Gene

KWMTBOMO09192  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003394

Annotation

PREDICTED:_serine/threonine-protein_phosphatase_2A_activator-like_[Amyelois_transitella]

Location

Bomo_Chr15(+):12851296-12852938      View in EpiBrowser

Full name

Serine/threonine-protein phosphatase 2A activator      

Alternative Name

Phosphotyrosyl phosphatase activator
PP2A, subunit B', PR53 isoform
Serine/threonine-protein phosphatase 2A regulatory subunit 4
Serine/threonine-protein phosphatase 2A regulatory subunit B'

Location in the cell

Cytoplasmic   Reliability : 2.833

CDS

ATGTCCAACACTGCAAATACTATTGGAGATGTGAAAAAGAGTGAAAACATCCACACTCTTCCTCCAGACCATCGCTTTGTTGAGCCACAAAAAGCTGTTAAATCCATTACAGATATGACCATTTGGGAAAAGTCTGAGGCGTACATGGAATATACCGGATTTGTTGCTACACTGAATGAGTCTATAAAAGGAAAACCATTAACAGTTGATTGCAAAGTATCAGATAATGTTAAAAAAATTATAAACATGTTGGATAAAATTGATAGAATAATTGATGAGTTCCCTCCAGTGGAACAACCTCAAAGATTTGGTAATGCTGCATTCAGAGAATGGTTTGAAAATGTAAAGACAAATTCCACACAGTTACTTCAAGAAGCATTACAGCCAGAACTACATTTGGCGATACCTGAAATAAAAGTTTACTTACAGGAAAGCTTTGGGAATGCTACAAGAATTGACTATGGTACAGGCCACGAGATGGCATTTGTCATGTTCTTATGTTGTTTGTATAAAATTGGTTTTTTACAGCTAGAAGATAATGTGGCAACTGTTCTTATAATTTTTAATAAATATTTGAACATTGCTAGGAGATTGCAGAAAACATACCGAATGGAGCCAGCTGGAAGTCATGGTGTTTGGAGCCTGGACGACTATCAGTTTATACCATTTATTTGGGGTAGTTCACAGTTGATAGATCAACCCAAAATTTACCCTCCAGCTAAATTCCTAGATGATGAAATAGTTGATAAATATGCCAATGAATACATGTTTTTGTCATGCATCAAATATATAAAAGAAGTGAAAAAAGGACCCTTTGCAGAACACTCAAATCAGTTGTGGAGCATTAGTGCAGTTGGTTCCTGGATGAAAATTAATCAAGGTCTTATTAAAATGTATAAGAAAGAAGTATTAGCCAAATTCCCTGTAATTCAACATGTCCTCTTTGGTTCACTGCTGCCGATCAGAAGGTTCCCGATAATTGATTAA

Protein

MSNTANTIGDVKKSENIHTLPPDHRFVEPQKAVKSITDMTIWEKSEAYMEYTGFVATLNESIKGKPLTVDCKVSDNVKKIINMLDKIDRIIDEFPPVEQPQRFGNAAFREWFENVKTNSTQLLQEALQPELHLAIPEIKVYLQESFGNATRIDYGTGHEMAFVMFLCCLYKIGFLQLEDNVATVLIIFNKYLNIARRLQKTYRMEPAGSHGVWSLDDYQFIPFIWGSSQLIDQPKIYPPAKFLDDEIVDKYANEYMFLSCIKYIKEVKKGPFAEHSNQLWSISAVGSWMKINQGLIKMYKKEVLAKFPVIQHVLFGSLLPIRRFPIID

Description

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity).

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Subunit

Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A) (By similarity). Interacts with PPP2CB (PubMed:12952889).
Associates with the serine/threonine-protein phosphatase 2A PP2A(D) heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB.

Similarity

Belongs to the PTPA-type PPIase family.

Keywords

Acetylation   ATP-binding   Complete proteome   Cytoplasm   Isomerase   Nucleotide-binding   Nucleus   Reference proteome   Rotamase  

Feature

chain  Serine/threonine-protein phosphatase 2A activator

Uniprot

H9J1K7   S4PYG6   A0A194PQX2   A0A2A4J4F9   A0A0L7KZF7   A0A2H1V3Z7   + More
A0A194R956   A0A1E1WCY8   A0A1E1WSE9   A0A067RGS5   A0A2J7RF16   A0A1B6EL82   A0A1B6LI59   T1IJQ0   A0A0L7R8J0   E2BD93   A0A2A3E367   A0A1B6DBC8   D6WM97   E0VDC3   E1ZV68   A0A088A6G7   A0A0J7KRS3   F4WZX5   A0A232ELN5   K7IRJ0   A0A026X276   A0A151ICH0   A0A151XAN8   A0A158NGP4   A0A195DY48   A0A1Y1N930   A0A1W7REM7   T1DLU5   J3SFA3   A0A0F7YZG1   A0A0N8EIL7   A0A1U7RJA3   A0A2R5LKF6   A0A164VAR6   A0A2Y9QT13   A0A151MFH6   A0A154PL07   A0A2Y9DKD6   A0A087TH70   Q8C0E1   A0A0B8RPM2   A0A3Q1BFN5   A0A1V4J6X3   A0A3Q1ETY7   A0A3P8TW89   Q543N6   P58389   A0A1S2ZZN6   A4QNH2   W5PG83   A0A250YFR9   L5K9S5   A0A293MNX0   A0A3B3ZQA8   A0A0P7U020   Q28717   A0A2Y9J8P5   A0A2I0M3J2   A0A286X7Z1   A0A2K5M120   G1MBY6   A0A1W5AD47   G3VB41   E9GG91   A0A0P6JHD5   G3VB42   A0A2K6AB86   A0A2K6CYQ3   G5ASC4   A0A2K6M4I5   A0A2K6PW99   A0A2K6PW97   A0A3Q2YIF6   A0A2K5KBL0   A0A2K5CIL5   A0A2K5TRS9   A0A096P0H8   A0A2K5M115   A0A3Q0DGI9   D2H160   A0A2K6GW48   B2RYQ2   K9J5A3   A0A3Q3G5C0   A0A2I3RVW9   A0A2K6ABG7   G9KI92   A0A2K6CYH7   A0A2K5TRN9   A0A2K6ABA6   A0A0D9RPY2   A0A2K5M0T4   G2HJ62   A0A2K5KBJ6  

EC Number

5.2.1.8

Pubmed

19121390    23622113    26354079    26227816    24845553    20798317    + More
18362917    19820115    20566863    21719571    28648823    20075255    24508170    30249741    21347285    28004739    26358130    23758969    23025625    22293439    10349636    11042159    11076861    11217851    12466851    16141073    25476704    21183079    15489334    12952889    20809919    28087693    23258410    25463417    8195217    14748741    16380387    23371554    21993624    20010809    21709235    21292972    21993625    25362486    26319212    15057822    15632090    23236062    21484476   

EMBL

BABH01023748    GAIX01003323    JAA89237.1    KQ459602    KPI93530.1    NWSH01003059    + More
PCG67027.1    JTDY01004208    KOB68456.1    ODYU01000358    SOQ35004.1    KQ460615    KPJ13790.1    GDQN01006211    JAT84843.1    GDQN01001298    JAT89756.1    KK852514    KDR22213.1    NEVH01004414    PNF39426.1    GECZ01031080    JAS38689.1    GEBQ01016639    JAT23338.1    JH430339    KQ414632    KOC67202.1    GL447585    EFN86321.1    KZ288405    PBC26167.1    GEDC01014342    JAS22956.1    KQ971343    EFA04240.1    DS235073    EEB11379.1    GL434441    EFN74927.1    LBMM01003913    KMQ93001.1    GL888480    EGI60265.1    NNAY01003547    OXU19222.1    KK107020    QOIP01000004    EZA62420.1    RLU23224.1    KQ978053    KYM97784.1    KQ982339    KYQ57338.1    ADTU01015164    KQ980107    KYN17632.1    GEZM01014431    JAV92107.1    GDAY02001827    JAV49605.1    GAAZ01001847    JAA96096.1    JU175902    GBEX01002568    AFJ51426.1    JAI11992.1    GBEW01000725    JAI09640.1    GDIQ01023132    JAN71605.1    GGLE01005888    MBY10014.1    LRGB01001363    KZS12139.1    AKHW03006215    KYO23269.1    KQ434936    KZC11910.1    KK115214    KFM64459.1    AK031591    BAC27466.1    GBSH01002032    JAG66994.1    LSYS01008925    OPJ67794.1    AK046288    AK049184    AK150029    BAC32672.1    BAC33594.1    BAE29253.1    AY035997    BC006626    BC052852    BC135674    AAI35675.1    AMGL01074774    AMGL01074775    AMGL01074776    AMGL01074777    GFFW01002404    JAV42384.1    KB030979    ELK07263.1    GFWV01022670    MAA47397.1    JARO02005133    KPP67288.1    X73479    AKCR02000043    PKK24233.1    AAKN02030172    ACTA01145201    ACTA01153200    ACTA01161199    AEFK01022359    AEFK01022360    AEFK01022361    AEFK01022362    GL732543    EFX81537.1    GEBF01000210    JAO03423.1    JH166728    EHA99934.1    AQIA01023355    AQIA01023356    AHZZ02008081    GL192421    EFB25065.1    AC098064    AC115341    BC166861    CH474001    AAI66861.1    EDL93307.1    GABZ01002076    JAA51449.1    JP016019    AES04617.1    AQIB01140350    AQIB01140351    AK306776    BAK63770.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000037510    UP000053240    UP000027135    + More
UP000235965    UP000053825    UP000008237    UP000242457    UP000007266    UP000009046    UP000000311    UP000005203    UP000036403    UP000007755    UP000215335    UP000002358    UP000053097    UP000279307    UP000078542    UP000075809    UP000005205    UP000078492    UP000189705    UP000076858    UP000248480    UP000050525    UP000076502    UP000054359    UP000257160    UP000190648    UP000257200    UP000265080    UP000000589    UP000079721    UP000002356    UP000010552    UP000261520    UP000034805    UP000001811    UP000248482    UP000053872    UP000005447    UP000233060    UP000008912    UP000192224    UP000007648    UP000000305    UP000233140    UP000233120    UP000006813    UP000233180    UP000233200    UP000264820    UP000233080    UP000233020    UP000233100    UP000028761    UP000189706    UP000233160    UP000002494    UP000261660    UP000002277    UP000029965   

PRIDE

H9J1K7    Q8C0E1    P58389    Q28717   

Pfam

PF03095   PTPA

Interpro

IPR037218   PTPA_sf        + More
IPR004327   Phstyr_phstse_ac       

SUPFAM

SSF140984   SSF140984       

CDD

cd04087  PTPA

ProteinModelPortal

H9J1K7   S4PYG6   A0A194PQX2   A0A2A4J4F9   A0A0L7KZF7   A0A2H1V3Z7   + More
A0A194R956   A0A1E1WCY8   A0A1E1WSE9   A0A067RGS5   A0A2J7RF16   A0A1B6EL82   A0A1B6LI59   T1IJQ0   A0A0L7R8J0   E2BD93   A0A2A3E367   A0A1B6DBC8   D6WM97   E0VDC3   E1ZV68   A0A088A6G7   A0A0J7KRS3   F4WZX5   A0A232ELN5   K7IRJ0   A0A026X276   A0A151ICH0   A0A151XAN8   A0A158NGP4   A0A195DY48   A0A1Y1N930   A0A1W7REM7   T1DLU5   J3SFA3   A0A0F7YZG1   A0A0N8EIL7   A0A1U7RJA3   A0A2R5LKF6   A0A164VAR6   A0A2Y9QT13   A0A151MFH6   A0A154PL07   A0A2Y9DKD6   A0A087TH70   Q8C0E1   A0A0B8RPM2   A0A3Q1BFN5   A0A1V4J6X3   A0A3Q1ETY7   A0A3P8TW89   Q543N6   P58389   A0A1S2ZZN6   A4QNH2   W5PG83   A0A250YFR9   L5K9S5   A0A293MNX0   A0A3B3ZQA8   A0A0P7U020   Q28717   A0A2Y9J8P5   A0A2I0M3J2   A0A286X7Z1   A0A2K5M120   G1MBY6   A0A1W5AD47   G3VB41   E9GG91   A0A0P6JHD5   G3VB42   A0A2K6AB86   A0A2K6CYQ3   G5ASC4   A0A2K6M4I5   A0A2K6PW99   A0A2K6PW97   A0A3Q2YIF6   A0A2K5KBL0   A0A2K5CIL5   A0A2K5TRS9   A0A096P0H8   A0A2K5M115   A0A3Q0DGI9   D2H160   A0A2K6GW48   B2RYQ2   K9J5A3   A0A3Q3G5C0   A0A2I3RVW9   A0A2K6ABG7   G9KI92   A0A2K6CYH7   A0A2K5TRN9   A0A2K6ABA6   A0A0D9RPY2   A0A2K5M0T4   G2HJ62   A0A2K5KBJ6  

PDB

2G62     E-value=2.35862e-105,     Score=976

KEGG

101742378    K17605 serine/threonine-protein phosphatase 2A activator | (RefSeq) serine/threonine-protein phospha

GO

GO:0005737   GO:0003755   GO:0019211   GO:0005634   GO:0007052   GO:0008160   GO:0000159   GO:0034704   GO:0042803   GO:0032515   GO:0043065   GO:0005102   GO:0005524   GO:0032516   GO:0016887   GO:0051721   GO:0005654   GO:0043666   GO:0035307   GO:0019888   GO:0035308   GO:0008270   GO:0006468   GO:0005739   GO:0016776   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR10012  

Subcellular location

Cytoplasm  
Nucleus  

Length:

328

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.29619

Exp number, first 60 AAs:

0.00015

Total prob of N-in:

0.06622

outside

1  -  328

 

 

Pi

80.148029

Theta

141.225159

Tajima's D

-1.316589

CLR

2.7654

CSRT

0.0863956802159892

Interpretation

Uncertain