Gene

KWMTBOMO09236  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003335

Annotation

PREDICTED:_proteasome_subunit_beta_type-6_[Papilio_machaon]

Location

Bomo_Chr15(-):13727812-13730127      View in EpiBrowser

Full name

Proteasome subunit beta      

Location in the cell

Cytoplasmic   Reliability : 1.681

CDS

ATGGCAACATCAGTGATCAATACCTACTCTGATCCTTGCCTACCGGAGTGGATGAGCGCCCCTCATAGTACGGGAACTTCAATCATGGCATGCGAGTTTGATGGTGGAGTCGTCATTGGAGCTGATTCCCGTACCACAACAGGCGCTTACATCGCCAATCGAGTCACCGACAAGCTGACGAAAATCACTGACCAGATATACTGCTGCCGCTCAGGATCCGCTGCCGACACTCAAGCCATAGCTGATATTGTAACATATCATTTGAACTTCCACAAGATGGAATTAGGAGATCCACCACTAGTGGAAACTGCCGCAGCGATATTCCGTGAGCTCTGCTACAACTATCGTGACTCATTGATGGCTGGTATTTTAGTTGCTGGATGGGACAAAAAGAAAGGAGCTCAAATTTACTCTATACCTATTGGTGGTATGGTGCAGCGCCAAGCGGTGTCAATTGGAGGCTCCGGATCCTCTTACGTCTATGGCTACGTTGACGCCAATTTCAAGCCCAATATGACCAAGGAAGAAGCCAAAAAATTTGTTACGGACACACTGACATTGGCTATCCTTCGTGACGGCTCTTCTGGTGGTGTTGTCAGACTCGGAGTAATTACTGAAGCTGGTGTGGAACGCTCTGTTATTCTTGGAGACCAACTTCCCAAATTTTATGAAGGTTAA

Protein

MATSVINTYSDPCLPEWMSAPHSTGTSIMACEFDGGVVIGADSRTTTGAYIANRVTDKLTKITDQIYCCRSGSAADTQAIADIVTYHLNFHKMELGDPPLVETAAAIFRELCYNYRDSLMAGILVAGWDKKKGAQIYSIPIGGMVQRQAVSIGGSGSSYVYGYVDANFKPNMTKEEAKKFVTDTLTLAILRDGSSGGVVRLGVITEAGVERSVILGDQLPKFYEG

Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Subunit

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.

Similarity

Belongs to the peptidase T1B family.

Uniprot

H9J1E8   A0A2A4K9J9   A0A2H1VFD5   A0A194RJQ3   A0A194PKP4   A0A3S2LYP7   + More
S4PHC9   I4DK39   A0A1E1WHA9   A0A212EXS6   A0A2P8YNA7   D6WT45   A0A0T6BB72   V5I9J7   K7J4Z1   A0A1Y1KTU2   J3JTW0   E1ZWG1   A0A2A3EMI3   V9II29   A0A0N0U515   A0A411G642   A0A232EYU2   A0A158NPP5   A0A0C9RFI6   A0A0L7R042   A0A195ESV4   A0A151X8H8   A0A195EM54   A0A1W4XAA1   A0A0J7L0J6   U4TYK1   N6TTR8   A0A026WTY8   A0A067R651   A0A226ERV9   U4U3C1   E9GZ78   A0A131XNR3   A0A224YG33   A0A131Z2F3   A0A023G7V6   A0A023FQ41   G3MRX7   A0A023FXX9   A0A0P5VFR9   A0A1E1X2R1   A0A0P6JVR0   A0A131XZ20   A0A154PEJ0   A0A0P5AUD2   A0A0P5WMP8   A0A0P4YC36   A0A0P5YL84   A0A0P5Y9B9   A0A151I8C8   E2BIK2   A0A2J7RR21   A0A023FNY4   A0A2R5LFX9   A0A1D2MXK3   A0A0P5BEP2   A0A0P4YZ09   K1QBT2   A0A3P9ADQ9   A9UWM7   A0A1Z5KYH6   F1RCM3   A0A1S3JWY0   B5X963   B5X8Y8   A0A060XEY9   A0A3B3RT78   C1BW52   A0A1W4Y7R5   A0A433UB52   A0A0P5RDI7   A0A3Q8QF21   B2GRB2   Q568V4   F4W7J5   B5XD66   O57332   R4UMP0   A0A444USC0   A0A060YSB5   A0A0P5ND39   A0A0K8RGM3   A0A1S3RIW7   A0A0B6ZXC6   A0A0P5N9Y1   W5USF9   A0A2D0QBT5   A0A151NTL8   A7RA95   C3ZIC3   A0A1P8DB30   A0A0L7KS96   A0A3P9DRT1   A0A3P8P4W9  

EC Number

3.4.25.1

Pubmed

19121390    26354079    23622113    22651552    22118469    29403074    + More
18362917    19820115    20075255    28004739    22516182    20798317    28648823    21347285    23537049    24508170    30249741    24845553    21292972    28049606    28797301    26830274    22216098    28503490    27289101    22992520    25069045    18273011    28528879    23594743    20433749    24755649    29240929    21719571    9550404    23127152    22293439    18563158    26227816    25186727   

EMBL

BABH01023829    NWSH01000012    PCG80887.1    ODYU01002066    SOQ39112.1    KQ460106    + More
KPJ17782.1    KQ459602    KPI93573.1    RSAL01000112    RVE47034.1    GAIX01003322    JAA89238.1    AK401657    BAM18279.1    GDQN01004758    JAT86296.1    AGBW02011690    OWR46298.1    PYGN01000474    PSN45694.1    KQ971354    EFA05865.1    LJIG01002358    KRT84582.1    GALX01002815    JAB65651.1    GEZM01080221    JAV62287.1    BT126669    AEE61632.1    GL434830    EFN74473.1    KZ288217    PBC32369.1    JR048567    AEY60700.1    KQ435808    KOX72982.1    MH365582    QBB01391.1    NNAY01001584    OXU23525.1    ADTU01022697    GBYB01007155    JAG76922.1    KQ414672    KOC64220.1    KQ981986    KYN31236.1    KQ982409    KYQ56673.1    KQ978730    KYN28959.1    LBMM01001609    KMQ96019.1    KB631660    ERL85103.1    APGK01054753    KB741253    ENN71781.1    KK107105    QOIP01000011    EZA59530.1    RLU16727.1    KK852675    KDR18713.1    LNIX01000002    OXA59521.1    ERL85106.1    GL732577    EFX75100.1    GEFH01000783    JAP67798.1    GFPF01005501    MAA16647.1    GEDV01002948    JAP85609.1    GBBM01005504    JAC29914.1    GBBK01001058    JAC23424.1    JO844628    AEO36245.1    GBBL01001765    JAC25555.1    GDIP01166746    GDIP01100512    LRGB01001920    JAM03203.1    KZS10019.1    GFAC01005641    JAT93547.1    GDIQ01006896    JAN87841.1    GEFM01003313    JAP72483.1    KQ434889    KZC10251.1    GDIP01194005    JAJ29397.1    GDIP01085017    JAM18698.1    GDIP01229604    JAI93797.1    GDIP01057619    JAM46096.1    GDIP01061021    JAM42694.1    KQ978364    KYM94605.1    GL448516    EFN84449.1    NEVH01000611    PNF43275.1    GBBK01001021    JAC23461.1    GGLE01004209    MBY08335.1    LJIJ01000411    ODM97767.1    GDIP01189852    JAJ33550.1    GDIP01220802    JAJ02600.1    JH818665    EKC18961.1    CH991548    EDQ90240.1    GFJQ02007119    JAV99850.1    CU896563    CU929143    BT047582    ACI67383.1    BT047507    ACI67308.1    FR905301    CDQ78193.1    BT078831    ACO13255.1    RQTK01000019    RUS91039.1    GDIQ01108457    JAL43269.1    MH683009    AZI95695.1    BC165062    AAI65062.1    BC092699    AAH92699.1    GL887844    EGI69868.1    BT048985    ACI68786.1    AF032392    AAB87681.1    KC571886    AGM32385.1    SCEB01010584    RXM91063.1    FR913120    CDQ92344.1    GDIQ01144248    JAL07478.1    GADI01003790    JAA70018.1    HACG01026082    CEK72947.1    GDIQ01152140    JAK99585.1    JT417950    AHH42563.1    AKHW03002060    KYO40227.1    DQ279100    ABB86551.1    GG666627    EEN47648.1    KU351251    APU53803.1    JTDY01006283    KOB66142.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000283053    UP000007151    + More
UP000245037    UP000007266    UP000002358    UP000000311    UP000242457    UP000053105    UP000215335    UP000005205    UP000053825    UP000078541    UP000075809    UP000078492    UP000192223    UP000036403    UP000030742    UP000019118    UP000053097    UP000279307    UP000027135    UP000198287    UP000000305    UP000076858    UP000076502    UP000078542    UP000008237    UP000235965    UP000094527    UP000005408    UP000265140    UP000001357    UP000000437    UP000085678    UP000087266    UP000193380    UP000261540    UP000192224    UP000271974    UP000007755    UP000221080    UP000050525    UP000001554    UP000037510    UP000265160    UP000265100   

PRIDE

H9J1E8    F1RCM3    Q568V4   

Pfam

PF00227   Proteasome        + More
PF08510   PIG-P

Interpro

IPR000243   Pept_T1A_subB        + More
IPR035140   Proteasome_beta6       
IPR029055   Ntn_hydrolases_N       
IPR023333   Proteasome_suB-type       
IPR001353   Proteasome_sua/b       
IPR037559   Proteasome_beta_Pre3       
IPR013717   PIG-P       
IPR016050   Proteasome_bsu_CS       

SUPFAM

SSF56235   SSF56235       

Gene 3D

3.60.20.10    

ProteinModelPortal

H9J1E8   A0A2A4K9J9   A0A2H1VFD5   A0A194RJQ3   A0A194PKP4   A0A3S2LYP7   + More
S4PHC9   I4DK39   A0A1E1WHA9   A0A212EXS6   A0A2P8YNA7   D6WT45   A0A0T6BB72   V5I9J7   K7J4Z1   A0A1Y1KTU2   J3JTW0   E1ZWG1   A0A2A3EMI3   V9II29   A0A0N0U515   A0A411G642   A0A232EYU2   A0A158NPP5   A0A0C9RFI6   A0A0L7R042   A0A195ESV4   A0A151X8H8   A0A195EM54   A0A1W4XAA1   A0A0J7L0J6   U4TYK1   N6TTR8   A0A026WTY8   A0A067R651   A0A226ERV9   U4U3C1   E9GZ78   A0A131XNR3   A0A224YG33   A0A131Z2F3   A0A023G7V6   A0A023FQ41   G3MRX7   A0A023FXX9   A0A0P5VFR9   A0A1E1X2R1   A0A0P6JVR0   A0A131XZ20   A0A154PEJ0   A0A0P5AUD2   A0A0P5WMP8   A0A0P4YC36   A0A0P5YL84   A0A0P5Y9B9   A0A151I8C8   E2BIK2   A0A2J7RR21   A0A023FNY4   A0A2R5LFX9   A0A1D2MXK3   A0A0P5BEP2   A0A0P4YZ09   K1QBT2   A0A3P9ADQ9   A9UWM7   A0A1Z5KYH6   F1RCM3   A0A1S3JWY0   B5X963   B5X8Y8   A0A060XEY9   A0A3B3RT78   C1BW52   A0A1W4Y7R5   A0A433UB52   A0A0P5RDI7   A0A3Q8QF21   B2GRB2   Q568V4   F4W7J5   B5XD66   O57332   R4UMP0   A0A444USC0   A0A060YSB5   A0A0P5ND39   A0A0K8RGM3   A0A1S3RIW7   A0A0B6ZXC6   A0A0P5N9Y1   W5USF9   A0A2D0QBT5   A0A151NTL8   A7RA95   C3ZIC3   A0A1P8DB30   A0A0L7KS96   A0A3P9DRT1   A0A3P8P4W9  

PDB

5M32     E-value=2.48668e-73,     Score=697

KEGG

101745852    K02738 20S proteasome subunit beta 1 [EC:3.4.25.1] | (RefSeq) proteasome subunit beta type-6

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0005839   GO:0004298   GO:0051603   GO:0010498   GO:0043161   GO:0004175   GO:0010499   GO:0005737   GO:0005634   GO:0016021   GO:0000502   GO:0008270   GO:0008408   GO:0003677   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR11599:SF46   PTHR11599:SF4  

Subcellular location

Cytoplasm  
Nucleus  

Length:

225

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05766

Exp number, first 60 AAs:

0.00855

Total prob of N-in:

0.14058

outside

1  -  225

 

 

Pi

335.763737

Theta

193.338319

Tajima's D

2.456193

CLR

0

CSRT

0.941902904854757

Interpretation

Uncertain