Gene

KWMTBOMO09144

Pre Gene Modal

BGIBMGA007552

Annotation

PREDICTED:_heparan-sulfate_6-O-sulfotransferase_2_[Bombyx_mori]

Location

Bomo_Chr15(-):12059751-12144137      View in EpiBrowser

Full name

Heparan-sulfate 6-O-sulfotransferase       + More
Non-specific serine/threonine protein kinase      

Location in the cell

Extracellular   Reliability : 1.868

CDS

ATGGAGCCGAGATCGAAGCTACGAAAAGTGATAGCCTTCTGTTTGTTGTTATCACTGTTTGGCATGGTAGCCTTTGGATATTTTTGCCCAGACCAGGTGTGTGCGTTGTCACAAAGGGAACGGATCTCGGAACCATTGGCACTTACATACTCTGAAAGTCTGGGCCGGCCACTGCCTGAGGTCATCGCTCAGCCAGGCCTCTCTTACGATGAGGTGCTGCATGACGACTTTAGGTTCGACCTCAACGCTCACGATGTCATGGTCTTCTTGCACATACAGAAAACCGGTGGCACATCGTTCGGAAGACACCTGGTTATGGACCTAGATCTAAAGAGGCCGTGCAACTGTCAACGGGCGCGAAAAAGATGCCATTGTTTTCGACCTCACAGCAACGAAATATGGCTCTTTTCGAGATACTCCACCGGCTGGAAGTGCGGTCTTCACGCTGATTTCACGGAGCTGACGGCGTGCGTAGGCGGAGAACTGGACCGACACGAGGGCTCAGCCGTCCACCGGAGGTACTTCTACATAACACTGCTGAGGGAGCCAGTTGCTAGGTATTTGTCGGAGTATCGTCACGTGAAACGAGGAGCCACATGGAAGGGCTCCCGTCACTGGTGTCAAGGACGAACCGCCACAGCTTACGAAGTCCCCTCGTGTTACATGGGCGACTCCTGGCGGGGCGTTACGCTTGAAGAGTTCATGTCCTGCCCTTGGAATTTAGCGAACAACCGCCAAACTCGAATGCTGGCGGACTTGGCTCTTGTTGGCTGCTACAACGGAACCCTGAGGCATAGAACGACCGACTCTGATCGAGTGCTACTCGCTTCTGCCAAGAGAAACTTGGCTGCAATGGCGTATTTTGGACTAACCGAATATCAAAAAAAATCCCAGTACGTGTTCGAGGAAACGTTCAACCTATTGTTCGCTGTGCCGTTCACGCAACACAACGCGACCGTGTCCGGAGCGACGCTGGCGGCCCTCTCGCCAGCGCAGGTGGCCCGCATTCAGCAGCTGAACTCCTTAGACTTGGAGCTTTACGATTTCGCCAAGAACCTTATGTTTAAAAGATTCGAAGCGCTAAAGAAACGAGACACTGACTTCGAGTACCGTTGGAGGCACCTCGGCGAAGTCTCCAGAAACGGGGTCACCGAGTTCGACTGGGACAGCAACCTGGAAGACGCCACCACAGAGAAGTACAGAGGCAAGTAG

Protein

MEPRSKLRKVIAFCLLLSLFGMVAFGYFCPDQVCALSQRERISEPLALTYSESLGRPLPEVIAQPGLSYDEVLHDDFRFDLNAHDVMVFLHIQKTGGTSFGRHLVMDLDLKRPCNCQRARKRCHCFRPHSNEIWLFSRYSTGWKCGLHADFTELTACVGGELDRHEGSAVHRRYFYITLLREPVARYLSEYRHVKRGATWKGSRHWCQGRTATAYEVPSCYMGDSWRGVTLEEFMSCPWNLANNRQTRMLADLALVGCYNGTLRHRTTDSDRVLLASAKRNLAAMAYFGLTEYQKKSQYVFEETFNLLFAVPFTQHNATVSGATLAALSPAQVARIQQLNSLDLELYDFAKNLMFKRFEALKKRDTDFEYRWRHLGEVSRNGVTEFDWDSNLEDATTEKYRGK

Description

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Catalytic Activity

3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the sulfotransferase 6 family.

Feature

chain  Heparan-sulfate 6-O-sulfotransferase

Uniprot

A0A437B8N0   A0A2A4JDS5   A0A1Q3G3W0   A0A1Q3G3U9   A0A2C9GSU1   U5ETD2   + More
A0A1Q3G3V9   A0A1Q3G3W5   A0A1Y9H201   A0A0P6K110   A0A453Z3I8   A0A2M4CWQ6   A0A2M4ARR8   A0A1Y9HDM5   B4M4T4   A0A1B0AG85   B4KE38   A0A1A9UVK0   B3LXU2   B4QSR8   A0A1B0BX79   A0A2P8YH15   Q9VDR6   B3NZ29   Q968Z7   A0A1B0G735   A0A3B0KE52   A0A1W4W929   B4GL90   A0A1I8PHC5   A0A2R7VYA6   D6WK54   A0A2J7PRR9   A0A1A9XIE3   A0A1B0Y0B7   A0A067R0F1   A0A1B6D808   A0A0L0CLU8   A0A1W4W5P1   A0A1W4WHD5   A0A0A9WY91   T1HN28   A0A0K8S626   Q7PXK2   A0A0T6B0P1   A0A023F3U7   A0A224XP14   N6U9S2   B4JSZ8   A0A0A1X2B4   A0A034WBM8   A0A1A9WQX8   A0A0K8TWS3   E0VFW1   B4K0W9   B4PP46   A0A0A1XDM1   A0A034WD89   A0A0K8V449   E2A704   A0A1J1HJM0   E2BMQ2   A0A2S2QCB0   A0A195FU72   A0A151X2K4   F4WC10   A0A158NAY9   A0A0C9RK38   A0A2S2P1W7   A0A2H8TNF4   A0A2A3E821   A0A087ZVC4   A0A232EX20   A0A0L7RGA3   J9K780   A0A154PNJ7   A0A151HZ44   A0A0M9A1I4   A0A151JCN5   A0A195D6X8   A0A1B6K1W1   A0A0A1WER8   A0A1S3CYE8   U4UTS8   B5DTF9   B4NGC8   A0A0M5J2H4   A0A3L8DNZ9   A0A026W1A7   A0A1B0DHJ7   A0A084VBI8   B4IHP7   K7IUP1   A0A293M914   A0A164ZMM3   A0A3S3PQM1  

EC Number

2.8.2.-
2.7.11.1

Pubmed

26999592    17994087    29403074    10731132    12537568    12537572    + More
12537573    12537574    16110336    17569856    17569867    26109357    26109356    11278892    18362917    19820115    24845553    26108605    25401762    26823975    12364791    14747013    17210077    25474469    23537049    25830018    25348373    20566863    17550304    20798317    21719571    21347285    28648823    15632085    30249741    24508170    24438588    20075255   

EMBL

RSAL01000115    RVE46906.1    NWSH01001796    PCG70121.1    GFDL01000561    JAV34484.1    + More
GFDL01000562    JAV34483.1    GANO01002828    JAB57043.1    GFDL01000553    JAV34492.1    GFDL01000555    JAV34490.1    GDUN01000371    JAN95548.1    GGFL01005594    MBW69772.1    GGFK01010184    MBW43505.1    CH940652    EDW59645.2    CH933806    EDW16059.1    CH902617    EDV41749.2    CM000364    EDX12278.1    JXJN01022119    PYGN01000600    PSN43547.1    AE014297    AY051902    AAF55724.2    AAK93326.1    CH954181    EDV48432.1    AB051856    BAB55594.1    CCAG010003770    OUUW01000008    SPP83956.1    CH479185    EDW38314.1    KK854168    PTY12484.1    KQ971343    EFA04507.1    NEVH01021953    PNF19027.1    KT000406    ANI86004.1    KK853131    KDR10904.1    GEDC01015487    JAS21811.1    JRES01000223    KNC33212.1    GBHO01030162    GDHC01017835    JAG13442.1    JAQ00794.1    ACPB03015125    GBRD01017109    JAG48718.1    AAAB01008987    EAA01731.5    LJIG01016322    KRT80950.1    GBBI01002636    JAC16076.1    GFTR01006246    JAW10180.1    APGK01037631    KB740948    ENN77396.1    CH916373    EDV94888.1    GBXI01008808    JAD05484.1    GAKP01006848    JAC52104.1    GDHF01033407    JAI18907.1    DS235124    EEB12267.1    CH916606    EDV90844.1    CM000160    EDW96085.2    GBXI01004798    JAD09494.1    GAKP01006847    JAC52105.1    GDHF01018969    JAI33345.1    GL437238    EFN70785.1    CVRI01000006    CRK88107.1    GL449285    EFN83037.1    GGMS01005629    MBY74832.1    KQ981272    KYN43842.1    KQ982577    KYQ54633.1    GL888068    EGI68268.1    ADTU01010515    ADTU01010516    ADTU01010517    ADTU01010518    ADTU01010519    ADTU01010520    GBYB01008575    JAG78342.1    GGMR01010801    MBY23420.1    GFXV01003892    MBW15697.1    KZ288331    PBC27897.1    NNAY01001797    OXU22891.1    KQ414598    KOC69875.1    ABLF02029562    KQ435007    KZC13446.1    KQ976724    KYM76639.1    KQ435762    KOX75430.1    KQ979060    KYN23177.1    KQ976750    KYN08645.1    GECU01002257    JAT05450.1    GBXI01016788    JAC97503.1    KB632364    ERL93601.1    CH475878    EDY71170.3    CH964251    EDW83345.2    CP012526    ALC47324.1    QOIP01000006    RLU22154.1    KK107494    EZA49847.1    AJVK01061193    ATLV01007260    ATLV01007261    ATLV01007262    ATLV01007263    KE524405    KFB35332.1    CH480840    EDW49414.1    AAZX01012182    AAZX01013482    GFWV01010716    MAA35445.1    LRGB01000704    KZS16521.1    NCKU01000696    RWS14535.1   

Proteomes

UP000283053    UP000218220    UP000075880    UP000075884    UP000076407    UP000075900    + More
UP000008792    UP000092445    UP000009192    UP000078200    UP000007801    UP000000304    UP000092460    UP000245037    UP000000803    UP000008711    UP000092444    UP000268350    UP000192221    UP000008744    UP000095300    UP000007266    UP000235965    UP000092443    UP000027135    UP000037069    UP000192223    UP000015103    UP000007062    UP000019118    UP000001070    UP000091820    UP000009046    UP000002282    UP000000311    UP000183832    UP000008237    UP000078541    UP000075809    UP000007755    UP000005205    UP000242457    UP000005203    UP000215335    UP000053825    UP000007819    UP000076502    UP000078540    UP000053105    UP000078492    UP000078542    UP000079169    UP000030742    UP000001819    UP000007798    UP000092553    UP000279307    UP000053097    UP000092462    UP000030765    UP000001292    UP000002358    UP000076858    UP000285301   

PRIDE

Q9VDR6    Q968Z7   

Pfam

PF03567   Sulfotransfer_2        + More
PF00786   PBD
PF00069   Pkinase

Interpro

IPR005331   Sulfotransferase        + More
IPR027417   P-loop_NTPase       
IPR010635   Heparan_SO4-6-sulfoTrfase       
IPR017441   Protein_kinase_ATP_BS       
IPR008271   Ser/Thr_kinase_AS       
IPR033923   PAK_BD       
IPR011009   Kinase-like_dom_sf       
IPR036936   CRIB_dom_sf       
IPR000095   CRIB_dom       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF52540   SSF52540        + More
SSF56112   SSF56112       

Gene 3D

3.90.810.10    

CDD

cd01093  CRIB_PAK_like

ProteinModelPortal

A0A437B8N0   A0A2A4JDS5   A0A1Q3G3W0   A0A1Q3G3U9   A0A2C9GSU1   U5ETD2   + More
A0A1Q3G3V9   A0A1Q3G3W5   A0A1Y9H201   A0A0P6K110   A0A453Z3I8   A0A2M4CWQ6   A0A2M4ARR8   A0A1Y9HDM5   B4M4T4   A0A1B0AG85   B4KE38   A0A1A9UVK0   B3LXU2   B4QSR8   A0A1B0BX79   A0A2P8YH15   Q9VDR6   B3NZ29   Q968Z7   A0A1B0G735   A0A3B0KE52   A0A1W4W929   B4GL90   A0A1I8PHC5   A0A2R7VYA6   D6WK54   A0A2J7PRR9   A0A1A9XIE3   A0A1B0Y0B7   A0A067R0F1   A0A1B6D808   A0A0L0CLU8   A0A1W4W5P1   A0A1W4WHD5   A0A0A9WY91   T1HN28   A0A0K8S626   Q7PXK2   A0A0T6B0P1   A0A023F3U7   A0A224XP14   N6U9S2   B4JSZ8   A0A0A1X2B4   A0A034WBM8   A0A1A9WQX8   A0A0K8TWS3   E0VFW1   B4K0W9   B4PP46   A0A0A1XDM1   A0A034WD89   A0A0K8V449   E2A704   A0A1J1HJM0   E2BMQ2   A0A2S2QCB0   A0A195FU72   A0A151X2K4   F4WC10   A0A158NAY9   A0A0C9RK38   A0A2S2P1W7   A0A2H8TNF4   A0A2A3E821   A0A087ZVC4   A0A232EX20   A0A0L7RGA3   J9K780   A0A154PNJ7   A0A151HZ44   A0A0M9A1I4   A0A151JCN5   A0A195D6X8   A0A1B6K1W1   A0A0A1WER8   A0A1S3CYE8   U4UTS8   B5DTF9   B4NGC8   A0A0M5J2H4   A0A3L8DNZ9   A0A026W1A7   A0A1B0DHJ7   A0A084VBI8   B4IHP7   K7IUP1   A0A293M914   A0A164ZMM3   A0A3S3PQM1  

PDB

5T0A     E-value=5.481e-97,     Score=904

KEGG

101737390    K02514 heparan sulfate 6-O-sulfotransferase HS6ST1 [EC:2.8.2.-] | (RefSeq) heparan-sulfate 6-O-sulfo

PATHWAY

00534    Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0008146   GO:0022416   GO:0007424   GO:0015012   GO:0008587   GO:0045570   GO:0015015   GO:0017095   GO:0004674   GO:0005524   GO:0016740   GO:0006508   GO:0015074   GO:0005739   GO:0016776   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR12812  

Subcellular location

Membrane  

SignalP

Position:   1 - 26,         Likelihood:  0.728262

 

 

Length:

403

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.94671

Exp number, first 60 AAs:

20.90634

Total prob of N-in:

0.94667

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  403

 

 

Pi

239.31307

Theta

170.116719

Tajima's D

1.47383

CLR

0.222604

CSRT

0.776861156942153

Interpretation

Uncertain