Gene

KWMTBOMO09097  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007522

Annotation

transcription_factor-like_protein_[Bombyx_mori]

Location

Bomo_Chr15(+):11213089-11216435      View in EpiBrowser

Full name

COP9 signalosome complex subunit 6      

Location in the cell

Cytoplasmic   Reliability : 0.918

CDS

ATGTCAAGTGCTGATCGAATTGATTTCGAAATGGAAGTGGAAGTAGAGAGTGCATCTTCAGGTCCGCCGATTGAAGTGCCTAACCCAACATCCCCGGCGCCTACAACACCAGGCAGCAATAAGAGTGTAGTAGTTACGACTGCTACAGCCGGTTCGGTGACCGTCTCTCTCCATCCTTTAGTTATTATGAATGTTTCAGAACATTGGACACGACTTAAGGCACAGGAAGGCTTTCCTCAAACAGTTGTTGGAGCTTTAATTGGGAAGCAAAAAGGTCGCAACATTGAAGTAATGAATTCATTTGAATTAGTGTTCAGTATGATTGATGGAGACATTATTATAGATAGAGATTATTATAATATGAAAGAGGAACAATTCAAACAAGTGTTTTCTGACATGGATTTCCTCGGATGGTATACAACTGGAGATGCTCCCTCAGAACGTGACATCGCAGTTCACAGACAGATCTGTGACATTAATGAGTGTCCTGTGATGTTGATGTTGAATCCGGCAGGCAGAAATGGTGATCAATTACCGGTAGTTTTGTATGAATCAGTAATTGATGTGGTTAATGGTCGCGCCACAATGCTACTAGCACCTTTAACATATACATTAGCCGCTGAAGAGGCTGAGAGAATTGGAGTAGATCATGTTGCCAGAGTTTCATCTGGAGAAGCTGCTCTCAATAGTTTAGTTGCCGAACATCTGACTGCACAAAGATCAGCTATAAAAATGTTAGTTTCTCGTGTACGGGCCGTACTTGCGACAGTACGCGCTATAAGGGATGGTAAACTTCAGCCTCGACCGGCTTTACTAAGGGAGGCGCGTGCTCTCGCCAACAGATTACCTCTGTTGACTTCACAGCAGTTCCGGACACATTTCTATAATCAATGCAACGATGTAGCCCTAATGACATACTTAGGGACGATCACGAAGGGCTGCAACGCTATCAATCAGCTTGTGAATAGATTCAACGTGCTCTACGACAGACAGGGCATGGGAAGGCGCATGCGAGGACTCTTCTTTTAG

Protein

MSSADRIDFEMEVEVESASSGPPIEVPNPTSPAPTTPGSNKSVVVTTATAGSVTVSLHPLVIMNVSEHWTRLKAQEGFPQTVVGALIGKQKGRNIEVMNSFELVFSMIDGDIIIDRDYYNMKEEQFKQVFSDMDFLGWYTTGDAPSERDIAVHRQICDINECPVMLMLNPAGRNGDQLPVVLYESVIDVVNGRATMLLAPLTYTLAAEEAERIGVDHVARVSSGEAALNSLVAEHLTAQRSAIKMLVSRVRAVLATVRAIRDGKLQPRPALLREARALANRLPLLTSQQFRTHFYNQCNDVALMTYLGTITKGCNAINQLVNRFNVLYDRQGMGRRMRGLFF

Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).

Subunit

Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.

Similarity

Belongs to the peptidase M67A family. CSN6 subfamily.

Keywords

Cytoplasm   Nucleus   Signalosome  

Feature

chain  COP9 signalosome complex subunit 6

Uniprot

Q2F614   A0A194R7S2   I4DK95   A0A2H1WXD9   A0A1E1WGT6   A0A212F057   + More
A0A0L7LJN6   A0A437BG99   A0A2J7R826   A0A067RHF0   D7EJD7   A0A1Y1KW96   A0A2A3EA71   A0A1S3I5P5   A0A088AHW7   A0A1B6I9Z0   A0A1B6GFA5   A0A0M8ZNJ3   A0A0L7RIH4   A0A1W4XV11   A0A0A9YIF8   A0A0P4VSH0   R4FN08   A0A1S3I6X6   A0A0V0GAI4   A0A154NZJ7   A0A069DYK5   E0VC87   T1IZT7   A0A023GL90   G3MM31   A0A1E1X5G8   A0A210R7L0   A0A224YTY4   A0A131YRZ1   L7M8Q5   A0A023FAK7   A0A224XU10   A0A131XBH9   Q16GS1   A0A023EQG2   E9J9M1   A0A026X3B0   K7IVD6   A0A0K8TNS5   A0A336MXR4   A0A182H1S6   A0A026WEB9   A0A232FER2   F4WV12   A0A195BTR5   A0A195EWF5   A0A158NNT0   A0A151WSY2   A0A151I785   A0A151J1S1   A0A131XQT3   A0A3L8DNC9   B0WCS9   E2A3E2   B7PXU3   A0A1B6C3C2   A0A1Q3F7G7   K1QRE1   U5EN36   A0A2P6KB68   J3JUA9   N6UCD4   A0A1L8DSS1   A0A2R5LJI6   A0A293M8D6   A0A0T6AXX7   A0A0C9RRB3   V3ZN90   R7T7A1   T1PGJ6   Q6NUC2   E9H1X8   B3M003   A0A084W842   W5N633   A0A0L0C0W8   W5JK60   A0A1B0C2W4   A0A1A9UZT8   A0A1I8QEL3   A0A3Q3KBF3   B4NAV6   A0A1I8MAB6   A0A1A9XMZ7   A0A2D0PRX6   D3TPD6   A0A3B4ZB79   G3PVK8   A0A1W5A2P7   A0A2M4ATQ6   A0A3Q4ALK0   A0A2M4ATV7   A0A0P6GF60  

Pubmed

19121390    26354079    22651552    22118469    26227816    24845553    + More
18362917    19820115    28004739    26383154    25401762    26823975    27129103    26334808    20566863    22216098    28503490    28812685    28797301    26830274    25576852    25474469    28049606    17510324    24945155    21282665    24508170    20075255    26369729    26483478    30249741    28648823    21719571    21347285    20798317    22992520    22516182    23537049    23254933    25315136    21292972    17994087    24438588    26108605    20920257    23761445    20353571   

EMBL

BABH01030112    DQ311258    ABD36203.1    KQ460615    KPJ13697.1    AK401713    + More
KQ459602    BAM18335.1    KPI93446.1    ODYU01011781    SOQ57721.1    GDQN01004841    JAT86213.1    AGBW02011160    OWR47120.1    JTDY01000861    KOB75640.1    RSAL01000065    RVE49422.1    NEVH01006723    PNF36983.1    KK852634    KDR19771.1    DS497702    EFA12663.1    GEZM01074861    JAV64450.1    KZ288310    PBC28627.1    GECU01023945    GECU01009297    JAS83761.1    JAS98409.1    GECZ01008627    JAS61142.1    KQ435969    KOX67875.1    KQ414583    KOC70767.1    GBHO01036231    GBHO01012198    GBRD01007120    GDHC01021558    GDHC01017720    GDHC01004598    JAG07373.1    JAG31406.1    JAG58701.1    JAP97070.1    JAQ00909.1    JAQ14031.1    GDKW01001708    JAI54887.1    ACPB03017525    GAHY01001519    JAA75991.1    GECL01001160    JAP04964.1    KQ434786    KZC05096.1    GBGD01002230    JAC86659.1    DS235049    EEB10993.1    JH431723    GBBM01001838    JAC33580.1    JO842932    AEO34549.1    GFAC01004693    JAT94495.1    NEDP02000041    OWF56821.1    GFPF01006905    MAA18051.1    GEDV01007209    JAP81348.1    GACK01005496    JAA59538.1    GBBI01000653    JAC18059.1    GFTR01004985    JAW11441.1    GEFH01005111    JAP63470.1    CH478240    EAT33443.1    GAPW01002260    JAC11338.1    GL769399    EFZ10439.1    KK107020    EZA62501.1    AAZX01005358    GDAI01002043    JAI15560.1    UFQS01000317    UFQS01001464    UFQT01000317    UFQT01001464    SSX02810.1    SSX30668.1    JXUM01103889    KQ564842    KXJ71657.1    KK107256    QOIP01000006    EZA54278.1    RLU21226.1    NNAY01000354    OXU28958.1    GL888384    EGI61900.1    KQ976417    KYM89814.1    KQ981953    KYN32481.1    ADTU01021753    KQ982766    KYQ50990.1    KQ978438    KYM93981.1    KQ980503    KYN15792.1    GEFM01006809    JAP68987.1    RLU21945.1    DS231890    EDS43805.1    GL436428    EFN72006.1    ABJB010098962    ABJB010591610    ABJB010816375    DS816156    EEC11415.1    GEDC01029404    JAS07894.1    GFDL01011535    JAV23510.1    JH817877    EKC33739.1    GANO01000746    JAB59125.1    MWRG01017377    PRD23550.1    BT126822    AEE61784.1    APGK01040869    KB740984    ENN76312.1    GFDF01004566    JAV09518.1    GGLE01005361    MBY09487.1    GFWV01010486    MAA35215.1    LJIG01022557    KRT79937.1    GBYB01009856    JAG79623.1    KB203567    ESO83905.1    AMQN01014936    KB311434    ELT89268.1    KA647927    AFP62556.1    BC068673    GL732584    EFX74250.1    CH902617    EDV44193.1    ATLV01021357    KE525317    KFB46386.1    AHAT01024680    JRES01001062    JRES01000065    KNC25907.1    KNC34432.1    ADMH02001270    ETN63280.1    JXJN01024713    CH964232    EDW80920.1    CCAG010015463    EZ423288    ADD19564.1    GGFK01010855    MBW44176.1    GGFK01010908    MBW44229.1    GDIP01053377    GDIQ01036832    LRGB01000725    JAM50338.1    JAN57905.1    KZS16283.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000037510    UP000283053    + More
UP000235965    UP000027135    UP000007266    UP000242457    UP000085678    UP000005203    UP000053105    UP000053825    UP000192223    UP000015103    UP000076502    UP000009046    UP000242188    UP000008820    UP000053097    UP000002358    UP000069940    UP000249989    UP000279307    UP000215335    UP000007755    UP000078540    UP000078541    UP000005205    UP000075809    UP000078542    UP000078492    UP000002320    UP000000311    UP000001555    UP000005408    UP000019118    UP000030746    UP000014760    UP000095301    UP000000305    UP000007801    UP000030765    UP000018468    UP000037069    UP000000673    UP000092460    UP000078200    UP000095300    UP000261600    UP000007798    UP000092443    UP000221080    UP000092444    UP000261400    UP000007635    UP000192224    UP000261620    UP000076858   

PRIDE

Q2F614   

Pfam

PF01398   JAB        + More
PF13012   MitMem_reg

Interpro

IPR024969   Rpn11/EIF3F_C        + More
IPR033859   MPN_CSN6       
IPR037518   MPN       
IPR000555   JAMM/MPN+_dom       

CDD

cd08063  MPN_CSN6

ProteinModelPortal

Q2F614   A0A194R7S2   I4DK95   A0A2H1WXD9   A0A1E1WGT6   A0A212F057   + More
A0A0L7LJN6   A0A437BG99   A0A2J7R826   A0A067RHF0   D7EJD7   A0A1Y1KW96   A0A2A3EA71   A0A1S3I5P5   A0A088AHW7   A0A1B6I9Z0   A0A1B6GFA5   A0A0M8ZNJ3   A0A0L7RIH4   A0A1W4XV11   A0A0A9YIF8   A0A0P4VSH0   R4FN08   A0A1S3I6X6   A0A0V0GAI4   A0A154NZJ7   A0A069DYK5   E0VC87   T1IZT7   A0A023GL90   G3MM31   A0A1E1X5G8   A0A210R7L0   A0A224YTY4   A0A131YRZ1   L7M8Q5   A0A023FAK7   A0A224XU10   A0A131XBH9   Q16GS1   A0A023EQG2   E9J9M1   A0A026X3B0   K7IVD6   A0A0K8TNS5   A0A336MXR4   A0A182H1S6   A0A026WEB9   A0A232FER2   F4WV12   A0A195BTR5   A0A195EWF5   A0A158NNT0   A0A151WSY2   A0A151I785   A0A151J1S1   A0A131XQT3   A0A3L8DNC9   B0WCS9   E2A3E2   B7PXU3   A0A1B6C3C2   A0A1Q3F7G7   K1QRE1   U5EN36   A0A2P6KB68   J3JUA9   N6UCD4   A0A1L8DSS1   A0A2R5LJI6   A0A293M8D6   A0A0T6AXX7   A0A0C9RRB3   V3ZN90   R7T7A1   T1PGJ6   Q6NUC2   E9H1X8   B3M003   A0A084W842   W5N633   A0A0L0C0W8   W5JK60   A0A1B0C2W4   A0A1A9UZT8   A0A1I8QEL3   A0A3Q3KBF3   B4NAV6   A0A1I8MAB6   A0A1A9XMZ7   A0A2D0PRX6   D3TPD6   A0A3B4ZB79   G3PVK8   A0A1W5A2P7   A0A2M4ATQ6   A0A3Q4ALK0   A0A2M4ATV7   A0A0P6GF60  

PDB

4WSN     E-value=3.45562e-95,     Score=888

KEGG

693095    K12179 COP9 signalosome complex subunit 6 | (RefSeq) transcription factor-like protein

GO

GO:0008180   GO:0000338   GO:0000502   GO:0005737   GO:0036099   GO:0046983   GO:0048140   GO:0007281   GO:0050821   GO:0042802   GO:0005515   GO:0008270   GO:0003924   GO:0010181   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  
Nucleus  

Length:

342

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.555370000000001

Exp number, first 60 AAs:

0.36549

Total prob of N-in:

0.02620

outside

1  -  342

 

 

Pi

217.077395

Theta

186.683539

Tajima's D

0.585578

CLR

0.147818

CSRT

0.543072846357682

Interpretation

Uncertain