Gene

KWMTBOMO09058  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007585

Annotation

nuclear_cap-binding_protein_subunit_2_[Bombyx_mori]

Location

Bomo_Chr15(-):10694836-10702194      View in EpiBrowser

Full name

Nuclear cap-binding protein subunit 2       + More
Nuclear cap-binding protein subunit 2B      
Nuclear cap-binding protein subunit 2-A      

Alternative Name

20 kDa nuclear cap-binding protein
NCBP 20 kDa subunit
20 kDa nuclear cap-binding protein B
NCBP 20 kDa subunit B
20 kDa nuclear cap-binding protein A
NCBP 20 kDa subunit A

Location in the cell

Nuclear   Reliability : 2.696

CDS

ATGAAGCGCAGTTATGATTCTATGAATTCTTCAATTGAAATAAGTTCCTATCGTGACCAACATTTTAAGGGATCCAGAAGCGAACAAGAAAAATTACTAAAAGCTTCGTCAACGCTTTACATTGGAAACCTTTCATTTTACACAACAGAAGAGCAAATTTATGAACTGTATTCACGATGCGGAGATATAAGAAGAGTAATAATGGGACTAGACAAATACAAGAAAACACCTTGTGGATTTTGTTTTGTAGAATACTATGCGCGGGAAGATGCCGAAAATTGTATGAGGTATATAAATGGCACGAGGCTGGATGACCGAATAATTCGCTGTGACTGGGATGCTGGATTCATTGAAGGTCGACAGTACGGTCGTGGCAAAACAGGAGGCCAGGTTAGAGATGAATATCGAACTGACTATGACGGTGGGCGTGGCGGTTATGGAAAAATAATAGCACAGAAAATAAACCCAAATACCCTAGAACGTTAA

Protein

MKRSYDSMNSSIEISSYRDQHFKGSRSEQEKLLKASSTLYIGNLSFYTTEEQIYELYSRCGDIRRVIMGLDKYKKTPCGFCFVEYYAREDAENCMRYINGTRLDDRIIRCDWDAGFIEGRQYGRGKTGGQVRDEYRTDYDGGRGGYGKIIAQKINPNTLER

Description

Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.

Subunit

Component of the nuclear cap-binding complex (CBC), a heterodimer composed of Cbp80 and Cbp20 that interacts with m7GpppG-capped RNA.
Component of the nuclear cap-binding complex (CBC), a heterodimer composed of Cbp80 and Cbp20 that interacts with m7GpppG-capped RNA. Interacts with Ars2 (By similarity).
Component of the nuclear cap-binding complex (CBC), a heterodimer composed of Cbp80 and Cbp20 that interacts with m7GpppG-capped RNA (By similarity). Interacts with Ars2.

Similarity

Belongs to the RRM NCBP2 family.

Keywords

Complete proteome   mRNA processing   mRNA splicing   Nucleus   Reference proteome   RNA-binding   RNA-mediated gene silencing  

Feature

chain  Nuclear cap-binding protein subunit 2

Uniprot

H9JDI8   S4P9H5   Q1HE01   I4DL42   A0A194R828   A0A2H1WMG3   + More
A0A2A4IZ84   A0A3S2NXE5   A0A212EP20   G3LHK0   A0A0L7R700   A0A088A289   A0A2A3E9T4   V9ICQ1   A0A154NWL5   A0A336LI33   E2A3N2   A0A1Y1MCN0   E2BZR2   V9IAX0   A0A444SV98   A0A0C9RG69   A0A1B0A379   A0A0J7KHR7   A0A1B6H1G3   A0A1A9WJK5   A0A1W4WSG3   U5EZ03   A0A139WHJ4   B4NB54   A0A151I6T1   A0A1B6KCH8   A0A1W4UKC9   B4KCD5   A0A1B0FCN3   A0A1A9VFM2   A0A1B0BL63   A0A3B0JSR5   B3P0D7   A0A151IHG8   B3LYP1   K7IQB1   A0A067RBF0   D6WM37   A0A232EMD7   B4JUT1   B4LZ88   N6U2F6   A0A1B6D912   A0A0M4EU17   B4PL68   A0A151JT06   F4W7G2   A0A158NPT2   A0A026WIT2   A0A195ATW7   V5G6M5   A0A1L8DGQ0   E0VZL3   A0A023FWR5   A0A1B2AJS4   B4QV17   B4IBA4   Q9V3L6   E9IX29   Q293V6   B4GLK8   A0A1E1WZA4   A0A195ELX1   W8BF96   A0A0K8VK80   A0A034WNU0   A0A1I8N678   A0A182J4Y4   T1JIT5   A0A1W4WHK9   A0A182XUB9   A0A182HSR2   A0A182THK9   Q7QCB6   A0A182QZA7   A0A023GF49   B4M205   A0A131XFD8   A0A1Q3F9S3   Q177H0   A0A023GIA2   G3MRC8   A0A182FSN8   A0A1E1XS28   A0A182MVK5   A0A2M4C1W1   L7M335   A0A0K8R3D5   T1DPN7   A0A2M4AWV9   B7P877   A0A023F904   W5JJG8   A0A0A9WJM4  

Pubmed

19121390    23622113    22651552    26354079    22118469    21840855    + More
20798317    28004739    18362917    19820115    17994087    20075255    24845553    28648823    23537049    21719571    21347285    24508170    30249741    20566863    10731132    12537572    12537569    19632183    21282665    15632085    28503490    24495485    25348373    25315136    12364791    28049606    17510324    22216098    29209593    25576852    25474469    20920257    23761445    25401762    26823975   

EMBL

BABH01030165    BABH01030166    BABH01030167    GAIX01003754    JAA88806.1    DQ497196    + More
AK402010    KQ459602    BAM18632.1    KPI93403.1    KQ460615    KPJ13659.1    ODYU01009673    SOQ54263.1    NWSH01004559    PCG64949.1    RSAL01000033    RVE51440.1    AGBW02013542    OWR43242.1    JN383803    AEN04479.1    KQ414645    KOC66623.1    KZ288311    PBC28485.1    JR038394    AEY58236.1    KQ434775    KZC04069.1    UFQT01000006    SSX17440.1    GL436457    EFN71924.1    GEZM01037472    JAV82055.1    GL451657    EFN78824.1    JR038393    AEY58235.1    SAUD01036024    SAUD01021932    RXG53043.1    RXG57328.1    GBYB01006046    JAG75813.1    LBMM01007405    KMQ89756.1    GECZ01001309    JAS68460.1    GANO01001670    JAB58201.1    KQ971343    KYB27267.1    CH964232    KQ978456    KYM93882.1    GEBQ01030836    JAT09141.1    CH933806    CCAG010010183    JXJN01016227    OUUW01000007    SPP83442.1    CH954181    KQ977606    KYN01432.1    CH902617    KK852751    KDR17129.1    EFA03363.2    NNAY01003394    OXU19488.1    CH916374    CH940650    APGK01044818    KB741028    KB632297    ENN74806.1    ERL91700.1    GEDC01015120    JAS22178.1    CP012526    ALC46492.1    CM000160    KQ982014    KYN30650.1    GL887844    EGI69835.1    ADTU01022743    KK107183    QOIP01000011    EZA55888.1    RLU17249.1    KQ976745    KYM75465.1    GALX01002731    JAB65735.1    GFDF01008451    JAV05633.1    DS235853    EEB18819.1    GBBL01002185    JAC25135.1    KX531599    ANY27409.1    CM000364    CH480827    AJ238969    AE014297    AY070578    GL766616    EFZ14881.1    CM000070    CH479185    GFAC01006825    JAT92363.1    KQ978730    KYN28922.1    GAMC01009165    GAMC01009163    JAB97392.1    GDHF01013046    JAI39268.1    GAKP01003097    JAC55855.1    JH431723    APCN01000326    AAAB01008859    AXCN02000007    GBBM01002911    JAC32507.1    CH940651    GEFH01002367    JAP66214.1    GFDL01010763    JAV24282.1    CH477376    GBBM01002938    JAC32480.1    JO844429    AEO36046.1    GFAA01001309    JAU02126.1    AXCM01002097    GGFJ01010152    MBW59293.1    GACK01006303    JAA58731.1    GADI01008206    JAA65602.1    GAMD01003189    JAA98401.1    GGFK01011966    MBW45287.1    DS656359    GBBI01000777    JAC17935.1    ADMH02001312    ETN63045.1    GBHO01038539    GBRD01007595    GDHC01012631    JAG05065.1    JAG58226.1    JAQ05998.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000283053    UP000007151    + More
UP000053825    UP000005203    UP000242457    UP000076502    UP000000311    UP000008237    UP000288706    UP000092445    UP000036403    UP000091820    UP000192223    UP000007266    UP000007798    UP000078542    UP000192221    UP000009192    UP000092444    UP000078200    UP000092460    UP000268350    UP000008711    UP000007801    UP000002358    UP000027135    UP000215335    UP000001070    UP000008792    UP000019118    UP000030742    UP000092553    UP000002282    UP000078541    UP000007755    UP000005205    UP000053097    UP000279307    UP000078540    UP000009046    UP000000304    UP000001292    UP000000803    UP000001819    UP000008744    UP000078492    UP000095301    UP000075880    UP000076407    UP000075840    UP000075902    UP000007062    UP000075886    UP000008820    UP000069272    UP000075883    UP000001555    UP000000673   

PRIDE

H9JDI8    Q1HE01    Q9V3L6   

Pfam

PF00076   RRM_1

Interpro

IPR027157   NCBP2        + More
IPR035979   RBD_domain_sf       
IPR034148   NCBP2_RRM       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       

SUPFAM

SSF54928   SSF54928       

Gene 3D

3.30.70.330    

CDD

cd12240  RRM_NCBP2

ProteinModelPortal

H9JDI8   S4P9H5   Q1HE01   I4DL42   A0A194R828   A0A2H1WMG3   + More
A0A2A4IZ84   A0A3S2NXE5   A0A212EP20   G3LHK0   A0A0L7R700   A0A088A289   A0A2A3E9T4   V9ICQ1   A0A154NWL5   A0A336LI33   E2A3N2   A0A1Y1MCN0   E2BZR2   V9IAX0   A0A444SV98   A0A0C9RG69   A0A1B0A379   A0A0J7KHR7   A0A1B6H1G3   A0A1A9WJK5   A0A1W4WSG3   U5EZ03   A0A139WHJ4   B4NB54   A0A151I6T1   A0A1B6KCH8   A0A1W4UKC9   B4KCD5   A0A1B0FCN3   A0A1A9VFM2   A0A1B0BL63   A0A3B0JSR5   B3P0D7   A0A151IHG8   B3LYP1   K7IQB1   A0A067RBF0   D6WM37   A0A232EMD7   B4JUT1   B4LZ88   N6U2F6   A0A1B6D912   A0A0M4EU17   B4PL68   A0A151JT06   F4W7G2   A0A158NPT2   A0A026WIT2   A0A195ATW7   V5G6M5   A0A1L8DGQ0   E0VZL3   A0A023FWR5   A0A1B2AJS4   B4QV17   B4IBA4   Q9V3L6   E9IX29   Q293V6   B4GLK8   A0A1E1WZA4   A0A195ELX1   W8BF96   A0A0K8VK80   A0A034WNU0   A0A1I8N678   A0A182J4Y4   T1JIT5   A0A1W4WHK9   A0A182XUB9   A0A182HSR2   A0A182THK9   Q7QCB6   A0A182QZA7   A0A023GF49   B4M205   A0A131XFD8   A0A1Q3F9S3   Q177H0   A0A023GIA2   G3MRC8   A0A182FSN8   A0A1E1XS28   A0A182MVK5   A0A2M4C1W1   L7M335   A0A0K8R3D5   T1DPN7   A0A2M4AWV9   B7P877   A0A023F904   W5JJG8   A0A0A9WJM4  

PDB

6D0Y     E-value=2.93098e-51,     Score=504

KEGG

733050    K12883 nuclear cap-binding protein subunit 2 | (RefSeq) Cbp20; nuclear cap-binding protein subunit 2

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)
03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)
03040    Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0000339   GO:0005846   GO:0045292   GO:0005634   GO:0031047   GO:0006397   GO:0003723   GO:0008380   GO:0045071   GO:0030422   GO:0031053   GO:0000398   GO:0071013   GO:0005681   GO:0071011   GO:0003729   GO:0016246   GO:0035195   GO:0003676   GO:0000166   GO:0008750   GO:0016021   GO:0050661   GO:0005254   GO:0006811   GO:0016020   GO:0016876   GO:0043039  

PANTHER

PTHR18847  

Subcellular location

Nucleus  

Length:

161

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00875

Exp number, first 60 AAs:

0.00875

Total prob of N-in:

0.40636

outside

1  -  161

 

 

Pi

205.061487

Theta

173.860589

Tajima's D

2.66624

CLR

0.902967

CSRT

0.960601969901505

Interpretation

Uncertain