Gene

KWMTBOMO09054  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007586

Annotation

NADPH-specific_isocitrate_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr15(-):10627596-10633824      View in EpiBrowser

Full name

Isocitrate dehydrogenase [NADP]      

Location in the cell

Cytoplasmic   Reliability : 3.431

CDS

ATGGCTAATACTAGTACAACAAAAATTCTAAAGTGTGTAAACCAGTTTGCATCACTGACTAGAAACTATGGAACTGCTAAGAGAGTTGTGGCTGCTAAACCAGTTGTCGAGATGGATGGTGATGAGATGACACGCATCATCTGGGCTAAGATCAAAGAGAGGCTGATATTTCCATATGTTAAGGTGGATTGTCTTTACTTTGACTTGGGCCTCCCGCATCGTGACGCCACTGATGATCAGGTCACCATCGACTCAGCGCATGCCATTCTAAAGCATAATGTGGGCATCAAATGCGCTACTATCACACCTGATGAACAAAGAGTAGAAGAGTTCAAGTTGAAGAAAATGTGGCTAAGTCCGAACGGAACGATCCGTAACATTTTGGGCGGTACAGTATTCCGTGAACCGATATTGTGTCAGAGTATCCCGAGGGTTGTGCCTGGTTGGACGAAACCTATTGTGATAGGCCGTCATGCGCACGGCGACCAATACAAGGCGCAAGATTTTGTTGTACCGAAACCCGGAAAGGTTGAACTCGTTTACACTACACAAGATGGTACGACTGAGAGGCGTGTATTATATGATTTTAAAACTCCAGGCGTTGCTATGGGCATGTACAATACCGACGAATCGATTCGGTCCTTTGCCCATTCCAGTTTTCAGGTAGCTTTACAGAAAAAATGGCCTCTATACCTGTCCACGAAGAATACCATTTTGAAACGTTACGATGGTCGTTTCAAAGACATTTTCGAAGAAGTTTTTCAGAGTGATTACAAGACTAAGTTTGATGAAGCCAAGATATGGTACGAGCATCGTTTAATTGACGACATGGTGGCACAGGCTATTAAGGGATCAGGTGGCTTTGTTTGGGCCTGCAAAAACTACGACGGAGATGTGCAGTCCGATATTGTTGCTCAGGGTTACGGGTCATTGGGAATGATGACATCAGTATTGATGTGTCCCGATGGCCGTACCGTGGAATCCGAAGCGGCGCACGGGACGGTGACGCGTCACTACCGTATGCACCAGCAAGGCAAGCCGACATCGACTAACCCGGTCGCTTCTATCTACGCCTGGACCAGAGGCCTTGCACACCGGGCCAAATTAGACGGGACTCCCGAATTGGAGCGCTTCGCTCTAGCCCTCGAAGAGGCGTGCGTCGAGTGCATCGATAGCGGTAAAATGACAAAAGATTTGGTTATTTGTATACACGGATTGGCGAACACGAAAGAAGGTATGTTTTTACACACCGAAGATTTCCTGGAGGCCATCGCCGAGCAGCTGGAACGCAAGTTGGGCGGCAAATAA

Protein

MANTSTTKILKCVNQFASLTRNYGTAKRVVAAKPVVEMDGDEMTRIIWAKIKERLIFPYVKVDCLYFDLGLPHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPILCQSIPRVVPGWTKPIVIGRHAHGDQYKAQDFVVPKPGKVELVYTTQDGTTERRVLYDFKTPGVAMGMYNTDESIRSFAHSSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKIWYEHRLIDDMVAQAIKGSGGFVWACKNYDGDVQSDIVAQGYGSLGMMTSVLMCPDGRTVESEAAHGTVTRHYRMHQQGKPTSTNPVASIYAWTRGLAHRAKLDGTPELERFALALEEACVECIDSGKMTKDLVICIHGLANTKEGMFLHTEDFLEAIAEQLERKLGGK

Catalytic Activity

isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH

Similarity

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Uniprot

Q1HQ47   Q2F682   S4PG03   C5IU79   A0A437BJH0   A0A194PJ03   + More
A0A2A4J839   A0A2H1WMR5   A0A0L7KS43   A0A336L332   A0A1L8E0T4   D6WMM9   U5EUN0   A0A2Z5RE44   A0A2J7QTH1   A0A182FQB7   A0A194RCL7   A0A182GWF1   A0A1Q3G3V0   W5JVS7   A0A0P6IWM1   A0A2M4AET7   A0A1B6DUK8   T1DNG1   A0A2M3ZH85   A0A2M4BN00   A0A182IQW4   A0A182MDB5   A0A182R385   A0A182TNU5   A0A182VLM9   A0A182XE67   A0A182LCC4   Q7PQQ3   A0A182HJ56   A0A067R707   A0A084VT63   A0A182PAH4   A0A182K1D2   A0A212EP23   A0A1B6H9E0   A0A182VXG5   A0A170ZT89   A0A182XWU0   A0A182QLM4   A0A1B0GPW4   A0A1B6L4T4   B0W8J6   R4WRJ5   A0A1Q3FH56   A0A1J1J8G1   A0A023ERF4   A0A182NFS3   A0A0P6GDX1   A0A164X3A6   T1HWW5   A0A0P5M0M1   V5G6Y6   A0A0P6IAQ5   A0A2S2P120   A0A0N7Z8U3   J9K5R3   A0A0C5Q4W6   E9GAE4   A0A069DU83   A0A3R7SZS6   A0A0P6CFA3   A0A023F9T3   A0A2P1JJ64   A0A224XDB6   A0A2H8TLD4   A0A1Y1KBI4   A0A0L8H5J4   R4G2N3   A0A0V0GA37   A0A182SBQ9   D3PJB8   A0A0P5G6F5   A0A1D2MS27   A0A226ELI4   A0A2L2XYP2   A0A0P5ZHN6   U4UK34   J3JWC0   V3ZNV5   A0A0N8CY74   E0VCW6   N6U0Y1   A0A1I8JHX3   A0A087TI66   A0A1I8IEN0   T1JA51   A0A1I8IA73   A0A2T7PFS0   A0A0V1DFM4   A0A267E1V2   K1RZE2   A0A0V1DGP9   A0A023GKA1   I1VYX6  

EC Number

1.1.1.42

Pubmed

19121390    23622113    26354079    26227816    18362917    19820115    + More
26760975    26483478    20920257    23761445    26999592    20966253    12364791    14747013    17210077    24845553    24438588    22118469    25244985    23691247    24945155    27129103    25702953    21292972    26334808    25474469    28004739    27289101    26561354    23537049    22516182    23254933    20566863    26392545    22992520    22491035   

EMBL

BABH01030171    DQ443205    ABF51294.1    DQ311190    ABD36135.1    GAIX01003827    + More
JAA88733.1    FJ959347    ACR46834.1    RSAL01000046    RVE50546.1    KQ459602    KPI93401.1    NWSH01002582    PCG67926.1    ODYU01009673    SOQ54266.1    JTDY01006605    KOB65844.1    UFQS01001784    UFQT01001784    SSX12346.1    SSX31797.1    GFDF01001773    JAV12311.1    KQ971343    EFA04299.1    GANO01002250    JAB57621.1    FX983736    BAX07235.1    NEVH01011194    PNF31876.1    KQ460615    KPJ13656.1    JXUM01094140    KQ564106    KXJ72785.1    GFDL01000563    JAV34482.1    ADMH02000324    ETN66969.1    GDUN01000615    JAN95304.1    GGFK01005827    MBW39148.1    GEDC01007945    JAS29353.1    GAMD01002915    JAA98675.1    GGFM01007176    MBW27927.1    GGFJ01005316    MBW54457.1    AXCM01007766    AAAB01008879    EAA08466.6    APCN01002125    KK852901    KDR14081.1    ATLV01016236    ATLV01016237    KE525072    KFB41157.1    AGBW02013542    OWR43245.1    GECU01036452    GECU01029594    GECU01008122    JAS71254.1    JAS78112.1    JAS99584.1    GEMB01001892    JAS01280.1    AXCN02000243    AJVK01064286    GEBQ01021312    JAT18665.1    DS231859    EDS39046.1    AK417312    BAN20527.1    GFDL01008159    JAV26886.1    CVRI01000073    CRL07750.1    GAPW01001833    JAC11765.1    GDIQ01034567    JAN60170.1    LRGB01001019    KZS13828.1    ACPB03018449    GDIQ01171422    JAK80303.1    GALX01002616    JAB65850.1    GDIQ01007229    JAN87508.1    GGMR01010423    MBY23042.1    GDKW01002387    JAI54208.1    ABLF02033188    KM609497    AJQ30121.1    GL732537    EFX83537.1    GBGD01001627    JAC87262.1    QCYY01000697    ROT83362.1    GDIP01016173    JAM87542.1    GBBI01000948    JAC17764.1    MF385062    AVN99057.1    GFTR01005991    JAW10435.1    GFXV01003149    MBW14954.1    GEZM01087167    JAV58873.1    KQ419114    KOF84561.1    GAHY01002456    JAA75054.1    GECL01001869    JAP04255.1    BT121724    HACA01002101    ADD38654.1    CDW19462.1    GDIQ01245752    JAK05973.1    LJIJ01000610    ODM95890.1    LNIX01000003    OXA58545.1    IAAA01001112    IAAA01001113    IAAA01001114    LAA01074.1    GDIP01043405    JAM60310.1    KB632357    ERL93482.1    BT127538    AEE62500.1    KB203188    ESO85992.1    GDIP01087255    JAM16460.1    DS235065    EEB11222.1    APGK01043801    KB741018    ENN75185.1    NIVC01001062    PAA72755.1    KK115333    KFM64805.1    JH431984    PZQS01000004    PVD32273.1    JYDI01000007    KRY60164.1    NIVC01002850    PAA54857.1    JH817892    EKC40376.1    KRY60163.1    GBBM01001107    JAC34311.1    JQ429383    AFI56368.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000218220    UP000037510    UP000007266    + More
UP000235965    UP000069272    UP000053240    UP000069940    UP000249989    UP000000673    UP000075880    UP000075883    UP000075900    UP000075902    UP000075903    UP000076407    UP000075882    UP000007062    UP000075840    UP000027135    UP000030765    UP000075885    UP000075881    UP000007151    UP000075920    UP000076408    UP000075886    UP000092462    UP000002320    UP000183832    UP000075884    UP000076858    UP000015103    UP000007819    UP000000305    UP000283509    UP000053454    UP000075901    UP000094527    UP000198287    UP000030742    UP000030746    UP000009046    UP000019118    UP000095280    UP000215902    UP000054359    UP000245119    UP000054653    UP000005408   

PRIDE

Q1HQ47    Q2F682   

Pfam

PF00180   Iso_dh        + More
PF00400   WD40

Interpro

IPR019818   IsoCit/isopropylmalate_DH_CS        + More
IPR004790   Isocitrate_DH_NADP       
IPR024084   IsoPropMal-DH-like_dom       
IPR019775   WD40_repeat_CS       
IPR017986   WD40_repeat_dom       
IPR036322   WD40_repeat_dom_sf       
IPR001680   WD40_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

Q1HQ47   Q2F682   S4PG03   C5IU79   A0A437BJH0   A0A194PJ03   + More
A0A2A4J839   A0A2H1WMR5   A0A0L7KS43   A0A336L332   A0A1L8E0T4   D6WMM9   U5EUN0   A0A2Z5RE44   A0A2J7QTH1   A0A182FQB7   A0A194RCL7   A0A182GWF1   A0A1Q3G3V0   W5JVS7   A0A0P6IWM1   A0A2M4AET7   A0A1B6DUK8   T1DNG1   A0A2M3ZH85   A0A2M4BN00   A0A182IQW4   A0A182MDB5   A0A182R385   A0A182TNU5   A0A182VLM9   A0A182XE67   A0A182LCC4   Q7PQQ3   A0A182HJ56   A0A067R707   A0A084VT63   A0A182PAH4   A0A182K1D2   A0A212EP23   A0A1B6H9E0   A0A182VXG5   A0A170ZT89   A0A182XWU0   A0A182QLM4   A0A1B0GPW4   A0A1B6L4T4   B0W8J6   R4WRJ5   A0A1Q3FH56   A0A1J1J8G1   A0A023ERF4   A0A182NFS3   A0A0P6GDX1   A0A164X3A6   T1HWW5   A0A0P5M0M1   V5G6Y6   A0A0P6IAQ5   A0A2S2P120   A0A0N7Z8U3   J9K5R3   A0A0C5Q4W6   E9GAE4   A0A069DU83   A0A3R7SZS6   A0A0P6CFA3   A0A023F9T3   A0A2P1JJ64   A0A224XDB6   A0A2H8TLD4   A0A1Y1KBI4   A0A0L8H5J4   R4G2N3   A0A0V0GA37   A0A182SBQ9   D3PJB8   A0A0P5G6F5   A0A1D2MS27   A0A226ELI4   A0A2L2XYP2   A0A0P5ZHN6   U4UK34   J3JWC0   V3ZNV5   A0A0N8CY74   E0VCW6   N6U0Y1   A0A1I8JHX3   A0A087TI66   A0A1I8IEN0   T1JA51   A0A1I8IA73   A0A2T7PFS0   A0A0V1DFM4   A0A267E1V2   K1RZE2   A0A0V1DGP9   A0A023GKA1   I1VYX6  

PDB

1LWD     E-value=6.14212e-178,     Score=1603

KEGG

100101164    K00031 isocitrate dehydrogenase [EC:1.1.1.42] | (RefSeq) NADPH-specific isocitrate dehydrogenase

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)
01210    2-Oxocarboxylic acid metabolism - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)
04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0006099   GO:0000287   GO:0006102   GO:0004450   GO:0051287   GO:0005739   GO:0046872   GO:0006739   GO:0016021   GO:0016616   GO:0005254   GO:0006811   GO:0016020   GO:0016876   GO:0043039   GO:0055114  

PANTHER

PTHR11822  

Length:

435

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00505999999999999

Exp number, first 60 AAs:

0.00119

Total prob of N-in:

0.01496

outside

1  -  435

 

 

Pi

205.507663

Theta

176.522733

Tajima's D

0.61056

CLR

0.656967

CSRT

0.545372731363432

Interpretation

Uncertain