Gene

KWMTBOMO09106  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007571

Annotation

PREDICTED:_eukaryotic_translation_initiation_factor_2A_[Amyelois_transitella]

Location

Bomo_Chr15(-):11286063-11296958      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 2A      

Alternative Name

65 kDa eukaryotic translation initiation factor 2A

Location in the cell

Mitochondrial   Reliability : 1.99

CDS

ATGACTAACCCGCATGTCGCAGGTCTAACCAATAAAAGTATATTCTTGCTTGAGTTTAAAGAGCCATATTGTGAGAAAACCTTAAGAGATGAATCAACAACAAATGTACGAGGCATTATATGTAGCCCTAAAGGGTCTTACTTGGCCTATAGAACGGATAGAAAATCTGAGATAGTCAGATGCTCAGACTGGTCTACGACAGCATCAATTGATGGAAACGTTAAGGAGATGTTTTTCTCTCCATTGGACAACTTTTTTATGGTTTGGGAAATGTATGCCATCACTAAAGATAATCCTGAGGGTAAACCAAACCTCAGAGTATTCAAAACAGATAATGGTAAATTAGTTGGATCATTTGTACAGAAAAATCAAATAGGATGGGAGCCAAAATGGTCTACGGATGAGAAGTTATTTGCCATTCAATTAAATAATAAAATCCAGATATATGAAGATGGGAACTTAGAACGCTATGTCCATCAATACAGTGCAGAAAAATTAAAGGCGTTCAGTCTCTCGCCGAGTCCTTCTCCGAATTATTACATTGCTGTATTTACATTAGGTAAACAAGGGCAGCCATCATTTTGGCGTGTATTTAAATACCCTCAATTTGATGTTAGTCAAGCTGTTGTCACCCGGTCATCCTTCCAAGCTGATAAGGCTGTGTTCCACTGGAACAGACGCGGTACAAATGTGTTTGCTATGACACAGACAGATGTTGACAAAACGGGCGGTTCGTACTACGGAAAACAAACGCTATCGCATGGCGACGTCAAAGGGAACTCTGGAATCGTATCGTTCAGTAAGGAAGGTCCCATCCACGCGATTAGTTGGAACCCGGGCAACTGGAACGAGTGGATAGCGGTGTACGGTCACGCCCCGGCCAAAGCGACGGTCTTCAATGCGAAATGCGAACCTCTTTTCGAGTTTGGCACCGGAGCTTGGAACTCGATTTACTTCTCCCCCGAAGGAACTCATGTCCTTTTGGGAGGCTTTGGGAACATAGCGACCGGCCACATCGAGGTGTGGGACATGCGCGGGTACAAAAAGGCGGGCACTTGTTCCGCTCCAGATACAACTTTCCTGCAATGGGACCCGAGGGGTGAAACCTTCCTGACTGCTACTACTTACCCTAGGCTCACTGTTAGCAATGGATATAAAATATGGCATTACACGGGCGTATTGATGCACAAGCGTTCGTGTAGCGAGAAGGAGAATCTTCTGGCAATATGCTGGCAGCCTGGATCATATCCCAAAACGGATCTATCGAAGAGCGCTCCTAAGGCTATCGAGGACTCAACGCCGAAGCCAATGGGCGCCTATCGCCCCCCAGGAGCTCGGAGCAGACCTTCAAACTTTACGCTACACGAACACGAGAAACCTCATAAACCTGGAGAGAGTCCTGCTGTTGGACCGTCAAAGCAAGCGATCAAGCAGAAAGAGAAACGTGAAGCTCGAAAAGCTCGTAAAGCTGAAGAAAAGGGGAAAGGCGACGTGTCCCCGGAAGATGGGTCCTCGCCGGTCCCCCCCACCACTACACGGCAACCCTTCGTCTCGACGGGCGATCCCGAAAAGGATAAGAAAATCAAGAACATCAACAAGAAATTAAACGACATAGACAAATTGAAACAGCAAAAAGCCGCCGGGAAGCCGCTAGAGTTGAACCAACTCGCCAAGATCGACAACGAACAAGCATTACTGCAAGAATTGTCTCAGCTGAAGTTATGA

Protein

MTNPHVAGLTNKSIFLLEFKEPYCEKTLRDESTTNVRGIICSPKGSYLAYRTDRKSEIVRCSDWSTTASIDGNVKEMFFSPLDNFFMVWEMYAITKDNPEGKPNLRVFKTDNGKLVGSFVQKNQIGWEPKWSTDEKLFAIQLNNKIQIYEDGNLERYVHQYSAEKLKAFSLSPSPSPNYYIAVFTLGKQGQPSFWRVFKYPQFDVSQAVVTRSSFQADKAVFHWNRRGTNVFAMTQTDVDKTGGSYYGKQTLSHGDVKGNSGIVSFSKEGPIHAISWNPGNWNEWIAVYGHAPAKATVFNAKCEPLFEFGTGAWNSIYFSPEGTHVLLGGFGNIATGHIEVWDMRGYKKAGTCSAPDTTFLQWDPRGETFLTATTYPRLTVSNGYKIWHYTGVLMHKRSCSEKENLLAICWQPGSYPKTDLSKSAPKAIEDSTPKPMGAYRPPGARSRPSNFTLHEHEKPHKPGESPAVGPSKQAIKQKEKREARKARKAEEKGKGDVSPEDGSSPVPPTTTRQPFVSTGDPEKDKKIKNINKKLNDIDKLKQQKAAGKPLELNQLAKIDNEQALLQELSQLKL

Description

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

Similarity

Belongs to the WD repeat EIF2A family.

Keywords

Coiled coil   Complete proteome   Initiation factor   Protein biosynthesis   Reference proteome   Repeat   Translation regulation   WD repeat   Acetylation   Alternative splicing   Direct protein sequencing   Phosphoprotein   Polymorphism  

Feature

chain  Eukaryotic translation initiation factor 2A
splice variant  In isoform 2.
sequence variant  In dbSNP:rs1132979.

Uniprot

S4PJP5   A0A2A4K3G1   A0A437BG91   A0A194R8X6   A0A2H1WNI0   D6WL38   + More
A0A232F8Z3   J3JVJ2   U4UPA3   A0A1W4X5H6   N6TMA7   A0A3L8DR28   A0A026WBK5   A0A158NJ56   A0A067RBG5   A0A088A5Z7   A0A0C9R134   A0A3B3SYS8   A0A1B6FTV9   A0A146NU77   A0A0K8SU85   A0A0A9WRR4   A0A3Q2QGX4   A0A3Q2C732   A0A3P8TLP2   A0A154P5M1   A0A1B6DER9   A0A3Q2T1S1   A0A3Q1AQ97   E9J1W3   A0A310SE97   A0A2Y9K6F0   A0A151JRM4   A0A1A8UZ93   A0A2K6QR05   A0A3P4RXD2   I3KL04   A0A2Y9JVU3   G3ST16   A0A0P4ZEA3   M3XU13   A0A0P5INM1   A0A0P5HTJ9   Q5ZKC1   A0A0P5H4Y6   A0A1A7ZYI5   A0A1A8DYX9   A0A1L1RYW0   A0A0P5PVP3   A0A0P5J0V7   A0A0P5SYA3   G3TZV7   A0A2K6LZJ4   A0A0P5SC65   A0A0P5B3Z1   A0A094L1U7   A0A093GHU5   A0A1Y1LMN8   A0A340XA42   A0A2K6QR10   A0A0A0AF29   A0A3Q2P5M9   A0A401SIW9   A0A1A8J2I6   A0A2I0TZU6   A0A091H4G0   A0A2K6LZK5   A0A3B3VQP9   A0A2I2V1V6   M3WEX5   A0A452FUT9   A0A3P8PBZ3   A0A3P9AXB8   A0A452FUY7   A0A452FUZ7   A0A1A8QL46   A0A1A8NJA5   A0A0N8AGY0   W5P328   A0A3B1IFN3   A0A1B0DCV7   A0A091WMI5   A0A3Q7R7E0   A0A250Y325   S7PDP4   E9FV01   I3M265   Q9BY44   A0A2K6SVD1   A0A1A8ER44   A0A091EQB9   A0A091L451   A0A0Q3TIZ1   F1PGT8   A0A3Q7U1J4   G1NEN3   A0A2K5F811   A0A2K5F7W4  

Pubmed

23622113    26354079    18362917    19820115    28648823    22516182    + More
23537049    30249741    24508170    21347285    24845553    29240929    25401762    26823975    21282665    25362486    25186727    15642098    15592404    28004739    30297745    17975172    20809919    25329095    28087693    21292972    12133843    14702039    16641997    15489334    17081983    18669648    19413330    19690332    20068231    21269460    21406692    22814378    23186163    24275569    16341006    20838655   

EMBL

GAIX01004865    JAA87695.1    NWSH01000191    PCG78589.1    RSAL01000065    RVE49429.1    + More
KQ460615    KPJ13705.1    ODYU01009822    SOQ54502.1    KQ971343    EFA03515.1    NNAY01000700    OXU26913.1    BT127260    AEE62222.1    KB632303    ERL91840.1    APGK01018933    KB740085    ENN81579.1    QOIP01000005    RLU22894.1    KK107293    EZA53440.1    ADTU01017494    KK852751    KDR17144.1    GBYB01006612    JAG76379.1    GECZ01016112    JAS53657.1    GCES01151596    JAQ34726.1    GBRD01008958    JAG56863.1    GBHO01036044    GDHC01018224    JAG07560.1    JAQ00405.1    KQ434809    KZC06488.1    GEDC01029044    GEDC01013100    JAS08254.1    JAS24198.1    GL767674    EFZ13269.1    KQ760706    OAD59323.1    KQ978579    KYN30006.1    HAEJ01012948    SBS53405.1    CYRY02044596    VCX39604.1    AERX01047804    AERX01047805    GDIP01215430    JAJ07972.1    AEYP01039192    AEYP01039193    AEYP01039194    AEYP01039195    AEYP01039196    AEYP01039197    GDIQ01212695    JAK39030.1    GDIQ01228943    JAK22782.1    AJ720163    GDIQ01238988    JAK12737.1    HADY01008968    SBP47453.1    HADZ01010323    HAEA01009519    SBQ37999.1    AADN05000526    GDIQ01125080    JAL26646.1    GDIQ01231193    JAK20532.1    GDIQ01098741    JAL52985.1    GDIP01141653    JAL62061.1    GDIP01189978    JAJ33424.1    KL360001    KFZ64805.1    KL216281    KFV68793.1    GEZM01051462    GEZM01051461    JAV74912.1    KL871660    KGL92766.1    BEZZ01000298    GCC30354.1    HAED01017382    HAEE01006454    SBR03827.1    KZ506511    PKU39356.1    KL448192    KFO81182.1    AANG04001816    LWLT01000001    HAEH01004536    HAEI01005653    SBR94261.1    HAEF01001712    HAEG01003269    SBR68897.1    GDIP01148497    JAJ74905.1    AMGL01010877    AJVK01014242    KK736027    KFR16857.1    GFFV01001908    JAV38037.1    KE161952    EPQ06037.1    GL732525    EFX88811.1    AGTP01103865    AGTP01103866    AF497978    AK027356    AK298586    AK293993    AF212241    AF109358    AF172818    AC107426    CH471052    BC011885    HAEB01002810    SBQ49337.1    KK718888    KFO59221.1    KL300671    KFP51209.1    LMAW01002523    KQK80542.1    AAEX03013679    AAEX03013680   

Proteomes

UP000218220    UP000283053    UP000053240    UP000007266    UP000215335    UP000030742    + More
UP000192223    UP000019118    UP000279307    UP000053097    UP000005205    UP000027135    UP000005203    UP000261540    UP000265000    UP000265020    UP000265080    UP000076502    UP000257160    UP000248482    UP000078492    UP000233200    UP000005207    UP000007646    UP000000715    UP000000539    UP000233180    UP000053875    UP000265300    UP000053858    UP000287033    UP000053760    UP000261500    UP000011712    UP000291000    UP000265100    UP000265160    UP000002356    UP000018467    UP000092462    UP000053605    UP000286641    UP000000305    UP000005215    UP000005640    UP000233220    UP000052976    UP000051836    UP000002254    UP000286640    UP000001645    UP000233020   

PRIDE

Q9BY44    F1PGT8   

Pfam

PF08662   eIF2A

Interpro

IPR013979   TIF_beta_prop-like        + More
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR011387   TIF2A       
IPR036322   WD40_repeat_dom_sf       
IPR011042   6-blade_b-propeller_TolB-like       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10     2.120.10.30    

ProteinModelPortal

S4PJP5   A0A2A4K3G1   A0A437BG91   A0A194R8X6   A0A2H1WNI0   D6WL38   + More
A0A232F8Z3   J3JVJ2   U4UPA3   A0A1W4X5H6   N6TMA7   A0A3L8DR28   A0A026WBK5   A0A158NJ56   A0A067RBG5   A0A088A5Z7   A0A0C9R134   A0A3B3SYS8   A0A1B6FTV9   A0A146NU77   A0A0K8SU85   A0A0A9WRR4   A0A3Q2QGX4   A0A3Q2C732   A0A3P8TLP2   A0A154P5M1   A0A1B6DER9   A0A3Q2T1S1   A0A3Q1AQ97   E9J1W3   A0A310SE97   A0A2Y9K6F0   A0A151JRM4   A0A1A8UZ93   A0A2K6QR05   A0A3P4RXD2   I3KL04   A0A2Y9JVU3   G3ST16   A0A0P4ZEA3   M3XU13   A0A0P5INM1   A0A0P5HTJ9   Q5ZKC1   A0A0P5H4Y6   A0A1A7ZYI5   A0A1A8DYX9   A0A1L1RYW0   A0A0P5PVP3   A0A0P5J0V7   A0A0P5SYA3   G3TZV7   A0A2K6LZJ4   A0A0P5SC65   A0A0P5B3Z1   A0A094L1U7   A0A093GHU5   A0A1Y1LMN8   A0A340XA42   A0A2K6QR10   A0A0A0AF29   A0A3Q2P5M9   A0A401SIW9   A0A1A8J2I6   A0A2I0TZU6   A0A091H4G0   A0A2K6LZK5   A0A3B3VQP9   A0A2I2V1V6   M3WEX5   A0A452FUT9   A0A3P8PBZ3   A0A3P9AXB8   A0A452FUY7   A0A452FUZ7   A0A1A8QL46   A0A1A8NJA5   A0A0N8AGY0   W5P328   A0A3B1IFN3   A0A1B0DCV7   A0A091WMI5   A0A3Q7R7E0   A0A250Y325   S7PDP4   E9FV01   I3M265   Q9BY44   A0A2K6SVD1   A0A1A8ER44   A0A091EQB9   A0A091L451   A0A0Q3TIZ1   F1PGT8   A0A3Q7U1J4   G1NEN3   A0A2K5F811   A0A2K5F7W4  

PDB

3WJ9     E-value=1.4233e-53,     Score=532

KEGG

101743108    K15026 translation initiation factor 2A | (RefSeq) eukaryotic translation initiation factor 2A

GO

GO:0003743   GO:0043022   GO:0022627   GO:0000049   GO:0016021   GO:0032933   GO:0009967   GO:0006468   GO:0042255   GO:0005850   GO:0006417   GO:0005737   GO:0045296   GO:0072562   GO:0005615   GO:1990928   GO:0005515   GO:0005524   GO:0006139   GO:0019205   GO:0005739   GO:0016776   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR13227  

Length:

574

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00941999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00073

outside

1  -  574

 

 

Pi

200.934158

Theta

146.483776

Tajima's D

0.420778

CLR

1.240975

CSRT

0.494475276236188

Interpretation

Uncertain