Gene

KWMTBOMO09122

Pre Gene Modal

BGIBMGA007560

Annotation

PREDICTED:_coiled-coil_domain-containing_protein_39_[Amyelois_transitella]

Location

Bomo_Chr15(-):11701592-11709630      View in EpiBrowser

Full name

Coiled-coil domain-containing protein 39      

Location in the cell

Cytoskeletal   Reliability : 1.835 Nuclear   Reliability : 1.454

CDS

ATGAGTGAACAACGAAAAAACCCGAGTTATATGGCTCAACTATTGGAAAAATTAGGATGGGATCAAGGCATCAGAATTCCATTAGCCAATCCCGGAAATCAAGAATTAGAGACTATTCTTATAAACAGGCAAAATGAAATTCAGCAGCTTAAAGAATCATTTATACTACAGCAACAAAAAAGAGAGGATCTTAATAAGTATAAGGAGTTTGTGCACTCTGAATATCAAGAGAATACTCGCCTCCTATTTGCTCACAAGCAGCAGCTGGAGCAGGAAGTTAAACTACGGCAGTTGGCTTGTAGTGAAACAGATGGACTTGATCGAGGAGTTATTGACTGTCAGAAACAATGCAAGGACATAGGAACTAGAGTTGATAGATTACAAATAAACATTGCTCGTCTGCTAAAAAAGGCTGATACATTGAAATCTGAGGTGTGTGGTGAACGTGGAGCCTTGCAGGAATGGAGAGCTGCTCTAGAGAGAAATTCTGGTGACATCACAGCTATAGAGCAGTTTACAAGACAAGACTTATCTAAGGCTAAAGCATTAGAAAATAAACGACAGAAACTGAAAGTGGAACATGATCGCATGCATGAGCGTATTAACCAACTTGTATCAAATTTAAATGCCGAGGAGAGGGCTTGTGATAGGATCTCAATTCAGGTAATGGAAGGTATGGAGCAAAGAAAACAAATGATGATTATGTGGAGAGGTGCTGTTGATAATCTGAGGCAGCGTGACACTGACATAAGACACATCAGGGAGGATTACGCGGTGTTAGAGGCGGAAGCGAACAAAATTGCGGAGCAGTGTCGCGAGCAGCAGGCGTTCTGTGACCAGCAACGCGGCAACAACGGGGACGCGCAGCGAGACAACCTCGCACTCGCCCAGCGGCTCAGCCACACGCGCCTCGCTCAGCAGCAGCTCGCCGAGCAGAACGCGACCTCGGACAGTGAGGCGCAGAGTCTCCAGCGTGAGCTGGCGAACTTGAGAGTAGTCCTGGAGAAGCTTCACATGGAGAACCGGCAGATAATGGATGAGCAACATCGCAAAGACTTGGCCATTCAATCTATCAACAGCAAGATTAGTGATCTTAAAGAAAAATTAACGGAGTCTCTCGATAAATCGAAATCGTCAGAGAAACGAGCCAAAGAACTAGAAGATATGTTGAACGAAGAAGAACGTTATGCAAGTCAGCTAACTGCGAATCAGCAACGTGCCATGCATTGCTCTTTTGTGGAGCAACAAAAGTTTCTGACGCTCAAAAACGAAGAGAAACTCTTCCACATGCATTTGAAAGCGTCGAAAGCAATCTTGAGCAAACTGGAGACGAAACAACGGAACCTCTTGAAGACTCTACAGAGCCAAAAGGAGTCTCTGTACGCTATTTGTTATCAAGTGGAGACATTGGGTGCTCGTGTCTCGCACATGGAGGGGGCGCAGGCCGAGAGGGAGTGCTCCGCTGAATTAATGGAGAGAGAGAATAGATTAAAAGACGTGTGCTCTCGGCACGCGGCCCGCGTGGCGCTGCTGGAGCGGCACTCCGCGAGGCTGCACGACGACATGCGGCGGCTGGCCAAGGATCTCGAGGCACAGAGCGTGGAACACGTTAAACTGCAAAGTCGTCTGAAAACATCGGTGCTGAACGTTGAGGGCGGCGAGAAGGAGCTGCGCGAGGCCCGCGAGGCGTGGCGTCGCGCGCGCGTGGAGGACGCGCTGCTGCGGCTGCGGGGCGCGCACGCCGCACGCGCGCTCGCCGCCGCCGACGGCGCCGCCTACTCGCTCGACCGACAGCGCCTGCAGCTGCACGCGGTCAGTGCGCCGTACACATGTCGTCTTCTCGCATAA

Protein

MSEQRKNPSYMAQLLEKLGWDQGIRIPLANPGNQELETILINRQNEIQQLKESFILQQQKREDLNKYKEFVHSEYQENTRLLFAHKQQLEQEVKLRQLACSETDGLDRGVIDCQKQCKDIGTRVDRLQINIARLLKKADTLKSEVCGERGALQEWRAALERNSGDITAIEQFTRQDLSKAKALENKRQKLKVEHDRMHERINQLVSNLNAEERACDRISIQVMEGMEQRKQMMIMWRGAVDNLRQRDTDIRHIREDYAVLEAEANKIAEQCREQQAFCDQQRGNNGDAQRDNLALAQRLSHTRLAQQQLAEQNATSDSEAQSLQRELANLRVVLEKLHMENRQIMDEQHRKDLAIQSINSKISDLKEKLTESLDKSKSSEKRAKELEDMLNEEERYASQLTANQQRAMHCSFVEQQKFLTLKNEEKLFHMHLKASKAILSKLETKQRNLLKTLQSQKESLYAICYQVETLGARVSHMEGAQAERECSAELMERENRLKDVCSRHAARVALLERHSARLHDDMRRLAKDLEAQSVEHVKLQSRLKTSVLNVEGGEKELREAREAWRRARVEDALLRLRGAHAARALAAADGAAYSLDRQRLQLHAVSAPYTCRLLA

Description

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.

Similarity

Belongs to the CCDC39 family.

Keywords

Cell projection   Ciliopathy   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Primary ciliary dyskinesia   Reference proteome  

Feature

chain  Coiled-coil domain-containing protein 39

Uniprot

H9JDG3   A0A437B1B5   A0A2H1V655   A0A212EL42   A0A2A4JZ83   A0A2J7Q227   + More
A0A2J7Q228   D6WKQ0   A0A1Y1LLS2   E0VFS7   B4NJR2   U4USP3   A0A195C0W2   A0A0T6AYL2   N6U9C5   A0A3L8DCC6   A0A026WN52   K7JCS6   A0A158NIG9   A0A067R7S9   W5J833   A0A182QA91   A0A182FRL9   A0A182VVU4   A0A151XDD9   A0A182PRP3   A0A182IQD4   A0A2J7Q214   A0A2J7Q213   E2BUY1   A0A182H3V4   A0A1Q3FT41   A0A182NQL3   Q295Y4   A0A084VXT5   B0X0Y8   A0A1S4EYH1   A0A1S3J4U9   B4GFI9   A0A182MEV4   A0A0A1X3M6   A0A1W4XT53   W8B9A6   Q17LI9   A0A3B0KE56   A0A154P893   A0A182ST49   A0A182RF36   A0A182YBF2   A0A2A3E9X8   Q7PX97   A0A1W4UQ40   A0A182X9J6   A0A182L8S0   A0A2B4SYM5   A0A0L7R3M7   A0A182HKH9   A0A182JYY3   A0A1A9W232   A0A182V2C5   G7YKC5   B4M531   A0A419PZG6   C3ZDB1   K1QZ54   A0A0M3QX63   A0A1I8PGA2   A0A1I8ME18   A0A3N0XPX8   F4X4H3   A0A2C9JF74   A0A1B0GH82   A0A1W4Y425   A0A182TM27   A0A0C9RH36   A0A0G2L8X4   A0A210Q7E9   P0CK98   A0A0J7KRK5   A0A0L0HEC6   A0A151JW82   A0A1W3JFY8   B4JSU7   A0A433TUP2   A0A2T7NAZ2   A0A3P9ANW3   A0A1A9UR53   A0A3P8Z808   A0A151M6A4   A0A1A9WS06   G1SE48   A0A3B4CIG8   W5LWV3  

Pubmed

19121390    22118469    18362917    19820115    28004739    20566863    + More
17994087    23537049    30249741    24508170    20075255    21347285    24845553    20920257    23761445    20798317    26483478    15632085    24438588    25830018    24495485    17510324    25244985    12364791    14747013    17210077    20966253    22023798    18563158    22992520    25315136    21719571    15562597    23594743    28812685    21131972    25069045    22293439    21993624   

EMBL

BABH01030080    BABH01030081    RSAL01000223    RVE43993.1    ODYU01000879    SOQ36308.1    + More
AGBW02014138    OWR42202.1    NWSH01000352    PCG77119.1    NEVH01019374    PNF22629.1    PNF22630.1    KQ971342    EFA03026.2    GEZM01054234    JAV73788.1    DS235124    EEB12233.1    CH964272    EDW85024.2    KB632348    ERL93196.1    KQ978379    KYM94482.1    LJIG01022555    KRT79949.1    APGK01037183    KB740948    ENN77251.1    QOIP01000010    RLU18170.1    KK107145    EZA57497.1    AAZX01018154    ADTU01016568    ADTU01016569    ADTU01016570    ADTU01016571    ADTU01016572    ADTU01016573    ADTU01016574    KK852880    KDR14419.1    ADMH02002105    ETN59020.1    AXCN02001517    KQ982294    KYQ58396.1    PNF22631.1    PNF22628.1    GL450772    EFN80518.1    JXUM01108130    KQ565204    KXJ71230.1    GFDL01004281    JAV30764.1    CM000070    EAL28574.1    ATLV01018205    KE525224    KFB42779.1    DS232249    EDS38380.1    CH479182    EDW34374.1    AXCM01006261    GBXI01009029    JAD05263.1    GAMC01008720    JAB97835.1    CH477215    EAT47547.1    OUUW01000008    SPP84569.1    KQ434844    KZC08145.1    KZ288311    PBC28528.1    AAAB01008987    EAA01209.5    LSMT01000007    PFX33980.1    KQ414663    KOC65356.1    APCN01000830    DF143488    GAA53407.1    CH940652    EDW59742.1    NIRI01001237    RJW67343.1    GG666612    EEN49466.1    JH816392    EKC36454.1    CP012526    ALC45383.1    RJVU01064619    ROJ13801.1    GL888645    EGI58653.1    AJWK01004041    GBYB01012522    JAG82289.1    CABZ01055306    FO704733    NEDP02004706    OWF44663.1    CABZ01021592    CABZ01055305    CABZ01055307    CABZ01055310    CABZ01068420    CABZ01068421    CABZ01080220    LBMM01003908    KMQ93007.1    KQ257457    KNC99815.1    KQ981659    KYN38536.1    CH916373    EDV94837.1    RQTK01000175    RUS85287.1    PZQS01000014    PVD18338.1    AKHW03006437    KYO20049.1    AAGW02014157    AHAT01022364    AHAT01022365   

Proteomes

UP000005204    UP000283053    UP000007151    UP000218220    UP000235965    UP000007266    + More
UP000009046    UP000007798    UP000030742    UP000078542    UP000019118    UP000279307    UP000053097    UP000002358    UP000005205    UP000027135    UP000000673    UP000075886    UP000069272    UP000075920    UP000075809    UP000075885    UP000075880    UP000008237    UP000069940    UP000249989    UP000075884    UP000001819    UP000030765    UP000002320    UP000085678    UP000008744    UP000075883    UP000192223    UP000008820    UP000268350    UP000076502    UP000075901    UP000075900    UP000076408    UP000242457    UP000007062    UP000192221    UP000076407    UP000075882    UP000225706    UP000053825    UP000075840    UP000075881    UP000091820    UP000075903    UP000008792    UP000001554    UP000005408    UP000092553    UP000095300    UP000095301    UP000007755    UP000076420    UP000092461    UP000192224    UP000075902    UP000000437    UP000242188    UP000036403    UP000053201    UP000078541    UP000001070    UP000271974    UP000245119    UP000265140    UP000078200    UP000050525    UP000001811    UP000261440    UP000018468   

PRIDE

H9JDG3    P0CK98   

Pfam

PF00756   Esterase

Interpro

IPR033290   CCDC39        + More
IPR014186   S-formylglutathione_hydrol       
IPR029058   AB_hydrolase       
IPR000801   Esterase_put       

SUPFAM

SSF53474   SSF53474       

Gene 3D

3.40.50.1820    

ProteinModelPortal

H9JDG3   A0A437B1B5   A0A2H1V655   A0A212EL42   A0A2A4JZ83   A0A2J7Q227   + More
A0A2J7Q228   D6WKQ0   A0A1Y1LLS2   E0VFS7   B4NJR2   U4USP3   A0A195C0W2   A0A0T6AYL2   N6U9C5   A0A3L8DCC6   A0A026WN52   K7JCS6   A0A158NIG9   A0A067R7S9   W5J833   A0A182QA91   A0A182FRL9   A0A182VVU4   A0A151XDD9   A0A182PRP3   A0A182IQD4   A0A2J7Q214   A0A2J7Q213   E2BUY1   A0A182H3V4   A0A1Q3FT41   A0A182NQL3   Q295Y4   A0A084VXT5   B0X0Y8   A0A1S4EYH1   A0A1S3J4U9   B4GFI9   A0A182MEV4   A0A0A1X3M6   A0A1W4XT53   W8B9A6   Q17LI9   A0A3B0KE56   A0A154P893   A0A182ST49   A0A182RF36   A0A182YBF2   A0A2A3E9X8   Q7PX97   A0A1W4UQ40   A0A182X9J6   A0A182L8S0   A0A2B4SYM5   A0A0L7R3M7   A0A182HKH9   A0A182JYY3   A0A1A9W232   A0A182V2C5   G7YKC5   B4M531   A0A419PZG6   C3ZDB1   K1QZ54   A0A0M3QX63   A0A1I8PGA2   A0A1I8ME18   A0A3N0XPX8   F4X4H3   A0A2C9JF74   A0A1B0GH82   A0A1W4Y425   A0A182TM27   A0A0C9RH36   A0A0G2L8X4   A0A210Q7E9   P0CK98   A0A0J7KRK5   A0A0L0HEC6   A0A151JW82   A0A1W3JFY8   B4JSU7   A0A433TUP2   A0A2T7NAZ2   A0A3P9ANW3   A0A1A9UR53   A0A3P8Z808   A0A151M6A4   A0A1A9WS06   G1SE48   A0A3B4CIG8   W5LWV3  

PDB

3JBH     E-value=0.01028,     Score=93

KEGG

101739443    no KO assigned | (RefSeq) coiled-coil domain-containing protein 39-like

GO

GO:0036159   GO:0003341   GO:0005930   GO:0060287   GO:0060285   GO:0046294   GO:0018738   GO:0070286   GO:0007368   GO:0016021   GO:0005829   GO:0007507  

PANTHER

PTHR18962   PTHR10061  

Subcellular location

  

Length:

615

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00057

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00163

outside

1  -  615

 

 

Pi

244.810259

Theta

210.081373

Tajima's D

0.634479

CLR

0.30145

CSRT

0.55797210139493

Interpretation

Uncertain