Gene

KWMTBOMO09198  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003351

Annotation

minichromosome_maintenance_complex_component_7_[Bombyx_mori]

Location

Bomo_Chr15(-):13144128-13153803      View in EpiBrowser

Full name

DNA replication licensing factor MCM7       + More
DNA replication licensing factor Mcm7      

Alternative Name

Minichromosome maintenance 7 protein

Location in the cell

Cytoplasmic   Reliability : 1.669

CDS

ATGCAGGGATTACTCTCGGACACATATCTTGAAGCCCACTCTGTATCGTGCCTCAACCAAAGTGACGAGAGTGAGTTGGCGGAGGCTCTAACGGAAGAAGAATTGGCAGAACTGGCCGAAGAGGACTTATATTCACGCATGGCACGTAGTCTTGCCCCCGAAATATATGGACACGAAGACGTGAAGAAAGCCTTGCTATTGCTACTCGTCGGTGGAGTTGATAAACGTCCAAACGGAATGAAGATTCGTGGCAACATCAACATCTGCTTGATGGGCGATCCTGGTGTTGCGAAGTCTCAGCTGCTCAACTACATCGACAGACTCGCCCCCAGGAGCCAGTACACCACGGGCCGGGGCTCCTCGGGCGTCGGCCTTACTGCTGCTGTTTTGAAGGACCCATTCACCGGGGAGATGATGCTAGAGGGCGGCGCGCTGGTGCTGGCCGACCAGGGTGTCTGCTGTATCGACGAGTTCGACAAGATGGCGGAGAACGACCGCACAGCCATACACGAAGTTATGGAACAACAGACCATAAGTATTGCGAAGGCGGGTATAATGACGTGCCTGAACGCGCGCGTGTCGATCCTGGCGGCCGCCAACCCGGCGTACGGCCGCTACAACCCGAAGCGGACCATCGAACAGAACATACAGCTGCCGGCCGCGCTGCTCTCGCGCTTTGATCTGCTCTGGCTCATACAGGATAAACCCAATCGCGAGAAAGATTTAGAGCTGGCGAAGCACATAGCGTATGTGCACCAGCACTCGACCCAGCCGCCCAGCAGCGTCCGCGCGCTGTCCATGAAGCTGGTCCGGCGCTACGTGGCGCTCACCAAGCGCAAGGAGCCCGCCGTGCCGCGCGCGCTCGCCGACTACATCGTCTCCTCATACGTCGAGCTACGGCGTGAAGCTAGGAACGCACGTGACGTCACATTCACGTCAGCCAGGAACTTGCTCGCCATACTGCGCCTCTCGACCGCACTCGCAAGGCTCAGATTATCAGACGTCGTTGAAAAGGAGGACGTATCTGAGGCAATTCGTCTCGTGGAGATGTCAAAGCAATCCCTACAACACGTGGAAGAAAACGTTCAGAGGGGTATAACGTCAACGGACCGTATATTCGCGATAGTGCGCGACCTGGCCGGCTCCAACAAGACCGTCAAAGTCGCCGATGTCATCGAGAGGTGCGTCGACAAAGGATTCAAACCAGATCAGGTGGACGCTTGCATCGAAGAATACGAGAACTTGAACGTGTGGCAAGTGAACCAGGTGCGGACCAAGATAACGTTCATGTGA

Protein

MQGLLSDTYLEAHSVSCLNQSDESELAEALTEEELAELAEEDLYSRMARSLAPEIYGHEDVKKALLLLLVGGVDKRPNGMKIRGNINICLMGDPGVAKSQLLNYIDRLAPRSQYTTGRGSSGVGLTAAVLKDPFTGEMMLEGGALVLADQGVCCIDEFDKMAENDRTAIHEVMEQQTISIAKAGIMTCLNARVSILAAANPAYGRYNPKRTIEQNIQLPAALLSRFDLLWLIQDKPNREKDLELAKHIAYVHQHSTQPPSSVRALSMKLVRRYVALTKRKEPAVPRALADYIVSSYVELRREARNARDVTFTSARNLLAILRLSTALARLRLSDVVEKEDVSEAIRLVEMSKQSLQHVEENVQRGITSTDRIFAIVRDLAGSNKTVKVADVIERCVDKGFKPDQVDACIEEYENLNVWQVNQVRTKITFM

Description

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (Probable).

Similarity

Belongs to the MCM family.

Keywords

ATP-binding   Cell cycle   Complete proteome   DNA replication   DNA-binding   Helicase   Hydrolase   Nucleotide-binding   Nucleus   Reference proteome  

Feature

chain  DNA replication licensing factor Mcm7

Uniprot

H9J1G4   Q60GE6   A0A194PQX7   A0A2H1V398   A0A212ENM9   S4PLC9   + More
V5KXP1   A0A336MAI7   A0A0L0BMS2   A0A1A9XQV9   A0A1B0ANR5   A0A1A9UP56   A0A1A9ZBZ2   A0A3R7QWK7   B0VZP1   A0A1Q3EVB9   A0A182FD81   A0A182JCW6   A0A182NJJ4   A0A1I8Q0B2   W5J7J6   A0A0J9RS32   B4QML9   B3NBM4   T1PBE8   A0A034VLS5   B3M5X9   A0A0A1WYP5   A0A1A9W3H0   N6TF82   Q9XYU0   A0A1W4VCI4   A0A3B0JBE8   A0A164WV78   A0A3B0JAA0   A0A182YJ55   A0A0P5QRX5   A0A0P5VZ60   A0A0N8D0M1   B4LEP6   A0A182P8V4   B4J3L8   A0A0P5L4W0   A0A0P5YH69   B4PFH7   A0A0M4EGR2   A0A0P5LUU5   A0A0P4ZUP8   A0A0P5UB98   A0A0P5X3W8   A0A0N8CFN4   A0A0P5TNF3   A0A0P5VNH4   A0A0P5T5D7   K1QMX8   A0A182R292   A0A0K8WEX4   Q29D32   A0A0P5QGT4   B4KZG3   A0A182USZ4   A0A182TQ64   A0A182KQ43   Q7Q6K1   A0A182I2B2   A0A182XMI2   W8BNL9   A0A182QL97   E9HG94   Q17ML5   A0A182M775   B4MMD1   A0A182WL62   A0A182K0B0   A0A210R0E8   A0A0P5SDQ8   A0A0P6C2W4   A0A2J7QTN3   A0A336N2Z5   A0A2J7QTP1   D6WK36   A0A1B0CLF2   V3ZXA6   A0A2P2I1N8   A0A182GAT2   A0A2S2NJC0   A0A1B0FDP1   J9JQ14   A0A0P5MJK3   A0A1J1IEB8   A0A067R721   A0A1B6MDL9   A0A0L8GN30   A0A1B6CHG2   A0A0L8GNE7   A0A2T7NCC0   R7T3M6   A0A2C9K7N9   A0A0B6ZXU6   A0A2B4STB2  

EC Number

3.6.4.12

Pubmed

19121390    26354079    22118469    23622113    26108605    20920257    + More
23761445    22936249    17994087    25315136    25348373    25830018    23537049    9795205    10023044    10731132    12537572    16798881    20122406    25244985    17550304    22992520    15632085    20966253    12364791    14747013    17210077    24495485    21292972    17510324    28812685    18362917    19820115    23254933    26483478    24845553    15562597   

EMBL

BABH01023773    BABH01023774    BABH01023775    AB177622    BAD61056.1    KQ459602    + More
KPI93535.1    ODYU01000468    SOQ35313.1    AGBW02013624    OWR43100.1    GAIX01004090    JAA88470.1    KF471134    AHA42534.1    UFQS01000305    UFQT01000305    SSX02684.1    SSX23058.1    JRES01001641    KNC21307.1    JXJN01000936    QCYY01001058    ROT80844.1    DS231815    EDS35133.1    GFDL01015790    JAV19255.1    ADMH02002122    ETN58769.1    CM002912    KMY98492.1    CM000363    EDX09773.1    CH954178    EDV50620.1    KA645984    AFP60613.1    GAKP01014691    JAC44261.1    CH902618    EDV39669.1    GBXI01010103    JAD04189.1    APGK01006422    APGK01006423    APGK01040416    APGK01040417    KB740979    KB736759    ENN76428.1    ENN83143.1    AB010109    AF124743    AE014296    BT001526    OUUW01000002    SPP77352.1    LRGB01001041    KZS13610.1    SPP77353.1    GDIQ01117335    JAL34391.1    GDIP01094035    JAM09680.1    GDIQ01108575    GDIQ01106284    GDIP01080479    JAL43151.1    JAM23236.1    CH940647    EDW69131.1    CH916366    EDV96220.1    GDIQ01175104    JAK76621.1    GDIP01059482    JAM44233.1    CM000159    EDW93103.1    CP012525    ALC43652.1    GDIQ01175103    JAK76622.1    GDIP01209378    JAJ14024.1    GDIP01115485    JAL88229.1    GDIP01077982    JAM25733.1    GDIP01136375    JAL67339.1    GDIP01127238    JAL76476.1    GDIP01097648    JAM06067.1    GDIP01130785    JAL72929.1    JH817474    EKC32434.1    GDHF01002715    JAI49599.1    CH379070    EAL30582.1    GDIQ01117336    JAL34390.1    CH933809    EDW17890.1    AAAB01008960    EAA10781.2    APCN01000138    GAMC01011579    JAB94976.1    AXCN02000443    GL732640    EFX69184.1    CH477205    EAT47909.1    AXCM01012290    CH963847    EDW73276.1    NEDP02001033    OWF54469.1    GDIQ01093278    JAL58448.1    GDIP01010171    GDIQ01014952    JAM93544.1    JAN79785.1    NEVH01011194    PNF31951.1    UFQS01002148    UFQT01002148    SSX13334.1    SSX32768.1    PNF31950.1    KQ971342    EFA03620.1    AJWK01017185    KB201549    ESO96163.1    IACF01002298    LAB67957.1    JXUM01001904    KQ560130    KXJ84283.1    GGMR01004662    GGMR01014383    MBY17281.1    MBY27002.1    CCAG010009795    ABLF02029364    GDIQ01166518    JAK85207.1    CVRI01000047    CRK98114.1    KK852901    KDR14096.1    GEBQ01005944    JAT34033.1    KQ421092    KOF78411.1    GEDC01024392    JAS12906.1    KOF78412.1    PZQS01000014    PVD18818.1    AMQN01015904    KB312341    ELT87392.1    HACG01026312    HACG01026313    CEK73177.1    CEK73178.1    LSMT01000007    PFX33904.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000037069    UP000092443    UP000092460    + More
UP000078200    UP000092445    UP000283509    UP000002320    UP000069272    UP000075880    UP000075884    UP000095300    UP000000673    UP000000304    UP000008711    UP000095301    UP000007801    UP000091820    UP000019118    UP000000803    UP000192221    UP000268350    UP000076858    UP000076408    UP000008792    UP000075885    UP000001070    UP000002282    UP000092553    UP000005408    UP000075900    UP000001819    UP000009192    UP000075903    UP000075902    UP000075882    UP000007062    UP000075840    UP000076407    UP000075886    UP000000305    UP000008820    UP000075883    UP000007798    UP000075920    UP000075881    UP000242188    UP000235965    UP000007266    UP000092461    UP000030746    UP000069940    UP000249989    UP000092444    UP000007819    UP000183832    UP000027135    UP000053454    UP000245119    UP000014760    UP000076420    UP000225706   

PRIDE

H9J1G4    Q60GE6    Q9XYU0   

Pfam

PF14551   MCM_N        + More
PF17207   MCM_OB
PF00493   MCM
PF17855   MCM_lid

Interpro

IPR012340   NA-bd_OB-fold        + More
IPR008050   MCM7       
IPR001208   MCM_dom       
IPR031327   MCM       
IPR003593   AAA+_ATPase       
IPR027417   P-loop_NTPase       
IPR033762   MCM_OB       
IPR041562   MCM_lid       
IPR027925   MCM_N       
IPR018525   MCM_CS       

SUPFAM

SSF52540   SSF52540        + More
SSF50249   SSF50249       

ProteinModelPortal

H9J1G4   Q60GE6   A0A194PQX7   A0A2H1V398   A0A212ENM9   S4PLC9   + More
V5KXP1   A0A336MAI7   A0A0L0BMS2   A0A1A9XQV9   A0A1B0ANR5   A0A1A9UP56   A0A1A9ZBZ2   A0A3R7QWK7   B0VZP1   A0A1Q3EVB9   A0A182FD81   A0A182JCW6   A0A182NJJ4   A0A1I8Q0B2   W5J7J6   A0A0J9RS32   B4QML9   B3NBM4   T1PBE8   A0A034VLS5   B3M5X9   A0A0A1WYP5   A0A1A9W3H0   N6TF82   Q9XYU0   A0A1W4VCI4   A0A3B0JBE8   A0A164WV78   A0A3B0JAA0   A0A182YJ55   A0A0P5QRX5   A0A0P5VZ60   A0A0N8D0M1   B4LEP6   A0A182P8V4   B4J3L8   A0A0P5L4W0   A0A0P5YH69   B4PFH7   A0A0M4EGR2   A0A0P5LUU5   A0A0P4ZUP8   A0A0P5UB98   A0A0P5X3W8   A0A0N8CFN4   A0A0P5TNF3   A0A0P5VNH4   A0A0P5T5D7   K1QMX8   A0A182R292   A0A0K8WEX4   Q29D32   A0A0P5QGT4   B4KZG3   A0A182USZ4   A0A182TQ64   A0A182KQ43   Q7Q6K1   A0A182I2B2   A0A182XMI2   W8BNL9   A0A182QL97   E9HG94   Q17ML5   A0A182M775   B4MMD1   A0A182WL62   A0A182K0B0   A0A210R0E8   A0A0P5SDQ8   A0A0P6C2W4   A0A2J7QTN3   A0A336N2Z5   A0A2J7QTP1   D6WK36   A0A1B0CLF2   V3ZXA6   A0A2P2I1N8   A0A182GAT2   A0A2S2NJC0   A0A1B0FDP1   J9JQ14   A0A0P5MJK3   A0A1J1IEB8   A0A067R721   A0A1B6MDL9   A0A0L8GN30   A0A1B6CHG2   A0A0L8GNE7   A0A2T7NCC0   R7T3M6   A0A2C9K7N9   A0A0B6ZXU6   A0A2B4STB2  

PDB

5V8F     E-value=5.06017e-102,     Score=948

KEGG

692463    K02210 DNA replication licensing factor MCM7 [EC:3.6.4.12] | (RefSeq) Mcm7; minichromosome maintenan

GO

GO:0003678   GO:0003677   GO:0006270   GO:0005634   GO:0042555   GO:0007049   GO:0005524   GO:0006260   GO:0004386   GO:0043138   GO:0003697   GO:0006271   GO:0006268   GO:0006267   GO:0000727   GO:0003688   GO:0005739   GO:0016776   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR11630   PTHR11630:SF26  

Subcellular location

Nucleus  

Length:

430

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01111

Exp number, first 60 AAs:

6e-05

Total prob of N-in:

0.00299

outside

1  -  430

 

 

Pi

309.405739

Theta

174.324888

Tajima's D

2.383867

CLR

0.10766

CSRT

0.933903304834758

Interpretation

Uncertain