Gene

KWMTBOMO09170

Pre Gene Modal

BGIBMGA003385

Annotation

serine/threonine-protein_kinase_polo_[Bombyx_mori]

Location

Bomo_Chr15(+):12600946-12607637      View in EpiBrowser

Full name

Serine/threonine-protein kinase polo       + More
Serine/threonine-protein kinase PLK      

Alternative Name

Polo-like kinase

Location in the cell

Nuclear   Reliability : 2.936

CDS

ATGACGTCGATCAAGGAAGATGAAAAGAAAGAAATCCCCGAAATCATTCACGATCCACAAACTAACAGCACCTACCAAAGATTACGGTTTTTTGGCAAGGGTGGCTTTGCAAAATGCTACGAGATCCAAGACATAGCCTCCAACCAGATATATGCTGGAAAAATTGTTTCAAAGAAACTAATAGTGAAGTCATCGCACAAAGAGAAGATGGCTCAAGAGATCTCCATTCACAGGTCTCTCCAGCACAAGCATGTAGTTGGCTTCCACAGTTTCTTCGAGGACTCTTTGAATATTTATATAATATTGGAGCTTTGTAAAAAACGGTCGATGATGGAGCTTCACAAGCGTAGAAAAGCAATTACAGAACCAGAGACTAGGTTCTACATGCACCAGATACTGCTTGGCGTGCAATATCTCCATAGTAAGAGGATAATACACCGAGACTTGAAACTTGGCAATTTGTTCCTTGATGACGATCTTCATGTAAAAATTGGAGATTTTGGTCTTGCAGCAAGGATTGAATATGAAGGAGAGAGAAAACAGACTCTGTGTGGTACCCCAAACTACATTGCCCCTGAGATATTAACAAAGAAGGGCCACTCATTTGAAGTGGATATCTGGAGTCTGGGCTGCATCATGTACACGCTGCTTGTTGGCAAACCGCCGTTTGAGACGTCCACCCTCAAGGATACATACAAAAGGATTAAACAGTGCGAATACAGGATTCCGTCGTCGCTTCGCAAACCGGCGGCGTCCATGATTGTACTGCAGTTGCAATCGAACCCTGCGCGTCGTCCGTCCGTGGACAAACTTCTGCAGCATGAATTCTTCTCATCGGGGATTTTGCCAGCCGGGCTGCCCGTCTCTTGCCTCACCACAGCGCCGCGCACTGACCAGCTCGAGGGCATGCTGGTACACCGCCGCCCTCTTAACGAAGTTCATGCTAACGAACAAGAGACGATGGCAGTGGACTCGCCCGTCAAACGCGAAGCTACCCCCGCGGGGCCACGAGCTGTGGAACCAACGTCGCACCGCCAGAATTTTATTGCACTGCGAGACCAGCTCGCTGCATTGTTGGTTAACAAGCTGAAATGCCGACCGGAGGCTCTGACAGACGAGCTGAGCGATCCCGCAGCACAGCCGCTGGTGTGGGTTGGCAAGTGGGTCGACTACAGCGACAAATACGGATTCGGATACCAGCTCTGCGACGAGAGCGTCGGTGTCATGTTCAACGATACTACCAAGCTTATCATGCTCGCTAATGGACTGAATGTGCACTACATCAATCGGCAGGGCCAAGAGCAGTACATGACGATGCGCGATTACCCGCAAGAACTCGACAAAAAAATGAAACTCCTTACATACTTTAGACGATACATGACCGAACATCTCATGAAAGCTGGTGCTTCAGTACCAGTGCGAGAGAGTGATGGTCTGTCTCGTTTGCCACATTTACACCAGTGGTTTCGAACAACTTTAGCTGTTATTATGTACCTGACTAATGGAACTTTACAGATAAACTTCCAAGATCACACAAAGATAATACTGTGTCCACTTATGCAAGCTGTCACCTACATAGATATAGAGAAGAATTTCAGAACATTCCGCTTTAATACCATTGAAGAGCATGGCTGTGATAAAAAGCTTTACACAAACCTCACATATGCATTGGAAAAACTAAACAGTGTATTGGCAAACAAACTGTGCTAG

Protein

MTSIKEDEKKEIPEIIHDPQTNSTYQRLRFFGKGGFAKCYEIQDIASNQIYAGKIVSKKLIVKSSHKEKMAQEISIHRSLQHKHVVGFHSFFEDSLNIYIILELCKKRSMMELHKRRKAITEPETRFYMHQILLGVQYLHSKRIIHRDLKLGNLFLDDDLHVKIGDFGLAARIEYEGERKQTLCGTPNYIAPEILTKKGHSFEVDIWSLGCIMYTLLVGKPPFETSTLKDTYKRIKQCEYRIPSSLRKPAASMIVLQLQSNPARRPSVDKLLQHEFFSSGILPAGLPVSCLTTAPRTDQLEGMLVHRRPLNEVHANEQETMAVDSPVKREATPAGPRAVEPTSHRQNFIALRDQLAALLVNKLKCRPEALTDELSDPAAQPLVWVGKWVDYSDKYGFGYQLCDESVGVMFNDTTKLIMLANGLNVHYINRQGQEQYMTMRDYPQELDKKMKLLTYFRRYMTEHLMKAGASVPVRESDGLSRLPHLHQWFRTTLAVIMYLTNGTLQINFQDHTKIILCPLMQAVTYIDIEKNFRTFRFNTIEEHGCDKKLYTNLTYALEKLNSVLANKLC

Description

May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (PubMed:1660828). Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles (PubMed:24829288). Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules (PubMed:24829288).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

Keywords

ATP-binding   Complete proteome   Cytoplasm   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   Transferase  

Feature

chain  Serine/threonine-protein kinase polo

Uniprot

S5MCV3   A0A2H1VSK7   A0A3S2NLC1   A0A194R7Z1   A0A194PKH7   H9J1J8   + More
A0A2A4JH03   A0A1J1J1R8   W8BU52   A0A1Y1K662   A0A067QKR3   A0A1I8NQ53   A0A0K8VZY6   A0A0L0BQ61   A0A034VQT5   A0A0A1WR64   A0A182PD71   A0A182FPT8   A0A1I8MUR0   A0A182U705   A0A1Q3EX04   A0A182XG43   A0A182V8Q7   W5JNY8   A0A182L735   Q7PQP3   A0A1B0GDB9   A0A1B0AVZ3   A0A1A9YKS6   B0WG03   A0A1B0A6S8   Q16JA1   A0A182QM94   A0A1A9XWC0   A0A182SVX0   A0A182M6E6   A0A182R476   A0A182INF7   A0A023ETT5   A0A1Q3EWP4   A0A0M9A7Z0   A0A1B0BL56   A0A182G7S2   B4J1S7   B4LFP6   Q2M0V5   A0A026X346   A0A151ILB6   B4GR15   B4KXR5   B3M4S1   B4MLL0   J9EBF5   A0A1W4W6J5   A0A291S6W5   A0A3B0JRH3   B4PFB6   B3NIJ3   B4QRW6   B4IA77   P52304   A0A232F0S7   A0A088A214   A0A195FVL4   A0A151X7V1   A0A0J7KW68   A0A195BKD0   A0A0T6AYD1   F4X6B9   A0A0M4EEZ1   E2A9S5   A0A151JNK7   A0A0L7QV00   D6WJH0   A0A0J9RYS6   A0A1A9WMT4   A0A1W4WHE2   A0A1B0AW41   B5DHT6   A0A3L8DIM9   A0A1A9XCK5   A0A1B6CVI3   A0A182GQ67   B4GJG9   A0A2R7WZS4   T1HEM6   A0A023F4H8   A0A2S2PWE0   A0A2A3ENH2   A0A1B6FL54   A0A1A9Y5U4   A0A2H8TV32   A0A2T7PIK5   A0A1B0BE15   A0A154PRF1   J9K8X2   F1NCX7   A0A0A9YYK5   A0A0K8SJ07   A0A0P4WFN1  

EC Number

2.7.11.21

Pubmed

26354079    19121390    24495485    28004739    24845553    26108605    + More
25348373    25830018    25315136    20920257    23761445    20966253    12364791    14747013    17210077    17510324    24945155    26483478    17994087    15632085    24508170    28992199    17550304    1660828    10731132    12537572    12537569    18327897    24829288    28648823    21719571    20798317    18362917    19820115    22936249    30249741    25474469    15592404    25401762   

EMBL

KC852199    AGR34361.1    ODYU01004208    SOQ43833.1    RSAL01000300    RVE42751.1    + More
KQ460615    KPJ13767.1    KQ459602    KPI93508.1    BABH01023712    BABH01023713    NWSH01001620    PCG70672.1    CVRI01000064    CRL05390.1    GAMC01001665    GAMC01001664    JAC04891.1    GEZM01094031    JAV55991.1    KK853323    KDR08523.1    GDHF01007913    JAI44401.1    JRES01001542    KNC22146.1    GAKP01014470    JAC44482.1    GBXI01013277    JAD01015.1    GFDL01015317    JAV19728.1    ADMH02000944    ETN64610.1    AAAB01008880    EAA08552.4    CCAG010004719    JXJN01004432    DS231922    EDS26644.1    CH478020    EAT34359.1    AXCN02001566    AXCM01001325    GAPW01000828    JAC12770.1    GFDL01015313    JAV19732.1    KQ435716    KOX79077.1    JXJN01016218    JXUM01046986    KQ561499    KXJ78382.1    CH916366    EDV98007.1    CH940647    EDW70364.1    CH379069    EAL30821.4    KK107019    EZA62672.1    KQ977121    KYN05543.1    CH479188    EDW40200.1    CH933809    EDW19772.1    CH902618    EDV39470.1    CH963847    EDW72866.1    EJY58036.1    MF433004    ATL75355.1    OUUW01000009    SPP84734.1    CM000159    EDW95202.2    CH954178    EDV52489.1    CM000363    EDX11212.1    CH480826    EDW44190.1    X63361    AE014296    AY095028    NNAY01001315    OXU24386.1    KQ981219    KYN44466.1    KQ982439    KYQ56404.1    LBMM01002672    KMQ94499.1    KQ976450    KYM85730.1    LJIG01022518    KRT80153.1    GL888807    EGI58003.1    CP012525    ALC44434.1    GL437919    EFN69812.1    KQ978837    KYN28013.1    KQ414735    KOC62296.1    KQ971342    EFA04647.1    CM002912    KMZ00738.1    JXJN01004474    CH379058    EDY69863.1    QOIP01000007    RLU20300.1    GEDC01020504    GEDC01019796    GEDC01001896    JAS16794.1    JAS17502.1    JAS35402.1    JXUM01079902    JXUM01079903    JXUM01079904    KQ563151    KXJ74387.1    CH479184    EDW36785.1    KK856156    PTY25059.1    ACPB03020069    GBBI01002778    JAC15934.1    GGMS01000655    MBY69858.1    KZ288215    PBC32591.1    GECZ01018833    JAS50936.1    GFXV01006299    MBW18104.1    PZQS01000003    PVD33252.1    JXJN01012741    KQ435078    KZC14453.1    ABLF02032386    AADN05000376    GBHO01008984    JAG34620.1    GBRD01012538    JAG53286.1    GDRN01029597    JAI67591.1   

Proteomes

UP000283053    UP000053240    UP000053268    UP000005204    UP000218220    UP000183832    + More
UP000027135    UP000095300    UP000037069    UP000075885    UP000069272    UP000095301    UP000075902    UP000076407    UP000075903    UP000000673    UP000075882    UP000007062    UP000092444    UP000092460    UP000092443    UP000002320    UP000092445    UP000008820    UP000075886    UP000075901    UP000075883    UP000075900    UP000075880    UP000053105    UP000069940    UP000249989    UP000001070    UP000008792    UP000001819    UP000053097    UP000078542    UP000008744    UP000009192    UP000007801    UP000007798    UP000192221    UP000268350    UP000002282    UP000008711    UP000000304    UP000001292    UP000000803    UP000215335    UP000005203    UP000078541    UP000075809    UP000036403    UP000078540    UP000007755    UP000092553    UP000000311    UP000078492    UP000053825    UP000007266    UP000091820    UP000192223    UP000279307    UP000015103    UP000242457    UP000245119    UP000076502    UP000007819    UP000000539   

PRIDE

S5MCV3    H9J1J8    P52304   

Pfam

PF00069   Pkinase        + More
PF00659   POLO_box
PF09139   Tam41_Mmp37
PF12572   DUF3752
PF04851   ResIII
PF10198   Ada3
PF00271   Helicase_C

Interpro

IPR033695   POLO_box_2        + More
IPR008271   Ser/Thr_kinase_AS       
IPR000959   POLO_box_dom       
IPR036947   POLO_box_dom_sf       
IPR000719   Prot_kinase_dom       
IPR033701   POLO_box_1       
IPR011009   Kinase-like_dom_sf       
IPR015222   Tam41       
IPR022226   DUF3752       
IPR017441   Protein_kinase_ATP_BS       
IPR001650   Helicase_C       
IPR014001   Helicase_ATP-bd       
IPR003604   Matrin/U1-like-C_Znf_C2H2       
IPR019340   Histone_AcTrfase_su3       
IPR036236   Znf_C2H2_sf       
IPR006935   Helicase/UvrB_N       
IPR027417   P-loop_NTPase       
IPR013087   Znf_C2H2_type       
IPR033702   PLK1_cat       

SUPFAM

SSF56112   SSF56112        + More
SSF57667   SSF57667       
SSF52540   SSF52540       

Gene 3D

3.30.1120.30    

CDD

cd13118  POLO_box_1
cd13117  POLO_box_2
cd00079  HELICc
cd14187  STKc_PLK1

ProteinModelPortal

S5MCV3   A0A2H1VSK7   A0A3S2NLC1   A0A194R7Z1   A0A194PKH7   H9J1J8   + More
A0A2A4JH03   A0A1J1J1R8   W8BU52   A0A1Y1K662   A0A067QKR3   A0A1I8NQ53   A0A0K8VZY6   A0A0L0BQ61   A0A034VQT5   A0A0A1WR64   A0A182PD71   A0A182FPT8   A0A1I8MUR0   A0A182U705   A0A1Q3EX04   A0A182XG43   A0A182V8Q7   W5JNY8   A0A182L735   Q7PQP3   A0A1B0GDB9   A0A1B0AVZ3   A0A1A9YKS6   B0WG03   A0A1B0A6S8   Q16JA1   A0A182QM94   A0A1A9XWC0   A0A182SVX0   A0A182M6E6   A0A182R476   A0A182INF7   A0A023ETT5   A0A1Q3EWP4   A0A0M9A7Z0   A0A1B0BL56   A0A182G7S2   B4J1S7   B4LFP6   Q2M0V5   A0A026X346   A0A151ILB6   B4GR15   B4KXR5   B3M4S1   B4MLL0   J9EBF5   A0A1W4W6J5   A0A291S6W5   A0A3B0JRH3   B4PFB6   B3NIJ3   B4QRW6   B4IA77   P52304   A0A232F0S7   A0A088A214   A0A195FVL4   A0A151X7V1   A0A0J7KW68   A0A195BKD0   A0A0T6AYD1   F4X6B9   A0A0M4EEZ1   E2A9S5   A0A151JNK7   A0A0L7QV00   D6WJH0   A0A0J9RYS6   A0A1A9WMT4   A0A1W4WHE2   A0A1B0AW41   B5DHT6   A0A3L8DIM9   A0A1A9XCK5   A0A1B6CVI3   A0A182GQ67   B4GJG9   A0A2R7WZS4   T1HEM6   A0A023F4H8   A0A2S2PWE0   A0A2A3ENH2   A0A1B6FL54   A0A1A9Y5U4   A0A2H8TV32   A0A2T7PIK5   A0A1B0BE15   A0A154PRF1   J9K8X2   F1NCX7   A0A0A9YYK5   A0A0K8SJ07   A0A0P4WFN1  

PDB

2V5Q     E-value=5.31079e-107,     Score=992

KEGG

101740671    K06631 polo-like kinase 1 [EC:2.7.11.21] | (RefSeq) PLK1; serine/threonine-protein kinase polo

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0004672   GO:0005524   GO:0004605   GO:0032049   GO:0032465   GO:0004674   GO:0005813   GO:0000278   GO:0000922   GO:0005737   GO:0005634   GO:0007406   GO:0048600   GO:0007112   GO:0034613   GO:1990023   GO:0007344   GO:0035046   GO:0035050   GO:0005828   GO:0000940   GO:0007098   GO:0005635   GO:0051257   GO:0000915   GO:0051315   GO:0030496   GO:0035044   GO:0030726   GO:0030954   GO:0007058   GO:0005814   GO:0000776   GO:0005874   GO:0007147   GO:0005819   GO:0006468   GO:0008104   GO:0007140   GO:0007143   GO:0016021   GO:0003677   GO:0016787   GO:0008270   GO:0000070   GO:0008017   GO:0000122   GO:0071168   GO:0051081   GO:0010800   GO:0043393   GO:0034451   GO:1904668   GO:0010997   GO:0016321   GO:0000281   GO:0045143   GO:0045184   GO:0032436   GO:0042802   GO:0072425   GO:1904776   GO:1901673   GO:0090435   GO:0045736   GO:0031648   GO:0000086   GO:0019901   GO:0001578   GO:0051233   GO:0043066   GO:0070194   GO:0000942   GO:0016567   GO:0000132   GO:0007094   GO:0005876   GO:0000287   GO:0018105   GO:0000795   GO:0000785   GO:0005515   GO:0005739   GO:0016776   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  

Length:

569

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.27448

Exp number, first 60 AAs:

0.00083

Total prob of N-in:

0.01020

outside

1  -  569

 

 

Pi

222.669016

Theta

201.066795

Tajima's D

0.198974

CLR

1.331567

CSRT

0.424678766061697

Interpretation

Uncertain