Gene

KWMTBOMO09094

Pre Gene Modal

BGIBMGA007520

Annotation

PREDICTED:_cyclin-C_[Bombyx_mori]

Location

Bomo_Chr15(+):11186879-11188673      View in EpiBrowser

Full name

Cyclin-C      

Location in the cell

Cytoplasmic   Reliability : 1.738

CDS

ATGGCTGGAAATTTTTGGCAAAGCTCACATCATCAACAATGGATACTCGATAAGCAAGAGCTAAGGCGCGATCGCCAGTTTGATTTGAATATTTTATCAGAAGAAGAATACCAAAAAGTATTTAATTTTTTTGCTAGTATAATTCAAGTTTTAGGCGAACAACTTAAACTTCGTCAGCAAGTAATCGCAACTGCAACAGTTTACTTTAAAAGATTTTATGCAAGGAACTCTTTGAAGTGTATTGATCCACTTCTTTTGGCACCAACATGCGTATTTCTTGCATCTAAAGTTGAAGAATTTGGTGTTATATCCAATTCCAGATTAATAACAACCTGCCAGACAGTTATAAAAAATAAGTTTAGTTATGCTTATGGACAACAAGAGTTCCCGTACAGGACAAATCACATTCTGGAGTGTGAATTTTATTTACTAGAAAATTTAGATTGTTGTTTAATTGTATACCAACCATATAGACCATTACTACTTTTTGTCCAAGACATAGGACAAGATGATCAACTTCTGACATACGCTTGGAGAATAGTAAACGATTCCTTGAGAACAGATGTTAGTTTGTTGTACCCACCCTATCAGATTGCAATTGGTGCCTTACAAATAGCATGTGTGATGCTTGGTAAAGACAATCTCAAACCTTGGTTTGCTGAGCTAAATGTTGACATGGATAAAATCCAAGAAATTGTGAGAGCTATCATTAACCTTTATGAGATGTGGAAAAGTTATGATGAAAAAAAAGAAATACAAGGGCTATTGTCCAAGATGCCCAAACCAAAGCCAGCTCCCCAGAGATAG

Protein

MAGNFWQSSHHQQWILDKQELRRDRQFDLNILSEEEYQKVFNFFASIIQVLGEQLKLRQQVIATATVYFKRFYARNSLKCIDPLLLAPTCVFLASKVEEFGVISNSRLITTCQTVIKNKFSYAYGQQEFPYRTNHILECEFYLLENLDCCLIVYQPYRPLLLFVQDIGQDDQLLTYAWRIVNDSLRTDVSLLYPPYQIAIGALQIACVMLGKDNLKPWFAELNVDMDKIQEIVRAIINLYEMWKSYDEKKEIQGLLSKMPKPKPAPQR

Description

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).

Subunit

Component of the Cdk8 module of the Mediator complex.

Similarity

Belongs to the cyclin family.
Belongs to the cyclin family. Cyclin C subfamily.

Keywords

Activator   Complete proteome   Cyclin   Nucleus   Reference proteome   Repressor   Transcription   Transcription regulation  

Feature

chain  Cyclin-C

Uniprot

A0A0L7LJV3   A0A194R864   A0A212F064   A0A194PKA7   A0A1E1WJP9   A0A2H1WZA6   + More
A0A3S2M2E2   S4PPT5   A0A182IYK6   A0A084VBH1   A0A2M4AWG6   A0A182FPT7   A0A2M4BX13   W5JKF3   A0A139WKR1   A0A182M663   A0A1Y9IVR9   A0A1W4XMK0   A0A1C7CZR3   A0A182UW05   A0A182UHK9   A0A182XG42   A0A182ID88   Q7QB13   A0A182Y5D5   A0A182PD70   A0A182JPK3   A0A182R477   A0A182NCZ8   A0A182SXS3   A0A182GQ68   Q16JA2   A0A2K7P6D9   A0A182QXU1   B0WG06   A0A154PEX1   A0A1Y1MFR1   A0A1Q3F1X3   A0A0K8TS88   A0A2P8ZE57   A0A2J7PT99   A0A067QQ27   E2B8N8   A0A240SWL0   A0A1A9ULZ1   A0A240SXE1   A0A1A9Z784   A0A3F2Z3G2   D3TR88   A0A026W9D3   A0A1I8P6N7   A0A0K8TX27   A0A034VKS7   E2AJG9   A0A1B6J314   A0A1B6F651   A0A336MPZ8   A0A1B6KBT6   W8C2K8   A0A0L0CBA3   A0A1I8NCU9   A0A2H8THR3   A0A2S2NT20   U5EVB7   A0A195DMN1   E9J3S1   F4W638   A0A195AWI7   A0A158P1W2   A0A151WP95   A0A2A3EAC0   A0A0B4J2L6   A0A0L7R907   C4WUT7   A0A1B0DP62   A0A151I7Q0   A0A195ERB3   A0A0A9YR96   A0A1L8DGR1   A0A0N0BFZ3   A0A1B0GLD5   A0A310SCK4   E0VVL2   N6T036   A0A1B6CXM8   J3JYL2   A0A0M5J4U4   A0A3B0KS11   B4G6F1   Q29AI1   B4K946   A0A1W4VZ72   B3LWQ7   B4M412   A0A0V0GCY4   A0A023F9F4   A0A0P4VSU9   R4FND8   B4JF36   B4PSN5  

Pubmed

26227816    26354079    22118469    23622113    24438588    20920257    + More
23761445    18362917    19820115    20966253    12364791    25244985    26483478    17510324    28004739    26369729    29403074    24845553    20798317    20353571    24508170    25348373    24495485    26108605    25315136    21282665    21719571    21347285    25401762    26823975    20566863    23537049    22516182    17994087    15632085    25474469    27129103    17550304   

EMBL

JTDY01000861    KOB75639.1    KQ460615    KPJ13694.1    AGBW02011160    OWR47123.1    + More
KQ459602    KPI93443.1    GDQN01003938    JAT87116.1    ODYU01011781    SOQ57724.1    RSAL01000065    RVE49418.1    GAIX01000022    JAA92538.1    ATLV01006810    KE524386    KFB35315.1    GGFK01011825    MBW45146.1    GGFJ01008401    MBW57542.1    ADMH02000944    ETN64611.1    KQ971327    KYB28405.1    AXCM01001325    APCN01005054    AAAB01008880    JXUM01046987    JXUM01079906    KQ563151    KQ561499    KXJ74388.1    KXJ78383.1    CH478020    AXCN02001566    DS231922    EDS26647.1    KQ434879    KZC09984.1    GEZM01032339    JAV84659.1    GFDL01013489    JAV21556.1    GDAI01000808    JAI16795.1    PYGN01000083    PSN54776.1    NEVH01021918    PNF19544.1    KK853149    KDR10660.1    GL446361    EFN87944.1    JXJN01002847    CCAG010021196    EZ423940    ADD20216.1    KK107321    EZA52712.1    GDHF01033491    JAI18823.1    GAKP01016527    JAC42425.1    GL439992    EFN66421.1    GECU01014127    JAS93579.1    GECZ01024115    JAS45654.1    UFQS01002503    UFQT01002089    UFQT01002503    SSX14173.1    SSX32624.1    GEBQ01031060    JAT08917.1    GAMC01006494    JAC00062.1    JRES01000641    KNC29693.1    GFXV01001437    MBW13242.1    GGMR01007599    MBY20218.1    GANO01001929    JAB57942.1    KQ980724    KYN14155.1    GL768069    EFZ12463.1    GL887707    EGI70173.1    KQ976731    KYM76329.1    ADTU01006900    KQ982892    KYQ49621.1    KZ288309    PBC28677.1    KQ414628    KOC67342.1    ABLF02025489    AK341217    BAH71657.1    AJVK01007918    KQ978397    KYM94205.1    KQ982021    KYN30419.1    GBHO01009475    GBHO01009468    GBRD01008244    GDHC01001628    JAG34129.1    JAG34136.1    JAG57577.1    JAQ17001.1    GFDF01008445    JAV05639.1    KQ435794    KOX74031.1    AJWK01034750    KQ761323    OAD57893.1    DS235812    EEB17418.1    APGK01050089    KB741165    KB632353    ENN73419.1    ERL93326.1    GEDC01019157    JAS18141.1    BT128341    AEE63299.1    CP012526    ALC46344.1    OUUW01000013    SPP88031.1    CH479179    EDW23909.1    CM000070    CH933806    EDW14459.1    CH902617    EDV42695.1    CH940652    EDW59373.1    GECL01000431    JAP05693.1    GBBI01000585    JAC18127.1    GDKW01001025    JAI55570.1    ACPB03006671    GAHY01000608    JAA76902.1    CH916369    EDV93317.1    CM000160    EDW97531.1   

Proteomes

UP000037510    UP000053240    UP000007151    UP000053268    UP000283053    UP000075880    + More
UP000030765    UP000069272    UP000000673    UP000007266    UP000075883    UP000075920    UP000192223    UP000075882    UP000075903    UP000075902    UP000076407    UP000075840    UP000007062    UP000076408    UP000075885    UP000075881    UP000075900    UP000075884    UP000075901    UP000069940    UP000249989    UP000008820    UP000075886    UP000002320    UP000076502    UP000245037    UP000235965    UP000027135    UP000008237    UP000092443    UP000078200    UP000092460    UP000092445    UP000091820    UP000092444    UP000053097    UP000095300    UP000000311    UP000037069    UP000095301    UP000078492    UP000007755    UP000078540    UP000005205    UP000075809    UP000242457    UP000005203    UP000053825    UP000007819    UP000092462    UP000078542    UP000078541    UP000053105    UP000092461    UP000009046    UP000019118    UP000030742    UP000092553    UP000268350    UP000008744    UP000001819    UP000009192    UP000192221    UP000007801    UP000008792    UP000015103    UP000001070    UP000002282   

Pfam

PF00134   Cyclin_N        + More
PF16899   Cyclin_C_2

Interpro

IPR028367   CyclinC/Ssn8        + More
IPR013763   Cyclin-like       
IPR031658   Cyclin_C_2       
IPR006671   Cyclin_N       
IPR036915   Cyclin-like_sf       

SUPFAM

SSF47954   SSF47954       

CDD

cd00043  CYCLIN

ProteinModelPortal

A0A0L7LJV3   A0A194R864   A0A212F064   A0A194PKA7   A0A1E1WJP9   A0A2H1WZA6   + More
A0A3S2M2E2   S4PPT5   A0A182IYK6   A0A084VBH1   A0A2M4AWG6   A0A182FPT7   A0A2M4BX13   W5JKF3   A0A139WKR1   A0A182M663   A0A1Y9IVR9   A0A1W4XMK0   A0A1C7CZR3   A0A182UW05   A0A182UHK9   A0A182XG42   A0A182ID88   Q7QB13   A0A182Y5D5   A0A182PD70   A0A182JPK3   A0A182R477   A0A182NCZ8   A0A182SXS3   A0A182GQ68   Q16JA2   A0A2K7P6D9   A0A182QXU1   B0WG06   A0A154PEX1   A0A1Y1MFR1   A0A1Q3F1X3   A0A0K8TS88   A0A2P8ZE57   A0A2J7PT99   A0A067QQ27   E2B8N8   A0A240SWL0   A0A1A9ULZ1   A0A240SXE1   A0A1A9Z784   A0A3F2Z3G2   D3TR88   A0A026W9D3   A0A1I8P6N7   A0A0K8TX27   A0A034VKS7   E2AJG9   A0A1B6J314   A0A1B6F651   A0A336MPZ8   A0A1B6KBT6   W8C2K8   A0A0L0CBA3   A0A1I8NCU9   A0A2H8THR3   A0A2S2NT20   U5EVB7   A0A195DMN1   E9J3S1   F4W638   A0A195AWI7   A0A158P1W2   A0A151WP95   A0A2A3EAC0   A0A0B4J2L6   A0A0L7R907   C4WUT7   A0A1B0DP62   A0A151I7Q0   A0A195ERB3   A0A0A9YR96   A0A1L8DGR1   A0A0N0BFZ3   A0A1B0GLD5   A0A310SCK4   E0VVL2   N6T036   A0A1B6CXM8   J3JYL2   A0A0M5J4U4   A0A3B0KS11   B4G6F1   Q29AI1   B4K946   A0A1W4VZ72   B3LWQ7   B4M412   A0A0V0GCY4   A0A023F9F4   A0A0P4VSU9   R4FND8   B4JF36   B4PSN5  

PDB

5HVY     E-value=1.7693e-100,     Score=932

KEGG

101737391    K15161 cyclin-C | (RefSeq) cyclin-C

GO

GO:0016592   GO:0016538   GO:0016301   GO:0006357   GO:0045944   GO:0005634   GO:0045498   GO:0036011   GO:0010508   GO:0003712   GO:0022416   GO:0034472  

PANTHER

PTHR10026:SF7  

Subcellular location

Nucleus  

Length:

268

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.39571

Exp number, first 60 AAs:

0.00209

Total prob of N-in:

0.04468

outside

1  -  268

 

 

Pi

306.466338

Theta

227.263289

Tajima's D

1.097505

CLR

0

CSRT

0.687565621718914

Interpretation

Uncertain