Gene

KWMTBOMO09069  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007582

Annotation

gamma-glutamylcysteine_ligase_[Bombyx_mori]

Location

Bomo_Chr15(-):10815336-10826734      View in EpiBrowser

Full name

Innexin      

Location in the cell

Cytoplasmic   Reliability : 2.287

CDS

ATGGGTTTGCTAACTGAAGGTAGCCCACTGTCTTGGGAGGAAACTAAAGCTTTGGCAGAGCACGTACGACAACATGGTGTAGAACAATTCATTAATTTGTACAGAAAACTTCAAGATCGCACTGGTGATGTTCTTAAGTGGGGTGATGAGGTGGAGTATGTGATAGTGAAGTTCGATGATAAGAATGAAAGAGCCACAGTAAGTCTTAGGGCAAATGAGCTATTGCCCAAGTTACAAGAAAAAGAACTTGCAGACCCACAGAATGTAAAATCCCTATGGCGGCCGGAGTATGGAGGCTACATGGTAGAGGGTACCCCAGGAAAGCCATATGGAGGACTTTTAGCACATTTCAACATTGTGGAAGCCAATATGCAGTATCGCCGAGCCGAAGCCAGCGCTCTGTTGCAGGATGGTGAAGTTATAATGAGTATAACTAACTTTCCTAGATTGGGTTGTACAAACTTCACAAGTCCACCTTATAAACCAACTCCTAATGAAGGCGTTACCAGATCTCATTATTTCCCAGACGAGGGAATATATCAAGGACATCCAAGATTTAAGACTCTGACTTCAAATATAAGACTGAGAAGAGGCGAAAAGGTTGCTATAAATATACCAGTGTTTCGTGATGTAAATACAAAGATACCAGTGGATAACTCTCATACACTTGAGCCGGATGCAGCAAAGCCAGATTGCGTGTATATGGACGCAATGGGTTTCGGTATGGGCTGTTGCTGTTTGCAACTCACCTTTCAAGCATGTTGCATTACCGAGGCACGCACTCTGTACGATCAGCTAGCCCCTTTATGTCCAATAATGTTGGCGTTATCGGCAGCGTCGCCCATATACCGTGGCTACCTCACCGACGTGGATTGTCGTTGGAACGTAATTTCTGCATCTGTGGACTGCCGCACGCGCGAGGAGAGAGGCCTCGAGCCGCTCAAGAACAATAAGTTTCGAATCCAAAAGTCGCGCTATGATTCAATCGATTCCTATCTCTCACCACAAAATGAAAAATACAACGACATTCCAATCGTGCACGACCAGAACATCTACAAACGACTCCGCGAGGGCGGAATCGACCACCCCCTCGCCCTGCACGTGGCACATCTCTTCATACGAGACACCGTCTCTCTCTTCTCTGAAAAAGTTCACCAGGATGACGAAAACGATACTGATCATTTTGAGAATATACAGTCGACGAATTGGCAGACCATGAGGTTCAAGCCGCCGCCTCCGAACTCTTCGATCGGTTGGCGCGTAGAGTTCCGCCCCTGTGAAGCTCAACTCACGGACTTCGAGAACGCGGCCTACGTCTGCTTTGTTGTCCTGCTCACACGGGTCATACTCTCCTATCAACTCAATTTCGTCATGCCCATCAGCAAGGTGGACGAGAACATGCAGCGTGCCCAGCGTCGAGGCGCGTGTCTGAATGAGAAGTTCTGGTGGAGGCGTGACGTGGGCGCGCCACGCGACGTCGCGCCGCCGCACAGCGACGCCACCGACGAGTACCACGAGATGTCCATCAACGACATCGTCAACGGAAAGGAGGGCGTGTTCCCCGGACTGATCCCGCTGATCGAGTCGTACCTGTCCGGGATGGACGTGGACGCGGACACGCACTGCTCCGTGCAGCAGTACCTCAAGCTCATCCAGCGCCGCGCCGCCGGGGACATCGTCACCACGGCCTCCTGGCTGCGAGCCTTTGTCACTAACCACCCGCATTACAAGAAAGACTCCGTTGTGACCGAGAAGATTAACTATGATTTGCTCAAGACGGCGCACGGAATACAGGACGGCAGTATCCCCGCGCCGACGCTGCTGGGCGGCGGCAACGTTTCGAAAACAAACGAAGACATTCCTAAAGCATTCACAAAGATGATGAGCAGGGATTGCTCTTAA

Protein

MGLLTEGSPLSWEETKALAEHVRQHGVEQFINLYRKLQDRTGDVLKWGDEVEYVIVKFDDKNERATVSLRANELLPKLQEKELADPQNVKSLWRPEYGGYMVEGTPGKPYGGLLAHFNIVEANMQYRRAEASALLQDGEVIMSITNFPRLGCTNFTSPPYKPTPNEGVTRSHYFPDEGIYQGHPRFKTLTSNIRLRRGEKVAINIPVFRDVNTKIPVDNSHTLEPDAAKPDCVYMDAMGFGMGCCCLQLTFQACCITEARTLYDQLAPLCPIMLALSAASPIYRGYLTDVDCRWNVISASVDCRTREERGLEPLKNNKFRIQKSRYDSIDSYLSPQNEKYNDIPIVHDQNIYKRLREGGIDHPLALHVAHLFIRDTVSLFSEKVHQDDENDTDHFENIQSTNWQTMRFKPPPPNSSIGWRVEFRPCEAQLTDFENAAYVCFVVLLTRVILSYQLNFVMPISKVDENMQRAQRRGACLNEKFWWRRDVGAPRDVAPPHSDATDEYHEMSINDIVNGKEGVFPGLIPLIESYLSGMDVDADTHCSVQQYLKLIQRRAAGDIVTTASWLRAFVTNHPHYKKDSVVTEKINYDLLKTAHGIQDGSIPAPTLLGGGNVSKTNEDIPKAFTKMMSRDCS

Description

Structural component of the gap junctions.

Similarity

Belongs to the pannexin family.

Uniprot

H9JDI5   A0A024BUM0   A0A194PQK5   A0A2H1WDL3   A0A194R769   A0A2A4JI27   + More
A0A212FIU5   A0A1Y1LR59   D6WMT3   A0A1Q3FKN8   A0A1Q3FKV2   B0WXU0   A0A2J7PEM3   N6TU59   A0A023EVH1   A0A0L0C9M0   A0A067QZ11   A0A182HEE1   A0A1L8E043   A0A182HBR3   A0A182FRQ1   Q0IER7   W5J784   A0A182NQD4   A0A2M4AE16   A0A0K8TTX2   A0A1B0CMK6   A0A182S952   A0A232F7L2   A0A1I8MHJ6   Q7PUX7   A0A182HL28   K7IQV8   A0A182WS79   A0A182VA52   A0A182IWX3   A0A1I8P6Y9   A0A182L9E5   U5EZ27   A0A182Q841   A0A182VWF6   A0A182YAI4   A0A182PGY0   A0A182MDJ0   A0A1A9W258   A0A0C9RPA2   A0A2A3E5I3   A0A182R4Y7   A0A0F6MTX0   A0A1B0AK35   A0A154NZU7   A0A1B0AX38   A0A0M9A6C5   A0A182JSQ6   D3TN86   A0A1A9X7N0   A0A1A9ULK3   E2BWC4   M9NY85   J9JNU8   A0A1B6EXE4   A0A195CCN2   A0A158NNF1   A0A0A1X671   A0A151WU98   A0A034VPX3   A0A1J1IHJ8   W8BLB9   A0A0P4W177   A0A0K8UFJ1   E0VFW3   A0A1B6MLF0   A0A026VVX6   A0A023F477   A0A0K8T088   A0A1E1WAA6   A0A0A9YHR1   A0A0P5JFM8   A0A0C9Q7V9   E9G6H2   A0A0P4ZS32   A0A164QPK4   A0A0P6B7G9   A0A336MRC6   A0A087ZPA6   E2APX7   A0A336MGZ6   A0A0P6FXG1   A0A0P5XA11   A0A0P4XHV7   T1PQP6   A0A131YIX0   A0A224YNI0   L7M9X0   A0A1E1XK40   T1IQF3   A0A1E1XA69   A0A0P6D1U2   A0A2L2YGB8   A0A0N8CPU6  

Pubmed

19121390    26354079    22118469    28004739    18362917    19820115    + More
23537049    24945155    26108605    24845553    26483478    17510324    20920257    23761445    26369729    28648823    25315136    12364791    14747013    17210077    20075255    20966253    25244985    20353571    20798317    21347285    25830018    25348373    24495485    27129103    20566863    24508170    30249741    25474469    25401762    21292972    26830274    28797301    25576852    29209593    28503490    26561354   

EMBL

BABH01030150    KJ576897    AHZ21071.1    KJ576898    AHZ21072.1    KQ459602    + More
KPI93415.1    ODYU01007888    SOQ51056.1    KQ460615    KPJ13668.1    NWSH01001498    PCG71062.1    AGBW02008329    OWR53652.1    GEZM01051600    JAV74780.1    KQ971341    EFA04528.1    GFDL01006950    JAV28095.1    GFDL01006939    JAV28106.1    DS232173    EDS36750.1    NEVH01026090    PNF14793.1    APGK01018912    KB740085    KB632303    ENN81558.1    ERL91823.1    GAPW01000460    JAC13138.1    JRES01000687    KNC29133.1    KK852865    KDR14761.1    JXUM01005866    KQ560203    KXJ83847.1    GFDF01002189    JAV11895.1    JXUM01032289    JXUM01032290    JXUM01032291    JXUM01032292    CH477486    EAT40137.1    EAT40138.1    ADMH02001952    ETN60317.1    GGFK01005631    MBW38952.1    GDAI01000203    JAI17400.1    AJWK01018841    NNAY01000802    OXU26433.1    AAAB01008987    EAA00862.4    APCN01000879    GANO01001548    JAB58323.1    AXCN02001526    AXCM01000786    GBYB01001724    GBYB01010250    JAG71491.1    JAG80017.1    KZ288381    PBC26516.1    JN703733    AFC76311.1    KQ434786    KZC05147.1    JXJN01004989    KQ435726    KOX78147.1    CCAG010001626    CCAG010001627    EZ422888    ADD19164.1    GL451103    EFN80028.1    JQ762262    AFU11126.1    ABLF02025361    ABLF02025362    GECZ01027288    JAS42481.1    KQ977935    KYM98562.1    ADTU01021463    ADTU01021464    ADTU01021465    ADTU01021466    ADTU01021467    ADTU01021468    ADTU01021469    ADTU01021470    ADTU01021471    ADTU01021472    GBXI01015971    GBXI01007508    GBXI01002087    JAC98320.1    JAD06784.1    JAD12205.1    KQ982730    KYQ51480.1    GAKP01015088    GAKP01015087    JAC43865.1    CVRI01000048    CRK99012.1    GAMC01012434    JAB94121.1    GDKW01001158    JAI55437.1    GDHF01026877    JAI25437.1    DS235124    EEB12269.1    GEBQ01003246    JAT36731.1    KK107770    QOIP01000012    EZA47820.1    RLU15849.1    GBBI01002411    JAC16301.1    GBRD01007015    JAG58806.1    GDQN01007122    JAT83932.1    GBHO01041227    GBHO01014530    GBHO01014529    GBRD01001186    JAG02377.1    JAG29074.1    JAG29075.1    JAG64635.1    GDIQ01203202    JAK48523.1    GBYB01010248    JAG80015.1    GL732533    EFX84992.1    GDIP01208720    JAJ14682.1    LRGB01002384    KZS07939.1    GDIP01019313    JAM84402.1    UFQT01002091    SSX32630.1    GL441630    EFN64509.1    UFQT01001166    SSX29220.1    GDIQ01052721    JAN42016.1    GDIP01075148    JAM28567.1    GDIP01240976    JAI82425.1    KA650535    AFP65164.1    GEDV01009313    JAP79244.1    GFPF01008021    MAA19167.1    GACK01005076    JAA59958.1    GFAA01003752    JAT99682.1    JH431307    GFAC01003048    JAT96140.1    GDIQ01084149    JAN10588.1    IAAA01019897    IAAA01019898    IAAA01019899    IAAA01019900    IAAA01019901    LAA07077.1    GDIP01110679    JAL93035.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000007266    + More
UP000002320    UP000235965    UP000019118    UP000030742    UP000037069    UP000027135    UP000069940    UP000249989    UP000069272    UP000008820    UP000000673    UP000075884    UP000092461    UP000075901    UP000215335    UP000095301    UP000007062    UP000075840    UP000002358    UP000076407    UP000075903    UP000075880    UP000095300    UP000075882    UP000075886    UP000075920    UP000076408    UP000075885    UP000075883    UP000091820    UP000242457    UP000075900    UP000092445    UP000076502    UP000092460    UP000053105    UP000075881    UP000092444    UP000092443    UP000078200    UP000008237    UP000007819    UP000078542    UP000005205    UP000075809    UP000183832    UP000009046    UP000053097    UP000279307    UP000000305    UP000076858    UP000005203    UP000000311   

PRIDE

H9JDI5   

Pfam

PF03074   GCS        + More
PF00876   Innexin

Interpro

IPR014746   Gln_synth/guanido_kin_cat_dom        + More
IPR004308   GCS       
IPR011990   TPR-like_helical_dom_sf       
IPR000990   Innexin       
IPR033891   TTC38       

SUPFAM

SSF55931   SSF55931        + More
SSF48452   SSF48452       

Gene 3D

1.25.40.10    

CDD

cd05804  StaR_like

ProteinModelPortal

H9JDI5   A0A024BUM0   A0A194PQK5   A0A2H1WDL3   A0A194R769   A0A2A4JI27   + More
A0A212FIU5   A0A1Y1LR59   D6WMT3   A0A1Q3FKN8   A0A1Q3FKV2   B0WXU0   A0A2J7PEM3   N6TU59   A0A023EVH1   A0A0L0C9M0   A0A067QZ11   A0A182HEE1   A0A1L8E043   A0A182HBR3   A0A182FRQ1   Q0IER7   W5J784   A0A182NQD4   A0A2M4AE16   A0A0K8TTX2   A0A1B0CMK6   A0A182S952   A0A232F7L2   A0A1I8MHJ6   Q7PUX7   A0A182HL28   K7IQV8   A0A182WS79   A0A182VA52   A0A182IWX3   A0A1I8P6Y9   A0A182L9E5   U5EZ27   A0A182Q841   A0A182VWF6   A0A182YAI4   A0A182PGY0   A0A182MDJ0   A0A1A9W258   A0A0C9RPA2   A0A2A3E5I3   A0A182R4Y7   A0A0F6MTX0   A0A1B0AK35   A0A154NZU7   A0A1B0AX38   A0A0M9A6C5   A0A182JSQ6   D3TN86   A0A1A9X7N0   A0A1A9ULK3   E2BWC4   M9NY85   J9JNU8   A0A1B6EXE4   A0A195CCN2   A0A158NNF1   A0A0A1X671   A0A151WU98   A0A034VPX3   A0A1J1IHJ8   W8BLB9   A0A0P4W177   A0A0K8UFJ1   E0VFW3   A0A1B6MLF0   A0A026VVX6   A0A023F477   A0A0K8T088   A0A1E1WAA6   A0A0A9YHR1   A0A0P5JFM8   A0A0C9Q7V9   E9G6H2   A0A0P4ZS32   A0A164QPK4   A0A0P6B7G9   A0A336MRC6   A0A087ZPA6   E2APX7   A0A336MGZ6   A0A0P6FXG1   A0A0P5XA11   A0A0P4XHV7   T1PQP6   A0A131YIX0   A0A224YNI0   L7M9X0   A0A1E1XK40   T1IQF3   A0A1E1XA69   A0A0P6D1U2   A0A2L2YGB8   A0A0N8CPU6  

PDB

3LVW     E-value=4.53385e-128,     Score=1175

KEGG

101745128    K11204 glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2] | (RefSeq) GLC; glutamate--cysteine

PATHWAY

00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006750   GO:0004357   GO:0017109   GO:0016021   GO:0005921   GO:0006811   GO:0005886   GO:0016491   GO:0005488   GO:0016579   GO:0010181   GO:0016020   GO:0016876   GO:0043039   GO:0003824  

PANTHER

PTHR11164  

Subcellular location

Cell membrane  
Cell junction  
Gap junction  

Length:

633

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.38503

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00019

outside

1  -  633

 

 

Pi

347.879617

Theta

217.476431

Tajima's D

1.953344

CLR

0.203311

CSRT

0.87625618719064

Interpretation

Uncertain