Gene

KWMTBOMO09053  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007501

Annotation

PREDICTED:_O-glucosyltransferase_rumi_homolog_[Papilio_machaon]

Location

Bomo_Chr15(+):10621325-10625529      View in EpiBrowser

Full name

O-glucosyltransferase rumi homolog       + More
O-glucosyltransferase rumi      

Location in the cell

Cytoplasmic   Reliability : 1.388 Nuclear   Reliability : 1.302

CDS

ATGTTAGATAGACCGTCGCTTATTATCTTATATTTTGTTTTATGTACTATTAGCTGCTATTTTTGTGAACATTATTGCAGCGGCGCCGAAAACACGTGTAAAGAAGATAAAAATAAATATAGTAGAGATGTAAATGAGTGGACTTCTAACTTAAAGAATGAAATAAAACGAGCCTTAGAACAATATGCTCCTTGCAAGAAAGAAAATTGTAGCTGTCATAGATCAGTAATTGATAGTGATCTGGCTCCATACCAGGATGGTATAACCAATGAAATGTTCATCTCAGCTCGAGCAAAGGGTACCAAGTACCAGGTCATAGATGGCAAGTTGTACCGAGAGGAAAATTGCCATTTTCCAGCCAGGTGTGCTGGTGTTGAACATTATATGAAATCTTTGAATTTAAAGAAGCTCTCAAATATGGAAGTATCCATTAATACTAGAGATTGGCCACAAGTTAACAAACTTTGGGGCCAAAAAAAAGCACCAGTGCTCTCTTTTAGTAAGACACAAGACTATTATGATATTATGTATCCTGCTTGGAGCTTTTGGGAAGGAGGGCCAGCCATAGCACTATACCCCACGGGTATAGGACGATGGGATGAACATAGAAAATCAATTTCCCTTGCAGCCAAAAAGAGCCCTTGGGATAAGAAAAAAGCAAAAGCATTCTTCCGAGGTTCAAGAACTAGTGAAGAAAGAGATGCTTTAATATTACTATCTCGTTCTAAACCTGATCTTGTAGATGCACAATATACCAAGAATCAGGCTTGGAAGTCAGATGCAGATACACTACATGCTCCTGCCGCCTCAGAAGTGTCCTTTGAAGATCATTGCAAATATAAATATCTGTTTAACTACAGAGGCGTAGCAGCTAGTTTCAGATTTAAACATTTATTTCTATGCAAATCCTTGGTTTTTCATGTCGGTGATGAATGGCTAGAATTCTTCTATCCGTCACTGAAGCCTTGGGTGCATTATATACCAATTAGCCCAAAGGCAAGCAAAGATGAAATTCAACAAGTCATAGAATTCTTTAAAGCTGAGGATGCACTTGCAAAGGAAATAGCAGATAGGGGATTTCAACATATTTGGGAAAACTTAGATGATGATGATGTGAAATGTTATTGGCAAATATTATTGAAGAAATATTCTAAACTAATAAAATATAAAGTTGTAAAAGATAAAGATCTGATAGAAATATAA

Protein

MLDRPSLIILYFVLCTISCYFCEHYCSGAENTCKEDKNKYSRDVNEWTSNLKNEIKRALEQYAPCKKENCSCHRSVIDSDLAPYQDGITNEMFISARAKGTKYQVIDGKLYREENCHFPARCAGVEHYMKSLNLKKLSNMEVSINTRDWPQVNKLWGQKKAPVLSFSKTQDYYDIMYPAWSFWEGGPAIALYPTGIGRWDEHRKSISLAAKKSPWDKKKAKAFFRGSRTSEERDALILLSRSKPDLVDAQYTKNQAWKSDADTLHAPAASEVSFEDHCKYKYLFNYRGVAASFRFKHLFLCKSLVFHVGDEWLEFFYPSLKPWVHYIPISPKASKDEIQQVIEFFKAEDALAKEIADRGFQHIWENLDDDDVKCYWQILLKKYSKLIKYKVVKDKDLIEI

Description

Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.
Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats (PubMed:27428513). Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.

Similarity

Belongs to the glycosyltransferase 90 family.

Keywords

Complete proteome   Disulfide bond   Endoplasmic reticulum   Glycoprotein   Glycosyltransferase   Reference proteome   Secreted   Signal   Transferase   Notch signaling pathway   3D-structure  

Feature

chain  O-glucosyltransferase rumi homolog

Uniprot

A0A2H1WMN1   H9JDA4   A0A2A4J764   A0A3S2NGL2   A0A194R8S8   A0A194PQJ1   + More
A0A182H7G6   A0A182XX24   A0A1B0CVG1   A0A182JUK6   A0A1Q3EX11   A0A182QC01   W5JGS3   A0A2M4BQH3   A0A2M4BQH5   D6WKX5   A0A182NCX2   A0A336LJ21   A0A2M4BQH7   A0A182PS68   Q16QY8   A0A182RX70   A0A182FPF5   A0A067R6Q8   B0X1Q4   A0A182JFZ3   A0A182M506   A0A182W175   A0NDG6   A0A1W4XG66   A0A182VID6   A0A182L706   A0A182XG15   A0A182U7P6   A0A0N7ZA70   E9GPM7   A0A182ID61   Q29AU6   A0A151XD45   E9IUB8   B4G5X6   A0A232EDB9   A0A164KP06   A0A0P5TNA4   A0A195FGP7   B3LZQ3   A0A0P6AAJ7   A0A0P5M9X3   A0A0P6IJ49   A0A1J1IR89   A0A0P5XKM7   A0A0P5A993   A0A158NGW7   F4WZU1   B4R0R3   A0A195B6N0   A0A1A9Z9Z7   A0A1W4VK38   B3P8J6   A0A226E664   B4PMF4   B4HET9   A0A0L0BN71   Q8T045   A0A0P6FRM3   A0A0P6F3Q6   A0A151II91   W8BTG6   A0A1B6HQ52   A0A0K8WM16   E2ARY7   A0A1A9W1A1   K1Q9M3   A0A3B0KBF9   A0A0P5LZ81   E0W3T1   A0A293LAX1   A0A099ZT40   A0A1B6DS49   A0A093HRN4   A0A091HKU8   A0A195DWF1   A0A093EZX5   A0A091U372   A0A093P427   A0A091K2M9   K7J7V2   A0A0A0ARU6   A0A091IZJ3   H0ZTH7   A0A091ELJ1   B4KBE5   A0A093F916   A0A091GH44   A0A2Y9DGJ0   A0A0Q3M9I3   U3JFL6   A0A093G990   A0A1U7QG35   A0A091U4A7  

EC Number

2.4.1.-

Pubmed

19121390    26354079    26483478    25244985    20920257    23761445    + More
18362917    19820115    17510324    24845553    12364791    20966253    21292972    15632085    21282665    17994087    28648823    21347285    21719571    17550304    26108605    10731132    12537572    12537569    18243100    27807076    27428513    24495485    20798317    22992520    20566863    20075255    20360741   

EMBL

ODYU01009673    SOQ54267.1    BABH01030171    NWSH01002582    PCG67925.1    RSAL01000046    + More
RVE50548.1    KQ460615    KPJ13655.1    KQ459602    KPI93400.1    JXUM01116197    KQ565958    KXJ70493.1    AJWK01030488    GFDL01015202    JAV19843.1    AXCN02001559    ADMH02001267    ETN63286.1    GGFJ01006194    MBW55335.1    GGFJ01006195    MBW55336.1    KQ971343    EFA03548.1    UFQT01000012    SSX17605.1    GGFJ01006196    MBW55337.1    CH477727    EAT36834.1    KK852661    KDR19100.1    DS232266    EDS38782.1    AXCM01004697    AAAB01008880    EAU76986.1    GDRN01103765    JAI58024.1    GL732557    EFX78410.1    APCN01005034    CM000070    EAL27253.1    KQ982294    KYQ58269.1    GL765937    EFZ15836.1    CH479179    EDW23731.1    NNAY01006883    OXU16351.1    LRGB01003275    KZS03426.1    GDIP01124302    JAL79412.1    KQ981625    KYN39174.1    CH902617    EDV43047.1    GDIP01033296    JAM70419.1    GDIQ01162930    JAK88795.1    GDIQ01010207    JAN84530.1    CVRI01000057    CRL02068.1    GDIP01070706    JAM33009.1    GDIP01202339    JAJ21063.1    ADTU01015296    GL888480    EGI60366.1    CM000364    EDX13986.1    KQ976574    KYM80173.1    CH954182    EDV54091.1    LNIX01000006    OXA53103.1    CM000160    EDW98059.1    CH480815    EDW43250.1    JRES01001623    KNC21462.1    AE014297    AY069564    AAL39709.1    AAN13920.1    GDIQ01046377    JAN48360.1    GDIQ01062015    JAN32722.1    KQ977492    KYN02298.1    GAMC01004078    JAC02478.1    GECU01030904    JAS76802.1    GDHF01000215    JAI52099.1    GL442209    EFN63761.1    JH816276    EKC30658.1    OUUW01000007    SPP83006.1    GDIQ01162929    JAK88796.1    AAZO01007449    DS235882    EEB20287.1    GFWV01000188    MAA24918.1    KL897324    KGL84343.1    GEDC01008829    JAS28469.1    KL206729    KFV85323.1    KL217544    KFO96486.1    KQ980204    KYN17218.1    KK379424    KFV47561.1    KK497091    KFQ66178.1    KL225051    KFW67027.1    KK539516    KFP30453.1    AAZX01012650    KL872973    KGL97294.1    KK501141    KFP12943.1    ABQF01024500    KK718540    KFO57462.1    CH933806    EDW16873.1    KK625205    KFV53060.1    KL447422    KFO73457.1    LMAW01002593    KQK79357.1    AGTO01011023    KL215807    KFV66770.1    KK414333    KFQ84872.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000069940    + More
UP000249989    UP000076408    UP000092461    UP000075881    UP000075886    UP000000673    UP000007266    UP000075884    UP000075885    UP000008820    UP000075900    UP000069272    UP000027135    UP000002320    UP000075880    UP000075883    UP000075920    UP000007062    UP000192223    UP000075903    UP000075882    UP000076407    UP000075902    UP000000305    UP000075840    UP000001819    UP000075809    UP000008744    UP000215335    UP000076858    UP000078541    UP000007801    UP000183832    UP000005205    UP000007755    UP000000304    UP000078540    UP000092445    UP000192221    UP000008711    UP000198287    UP000002282    UP000001292    UP000037069    UP000000803    UP000078542    UP000000311    UP000091820    UP000005408    UP000268350    UP000009046    UP000053641    UP000053584    UP000054308    UP000078492    UP000054081    UP000002358    UP000053858    UP000053119    UP000007754    UP000052976    UP000009192    UP000053760    UP000248480    UP000051836    UP000016665    UP000053875    UP000189706   

PRIDE

H9JDA4    Q8T045   

Pfam

PF05686   Glyco_transf_90        + More
PF00173   Cyt-b5
PF00487   FA_desaturase

Interpro

IPR006598   CAP10        + More
IPR001199   Cyt_B5-like_heme/steroid-bd       
IPR005804   FA_desaturase_dom       
IPR036400   Cyt_B5-like_heme/steroid_sf       
IPR018506   Cyt_B5_heme-BS       

SUPFAM

SSF55856   SSF55856       

Gene 3D

3.10.120.10    

ProteinModelPortal

A0A2H1WMN1   H9JDA4   A0A2A4J764   A0A3S2NGL2   A0A194R8S8   A0A194PQJ1   + More
A0A182H7G6   A0A182XX24   A0A1B0CVG1   A0A182JUK6   A0A1Q3EX11   A0A182QC01   W5JGS3   A0A2M4BQH3   A0A2M4BQH5   D6WKX5   A0A182NCX2   A0A336LJ21   A0A2M4BQH7   A0A182PS68   Q16QY8   A0A182RX70   A0A182FPF5   A0A067R6Q8   B0X1Q4   A0A182JFZ3   A0A182M506   A0A182W175   A0NDG6   A0A1W4XG66   A0A182VID6   A0A182L706   A0A182XG15   A0A182U7P6   A0A0N7ZA70   E9GPM7   A0A182ID61   Q29AU6   A0A151XD45   E9IUB8   B4G5X6   A0A232EDB9   A0A164KP06   A0A0P5TNA4   A0A195FGP7   B3LZQ3   A0A0P6AAJ7   A0A0P5M9X3   A0A0P6IJ49   A0A1J1IR89   A0A0P5XKM7   A0A0P5A993   A0A158NGW7   F4WZU1   B4R0R3   A0A195B6N0   A0A1A9Z9Z7   A0A1W4VK38   B3P8J6   A0A226E664   B4PMF4   B4HET9   A0A0L0BN71   Q8T045   A0A0P6FRM3   A0A0P6F3Q6   A0A151II91   W8BTG6   A0A1B6HQ52   A0A0K8WM16   E2ARY7   A0A1A9W1A1   K1Q9M3   A0A3B0KBF9   A0A0P5LZ81   E0W3T1   A0A293LAX1   A0A099ZT40   A0A1B6DS49   A0A093HRN4   A0A091HKU8   A0A195DWF1   A0A093EZX5   A0A091U372   A0A093P427   A0A091K2M9   K7J7V2   A0A0A0ARU6   A0A091IZJ3   H0ZTH7   A0A091ELJ1   B4KBE5   A0A093F916   A0A091GH44   A0A2Y9DGJ0   A0A0Q3M9I3   U3JFL6   A0A093G990   A0A1U7QG35   A0A091U4A7  

PDB

5F87     E-value=1.27808e-112,     Score=1039

KEGG

101746748    K13667 protein glucosyltransferase [EC:2.4.1.-] | (RefSeq) O-glucosyltransferase rumi homolog

PATHWAY

00514    Other types of O-glycan biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0016740   GO:0005788   GO:0035251   GO:0046527   GO:0045747   GO:0035252   GO:0006493   GO:0005576   GO:0018242   GO:0042052   GO:0007219   GO:0045746   GO:0060537   GO:0007030   GO:0033577   GO:2000035   GO:0006629   GO:0016021   GO:0020037   GO:0046872   GO:0016491   GO:0012505   GO:0001756   GO:0010470   GO:0072358   GO:0048318   GO:0048339  

Subcellular location

Endoplasmic reticulum lumen  
Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.927324

 

 

Length:

400

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.50371

Exp number, first 60 AAs:

3.45324

Total prob of N-in:

0.14698

outside

1  -  400

 

 

Pi

223.664157

Theta

176.131704

Tajima's D

0.859654

CLR

1.613191

CSRT

0.620418979051047

Interpretation

Uncertain