Gene

KWMTBOMO09033

Pre Gene Modal

BGIBMGA007494

Annotation

ATP-binding_cassette_sub-family_B_member_1_[Trichoplusia_ni]

Location

Bomo_Chr15(+):10090901-10118811      View in EpiBrowser

Full name

Multidrug resistance protein 1A       + More
Multidrug resistance protein 1B      

Alternative Name

ATP-binding cassette sub-family B member 1A
MDR1A
Multidrug resistance protein 3
P-glycoprotein 3
ATP-binding cassette sub-family B member 1B
P-glycoprotein 1

Location in the cell

PlasmaMembrane   Reliability : 4.137

CDS

ATGAAGGAAATCAAAGAAGACAATTGGGATCCTGGCCTAGGCGGTGACAAAAACAAATATAAAGTCAGCGGTTTCTCTGATGGCGATTATCAAAAAAGAAAGCAATCTGATAGTTCCGAAAAAAACGCCAAAGATGATGTGCCGAGCATTTCATTTTTTACGCTGTTTCGTTTCGCCACTACAACAGATGTTTTGTATATTATCATAGCCCTGGTATCATCGGCTGTGGCAGCCTGTTCCACGCCATTGAATACCTTGCTATTAGCTGACTTACTGCAAAGCATGGTGGATTTTGGCATCTCCGTAGTTCAAGAGAATCCAAATGGAGACGCATTTTTGGAATCACTTTTCTACTTCGCCGTGTATAATTCTATCATAGGCATACTGTTGGTCATTTTCACTTATATCGCAACGGTACTAATGAATATCGCAGCATATAATCAGGTATATAAAATAAGACAAGAATATCTCAAAGCAGCTTTGAACCAGGATTTCGAGTATTTTGATATCCATAAAACTGGGGATATAGCTACCAAGATAAACAGCGATATACTGAAATTAGAAGATGGCATTGGTGAAAAGCTGGCCACTTTCATATTTTACCAGTGCTCATTTATCAGTTCAATTATCATGGCGCTTATAAAAGGCTGGAAGCTGGCCCTCCTTTGTCTGATATCATTTCCGGTTACAATGACACTTGTTGGAGTAGCTGGACTGGTGGCTTCAAGGCTATCAAAGAAAGAAGCAATAGCGTCCGGTAAGGCCGGAGCGATCGCCGAAGAAGTGTTATCGTCTATTAGAACAGTGTACGCGTTTACGGGCATGCAAAAGGAAATCGAACGATATGAAAAATACCTTATAGAGGCGAGAAAGATCAATATTCAGAAAGGTCTTTTCAACGGTCTCGCTATGGGCTTCCTTTTCTTTTGTATATTCTGTGCGTACGCATTATCCTTCTGGTTCGGCTACAGACTTATGGTTGACGAACCAGAGAATTATGATGTATCAACAATGATCGCAGTTTTCTTTGGTGTAATGACCGGATCCGCTAATTTCGGTGTATCATCAACTCTAATGGAAGTGTTCGGTAGAGCCCGCGGTGCGGGTGCCCAAATCTTTAATTTAATTGATAATGTACCAATAATTAACCCATTGCGGAATCTCGGAGTCACGCCGCCATCCATTGATGGCAACATTGAGCTAAAAGATGTTGTATTTCATTATCCTTCTAGACCTGATGTACCAGTACTCAAAGGCGTAAACCTAAGGGTGAAAAGAGGGCAATCTGTCGCGCTTGTTGGACATTCGGGATGTGGAAAGTCAACGATCATACAACTCATATCTAGATATTATGATGTTATAGACGGAAATGTGTGCATTGATGGCAATGATGTTCGTCAACTGTCTGTTCGATGGCTTCGGTCTCAGATTGGTCTGGTCGGTCAAGAGCCTGCGCTTTTTAACATGACAGTTCGCCAAAACATTCGCTTTGGTCGTGAGGAAGCTACAGATCAAGACATCGAAGCAGCAGCAAAGCAGGCAAATGCTCACGAATTCATCATGAAACTTCCCAATGGTTACGATACGCTGGTTGGTGAAAGAGGTGCTTCGATATCTGGTGGACAAAAGCAAAGGATTGCTATAGCTCGAGCTTTAGTCAGAAATCCTCCTATTCTCCTCCTAGACGAAGCGACGAGCGCTCTAGATACGTCATCTGAAGCCAAAGTACAAAAGGCTTTAGATAAAGCCCAAGAAGGTCGCACAACAATTGTAGTGGCACACAGACTTTCAACTATCAGAAATGTTGATGTTATTTACGTTTTCAAAGAGGGCTCTGTAATTGAGACTGGTAACCACGATGAACTGATGAAGTTAAAAGGACATTACTACGATATGGTTATGCTGCAAACGTTCCCTGGAAGTGAGGAGGACGACGACAATAACGGAGACAACGAAAGTCGGCTGTCTCGAAAAATATCTAATATGAATATAAACGATGATGACGACATTATAGATATAAAAAATTATGGTGTTGAGGAACACAGTGACGTTCCAACTGATGTGTCATTCTGGAGAGTAGTCCGCTTAAATTCGCCAGAATGGAAATCCGTTTCTCTAGCCAGTTTTTGCGCTTTTCTTAGTGGATTTGCCATGCCTCTCATCGCAGTAATCTTTGGTGATTTTATTGGGATACTTTCAAATCCAGACGAAGAAAAAGTTTTAGCAGAAGTACAACGTTTCGCGTTGATATTCGTTGGCATAGGCTTATATTCTGGCGTTGCTAATTTCACCATGGTATTTTTGTACGCCATTGCTGGGGAACATCTAACGGAACGTTTGAGAAAGATGATGTTTGAAAAACTCCTTCAACAAGAAGTCGCATTTTATGACGACAAGAACAACACAACTGGAGCACTGTGCGCTAGATTGTCGGGTGAAGCAGCTGCTGTACAAGGGGCCACAGGGCAGCGTATCGGTACTGTATTGCAAGCAATCGGGACATTTGGTTTTGCTCTGGTACTTTCCTTAGTGTACGAATGGCGAGTGGGTCTAGTTGCTTTAACATTTATTCCAATATTGGTTTTTGTACTGTATAAAGAAGTAAGGATGGCCTACGCTGAATCCTTCGGAACTGCGAAGACAATGGAAGCTAGCTCAAAGACTGCGGTAGAGGCAGTGGCTAATGTACGAACAGTAGCCTCGTTGGGTGGAGAAACGAAAATCTTACAAGACTATATAATACAGTTATTGCCAGCACTTTTGTCAGCAAAGCGTGCTTCGCATTGGCGTGGTGTTGTCTTTGGACTTTCAAGATCTTTATTTAACTTCGTTATTGCTGCATCTCTGTACTACGGTGGTACTCTTATAGTGTATGAAAAAATCGAATATGAAGTTGTATTTAAGTCAGCCCAAGCTCTTCTCTTAGGTGCTTCATCTGCAGCACAGGCTTTCGCTTTTGCGCCCAATTTCCAAAAGGGAATCAAGGCAGCAGGACGGGTTGTTTCATTGCTAAACAGAGAGTCTAAAATTACCGATCCCCACGAACCAGTAACCAAGGACTTCTGTGGATCAGGTGAAGCGAGCATTCAAGCAGTTCAGTTTAAATACCCGAATCGTCCAGCCATACAGGTGCTTAAGAATTTCAATCTGGAAATTGAGAAGGGAAAAACATTTGCACTCGTCGGCAGTAGTGGCTGTGGTAAAAGTACTGTCATTCAACTTCTTCAAAGGTTCTATGATCCTGACGACGGCATTGTGGCTCAAGATGGTATTCCTCTACCGAAGCTTACACTTGCAAACGCAAGACAATCAATAGGATTCGTACAACAAGAACCAGTTCTGTTTGATAGAACTATCGGGGAGAACATAGCATATGGAAATAATGCAAAGAAAGTCAACATGGATGACATTATCGAGGCTGCAAAGCAAGCTAATATACATAACTTCATTACTTCGCTGCCTTTGGGTTACGAGACGAACATCGGTACTAAAGGCACTCAACTGTCTGGTGGACAGAAGCAAAGAATAGCTATAGCCAGAGCTTTGATAAGACGACCGAAAATGCTGTTGCTTGATGAAGCGACTAGCGCATTGGATACAGAGAGCGAGAAGGTTGTCCAGGAAGCGTTGGACGCTGCTAAAGCTGGTCGAACTTGCGTGATGATTGCCCACAGACTAAGCACCGTGCGTGATGCGGACAGCATTTGTGTTGTAAGCGACGGGAGAATAGCCGAGAAGGGCAAACACCACGAACTATTAGAACTTAAGGGCTTATACTATAACTTAAATAGACGTGCGCATTCATAG

Protein

MKEIKEDNWDPGLGGDKNKYKVSGFSDGDYQKRKQSDSSEKNAKDDVPSISFFTLFRFATTTDVLYIIIALVSSAVAACSTPLNTLLLADLLQSMVDFGISVVQENPNGDAFLESLFYFAVYNSIIGILLVIFTYIATVLMNIAAYNQVYKIRQEYLKAALNQDFEYFDIHKTGDIATKINSDILKLEDGIGEKLATFIFYQCSFISSIIMALIKGWKLALLCLISFPVTMTLVGVAGLVASRLSKKEAIASGKAGAIAEEVLSSIRTVYAFTGMQKEIERYEKYLIEARKINIQKGLFNGLAMGFLFFCIFCAYALSFWFGYRLMVDEPENYDVSTMIAVFFGVMTGSANFGVSSTLMEVFGRARGAGAQIFNLIDNVPIINPLRNLGVTPPSIDGNIELKDVVFHYPSRPDVPVLKGVNLRVKRGQSVALVGHSGCGKSTIIQLISRYYDVIDGNVCIDGNDVRQLSVRWLRSQIGLVGQEPALFNMTVRQNIRFGREEATDQDIEAAAKQANAHEFIMKLPNGYDTLVGERGASISGGQKQRIAIARALVRNPPILLLDEATSALDTSSEAKVQKALDKAQEGRTTIVVAHRLSTIRNVDVIYVFKEGSVIETGNHDELMKLKGHYYDMVMLQTFPGSEEDDDNNGDNESRLSRKISNMNINDDDDIIDIKNYGVEEHSDVPTDVSFWRVVRLNSPEWKSVSLASFCAFLSGFAMPLIAVIFGDFIGILSNPDEEKVLAEVQRFALIFVGIGLYSGVANFTMVFLYAIAGEHLTERLRKMMFEKLLQQEVAFYDDKNNTTGALCARLSGEAAAVQGATGQRIGTVLQAIGTFGFALVLSLVYEWRVGLVALTFIPILVFVLYKEVRMAYAESFGTAKTMEASSKTAVEAVANVRTVASLGGETKILQDYIIQLLPALLSAKRASHWRGVVFGLSRSLFNFVIAASLYYGGTLIVYEKIEYEVVFKSAQALLLGASSAAQAFAFAPNFQKGIKAAGRVVSLLNRESKITDPHEPVTKDFCGSGEASIQAVQFKYPNRPAIQVLKNFNLEIEKGKTFALVGSSGCGKSTVIQLLQRFYDPDDGIVAQDGIPLPKLTLANARQSIGFVQQEPVLFDRTIGENIAYGNNAKKVNMDDIIEAAKQANIHNFITSLPLGYETNIGTKGTQLSGGQKQRIAIARALIRRPKMLLLDEATSALDTESEKVVQEALDAAKAGRTCVMIAHRLSTVRDADSICVVSDGRIAEKGKHHELLELKGLYYNLNRRAHS

Description

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic Activity

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Subunit

Interacts with PSMB5.

Miscellaneous

In mouse the MDR gene family includes three or more related but distinct cellular genes.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Keywords

3D-structure   ATP-binding   Cell membrane   Complete proteome   Direct protein sequencing   Glycoprotein   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Multidrug resistance protein 1A

Uniprot

H9JD97   A0A2A4K8F6   E9LP50   A0A2A4K6T5   A0A212FQ10   A0A437BKK5   + More
A0A194PQN7   A0A194QSU8   A0A194PRQ0   A0A212EWG1   A0A2H4KAX2   A0A2A4JNT0   A0A1W4WGR5   D6WES5   A0A1L8E4C0   A0A067RRF5   A0A0U9HUH2   E0W1L6   A0A1Y1MIL9   D3YHE3   A0A1I8PUF9   T1PCQ9   A0A0A1X1T2   W8BMX2   W8B7Y6   A0A034VZ05   A0A1Y1LW74   A0A0K8VT37   A0A0M3QV22   U4ULJ8   D6WG66   B4LLD6   A0A3B0J1B9   A0A1A9XPS2   Q5BI62   T1GWC7   A0A1W4WBG8   B4QFE8   A0A0J9RCP5   B3NR69   A0A1B0AKC4   A0A1L8E4G9   B4HRA1   A0A2J7QW27   Q24393   E9G5N8   Q9JK64   P21447   Q6PSM0   Q6PSM2   A0A3Q7U962   C0KKU9   Q4PLA8   B2RUR3   A0A2R8MFH3   F7HUX3   P06795   O46605   U3CBT4   Q8HZQ9   D4A0Y9   A0A2R8M8S0   A0A340WFX8   A0A0K8WAD1   D2KKF0   A0A2K6JNL7   A0A2K6JNJ2   A0A2I3LFS2   A0A2Y9PFH2   A0A096NZY5   A0A096NZY6   A0A2U3WPH7   J9R1J6   A0A2K6JNM6   A0A2K6Q9N0   A0A2Y9RED6   A0A2K6Q9U5   A0A2K6CD97   A0A2K5YD05   W6RXN0   A0A2K6Q9V9   A0A2Y9F6F9   A0A383Z5J0   A0A2I2UET2   G3QFQ2   A0A2K6S1J8   A0A3Q2ZN91   A0A091DH33   A0A2K5CHQ4   A0A2K6Q9S3   A0A2K5NII8   A0A2K5NIR6   A0A2K5NI67   A0A2I2UTT2   A0A2U3ZRF7   A0A3Q7P4Q7   A0A337SRP6   A0A1L8FW23   A0A2K5CHH3  

EC Number

7.6.2.2

Pubmed

19121390    23170973    22118469    26354079    18362917    19820115    + More
24845553    20566863    28004739    25315136    25830018    24495485    25348373    23537049    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    7691715    21292972    15057822    15632090    22673903    1969610    1972547    2473069    21183079    19325113    16545584    16341006    17199425    12040188    15489334    19144319    25243066    3768958    2570420    2248681    12559367    25362486    17975172    22398555    27762356   

EMBL

BABH01030221    BABH01030222    NWSH01000073    PCG79952.1    HQ116791    ADV76536.1    + More
PCG79951.1    AGBW02000285    OWR55800.1    RSAL01000041    RVE50879.1    KQ459595    KPI95627.1    KQ461154    KPJ08552.1    KPI95628.1    AGBW02012004    OWR45811.1    KY484774    ASS36016.1    NWSH01000966    PCG73368.1    KQ971326    EFA00893.1    GFDF01000513    JAV13571.1    KK852510    KDR22339.1    GARF01000047    JAC88902.1    DS235872    EEB19522.1    GEZM01030316    JAV85639.1    GU462154    ADC97877.1    KA646531    AFP61160.1    GBXI01009659    JAD04633.1    GAMC01011834    JAB94721.1    GAMC01011833    JAB94722.1    GAKP01011837    JAC47115.1    GEZM01046271    JAV77371.1    GDHF01010275    JAI42039.1    CP012524    ALC41659.1    KB632353    ERL93338.1    KQ971320    EFA00537.1    CH940648    EDW61888.1    OUUW01000001    SPP74665.1    AE013599    BT021362    AAF58271.3    AAX33510.1    CAQQ02055001    CAQQ02055002    CAQQ02055003    CM000362    EDX07058.1    CM002911    KMY93731.1    CH954179    EDV56058.2    GFDF01000528    JAV13556.1    CH480816    EDW47830.1    NEVH01009768    PNF32772.1    L07065    AAA16186.1    GL732532    EFX85237.1    AABR07059500    AABR07059501    AABR07059502    AABR07059503    AABR07072972    AC133679    AF257746    CH474013    AAF69007.1    EDL84318.1    M30697    M33581    M33580    AY864315    CH466600    M24417    AY582535    AAS91649.1    AY582533    AAS91647.1    FJ617477    ACM77791.1    AAEX03009294    AAEX03009295    DQ068953    AAY67840.1    BC141363    BC150811    AAI41364.1    EDL14680.1    GAMS01006770    GAMR01005477    GAMP01001072    JAB16366.1    JAB28455.1    JAB51683.1    M14757    M60348    AF045016    AAC02113.1    GAMS01006769    JAB16367.1    AF536758    AAN05645.1    GDHF01004310    JAI48004.1    GU222365    ADA77532.1    AHZZ02023134    AHZZ02023135    JX312084    AFR33964.1    HG917103    CDM63424.1    AANG04003224    CABD030053717    CABD030053718    CABD030053719    KN122584    KFO29585.1    CM004476    OCT75761.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053268    UP000053240    + More
UP000192223    UP000007266    UP000027135    UP000009046    UP000095300    UP000095301    UP000092553    UP000030742    UP000008792    UP000268350    UP000092443    UP000000803    UP000015102    UP000192221    UP000000304    UP000008711    UP000092445    UP000001292    UP000235965    UP000000305    UP000002494    UP000000589    UP000286640    UP000002254    UP000008225    UP000265300    UP000233180    UP000028761    UP000248483    UP000245340    UP000233200    UP000248480    UP000233120    UP000233140    UP000248484    UP000261681    UP000011712    UP000001519    UP000233220    UP000264800    UP000028990    UP000233020    UP000233060    UP000286641    UP000186698   

PRIDE

H9JD97    Q5BI62    Q24393    P21447    P06795    D4A0Y9    + More

Pfam

PF00664   ABC_membrane        + More
PF00005   ABC_tran
PF00856   SET
PF01753   zf-MYND

Interpro

IPR003439   ABC_transporter-like        + More
IPR017871   ABC_transporter_CS       
IPR039421   Type_I_exporter       
IPR036640   ABC1_TM_sf       
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR003593   AAA+_ATPase       
IPR002893   Znf_MYND       
IPR001214   SET_dom       
IPR030258   MDR1       
IPR030275   MDR3       

SUPFAM

SSF90123   SSF90123        + More
SSF52540   SSF52540       

Gene 3D

1.20.1560.10    

ProteinModelPortal

H9JD97   A0A2A4K8F6   E9LP50   A0A2A4K6T5   A0A212FQ10   A0A437BKK5   + More
A0A194PQN7   A0A194QSU8   A0A194PRQ0   A0A212EWG1   A0A2H4KAX2   A0A2A4JNT0   A0A1W4WGR5   D6WES5   A0A1L8E4C0   A0A067RRF5   A0A0U9HUH2   E0W1L6   A0A1Y1MIL9   D3YHE3   A0A1I8PUF9   T1PCQ9   A0A0A1X1T2   W8BMX2   W8B7Y6   A0A034VZ05   A0A1Y1LW74   A0A0K8VT37   A0A0M3QV22   U4ULJ8   D6WG66   B4LLD6   A0A3B0J1B9   A0A1A9XPS2   Q5BI62   T1GWC7   A0A1W4WBG8   B4QFE8   A0A0J9RCP5   B3NR69   A0A1B0AKC4   A0A1L8E4G9   B4HRA1   A0A2J7QW27   Q24393   E9G5N8   Q9JK64   P21447   Q6PSM0   Q6PSM2   A0A3Q7U962   C0KKU9   Q4PLA8   B2RUR3   A0A2R8MFH3   F7HUX3   P06795   O46605   U3CBT4   Q8HZQ9   D4A0Y9   A0A2R8M8S0   A0A340WFX8   A0A0K8WAD1   D2KKF0   A0A2K6JNL7   A0A2K6JNJ2   A0A2I3LFS2   A0A2Y9PFH2   A0A096NZY5   A0A096NZY6   A0A2U3WPH7   J9R1J6   A0A2K6JNM6   A0A2K6Q9N0   A0A2Y9RED6   A0A2K6Q9U5   A0A2K6CD97   A0A2K5YD05   W6RXN0   A0A2K6Q9V9   A0A2Y9F6F9   A0A383Z5J0   A0A2I2UET2   G3QFQ2   A0A2K6S1J8   A0A3Q2ZN91   A0A091DH33   A0A2K5CHQ4   A0A2K6Q9S3   A0A2K5NII8   A0A2K5NIR6   A0A2K5NI67   A0A2I2UTT2   A0A2U3ZRF7   A0A3Q7P4Q7   A0A337SRP6   A0A1L8FW23   A0A2K5CHH3  

PDB

4M1M     E-value=0,     Score=2522

KEGG

101735691    K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] | (RefSeq) multidrug resis

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0042626   GO:0016021   GO:0005886   GO:0015721   GO:0015440   GO:0008559   GO:0046872   GO:0097254   GO:0017085   GO:0015562   GO:0009636   GO:0043190   GO:0042908   GO:0043278   GO:1902065   GO:1904478   GO:0006855   GO:1905233   GO:0071407   GO:0071312   GO:0071475   GO:0033762   GO:2001025   GO:1905231   GO:0016020   GO:0071549   GO:0071217   GO:0009914   GO:0001890   GO:0032355   GO:0036146   GO:0071548   GO:0014072   GO:0031526   GO:0010033   GO:0046618   GO:0071392   GO:0033189   GO:1990962   GO:0042493   GO:0050892   GO:0046686   GO:0071236   GO:0060548   GO:1904446   GO:0007623   GO:0032496   GO:0045177   GO:1902396   GO:0033231   GO:0097068   GO:1905235   GO:0007420   GO:0007595   GO:1903416   GO:0060856   GO:1905232   GO:0010046   GO:1990963   GO:0043215   GO:0033280   GO:0001666   GO:0035633   GO:0014070   GO:1905237   GO:0031667   GO:0097327   GO:0016324   GO:0009986   GO:1901529   GO:0045332   GO:0099040   GO:0046581   GO:2001225   GO:0099038   GO:0072089   GO:0015893   GO:0000086   GO:0090555   GO:0042623   GO:0047484   GO:0090554   GO:0014045   GO:0061843   GO:0005739   GO:0005215   GO:0000139   GO:0016887   GO:0006810   GO:0005254   GO:0006811   GO:0016876   GO:0043039   GO:0055085  

PANTHER

PTHR24221   PTHR24221:SF251   PTHR24221:SF241  

Subcellular location

Cell membrane  

Length:

1268

Number of predicted TMHs:

11

Exp number of AAs in TMHs:

240.470600000001

Exp number, first 60 AAs:

0.1975

Total prob of N-in:

0.99735

inside

1  -  63

TMhelix

64  -  86

outside

87  -  123

TMhelix

124  -  146

inside

147  -  194

TMhelix

195  -  214

outside

215  -  218

TMhelix

219  -  241

inside

242  -  298

TMhelix

299  -  321

outside

322  -  335

TMhelix

336  -  358

inside

359  -  703

TMhelix

704  -  726

outside

727  -  748

TMhelix

749  -  771

inside

772  -  824

TMhelix

825  -  844

outside

845  -  847

TMhelix

848  -  865

inside

866  -  938

TMhelix

939  -  958

outside

959  -  1268

 

 

Pi

192.116469

Theta

164.202303

Tajima's D

0.561203

CLR

0.506737

CSRT

0.534023298835058

Interpretation

Uncertain