Silkworm Genome Informatics Database

Gene

KWMTBOMO09200 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003396

Annotation

PREDICTED:_DNA_polymerase_alpha_catalytic_subunit_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr15(+):13157114-13166356 View in EpiBrowser

Full name

DNA polymerase + More
DNA polymerase alpha catalytic subunit

Alternative Name

DNA polymerase alpha catalytic subunit p180

Location in the cell

Nuclear Reliability : 4.283

CDS

ATGGCCGATTCAATAGCTGCTCAGCGTGCGAAGCGACAAAAAACAGACCGACACGGTCGATTCTCGGCGTTTGAGAAGCTAAAACAATTAAAAGGGAAAGGTGTAAAGCATAAGTACGATGTGGATGTGCTTGAGAATGTGTACGACACTGTTGACGAGAAAGAATACACAGAAAGAGTTCTACAGCGACAAGAAGACGATTGGATAGAAGATGATGGTACTGGCTATGTTGAAGATGGAAGGGAGATATTTGATGATGATGATGATGCTTATGAAGCAACAAATAGTAAAGATACAGGCAGAGGACAGAAAAGGAAGGCCAAAGTTGCAGCACAGTCCTCAGGAAAAGGGAATATACGAAACTTAATTGGTAACATGCCTAGTAAGAAAAAAGAGGATGTAAAGATTTCAGAAGATAATATTTTATCTGATATTATATCTGATTTGGATGCTAACACTGCATCAAATGTAGTAAAATCTACACTGCCTATAACTAAAACTAACATTGTGGATACAAGTAAGAGAGATGCACAAAACTACTTCAAAAGTCTTTCTGCTAACGTCAAGAAACCTTCTGTACTAAAAACATTCAAGGAAGAAAAGGAGACTGAAAGTATTGAGCCAGACACATCTGCAGTACAGTGTGAAAAAAATATGATAAATCATGTGGTAAATGAACCTGCAAATAAGAAAATCAAGAAACCAGAATGGAACATTGAAAAAGAAATCAAGCAAGAACTTAATGAAACGCTTACTCCTAATATAGAAGAATTTGAAACACAAGATATTGACTTTGACGATGACTTCAGCAATGATGCAAAAACGTCCCAAGTGAAAAACGAGCCTGTCAGCACCGGAACTATCACCGAAAATCCTACAACAGACATCACTGATGAATTTTTCAATGACGAATTTGAAATATTCCCTTTACCAAAGAAAGAAACTACGAAAGAACTGAAACCATTGACTAGTACATGGCCAGAACAAGGAGGTGACAACCAAACTGTGTCTTCAGTTCAAAGTGATGGTCAATTACCACTGCAAACCAATGAAACAGGGGAGAAAGTGCTTAGATTTTACTGGCTTGATGCATGGGAAGATCGGTTTGTAAAACCAGGCGTTATATACCTATTTGGAAAAGTTTATGTTGACCCATCAAAAAAGAAGGCTGGATGTGTATCATGCTGCCTTGTTGTGAAGAATGTTAATAGGCAGATATTCCTGTTGCCAAGAGAATATAAACTTGACCCAATAACCCTTGAGCCAACAGAACAAGAGGTGACGATGATGGATATGTATGAAGAGTTCAATAGTTCTGTGGCAAGTGAACTCAGTCTCCAAGAATTTAAATCACGAAAGGTCACCAAGAACTACTGTTTCAATTTGCCAGATATACCAGCTCAATCTGATTATTTAGAAGTTAGATACTCGGCAACTCTCCCTCCGCCTCCTACCAACAAAAAATATTTGACATTCTCACATATATTCGGAACGAACACATCTTCACTAGAAATATTCCTACTAGAGAGGAAAATCAAAGGGCCCTGTTGGCTTGAGATCAAGAACCCGGAAAGCGTCCAAGCCAAAGTGTCTTGGTGTAAATTGGAAGCCTCGTGTGAGAAGATGGAACATGTTAATGTTGTCCGAACGGACGGTGACTTAGAACCACCTCCGATAGTCACAGCTGCTATAAACATGCGCACAACTATGGATCCGAAAACGCGAAAAACAAAGATTGTGATGTTGAGTTGCTTGACTCACAGCAGTTTCCCGATACACAAGTCGCCTCCGAATCCACCGTTTCAGCAGCATTTTAGCATAATAACAAAATGTAACGAAATATGGCCATTGGATCTAAAACAGGCTCTACCGCAATATAAAGCGACGAAATTAACCAAATGCGATACAGAGAGAGAACTCCTCAATTATTTCATGGTGCAGTTTTGGAAACTTGACCCGGACTTGGTGGTCGGTCACGACCTGCAAGGTTTCCAACAGGACCTGCTCATAGGGAACGTACTGGACCTCAACATACCGAACTGGTCGCGGCTGGGCCGTCTGAAGAGATCTGTCGCTCCGCAGAGGAAATTCGCAGCGAAAGACGCGTTCTTGGGCCGTTTAGTTTGCGATGTAAAGATATCCGCAATGGAACTTATCAGGGCCCGGAGTTTCGATCTCGAAACCCTTTGCACTAATGTATTGAAAATGAAAGAGGGCGAGCGTATCGATGTGGCACTCGAGGATTTACCGAAGTACTATGAAAACAGTAGGGATTTATTCCAGCTCGTGTCGCTCAGTATGCAGGACGCGTCGTACGTGCTGAGGATAATGTGCGAGCTCAACGCTATACCTCTGGCTCTTCAGATCACGCAGATAGCGGGCAACGTCATGTCTCGAACCCTACTCGGCGGCAGATCTGAACGCAACGAGTTCTTATTGCTCCACGCCTTCACTGAGAAAAATTATATAGTACCTGATAAGATTTATGGCAAGAAGACAACTGCTGAAGACGGAATTCAAGAAGACCAAGAAGAAGGTGCAAACGCTCCCAAGAAACAAGGAAAGAAAAAGGCGGCCTATTCCGGAGGTCTGGTACTAGATCCAAAAAAAGGCTTCTACGATAAACTAATTCTACTCATGGACTTCAATTCCTTATATCCTAGTATCATTCAAGAGTATAACATTTGCTTTACGACGATTAAAAGAAAAAACGGGATCATGTCCGATGAAGATGTGTCTAACCTTATATTGCCAGCACCGAAAACCGACTTAGGTGTTTTGCCCACGCAAATACGGAAATTGGTTGAAAGTAGAAGGGAAGTCAAGAAGTTAATGAAGTCACCGGATTTGGCGAGCGATCAATACATACAGTACAACATCCGACAAACTGCCCTCAAGCTAACGGCCAACTCTATGTACGGATGTCTCGGGTTTTCGCACTCTAGGTTTTATGCGAAGCCGCTGGCGGCGCTCGTCACAATGAAAGGAAGAGAAATTCTGATGGACACAAAAGAAATTGTCCAAAAAATGAACTATGACGTTGTCTACGGCGACACGGACAGTATAATGATCAACACTAATTGTCTAGATTACGACGCGGTTTTCAAAATAGGAGTGGATCTAAAAAAAGAAATAAACAAAAAATACAGACAAATTGAACTCGACATAGACGGCGTGTTCAGATACCTCCTTCTGTTAAAGAAAAAGAAATATGCGGCAGTTTTAATCAGCAGGAATAAAAATGGCGAATTCGTTTTCACTCAAGAACACAAAGGTTTAGACATCGTCCGTCGAGACTGGTCACAACTGGCCGCCGAGGCCGGGAAATTTATTCTTAGTCAAATCCTTTCCGAACAGACTCCCGATGATCGATTGGAAAGCATACAAAATCATCTAAATAAATTAAAAGACGATCTGATCGGTAATAAAATGCCCCTCTCGGTTTTAGCCATAACAAAGCAACTCACTAAAAACCCCAATGAATACGCTGATAAACATACGCAATCTCACGTCCAAGTGGCATTGAGGCTTAACAGTAAAAACAGTAGGAGATTCAAAAAAGGCGACATTGTGCCTTACATTATATGTGAAGATGGAACCGCTAACTCAGCCACGCAAAGGGCTTACCACATAGAAGAATTAAAGAATTCCGAACATCTCAAAGTCGATTTTAAGTATTATCTAGCACATCAGCTACATCCTGTAATATCAAGAATATGCGAACCAATAGAAGGCATGGATCCAGCCCGCGTTGCAGACTGCCTCGGCCTAGATCCCTCCGGATACAAACAAGCTGTTAAAAGAGAAACCAACGACTCGGAAACTTATGAGGTCGAGAACGAACAAGAAAAGTACCGACAATGCAAAGAGTTTGTCTTCGAATGCGTCGATGAAAACTGTAAAACTTTGAACAGAGTACGAGAATCGATCTATAAACTGGACAAAGAGAACATTTCGTTTTTAGATCGCTGTCAGAATGAAAAGTGTAATGTGAAGCCGTTAGATTATTTATCTAGCGTGCAAAATCAGTTGAGCCTGCAAATTCGACAGTACCACGCACAGTACTATGCGGGCTGGTTATCGTGTGAAGACCCGGCGTGTGGACACCGTACCGCGAGATTGCCTCAGACGTTCGCAGGAGGCTACCCCCTTTGTAGACAATGTGAGAAAGGGGTCATGTTTCGAGAATATACAGAAAAAGATTTATATTTACAGATAAACTTTTTCTTGTTTCTGTTCGATCTCAGCAAAAGCAATAAATTAAAAGTACCAGTACCTCCAACGATTGTCTCAGCATTCGAAACGCTAAAGGAAATGGTTGAAGATTGTTTAGGGCATTCCGCCTACTCAATTATAAATTTATCAAAACTATTCAGATTTTTTACTTTGGACACCAAAGCCAACAAAATGAAGGCGGAACCGACTGATTTAGATATTCTCCCAGAAACTGAACAAATAGACGCTCTTCTGGAGATGGGTGTTTTCTAA

Protein

MADSIAAQRAKRQKTDRHGRFSAFEKLKQLKGKGVKHKYDVDVLENVYDTVDEKEYTERVLQRQEDDWIEDDGTGYVEDGREIFDDDDDAYEATNSKDTGRGQKRKAKVAAQSSGKGNIRNLIGNMPSKKKEDVKISEDNILSDIISDLDANTASNVVKSTLPITKTNIVDTSKRDAQNYFKSLSANVKKPSVLKTFKEEKETESIEPDTSAVQCEKNMINHVVNEPANKKIKKPEWNIEKEIKQELNETLTPNIEEFETQDIDFDDDFSNDAKTSQVKNEPVSTGTITENPTTDITDEFFNDEFEIFPLPKKETTKELKPLTSTWPEQGGDNQTVSSVQSDGQLPLQTNETGEKVLRFYWLDAWEDRFVKPGVIYLFGKVYVDPSKKKAGCVSCCLVVKNVNRQIFLLPREYKLDPITLEPTEQEVTMMDMYEEFNSSVASELSLQEFKSRKVTKNYCFNLPDIPAQSDYLEVRYSATLPPPPTNKKYLTFSHIFGTNTSSLEIFLLERKIKGPCWLEIKNPESVQAKVSWCKLEASCEKMEHVNVVRTDGDLEPPPIVTAAINMRTTMDPKTRKTKIVMLSCLTHSSFPIHKSPPNPPFQQHFSIITKCNEIWPLDLKQALPQYKATKLTKCDTERELLNYFMVQFWKLDPDLVVGHDLQGFQQDLLIGNVLDLNIPNWSRLGRLKRSVAPQRKFAAKDAFLGRLVCDVKISAMELIRARSFDLETLCTNVLKMKEGERIDVALEDLPKYYENSRDLFQLVSLSMQDASYVLRIMCELNAIPLALQITQIAGNVMSRTLLGGRSERNEFLLLHAFTEKNYIVPDKIYGKKTTAEDGIQEDQEEGANAPKKQGKKKAAYSGGLVLDPKKGFYDKLILLMDFNSLYPSIIQEYNICFTTIKRKNGIMSDEDVSNLILPAPKTDLGVLPTQIRKLVESRREVKKLMKSPDLASDQYIQYNIRQTALKLTANSMYGCLGFSHSRFYAKPLAALVTMKGREILMDTKEIVQKMNYDVVYGDTDSIMINTNCLDYDAVFKIGVDLKKEINKKYRQIELDIDGVFRYLLLLKKKKYAAVLISRNKNGEFVFTQEHKGLDIVRRDWSQLAAEAGKFILSQILSEQTPDDRLESIQNHLNKLKDDLIGNKMPLSVLAITKQLTKNPNEYADKHTQSHVQVALRLNSKNSRRFKKGDIVPYIICEDGTANSATQRAYHIEELKNSEHLKVDFKYYLAHQLHPVISRICEPIEGMDPARVADCLGLDPSGYKQAVKRETNDSETYEVENEQEKYRQCKEFVFECVDENCKTLNRVRESIYKLDKENISFLDRCQNEKCNVKPLDYLSSVQNQLSLQIRQYHAQYYAGWLSCEDPACGHRTARLPQTFAGGYPLCRQCEKGVMFREYTEKDLYLQINFFLFLFDLSKSNKLKVPVPPTIVSAFETLKEMVEDCLGHSAYSIINLSKLFRFFTLDTKANKMKAEPTDLDILPETEQIDALLEMGVF

Description

Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes (By similarity).
Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses.

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

[4Fe-4S] cluster

Subunit

The DNA polymerase alpha complex is composed of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Interacts with PARP1; this interaction functions as part of the control of replication fork progression. Interacts with MCM10 and WDHD1; these interactions recruit the polymerase alpha complex to the pre-replicative complex bound to DNA. Interacts with RPA1; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp (By similarity).

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Conserved regions II, IV, III and I are thought to be involved in substrate recognition, binding or PP(i) hydrolysis.

Similarity

Belongs to the DNA polymerase type-B family.

Keywords

4Fe-4S DNA replication DNA-binding DNA-directed DNA polymerase Iron Iron-sulfur Metal-binding Nucleotidyltransferase Nucleus Transferase Zinc Zinc-finger Acetylation Complete proteome Cytoplasm Direct protein sequencing Phosphoprotein Reference proteome

Feature

chain DNA polymerase alpha catalytic subunit

Uniprot

H9J1K9 A0A2A4K603 A0A2H1V4W9 A0A3S2TDF8 A0A212ENS6 A0A194RJL8 + More
A0A194PJD5 A0A1W4WWT3 A0A1Y1MD02 A0A2J7R5V6 A0A3R7SYW8 A0A1Y1MEW6 A0A1Y1MG55 V4BGE0 T1HRY3 E0VHS7 A0A1A9W2C3 F6Z608 Q9DE46 A0A3B0JNT8 B7ZRF3 B1WBE2 A0A2H8TE39 A0A0L0C8J8 A0A0P4WRT5 B4JUI4 A0A3S1BNN2 A0A1I8NT16 N6UD33 H0UXU4 A0A402E838 A0A146Z3N8 A0A146Z3R4 A0A146Z5C8 Q59J88 A0A182JSL2 A0A1I8NFE5 A0A146Z3M3 A0A250Y7Q6 A0A0A0B0P6 A0A182RD86 W5M1E0 A0A093NT24 A0A087QXI3 P33609 Q59J89 A0A093GZU5 A0A091EGF6 A0A218VCD3 Q59J86 R0M0Z7 B4M575 A0A1B0BBM8 A0A091HS64 U3INC5 A0A2D0PRQ1 G3NDJ8 A0A091J0T3 A0A1B0A0E8 A0A3P8VYC2 A0A151N032 W5UKD0 A0A2D0PT96 A0A3P8VYE7 Q59J90 A0A146M002 A0A1W5AV18 A0A1W5AM56 A0A1W5AM54 A0A401SQY7 B4PQW9 A0A091WJA5 A0A1W5AT36 A0A3Q2NVX2 A0A1W5AM61 A0A3P9PHX0 C3ZEE6 K1QMH2 A0A146Z3V0 E9QIM3 A0A091DHU4 E7FB68 A0A3B0JP37 A0A3S2NXD9 D6WK37 G3WJA6 A0A182N602 E9GKX5 A0A1U7R9B9 Q295K1 A0A1S3NBE2 A0A0M3QY78 A0A401PDX8 A0A1S3NB92 A0A1S3NC92 A0A3P9D375 A0A061HZJ2

EC Number

2.7.7.7

Pubmed

19121390 22118469 26354079 28004739 23254933 20566863 + More
20431018 10886370 26108605 17994087 23537049 21993624 15625185 25315136 28087693 8463324 8026492 21183079 23806337 8125989 23749191 24487278 22293439 23127152 26823975 30297745 17550304 18563158 22992520 23594743 18362917 19820115 21709235 21292972 15632085 25186727 23929341

EMBL

BABH01023775 NWSH01000144 PCG79102.1 ODYU01000468 SOQ35314.1 RSAL01000296 + More
RVE42823.1 AGBW02013624 OWR43101.1 KQ460106 KPJ17747.1 KQ459602 KPI93536.1 GEZM01036229 JAV82878.1 NEVH01006988 PNF36210.1 QCYY01000840 ROT82337.1 GEZM01036233 GEZM01036221 JAV82875.1 GEZM01036231 JAV82876.1 KB199651 ESP04902.1 ACPB03009186 DS235171 EEB12850.1 AAMC01024916 AAMC01024917 AAMC01024918 AAMC01024919 AAMC01024920 AAMC01024921 AAMC01024922 AAMC01024923 AAMC01024924 AAMC01024925 AF202992 OUUW01000008 SPP83894.1 BC170147 BC170149 AAI70147.1 BC161721 AAI61721.1 GFXV01000554 MBW12359.1 JRES01000752 KNC28763.1 GDRN01067679 JAI64333.1 CH916374 EDV91154.1 RQTK01000097 RUS87909.1 APGK01028388 KB740686 ENN79575.1 AAKN02043886 AAKN02043887 AAKN02043888 AAKN02043889 AAKN02043890 BDOT01000002 GCF40379.1 GCES01025319 JAR61004.1 GCES01025320 JAR61003.1 GCES01025321 JAR61002.1 AB178527 BAD92009.1 GCES01025323 JAR61000.1 GFFV01000305 JAV39640.1 KL876371 KGL99741.1 AHAT01003330 AHAT01003331 AHAT01003332 KL224873 KFW65100.1 KL225966 KFM05937.1 D13543 D17384 AB178526 BAD92008.1 KL205873 KFV75823.1 KK718327 KFO55732.1 MUZQ01000009 OWK63744.1 AB178529 BAD92011.1 KB742496 EOB07765.1 CH940652 EDW59786.1 JXJN01011549 KL217721 KFO98004.1 ADON01012838 ADON01012839 ADON01012840 ADON01012841 ADON01012842 ADON01012843 ADON01012844 KK501204 KFP13320.1 AKHW03004278 KYO30161.1 JT413152 AHH40127.1 AB178525 BAD92007.1 GDHC01006522 JAQ12107.1 BEZZ01000463 GCC32811.1 CM000160 EDW96293.1 KK735615 KFR14913.1 GG666612 EEN49102.1 JH817876 EKC30035.1 GCES01025322 JAR61001.1 BX470095 KN124084 KFO22356.1 SPP83895.1 CM012456 RVE58882.1 KQ971342 EFA04623.2 AEFK01105726 AEFK01105727 AEFK01105728 AEFK01105729 AEFK01105730 AEFK01105731 AEFK01105732 AEFK01105733 AEFK01105734 AEFK01105735 GL732550 EFX79893.1 CM000070 EAL28710.2 CP012526 ALC47203.1 BFAA01000346 GCB71312.1 KE685873 ERE64154.1

Proteomes

UP000005204 UP000218220 UP000283053 UP000007151 UP000053240 UP000053268 + More
UP000192223 UP000235965 UP000283509 UP000030746 UP000015103 UP000009046 UP000091820 UP000008143 UP000268350 UP000037069 UP000001070 UP000271974 UP000095300 UP000019118 UP000005447 UP000288954 UP000265000 UP000075881 UP000095301 UP000053858 UP000075900 UP000018468 UP000054081 UP000053286 UP000000589 UP000053584 UP000052976 UP000197619 UP000008792 UP000092460 UP000054308 UP000016666 UP000221080 UP000007635 UP000053119 UP000092445 UP000265120 UP000050525 UP000192224 UP000287033 UP000002282 UP000053605 UP000242638 UP000001554 UP000005408 UP000000437 UP000028990 UP000007266 UP000007648 UP000075884 UP000000305 UP000189705 UP000001819 UP000087266 UP000092553 UP000288216 UP000265160 UP000030759

PRIDE

H9J1K9 Q9DE46 P33609 E7FB68

Pfam

PF08996   zf-DNA_Pol        + More
PF00136   DNA_pol_B
PF03104   DNA_pol_B_exo1
PF12254   DNA_pol_alpha_N
PF04430   DUF498

Interpro

IPR017964   DNA-dir_DNA_pol_B_CS        + More
IPR036397   RNaseH_sf
IPR006172   DNA-dir_DNA_pol_B
IPR006134   DNA-dir_DNA_pol_B_multi_dom
IPR006133   DNA-dir_DNA_pol_B_exonuc
IPR015088   Znf_DNA-dir_DNA_pol_B_alpha
IPR024647   DNA_pol_a_cat_su_N
IPR012337   RNaseH-like_sf
IPR038256   Pol_alpha_znc_sf
IPR042087   DNA_pol_B_C
IPR023211   DNA_pol_palm_dom_sf
IPR034095   NDUF3
IPR036748   MTH938-like_sf
IPR007523   NDUFAF3/AAMDC

SUPFAM

SSF53098 SSF53098 + More
SSF64076 SSF64076

Gene 3D

1.10.132.60 1.10.3200.20 3.30.420.10 3.90.1600.10 3.40.1230.10

CDD

cd05125 Mth938_2P1-like

ProteinModelPortal

H9J1K9 A0A2A4K603 A0A2H1V4W9 A0A3S2TDF8 A0A212ENS6 A0A194RJL8 + More
A0A194PJD5 A0A1W4WWT3 A0A1Y1MD02 A0A2J7R5V6 A0A3R7SYW8 A0A1Y1MEW6 A0A1Y1MG55 V4BGE0 T1HRY3 E0VHS7 A0A1A9W2C3 F6Z608 Q9DE46 A0A3B0JNT8 B7ZRF3 B1WBE2 A0A2H8TE39 A0A0L0C8J8 A0A0P4WRT5 B4JUI4 A0A3S1BNN2 A0A1I8NT16 N6UD33 H0UXU4 A0A402E838 A0A146Z3N8 A0A146Z3R4 A0A146Z5C8 Q59J88 A0A182JSL2 A0A1I8NFE5 A0A146Z3M3 A0A250Y7Q6 A0A0A0B0P6 A0A182RD86 W5M1E0 A0A093NT24 A0A087QXI3 P33609 Q59J89 A0A093GZU5 A0A091EGF6 A0A218VCD3 Q59J86 R0M0Z7 B4M575 A0A1B0BBM8 A0A091HS64 U3INC5 A0A2D0PRQ1 G3NDJ8 A0A091J0T3 A0A1B0A0E8 A0A3P8VYC2 A0A151N032 W5UKD0 A0A2D0PT96 A0A3P8VYE7 Q59J90 A0A146M002 A0A1W5AV18 A0A1W5AM56 A0A1W5AM54 A0A401SQY7 B4PQW9 A0A091WJA5 A0A1W5AT36 A0A3Q2NVX2 A0A1W5AM61 A0A3P9PHX0 C3ZEE6 K1QMH2 A0A146Z3V0 E9QIM3 A0A091DHU4 E7FB68 A0A3B0JP37 A0A3S2NXD9 D6WK37 G3WJA6 A0A182N602 E9GKX5 A0A1U7R9B9 Q295K1 A0A1S3NBE2 A0A0M3QY78 A0A401PDX8 A0A1S3NB92 A0A1S3NC92 A0A3P9D375 A0A061HZJ2

PDB

5EXR E-value=0, Score=2709

KEGG

101743300 K02320 DNA polymerase alpha subunit A [EC:2.7.7.7] | (RefSeq) DNA polymerase alpha catalytic subunit

PATHWAY

03030 DNA replication - Bombyx mori (domestic silkworm)

GO

GO:0046872 GO:0005634 GO:0000166 GO:0003887 GO:0006260 GO:0003677 GO:0001882 GO:0051539 GO:0005658 GO:0006273 GO:0003697 GO:0019103 GO:0003682 GO:0003688 GO:1902975 GO:0006272 GO:0017076 GO:0005654 GO:0006270 GO:0016363 GO:0005635 GO:0006271 GO:0005730 GO:0006303 GO:0006269 GO:0008283 GO:0046982 GO:0005829 GO:0019901 GO:0071897 GO:0000731 GO:0003690 GO:0045596 GO:0006298 GO:0030337 GO:0003896 GO:0046677 GO:0030154 GO:0044877 GO:0019899 GO:0006261 GO:0032981 GO:0003676 GO:0008408 GO:0016020 GO:0016876 GO:0043039

Subcellular location

Nucleus
Cytoplasm   In the cytosol, colocalizes with RNA:DNA hybrids with a speckled pattern.   With evidence from 4 publications.
Cytosol   In the cytosol, colocalizes with RNA:DNA hybrids with a speckled pattern.   With evidence from 4 publications.

Length:

1495

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03169

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00001

outside

1 - 1495

Pi

237.68679

Theta

183.767608

Tajima's D

0.866507

CLR

0.12766

CSRT

0.622118894055297

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics