    GDAI01000931    JAI16672.1    AHAT01026502    CH954179    EDV56557.1    CH480816    EDW47320.1    CH933808    EDW09956.1    AE013599    AY075465    BT044570    AAL68278.1    ACI16532.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007151    UP000053268    UP000007266    + More
UP000192223    UP000027135    UP000076502    UP000075884    UP000008820    UP000069940    UP000249989    UP000075881    UP000235965    UP000075885    UP000075883    UP000075900    UP000075920    UP000053105    UP000075886    UP000075882    UP000007062    UP000075840    UP000076407    UP000075903    UP000000673    UP000075880    UP000076408    UP000075902    UP000053825    UP000036403    UP000078492    UP000005205    UP000078542    UP000092462    UP000030765    UP000002320    UP000242457    UP000069272    UP000245037    UP000005203    UP000000311    UP000075809    UP000092461    UP000007755    UP000053097    UP000279307    UP000078541    UP000078540    UP000030742    UP000268350    UP000008792    UP000076858    UP000007798    UP000001819    UP000008744    UP000092553    UP000192221    UP000018468    UP000265140    UP000008711    UP000001292    UP000009192    UP000000803   

PRIDE

H9J1N4    A1Z8D0   

Pfam

PF00400   WD40        + More
PF16533   SOAR
PF07647   SAM_2

Interpro

IPR020472   G-protein_beta_WD-40_rep        + More
IPR019775   WD40_repeat_CS       
IPR036322   WD40_repeat_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR001660   SAM       
IPR011992   EF-hand-dom_pair       
IPR013761   SAM/pointed_sf       
IPR037608   STIM       
IPR032393   SOAR       

SUPFAM

SSF50978   SSF50978        + More
SSF47769   SSF47769       
SSF47473   SSF47473       

Gene 3D

2.130.10.10     1.10.150.50    

CDD

cd11722  SOAR

ProteinModelPortal

H9J1N4   A0A2H1X2Z1   A0A3S2TQ38   S4NVK0   A0A2A4JTT9   A0A2H1WEN6   + More
A0A1E1WJJ6   A0A212ENF4   A0A194PJU5   D2A2W9   A0A1W4WLB0   A0A067RBE6   A0A154PK80   A0A182NND2   Q16KW1   A0A182G5J3   A0A182JUR4   A0A2J7RI32   A0A1S4FXN6   A0A182P8D5   A0A182M3T8   A0A182RXF8   A0A182WCM1   A0A0M8ZXK5   A0A336LNU4   A0A182QJ92   A0A1L8DNE1   A0A182LI61   Q7PMW1   A0A182HXJ0   A0A182WYK3   A0A182VCZ0   W5JWM1   A0A2M3Z2D4   A0A2M3Z2E3   A0A182JIM5   A0A182YI22   A0A182UKI4   A0A0L7R0A1   U5EIW8   A0A310SBE1   A0A2M4BLG7   A0A0J7L7X5   A0A195EIQ7   A0A2M4BLV1   A0A2M4ACN0   A0A2M4ACQ3   A0A158NK95   A0A151I7K3   A0A1B0D6I7   A0A084VZR4   J3JTQ3   A0A1Q3F3W9   B0XGX9   A0A0C9QWZ0   A0A2A3EKL7   A0A182FLR3   A0A2P8XRC7   A0A088AKJ4   E2AU07   A0A034VJF1   A0A151WJ65   A0A1B0CEK8   F4W8J5   A0A0K8W8T9   C1BVG9   W8B554   A0A026WL90   A0A0A1WER5   E9JAR8   A0A195FBB5   A0A195B9Y3   A0A0K2TCV2   U4U694   A0A1Y1LJ22   A0A0P4WA21   A0A3B0J787   B4LMS5   A0A0P5G8Q0   A0A164VH10   A0A0N8DHL3   B4MKC1   Q28YL5   B4H8G8   A0A0M4EM32   A0A1W4VDE4   A0A0K8TQM8   W5NDU3   A0A3P8ZBG9   B3NN37   B4HN16   B4KNA3   A1Z8D0  

PDB

5WJC     E-value=2.68775e-09,     Score=149

KEGG

101735859    K14791 periodic tryptophan protein 1 | (RefSeq) periodic tryptophan protein 1 homolog

GO

GO:0005634   GO:0016021   GO:0005246   GO:0036098   GO:0031490   GO:0090070   GO:0035327   GO:0030707   GO:0005654   GO:1901838   GO:0045945   GO:0032869   GO:0030723   GO:0005730   GO:0008584   GO:0007281   GO:0005694   GO:0042254   GO:0010468   GO:0005515   GO:0000723   GO:0003678   GO:0006281   GO:0008270   GO:0003677   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR15136  

Subcellular location

Nucleus   Co-localizes with active forms of RNA polymerase II (PubMed:21752937). Associates with open chromatin and chromosomal puffs of polytene chromosomes in larval salivary glands (PubMed:21752937). Nucleolar localization is controlled by mTORC1 signaling (PubMed:29065309).   With evidence from 2 publications.
Nucleolus   Co-localizes with active forms of RNA polymerase II (PubMed:21752937). Associates with open chromatin and chromosomal puffs of polytene chromosomes in larval salivary glands (PubMed:21752937). Nucleolar localization is controlled by mTORC1 signaling (PubMed:29065309).   With evidence from 2 publications.
Chromosome   Co-localizes with active forms of RNA polymerase II (PubMed:21752937). Associates with open chromatin and chromosomal puffs of polytene chromosomes in larval salivary glands (PubMed:21752937). Nucleolar localization is controlled by mTORC1 signaling (PubMed:29065309).   With evidence from 2 publications.
Nucleoplasm   Co-localizes with active forms of RNA polymerase II (PubMed:21752937). Associates with open chromatin and chromosomal puffs of polytene chromosomes in larval salivary glands (PubMed:21752937). Nucleolar localization is controlled by mTORC1 signaling (PubMed:29065309).   With evidence from 2 publications.

Length:

464

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00360000000000001

Exp number, first 60 AAs:

0.00091

Total prob of N-in:

0.00355

outside

1  -  464

 

 

Pi

157.676541

Theta

150.679051

Tajima's D

0.093402

CLR

0.507553

CSRT

0.39878006099695

Interpretation

Uncertain