SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO09234  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA003336
Annotation
PREDICTED:_mRNA_cap_guanine-N7_methyltransferase_[Papilio_machaon]
Full name
mRNA cap guanine-N7 methyltransferase      
Alternative Name
RG7MT1
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase
Location in the cell
Cytoplasmic   Reliability : 1.968 Nuclear   Reliability : 2.161
 

Sequence

CDS
ATGTCAGAATTGGGAGATTCCGAACTTTCGCTACAAAAACAAACTGAAAATGTCGATGAAAACAAAATCAATGCCAATAATTCAAATCATGAACCTCCTCCCAAAAAACATAGCAGCGTTGTAGCAGCACACTACAACCATCTGGAAGAAAAAGGTCTAAAAGAACGATACAATTCCCCAATATTTCACTTAAGGAATTTCAACAACTGGGTGAAAAGTGTTCTAATCCAAGAATTCACAGATAAAATACGCGAAAAAGACTACGGCCGTCCGCTCCGTATTTTAGACATCTGCTGTGGAAAAGGTGGAGATCTAAGTAAATGGCAAAAAGTTCGGCCGGAACATGCAATTTTCGCTGACATAGCTGAGGTTTCCGTTCAGCAATGCGAAACTCGTTACGAAGAACTTCGTAGGAGATGCGGTCGGCTCTTTTCAGCCGAATTCATTGCTACGGATTGTACAAAAGACACACTTAGAGATAAATACAAAGATCCATCAATCAGTTTTGATATAGTTAGCTGTCAATTTGGATTACATTATAGTTTTGAAAGCTTACCACAAGCAAGAAGAATGTTGACCAACATTTCTGAATGTCTAAAGCCTGGGGGCTATTTTTTTGGCACAATTCCGAATGCTAACGAGATTGTTTCAAGGGCACAGAAGACCCAAGATTACGCATTTGGTAACAGGATTTACAATATAAAACTACTGTTTGATCCCAAAGATGGCTATCCGCTTTTTGGAGCGAAATATGACTTTCACTTGGAAGGTGTGGTAGACTGTCCGGAGTTCTTAGTCAACTTTGAGCTGTTTAAGAAATTAGCTTCAGAATATGGCTTGGAATTAGTTTATAAAGCAGGCTTTGATCATTTTTATAAGGACCACTGGGAAAATCACAAACAGCTGTTTCAAAGGATAATGTGTTTTGAGACTTATCCAGCGCCAAATGGTAAAACCCTTATGGGTGAAGAGTCTGAATATGAGCACGCAAAAAAATACTGGGACAGTAAAGAGTATAAGGCTGACCAAAATTGTATCGGCACCATGAGTATATGTGAATGGGAGGTTGCTACAATATACATGGCCTTTGCATTTAAGAAATTGAAATGCACTCAGTGGAGTTCTGATGGGAAGCCAACTTATACAGTTTCCAAAGAAACTAATCAGTCAACTAGTAAGCAATGA
Protein
MSELGDSELSLQKQTENVDENKINANNSNHEPPPKKHSSVVAAHYNHLEEKGLKERYNSPIFHLRNFNNWVKSVLIQEFTDKIREKDYGRPLRILDICCGKGGDLSKWQKVRPEHAIFADIAEVSVQQCETRYEELRRRCGRLFSAEFIATDCTKDTLRDKYKDPSISFDIVSCQFGLHYSFESLPQARRMLTNISECLKPGGYFFGTIPNANEIVSRAQKTQDYAFGNRIYNIKLLFDPKDGYPLFGAKYDFHLEGVVDCPEFLVNFELFKKLASEYGLELVYKAGFDHFYKDHWENHKQLFQRIMCFETYPAPNGKTLMGEESEYEHAKKYWDSKEYKADQNCIGTMSICEWEVATIYMAFAFKKLKCTQWSSDGKPTYTVSKETNQSTSKQ

Summary

Description
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884).
Catalytic Activity
a 5'-(5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] + S-adenosyl-L-homocysteine
Subunit
Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity.
Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity (PubMed:11114884). Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates (PubMed:11114884). Interacts with elongating form of polymerase II and RNGTT (PubMed:9705270). Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity (PubMed:22099306, Ref.14).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
Keywords
Complete proteome   Methyltransferase   mRNA capping   mRNA processing   Nucleus   Phosphoprotein   RNA-binding   S-adenosyl-L-methionine   Transferase   3D-structure   Alternative splicing   Reference proteome  
Feature
chain  mRNA cap guanine-N7 methyltransferase
splice variant  In isoform 2.
EC Number
2.1.1.56
EMBL
BABH01023826    RSAL01000077    RVE48809.1    NWSH01003201    PCG66797.1    ODYU01010974    + More
SOQ56418.1    KQ460709    KPJ12716.1    JTDY01006928    KOB65588.1    KQ459598    KPI94693.1    AGBW02014506    OWR41551.1    GECZ01013040    JAS56729.1    AJWK01000610    NNAY01000821    OXU26332.1    NEVH01019395    PNF22472.1    GFDF01008432    JAV05652.1    GDKW01003025    JAI53570.1    GFDF01008467    JAV05617.1    GL448604    EFN84098.1    LJIG01022805    KRT78621.1    GFTR01005566    JAW10860.1    GECL01002834    JAP03290.1    GDAI01000836    JAI16767.1    JXUM01001747    KQ560127    KXJ84322.1    GEDC01012419    JAS24879.1    GEBQ01006812    JAT33165.1    GL438172    EFN69462.1    GBBI01003489    JAC15223.1    KK107019    QOIP01000007    EZA62748.1    RLU20528.1    CH477788    EAT36219.1    GBYB01008211    JAG77978.1    GBGD01002045    JAC86844.1    ADTU01024723    GL887726    EGI70084.1    KQ977171    KYN05141.1    AJVK01031282    KK852432    KDR24008.1    GFDL01012465    JAV22580.1    GFDL01012412    JAV22633.1    KU659970    AOG17768.1    DS231912    EDS25849.1    KQ979602    KYN20525.1    KQ971342    EFA03004.2    GALX01000526    JAB67940.1    PNF22471.1    MG596905    AVP12660.1    KU659917    AOG17716.1    KZ288250    PBC31077.1    RQTK01000024    RUS90792.1    KQ414722    KOC62706.1    NEDP02000186    OWF56493.1    GANO01002856    JAB57015.1    KQ982045    KYQ60744.1    CM001293    EHH58736.1    AQIB01129447    AHZZ02012178    AHZZ02012179    JSUE03019118    JSUE03019119    JU336902    JU477644    JV048578    CM001270    AFE80655.1    AFH34448.1    AFI38649.1    EHH29151.1    AB168817    ADFV01096840    GAMT01001012    GAMS01002790    GAMR01008598    GAMQ01004106    GAMP01008253    JAB10849.1    JAB20346.1    JAB25334.1    JAB37745.1    JAB44502.1    JRES01001003    KNC26203.1    BC146125    AAI46126.1    AB022604    AB022605    AF067791    AB020966    AB007858    EF445026    CH471113    BC036798    AACZ04060022    GABC01008892    GABF01003328    GABD01003664    GABE01008602    NBAG03000406    JAA02446.1    JAA18817.1    JAA29436.1    JAA36137.1    PNI28336.1    AJFE02023052    CABD030106927    AEYP01011347    AEYP01011348    GDHF01013587    JAI38727.1    LWLT01000023    AMGL01066958    AGTP01079821    GBHO01007675    GBRD01000703    JAG35929.1    JAG65118.1    ACTA01067257    ACTA01075257    ACTA01083257    ACTA01091257    ACTA01099257    JH880802    ELR58800.1    GDHC01016620    JAQ02009.1    APGK01054294    APGK01054295    APGK01054296    KB741248    KB631794    ENN71965.1    ERL86187.1    KL448232    KFO81419.1   
Pfam
PF03291   Pox_MCEL
Interpro
IPR029063   SAM-dependent_MTases        + More
IPR004971   mRNA_G-N7_MeTrfase_dom       
IPR016899   mRNA_G-N7_MeTrfase_euk       
IPR039753   RG7MT1       
SUPFAM
SSF53335   SSF53335       
PDB
3EPP     E-value=6.16596e-80,     Score=757

Ontologies

Topology

Subcellular location
Nucleus  
Length:
394
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0205
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00164
outside
1  -  394
 
 

Population Genetic Test Statistics

Pi
200.861197
Theta
173.869344
Tajima's D
0.472677
CLR
0.135745
CSRT
0.504474776261187
Interpretation
Uncertain
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