Silkworm Genome Informatics Database

Gene

KWMTBOMO09084 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007514

Annotation

PREDICTED:_methionine-R-sulfoxide_reductase_B1_isoform_X2_[Papilio_polytes]

Location

Bomo_Chr15(+):11033909-11037145 View in EpiBrowser

Full name

Peptide-methionine (R)-S-oxide reductase + More
Methionine-R-sulfoxide reductase B1

Alternative Name

Selenoprotein R

Location in the cell

Extracellular Reliability : 1.357 Mitochondrial Reliability : 1.642

CDS

ATGCGTATTTTACTGAGATCAATTACTGTACTCAGAAAAGTAGTCAACGCCAGTGCTAATAAATCGGCGCAGTTGAAACATCCGTTTACAACAGCATTAGTGTGGAGAGCCATGGAAGATAAAGAGTCTTTGAAAAAACGTTTAACACCACTGCAGTATCATGTTACGCAGGAAGCGGGGACCGAGAGGCCGTTTACAGGTTGCTATAATAAATGTTATGATGAAGGAATGTATGTATGTATAGTATGTAGACAAGACCTCTTCAGCTCGAAAACAAAATTTGATTCTGGATGTGGCTGGCCTGCATTCAATGATGTTCTTGCTAAAGAAAAAGTGACACTTCACCGTGATACTAGTGCAGGTTTGGTGCGAACCGAGGTGCGTTGTTCCAAGTGCGCCGCTCATCTGGGCCACGTGTTTGATGACGGGCCAGCACCCACCCGAAAACGTTTTTGTATAAATTCAGCATCTTTGGACTTCATACCCGCTGAAGAAAGGAAAGATTAA

Protein

MRILLRSITVLRKVVNASANKSAQLKHPFTTALVWRAMEDKESLKKRLTPLQYHVTQEAGTERPFTGCYNKCYDEGMYVCIVCRQDLFSSKTKFDSGCGWPAFNDVLAKEKVTLHRDTSAGLVRTEVRCSKCAAHLGHVFDDGPAPTRKRFCINSASLDFIPAEERKD

Description

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.

Catalytic Activity

[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]

Cofactor

Zn(2+)

Similarity

Belongs to the MsrB Met sulfoxide reductase family.

Keywords

Alternative splicing Complete proteome Cytoplasm Cytoskeleton Disulfide bond Metal-binding Nucleus Oxidoreductase Reference proteome Zinc

Feature

chain Methionine-R-sulfoxide reductase B1
splice variant In isoform A, isoform B, isoform G and isoform H.

Uniprot

H9JDB7 A0A2H1WBL0 A0A2A4JZ94 A0A194PJC9 A0A194R7Q7 A0A212EL04 + More
S4PGU8 A0A3S2NLV3 A0A0L7KRE5 F5HKC4 A0A182THV1 A0A182VEX1 A0A2M3Z898 A0A2M4BYN1 A0A2M4BYN5 A0A2M4BYT8 A0A2M4BYR2 A0A1Q3FK35 A0A2M4BZ31 A0A1Y9G9L5 A0A2M3Z8X9 F5HKC6 A0A2M4CJM4 A0A2M4CJK7 A0A2M4C2L0 A0A2M4C298 A0A1Y9G9E4 A0A2M4AMH7 A0A2M4APH0 A0A1S4G6M1 B0WKV0 A0A0Q9WEV8 A0A1Y9J080 A0A1L8DIE1 A0A1L8DI86 B4JGE2 A0A1L8EE99 A0A0P8YH25 Q8INK9-7 A0A182H9L1 A0A1I8M3G5 A0A0R1E6S9 A0A023EDT6 A0A1I8Q118 A0A1Y9G9M0 D3DMP0 A0A0Q9XA34 A0A1W4USN2 A0A1I8M3H1 A0A1L8E631 A0A1Y9J0N9 A0A2M4APD0 A0A1Y9G895 I5APV0 A0A2A3E754 A0A182J4G3 A0A1L8EDX6 A0A0Q9WR21 A0A1L8E6H8 A0A2M4CNK7 A0A034VLD3 A0A0L0C7A2 A0A1I8M3G8 A0A1Q3FK65 A0A1I8Q127 Q8INK9-6 A0A1B2AJD1 A0A0P8Y0B7 T1PFN5 B3P1I6 A0A182MU06 B4HIN4 A0A1I8Q116 W5JK84 A0A0A1WY48 A0A0Q9X858 A0A0P9A1Z4 A0A1L8EJ07 A0A1L8E623 A0A182Y477 A0A0Q9WRC9 T1E9M8 D6WMU3 A0A1I8Q0Z3 A0A0P9ATJ3 A0A139WHX8 A0A1W4V4Z9 A0A0Q9X994 A0A0Q9WFG0 A0A0F7Q005 V9IEF3 A0A1I8M3H5 A0A0R3NK26 Q17HS9 A0A1L8DI14 N6U6X1 Q8INK9-2 A0A1B2AJI9 A0A0Q9XC97 A0A1L8EIZ9

EC Number

1.8.4.12

Pubmed

19121390 26354079 22118469 23622113 26227816 12364791 + More
14747013 17210077 17510324 17994087 11929995 10731132 12537572 12537569 12145281 24212093 26483478 25315136 17550304 24945155 12537568 12537573 12537574 16110336 17569856 17569867 26109357 26109356 15632085 25348373 26108605 20920257 23761445 25830018 25244985 18362917 19820115 23537049

EMBL

BABH01030135 ODYU01007507 SOQ50336.1 NWSH01000353 PCG77096.1 KQ459602 + More
KPI93432.1 KQ460615 KPJ13682.1 AGBW02014166 OWR42159.1 GAIX01003492 JAA89068.1 RSAL01000040 RVE50993.1 JTDY01006854 KOB65645.1 AAAB01008859 EGK96679.1 GGFM01003970 MBW24721.1 GGFJ01009029 MBW58170.1 GGFJ01009028 MBW58169.1 GGFJ01009031 MBW58172.1 GGFJ01009032 MBW58173.1 GFDL01007150 JAV27895.1 GGFJ01009030 MBW58171.1 GGFM01004204 MBW24955.1 EGK96677.1 GGFL01001349 MBW65527.1 GGFL01001348 MBW65526.1 GGFJ01010260 MBW59401.1 GGFJ01010258 MBW59399.1 GGFK01008659 MBW41980.1 GGFK01009349 MBW42670.1 DS231976 EDS30073.1 CH940650 KRF83164.1 GFDF01007990 JAV06094.1 GFDF01007989 JAV06095.1 CH916369 EDV92611.1 GFDG01001896 JAV16903.1 CH902617 KPU80631.1 AF486578 AE014297 AY070627 BT001621 BT001854 BT011487 AAN13491.1 JXUM01121056 KQ566457 KXJ70123.1 CM000160 KRK03410.1 GAPW01005845 JAC07753.1 BT120206 ADB91454.1 AFH06354.1 CH933806 KRG01409.1 GFDG01004636 JAV14163.1 GGFK01009147 MBW42468.1 CM000070 EIM52985.2 KZ288347 PBC27530.1 GFDG01001897 JAV16902.1 KRF83166.1 GFDG01004634 JAV14165.1 GGFL01002320 MBW66498.1 GAKP01016332 JAC42620.1 JRES01001389 JRES01000819 KNC23199.1 KNC28121.1 GFDL01007169 JAV27876.1 KX531452 ANY27262.1 KPU80635.1 KA647561 AFP62190.1 CH954181 EDV49585.1 AXCM01000193 CH480815 EDW42681.1 ADMH02001204 ETN63723.1 GBXI01010999 JAD03293.1 KRG01412.1 KPU80630.1 GFDG01000190 JAV18609.1 GFDG01004641 JAV14158.1 KRF83163.1 GAMD01001202 JAB00389.1 KQ971342 EFA03067.1 KPU80633.1 KYB27499.1 KRG01410.1 KRF83162.1 KP317814 AKI05741.1 JR039788 AEY58846.1 KRT01266.1 CH477246 EAT46160.1 GFDF01007988 JAV06096.1 APGK01037630 APGK01037631 KB740948 KB632364 ENN77395.1 ERL93602.1 KX531300 ANY27110.1 KRG01411.1 GFDG01000193 JAV18606.1

Proteomes

UP000005204 UP000218220 UP000053268 UP000053240 UP000007151 UP000283053 + More
UP000037510 UP000007062 UP000075902 UP000075903 UP000069272 UP000002320 UP000008792 UP000076407 UP000001070 UP000007801 UP000000803 UP000069940 UP000249989 UP000095301 UP000002282 UP000095300 UP000009192 UP000192221 UP000001819 UP000242457 UP000075880 UP000037069 UP000008711 UP000075883 UP000001292 UP000000673 UP000076408 UP000007266 UP000008820 UP000019118 UP000030742

PRIDE

H9JDB7 Q8INK9 D3DMP0

Pfam

PF01641 SelR

Interpro

IPR002579   Met_Sox_Rdtase_MsrB        + More
IPR028427   Met_Sox_Rdtase
IPR011057   Mss4-like_sf

SUPFAM

SSF51316 SSF51316

ProteinModelPortal

H9JDB7 A0A2H1WBL0 A0A2A4JZ94 A0A194PJC9 A0A194R7Q7 A0A212EL04 + More
S4PGU8 A0A3S2NLV3 A0A0L7KRE5 F5HKC4 A0A182THV1 A0A182VEX1 A0A2M3Z898 A0A2M4BYN1 A0A2M4BYN5 A0A2M4BYT8 A0A2M4BYR2 A0A1Q3FK35 A0A2M4BZ31 A0A1Y9G9L5 A0A2M3Z8X9 F5HKC6 A0A2M4CJM4 A0A2M4CJK7 A0A2M4C2L0 A0A2M4C298 A0A1Y9G9E4 A0A2M4AMH7 A0A2M4APH0 A0A1S4G6M1 B0WKV0 A0A0Q9WEV8 A0A1Y9J080 A0A1L8DIE1 A0A1L8DI86 B4JGE2 A0A1L8EE99 A0A0P8YH25 Q8INK9-7 A0A182H9L1 A0A1I8M3G5 A0A0R1E6S9 A0A023EDT6 A0A1I8Q118 A0A1Y9G9M0 D3DMP0 A0A0Q9XA34 A0A1W4USN2 A0A1I8M3H1 A0A1L8E631 A0A1Y9J0N9 A0A2M4APD0 A0A1Y9G895 I5APV0 A0A2A3E754 A0A182J4G3 A0A1L8EDX6 A0A0Q9WR21 A0A1L8E6H8 A0A2M4CNK7 A0A034VLD3 A0A0L0C7A2 A0A1I8M3G8 A0A1Q3FK65 A0A1I8Q127 Q8INK9-6 A0A1B2AJD1 A0A0P8Y0B7 T1PFN5 B3P1I6 A0A182MU06 B4HIN4 A0A1I8Q116 W5JK84 A0A0A1WY48 A0A0Q9X858 A0A0P9A1Z4 A0A1L8EJ07 A0A1L8E623 A0A182Y477 A0A0Q9WRC9 T1E9M8 D6WMU3 A0A1I8Q0Z3 A0A0P9ATJ3 A0A139WHX8 A0A1W4V4Z9 A0A0Q9X994 A0A0Q9WFG0 A0A0F7Q005 V9IEF3 A0A1I8M3H5 A0A0R3NK26 Q17HS9 A0A1L8DI14 N6U6X1 Q8INK9-2 A0A1B2AJI9 A0A0Q9XC97 A0A1L8EIZ9

PDB

2K8D E-value=3.29238e-37, Score=384

KEGG

101744023 K07305 peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12] | (RefSeq) methionine-R-sulfoxide redu

GO

GO:0046872 GO:0030091 GO:0033743 GO:0006979 GO:0034599 GO:0008270 GO:0008407 GO:0030240 GO:0030041 GO:0007411 GO:0005654 GO:0005829 GO:0005856 GO:0007015 GO:0055114

PANTHER

PTHR10173

Subcellular location

Cytoplasm
Nucleus
Cytoskeleton

Length:

168

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00017

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.12719

outside

1 - 168

Pi

210.941535

Theta

166.625817

Tajima's D

0.310445

CLR

0.580991

CSRT

0.459927003649818

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics