Gene

KWMTBOMO09100

Pre Gene Modal

BGIBMGA007523

Annotation

GTP:AMP_phosphotransferase_AK3?_mitochondrial_[Plutella_xylostella]

Location

Bomo_Chr15(+):11235729-11236454      View in EpiBrowser

Full name

GTP:AMP phosphotransferase, mitochondrial       + More
GTP:AMP phosphotransferase AK3, mitochondrial      

Alternative Name

Adenylate kinase 3
Adenylate kinase 3 alpha-like 1

Location in the cell

Cytoplasmic   Reliability : 2.916

CDS

ATGTCTGTGAAATCTAAGCTACTGAAAGCATTGATTTTAGGCGCTCCAGCATCCGGAAAAGGAACTATATCGTCTCGTATAGTGAAAAAATACAATATTGAGCATGTGTCTAGTGGAGATAAGCTCAGGGACCACATAGCAAAACAAACAGAACTGGGCAAAGAGGTTAAAGCATACCTTGACGAAGGAAAACTTGTACCTGATGATTTAATGATTAAATTCATGATAAAGGAATTGAAGGAAGTCAACAACAAACCATGGCTCTTAGATGGATTTCCGAGAACAGTAGAACAAGCTAATGCTCTATGGAAAGTTCAGCCTGTGGATGTGGTACTTAATCTTGTAGTGCCATTTGATGTGATTATAGATCGGGTGAAAAGTAGATGGGTGCATTTACCTTCAGGACGGGTGTACAACATTGGGTTCAACACACCTAAACAAGAAGGTAAGGATGATGTGACAGGAGAACCTCTAGTACAGCGACCTGATGATAAACCCGAAGCCGTAAAGAAGAGGCTAGAAATATACGAAAATATAACCAGACCTGTTATTGAGTTTTACAAGCAAAAGGGTATCCTAAAAGAATTTGAAGGGCGCACATCAGATGAAATATGGCCAAAAGTCACAAAATATTTAGATCCAATTTTTAAATAA

Protein

MSVKSKLLKALILGAPASGKGTISSRIVKKYNIEHVSSGDKLRDHIAKQTELGKEVKAYLDEGKLVPDDLMIKFMIKELKEVNNKPWLLDGFPRTVEQANALWKVQPVDVVLNLVVPFDVIIDRVKSRWVHLPSGRVYNIGFNTPKQEGKDDVTGEPLVQRPDDKPEAVKKRLEIYENITRPVIEFYKQKGILKEFEGRTSDEIWPKVTKYLDPIFK

Description

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.

Catalytic Activity

a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP

Subunit

Monomer.

Similarity

Belongs to the adenylate kinase family. AK3 subfamily.
Belongs to the adenylate kinase family.

Uniprot

H9JDC6   A0A2A4K4J8   G3LHK4   A0A0L7L0A0   A0A2H1WXC1   A0A212F041   + More
A0A194R868   A0A194PKB1   D6WR14   N6TGG1   A0A1W4WPZ8   A0A182F291   A0A2M4BZB2   A0A2M3ZJE1   W5JEZ5   A0A2M4AL50   A0A2M3ZC27   Q17NS5   A0A182GM94   A0A2R7WAQ0   A0A1Y1NEA7   A0A182JXF5   A0A084VK62   A0A182VTX3   A0A182MIW8   A0A1Q3FGR8   A0A182NBJ3   A0A182RGR2   A0A182PUV4   V5H3V9   E2AN46   B0WVD2   R4WSG6   A0A182IXK3   A0A182VIL9   A0A182Y8A4   A0A1S4H1P5   A0A182WZD1   A0A0C9RBE8   A0A195CWV5   A0A182QY40   E9J4W9   A0A1I8NLN5   A0A0B4J2T5   T1PC99   A0A1B6GBH4   A0A1I8N396   A0A151JYA1   E2BJN0   U5ERQ8   A0A1B6I5Y9   A0A182TZ58   A0A0L0CLN8   F4WFG6   A0A182ICT6   A0A0A1WEC0   W8AVW6   A0A195BRU8   A0A158NSA6   A0A2J7PP94   A0A151XJY6   A0A0B4J2L9   A0A034WWK5   A0A0K8WGK4   A0A1L8DXK8   A0A1B0F000   A0A151JLM2   A0A1B6LWM4   A0A1B6DIL6   A0A1L8DXR0   A0A026X417   A0A0M4FKP6   A0A1S3JVP3   T1I6L5   A0A0L7QUL7   A0A0K8TFN3   B4KAI4   A0A3L8DJD3   A0A2S2NL65   A0A2A3ELU8   A0A2H8TCV0   A0A067RMG2   A0A2T7NPR2   A0A1B0CME7   A0A336M724   A0A151M8R9   H0WWD5   T1H4H6   A0A2D4JZP7   A0A3P9IQ30   A0A3P9M6I1   A0A1U7S4K4   A0A3S1HGQ6   A0A154P4P7   J9JPU2   A0A1W4V545   A0A3R7PW39   A0A091I2G3   A0A2Y9DFB4   A0A2D4P990  

EC Number

2.7.4.10

Pubmed

19121390    21840855    26227816    22118469    26354079    18362917    + More
19820115    23537049    20920257    23761445    17510324    26483478    28004739    24438588    20798317    23691247    25244985    12364791    21282665    20075255    25315136    26108605    21719571    25830018    24495485    21347285    25348373    24508170    26823975    17994087    18057021    30249741    24845553    22293439    17554307   

EMBL

BABH01030112    NWSH01000191    PCG78580.1    JN383807    AEN04483.1    JTDY01003909    + More
KOB68840.1    ODYU01011781    SOQ57719.1    AGBW02011160    OWR47118.1    KQ460615    KPJ13699.1    KQ459602    KPI93448.1    KQ971351    EFA06480.1    APGK01039147    KB740967    KB632399    ENN76868.1    ERL94644.1    GGFJ01009265    MBW58406.1    GGFM01007807    MBW28558.1    ADMH02001394    ETN62666.1    GGFK01008192    MBW41513.1    GGFM01005375    MBW26126.1    CH477197    EAT48328.1    JXUM01074195    JXUM01074196    JXUM01074197    JXUM01074198    KQ562816    KXJ75072.1    KK854549    PTY16756.1    GEZM01005796    JAV95908.1    ATLV01014114    KE524943    KFB38356.1    AXCM01006274    GFDL01008299    JAV26746.1    GALX01000978    JAB67488.1    GL441072    EFN65143.1    DS232122    EDS35532.1    AK417647    BAN20862.1    AAAB01008980    GBYB01010467    JAG80234.1    KQ977171    KYN05151.1    AXCN02000674    GL768121    EFZ12116.1    AAZX01012576    AAZX01014363    KA646314    AFP60943.1    GECZ01009997    JAS59772.1    KQ981486    KYN41428.1    GL448604    EFN84088.1    GANO01002706    JAB57165.1    GECU01025396    GECU01004497    JAS82310.1    JAT03210.1    JRES01000223    KNC33210.1    GL888116    EGI67038.1    APCN01005760    GBXI01017035    GBXI01013188    JAC97256.1    JAD01104.1    GAMC01017687    JAB88868.1    KQ976421    KYM89087.1    ADTU01024688    NEVH01023279    PNF18126.1    KQ982045    KYQ60732.1    GAKP01000775    GAKP01000774    JAC58178.1    GDHF01005981    GDHF01002041    JAI46333.1    JAI50273.1    GFDF01002901    JAV11183.1    AJVK01006587    KQ979011    KYN26628.1    GEBQ01011884    JAT28093.1    GEDC01011757    JAS25541.1    GFDF01002902    JAV11182.1    KK107019    EZA62756.1    KR676451    ALC78851.1    ACPB03021609    KQ414735    KOC62161.1    GBRD01004178    GBRD01001423    GBRD01001420    GDHC01019214    GDHC01009448    GDHC01002882    JAG64398.1    JAP99414.1    JAQ09181.1    JAQ15747.1    CH933806    EDW15697.1    KRG01685.1    QOIP01000007    RLU20530.1    GGMR01005285    MBY17904.1    KZ288215    PBC32698.1    GFXV01000141    MBW11946.1    KK852539    KDR21790.1    PZQS01000010    PVD23158.1    AJWK01018614    UFQS01000215    UFQT01000215    SSX01448.1    SSX21828.1    AKHW03006358    KYO20840.1    AAQR03014697    CAQQ02388574    CAQQ02388575    IACL01021521    LAB01942.1    RQTK01000475    RUS79032.1    KQ434819    KZC06915.1    ABLF02026921    QCYY01000537    ROT84452.1    ROT84456.1    KL218151    KFP02734.1    IACN01058321    LAB54550.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000007151    UP000053240    UP000053268    + More
UP000007266    UP000019118    UP000030742    UP000192223    UP000069272    UP000000673    UP000008820    UP000069940    UP000249989    UP000075881    UP000030765    UP000075920    UP000075883    UP000075884    UP000075900    UP000075885    UP000000311    UP000002320    UP000075880    UP000075903    UP000076408    UP000076407    UP000078542    UP000075886    UP000095300    UP000002358    UP000095301    UP000078541    UP000008237    UP000075902    UP000037069    UP000007755    UP000075840    UP000078540    UP000005205    UP000235965    UP000075809    UP000005203    UP000092462    UP000078492    UP000053097    UP000085678    UP000015103    UP000053825    UP000009192    UP000279307    UP000242457    UP000027135    UP000245119    UP000092461    UP000050525    UP000005225    UP000015102    UP000265200    UP000265180    UP000189705    UP000271974    UP000076502    UP000007819    UP000192221    UP000283509    UP000054308    UP000248480   

PRIDE

H9JDC6   

Pfam

PF05191   ADK_lid        + More
PF05225   HTH_psq
PF00586   AIRS
PF02769   AIRS_C

Interpro

IPR000850   Adenylat/UMP-CMP_kin        + More
IPR007862   Adenylate_kinase_lid-dom       
IPR027417   P-loop_NTPase       
IPR036193   ADK_active_lid_dom_sf       
IPR006259   Adenyl_kin_sub       
IPR028586   AK3/Ak4_mitochondrial       
IPR033690   Adenylat_kinase_CS       
IPR007889   HTH_Psq       
IPR009057   Homeobox-like_sf       
IPR010918   PurM-like_C_dom       
IPR023061   SelD_I       
IPR036921   PurM-like_N_sf       
IPR016188   PurM-like_N       
IPR004536   SPS/SelD       
IPR036676   PurM-like_C_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF57774   SSF57774       
SSF46689   SSF46689       
SSF55326   SSF55326       
SSF56042   SSF56042       

Gene 3D

3.30.1330.10     3.90.650.10    

CDD

cd01428  ADK
cd02195  SelD

ProteinModelPortal

H9JDC6   A0A2A4K4J8   G3LHK4   A0A0L7L0A0   A0A2H1WXC1   A0A212F041   + More
A0A194R868   A0A194PKB1   D6WR14   N6TGG1   A0A1W4WPZ8   A0A182F291   A0A2M4BZB2   A0A2M3ZJE1   W5JEZ5   A0A2M4AL50   A0A2M3ZC27   Q17NS5   A0A182GM94   A0A2R7WAQ0   A0A1Y1NEA7   A0A182JXF5   A0A084VK62   A0A182VTX3   A0A182MIW8   A0A1Q3FGR8   A0A182NBJ3   A0A182RGR2   A0A182PUV4   V5H3V9   E2AN46   B0WVD2   R4WSG6   A0A182IXK3   A0A182VIL9   A0A182Y8A4   A0A1S4H1P5   A0A182WZD1   A0A0C9RBE8   A0A195CWV5   A0A182QY40   E9J4W9   A0A1I8NLN5   A0A0B4J2T5   T1PC99   A0A1B6GBH4   A0A1I8N396   A0A151JYA1   E2BJN0   U5ERQ8   A0A1B6I5Y9   A0A182TZ58   A0A0L0CLN8   F4WFG6   A0A182ICT6   A0A0A1WEC0   W8AVW6   A0A195BRU8   A0A158NSA6   A0A2J7PP94   A0A151XJY6   A0A0B4J2L9   A0A034WWK5   A0A0K8WGK4   A0A1L8DXK8   A0A1B0F000   A0A151JLM2   A0A1B6LWM4   A0A1B6DIL6   A0A1L8DXR0   A0A026X417   A0A0M4FKP6   A0A1S3JVP3   T1I6L5   A0A0L7QUL7   A0A0K8TFN3   B4KAI4   A0A3L8DJD3   A0A2S2NL65   A0A2A3ELU8   A0A2H8TCV0   A0A067RMG2   A0A2T7NPR2   A0A1B0CME7   A0A336M724   A0A151M8R9   H0WWD5   T1H4H6   A0A2D4JZP7   A0A3P9IQ30   A0A3P9M6I1   A0A1U7S4K4   A0A3S1HGQ6   A0A154P4P7   J9JPU2   A0A1W4V545   A0A3R7PW39   A0A091I2G3   A0A2Y9DFB4   A0A2D4P990  

PDB

1ZD8     E-value=4.61592e-58,     Score=565

KEGG

101742093    K00944 nucleoside-triphosphate--adenylate kinase [EC:2.7.4.10] | (RefSeq) GTP:AMP phosphotransferase

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)

GO

GO:0005759   GO:0046041   GO:0046899   GO:0004017   GO:0046039   GO:0006172   GO:0005524   GO:0005525   GO:0046033   GO:0005739   GO:0016021   GO:0005634   GO:0003677   GO:0004756   GO:0016260   GO:0046051   GO:0006139   GO:0019205   GO:0016776   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR23359   PTHR10256  

Subcellular location

Mitochondrion matrix  
Nucleus  

Length:

217

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02139

Exp number, first 60 AAs:

0.01831

Total prob of N-in:

0.09142

outside

1  -  217

 

 

Pi

222.475954

Theta

200.984532

Tajima's D

0.227206

CLR

0

CSRT

0.44102794860257

Interpretation

Uncertain