Gene

KWMTBOMO09172  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003386

Annotation

PREDICTED:_steroid_receptor_RNA_activator_1-like_[Plutella_xylostella]

Location

Bomo_Chr15(+):12619986-12621630      View in EpiBrowser

Full name

Steroid receptor RNA activator 1      

Alternative Name

Steroid receptor RNA activator protein

Location in the cell

Nuclear   Reliability : 3.585

CDS

ATGGATAACTGCGACTCTACACCAACTCAGGGTACAAAACCTTCATATGATCCTGGTTGGAATGACCCTCCCAAACTCTCTTATAATGGACAGCAACCAACGCCGAATAGACCACGAAACTTTTTGAATAAGAGAGTTGCATTCCCTCTATCAAATACTCCTTCAAGCACCCCTGCCCCTCAGCCTGTGAACTTACCTCCAATGCCCACATTAATTCCACCTGTGCCACCGATACAAAGTATGCGTCAGCCTACACAAAATGAAGAGATTGAAATTGACAGCAATAACACACTCAAGGAAGTTAAAGATATTTTATTAGAATTTTTGGAAAGTAGTTCTGAGCTGGGACCAAAAGGGAATGATATCAAAAGACGAATAAGTGTAATGGAGGATATGTGGATTAGTGGAAAATTAAATAAAAGCATACATATACAGATGAAGGAATTGGCTTATGCGATCAGAGATGACCAGCCAAACAAAGCAGATGAGATTCACAGGGCTTTGATGGTGGACCATGTGAGCGGAGTTGGAAGTTGGATGCCAGGCATCAAACAGCTTATTCATCATTGTGTAGCAAAATCAGAATTATTAGCATTTGATAAGGAATGA

Protein

MDNCDSTPTQGTKPSYDPGWNDPPKLSYNGQQPTPNRPRNFLNKRVAFPLSNTPSSTPAPQPVNLPPMPTLIPPVPPIQSMRQPTQNEEIEIDSNNTLKEVKDILLEFLESSSELGPKGNDIKRRISVMEDMWISGKLNKSIHIQMKELAYAIRDDQPNKADEIHRALMVDHVSGVGSWMPGIKQLIHHCVAKSELLAFDKE

Description

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.

Subunit

SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.

Miscellaneous

Appears to be the first example of a new class of functional RNAs also able to encode a protein.
Appears to be the first example of a new class of functional RNAs also able to encode a protein. Rat SRAP1 may act as a protein rather than an RNA transcript.

Similarity

Belongs to the SRA1 family.

Keywords

3D-structure   Activator   Apoptosis   Complete proteome   Cytoplasm   Nucleus   Phosphoprotein   Polymorphism   Receptor   Reference proteome   Ribonucleoprotein   Transcription   Transcription regulation   Alternative splicing  

Feature

chain  Steroid receptor RNA activator 1
sequence variant  In dbSNP:rs35610885.
splice variant  In isoform 2.

Uniprot

H9J1J9   A0A194PQV2   A0A194R8E1   A0A212EIX8   A0A3S2L0G0   A0A1E1WMZ2   + More
A0A2A4JGX2   A0A0L7L127   A0A2H1VSL6   K7J7A1   A0A1B6JAM0   A0A1B6LY85   A0A232EXQ0   A0A310SKD6   A0A1B6JED1   A0A1B6GMY2   A0A0L7QQA3   A0A2J7RPX6   V9L3I4   A0A2A3E3M5   A0A1B6E3I7   A0A088ALT0   A0A3N0XUG0   A0A154PFU2   A4VCF0   A9ULF3   A0A1L8GR95   A0A3P8X0E9   F1QPE4   A0A067RIM2   Q6IQU0   A0A069DQ70   A0A224XT59   A0A401RV10   A0A0J7NQY9   A0A0P7TQ58   E2A0C3   A0A1W4ZUK2   A0A195BV97   A0A3Q3M6J4   A0A3Q2U026   A0A147AU12   A0A131XEF7   H3AGD8   H0XPY9   F6V5E0   A0A0V0GDB1   K9IS53   A0A3B5AMQ4   M3YAS1   A0A151WSR0   F1RGE7   I3N469   A0A2K6ENT9   G9KR39   A0A1U8BXB7   A0A452QLB7   A0A340XJD6   E0VC86   F7CNG7   A0A2K5C7C5   A0A452QLB1   A0A2Y9IRT8   L9JUM5   A0A3B4X1P8   H2PGS2   A0A2K6S4B1   A0A444V413   A0A2I3HAK7   G3X8R2   A0A3B3Q5Z0   Q5R4N0   A0A3B4WZY7   A0A1U7QC64   A0A2U3V5K4   Q9HD15   A0A250XWU7   G3QDG7   H2R218   A0A2R9AUP5   Q2HJF6   A0A091CQ03   A0A3Q7MLQ9   A0A3B5KF26   A0A384C5S4   L8IAH6   F1PLB9   H0VV40   Q6QGW5   A0A452UB76   A0A2K5R414   G1LWX2   D2GUP3   A0A3Q7UJF6   W5Q9N9   A0A1S2ZDC5   A0A452EHS4   A0A2I4D7S7   A0A341C217  

Pubmed

19121390    26354079    22118469    26227816    20075255    28648823    + More
24402279    20431018    27762356    24487278    23594743    24845553    26334808    30297745    20798317    28049606    9215903    23236062    20566863    19892987    23385571    19468303    21183079    29240929    12565891    15498874    10199399    15489334    12943696    14517287    15351741    15147866    18669648    20068231    21269460    23186163    24275569    28087693    22398555    16136131    22722832    19393038    21551351    22751099    16341006    21993624    12350225    22673903    24813606    20010809    20809919   

EMBL

BABH01023716    KQ459602    KPI93510.1    KQ460615    KPJ13769.1    AGBW02014558    + More
OWR41439.1    RSAL01000300    RVE42753.1    GDQN01002736    JAT88318.1    NWSH01001620    PCG70670.1    JTDY01003700    KOB69125.1    ODYU01004208    SOQ43835.1    GECU01011487    JAS96219.1    GEBQ01029933    GEBQ01011315    JAT10044.1    JAT28662.1    NNAY01001717    OXU23142.1    KQ763867    OAD54686.1    GECU01010132    JAS97574.1    GECZ01006008    JAS63761.1    KQ414786    KOC60807.1    NEVH01001354    PNF42879.1    JW873544    AFP06061.1    KZ288391    PBC26353.1    GEDC01019432    GEDC01004808    JAS17866.1    JAS32490.1    RJVU01059915    ROJ62464.1    KQ434896    KZC10746.1    BC139499    AAI39500.1    AAMC01100000    AAMC01100001    AAMC01100002    AAMC01100003    BC157234    BC171161    BC171163    AAI57235.1    AAI71161.1    CM004471    OCT86378.1    CU694443    KK852482    KDR22888.1    BC071314    AAH71314.1    GBGD01002879    JAC86010.1    GFTR01003418    JAW13008.1    BEZZ01000004    GCC21951.1    LBMM01002393    KMQ94880.1    JARO02011440    KPP59894.1    GL435569    EFN73126.1    KQ976401    KYM92549.1    GCES01004412    JAR81911.1    GEFH01004113    JAP64468.1    AFYH01184436    AFYH01184437    AFYH01184438    AAQR03009103    GECL01000436    JAP05688.1    GABZ01002598    JAA50927.1    AEYP01016636    AEYP01016637    KQ982769    KYQ50831.1    AEMK02000012    AGTP01047352    JP018770    AES07368.1    DS235049    EEB10992.1    KB320943    ELW54053.1    ABGA01153848    ABGA01153849    NDHI03003414    PNJ59377.1    SCEB01002622    SCEB01002385    RXM95148.1    RXM95444.1    ADFV01033252    AC115631    CR861215    CAH93286.1    AF293024    AF293025    AF293026    AF318361    AF092038    BC040043    AAG02114.1    AAH40043.2    GFFV01004127    JAV35818.1    CABD030041331    AACZ04009833    GABC01010752    GABF01009046    GABD01010712    GABE01009486    NBAG03000455    JAA00586.1    JAA13099.1    JAA22388.1    JAA35253.1    PNI22639.1    AJFE02102678    AJFE02102679    BC105460    AAI05461.1    KN125101    KFO19335.1    JH881616    ELR53181.1    AAEX03001392    AAKN02009895    AY026354    AY542868    AAO45011.1    AAS48375.1    ACTA01128719    GL192344    EFB21014.1    AMGL01093101    LWLT01000008   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000283053    UP000218220    + More
UP000037510    UP000002358    UP000215335    UP000053825    UP000235965    UP000242457    UP000005203    UP000076502    UP000008143    UP000186698    UP000265120    UP000000437    UP000027135    UP000287033    UP000036403    UP000034805    UP000000311    UP000192224    UP000078540    UP000261640    UP000265000    UP000008672    UP000005225    UP000008225    UP000261400    UP000000715    UP000075809    UP000008227    UP000005215    UP000233160    UP000189706    UP000291022    UP000265300    UP000009046    UP000002281    UP000233020    UP000248482    UP000011518    UP000261360    UP000001595    UP000233220    UP000001073    UP000000589    UP000261540    UP000245320    UP000005640    UP000001519    UP000002277    UP000240080    UP000009136    UP000028990    UP000286641    UP000005226    UP000261680    UP000002254    UP000005447    UP000002494    UP000291021    UP000233040    UP000008912    UP000286640    UP000002356    UP000079721    UP000291000    UP000192220    UP000252040   

PRIDE

H9J1J9    F1RGE7    G3X8R2    Q9HD15    Q6QGW5   

Pfam

PF07304   SRA1

Interpro

IPR009917   SRA1-protein/COPII_Sec31        + More
IPR040243   Steroid_recept_RNA_1       

ProteinModelPortal

H9J1J9   A0A194PQV2   A0A194R8E1   A0A212EIX8   A0A3S2L0G0   A0A1E1WMZ2   + More
A0A2A4JGX2   A0A0L7L127   A0A2H1VSL6   K7J7A1   A0A1B6JAM0   A0A1B6LY85   A0A232EXQ0   A0A310SKD6   A0A1B6JED1   A0A1B6GMY2   A0A0L7QQA3   A0A2J7RPX6   V9L3I4   A0A2A3E3M5   A0A1B6E3I7   A0A088ALT0   A0A3N0XUG0   A0A154PFU2   A4VCF0   A9ULF3   A0A1L8GR95   A0A3P8X0E9   F1QPE4   A0A067RIM2   Q6IQU0   A0A069DQ70   A0A224XT59   A0A401RV10   A0A0J7NQY9   A0A0P7TQ58   E2A0C3   A0A1W4ZUK2   A0A195BV97   A0A3Q3M6J4   A0A3Q2U026   A0A147AU12   A0A131XEF7   H3AGD8   H0XPY9   F6V5E0   A0A0V0GDB1   K9IS53   A0A3B5AMQ4   M3YAS1   A0A151WSR0   F1RGE7   I3N469   A0A2K6ENT9   G9KR39   A0A1U8BXB7   A0A452QLB7   A0A340XJD6   E0VC86   F7CNG7   A0A2K5C7C5   A0A452QLB1   A0A2Y9IRT8   L9JUM5   A0A3B4X1P8   H2PGS2   A0A2K6S4B1   A0A444V413   A0A2I3HAK7   G3X8R2   A0A3B3Q5Z0   Q5R4N0   A0A3B4WZY7   A0A1U7QC64   A0A2U3V5K4   Q9HD15   A0A250XWU7   G3QDG7   H2R218   A0A2R9AUP5   Q2HJF6   A0A091CQ03   A0A3Q7MLQ9   A0A3B5KF26   A0A384C5S4   L8IAH6   F1PLB9   H0VV40   Q6QGW5   A0A452UB76   A0A2K5R414   G1LWX2   D2GUP3   A0A3Q7UJF6   W5Q9N9   A0A1S2ZDC5   A0A452EHS4   A0A2I4D7S7   A0A341C217  

PDB

4NBO     E-value=1.26253e-10,     Score=156

KEGG

101740123    no KO assigned | (RefSeq) steroid receptor RNA activator 1

GO

GO:0006357   GO:0030374   GO:0005634   GO:0060047   GO:1990904   GO:0005667   GO:0005886   GO:0045662   GO:0008283   GO:0015630   GO:0071391   GO:0045944   GO:0042981   GO:0030154   GO:0005654   GO:0005829   GO:0003677   GO:0002153   GO:0031252   GO:0045171   GO:0005737   GO:0006915   GO:0003713   GO:0016922  

PANTHER

PTHR18834  

Subcellular location

Nucleus  
Cytoplasm  

Length:

202

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00275

Exp number, first 60 AAs:

0.00015

Total prob of N-in:

0.20115

outside

1  -  202

 

 

Pi

137.577129

Theta

79.274571

Tajima's D

0.658655

CLR

2.173327

CSRT

0.563121843907805

Interpretation

Uncertain