Gene

KWMTBOMO09024

Pre Gene Modal

BGIBMGA010849

Annotation

PREDICTED:_probable_multidrug_resistance-associated_protein_lethal(2)03659_[Bombyx_mori]

Location

Bomo_Chr15(-):9884645-9916355      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.528

CDS

ATGATAATATTGAGTAAGGCTCAGCCAATATTTCTTGGTTGGCTGGTGGAATATTACAGCCCCGACAGTAAAATGACGCCCTCGGACGCATATCTCTGCGCTGCGGCAGTCGTAGTATGCTCAGCTCTTAATGTATTCGTCATGCATCCATATATGATGGCCATATTACACATGGGAATGAAGTTCAGGGTCGCTTGCTGCTCGCTCATCTACAGAAAGTCTCTGCGATTATCCAAGACCGCTCTCGGCGAGACGACAATCGGTCAAGTCGTCAACCTGTTGTCGAACGATGTGAATCGTTTCGACGTCGCGGTGATATTCATCCACTATCTATGGATCGGGCCGCTGGTCACCGTGATCATCACATACTTTATGTGGCTGGAGATCAACTGGGCCGCGGTGGTCGGAGTAGCTTTCATGCTGGCATTCATACCGCTGCAAGCTTACTTGGGAAAGAAGACTTCGGTTTTGAGACTAAAAACGGCATTAAGGACCGACGAACGTGTCCGACTTATGAATGAAATTCTATCCGGTATTCAAGTCATCAAGATGTACACTTGGGAGAAACCTTTCGCTGACCTCGTCGCCAAAGCTAGGAAACACGAAATAAAACAAATCCGAGCGACGTCTTATATCCGAGGAGTGCTCACTTCGTTCATAATGTTCACGACGCGCAGTTGCTTATTCTGTTCGATACTGGCGTACGTGCTGGTGAACAATGTGATCACCGCCAAACAAGTGTTCGTTATAACGAGCTTCTACAGTATATTGAGGCAGTCCATGACCGTGTTCTTTCCGCAAGGTATTGCTCAAGTAGCTGAAGCTTTGATATCCATAAAACGGCTTCAGAGCTTCATGTTATACGAAGACACAAACAAACCCGTTCCCGGACTGGCCGAGATACAAACCTCAACGAAACCCAAGGAGGTGACAAAGGATTCTCTGTTGCCCGCCAGCGATGAGTTGGATGTGAAAAAGGATGATTCGAAATTGACAGCCACCGGTGATAGTTCCACAGAAACCAAAGAAGCCAAGGGTAATGGAAACGTGAACTTAGCCCCCATAGAGGCGAGCGAAGAGGACGAACAAGAACTATCGGCTCGCGTCGAAGAGGACTCCCGCGGCGTGAGACTCAAGCACGCCACCGCCAAATGGATACAGTCTCATCCGGAAAACACTCTCACCGATCTTTCTCTCACCATAAAACCGGGGAAGTTAATAGCAGTAATAGGCCCAGTCGGAGCGGGCAAGTCGTCCCTGTTGCACGTGTTGCTACGGGAGTTGCCGCTCGCGTCGGGAAGCGTCCACGTCGGCGGAACCGTGTCCTACGCGAGCCAGGAGCCTTGGCTCTTTGCGGGGAGCGTCCGTCAGAATATATTGTTCGGTCAGCCGATGGATCGTCCCCGGTACAACACGGTGGTGCGGCGGTGCGCGCTCGACCGCGACTTCGCGCTTTTCCCGCACGGAGACAAGACCGTCGTCGGCGAACGTGGCGTCAGTCTCAGTGGAGGTCAACGCGCCCGTATATCTCTGGCTCGCGCGGTGTACAAGCGCGCCGACATATACTTGCTGGACGACCCGCTGTCCGCCGTCGACGCGCACGTCGGTCGGCACTTGTTCGAGTCGTGCGTGGTCGGCTACCTGCGGAACTCAACGCGGATACTCGTCACGCATCAGCTGCAGTTCCTCAGGGACGTCGATCAGATAATAATATTGAAAAATGGCACAATAGCGGCGGCCGGTAACTTCGATACTTTGAGCGCGTCTGGTCTTGATTTTGCGACATTGTTGGCTCGGGATCAGCACGAGGAAGAGAAACCGACCGAGGCCGCGGTCCTCACCGACACCGAGGATAATAACTCGGTTCTCCACGGAAGCTTTAGGAAACGACAACTGAGTATTCATTCCGTGAGCTCGGTGGACAACCTGACGGCGACGGCGCCCCCGGAAGGCACCCGCGAGGAGGCGGAGATGAAGTCTGCGGGCGCGGTGTCGGGGCGCGTGTACGGCGCCTACCTGCGAGCCTGCGGTAACGCATTCGTGATCACATTGATGCTGCTTGTCGCCGTCTTGGCGCAACTACTCGGTTCTGCCTCCGATTGGTGGACCAGCTTCTGGGTAAAGTTAGAAGAGAAAAATTACGCATCTCATACGTTGCGCACTTTCGATGATCGAAATGAGACGGGAAGTTTACAAGCCGCGGACCCTAGAGTCGATAATGCGATCTTCTCTGACGTCGGCCTGTCTCGCTATGATTGCATTTATATTTACACTGGTATCGTAGCGGCTCTGGTAGCGGTCACGTTGCTGCGTTCGTTTATGTTCTTCTGGATAGCGATGCGCGCCTCGACCCGCCTGCACAACAACATGTTCGCGGCCATCACCCGCGCCCCCATGCGCTTCTTCCACGTCAACCCCTCGGGCCGGATCCTCAACCGCTTCTCCAAGGACATGGGCGCTGTCGATGAAGTGCTGCCCTCTGCCGTTATTGATGTCCTACAAATTGGTCTGTCGCTGATCGGTATCGTGGTCGTGGTGGCGATAGTGAACTACTGGCTTCTGGTGCCGACGGTGGCGATCGGCGTCATCTTCTACGGGCTCCGCATATTCTACCTGGCCACGTCGCGGAACATCAAACGCCTCGAGGGTGTGACTCGGAGTCCCGTGTTCTCGCACCTCAACGCTTCGTTGCAAGGTATCACCACTATCAGAGCGTTCGGCGCTCAAGAGGCTCTCATCAGGGAATTCGACAATCATCAGGATCTGCACAGCTCAGCTTGGTACATGTTCATCGCGAGCTCAAGAGCGTTCGGTTTCTGGCTGGACCTGGTGTGCGTTGTGTACATCGCGGTGGTCACTATGAGCTTCCTCGTGCTCGGCAATGAGAAGTACGGAGGGGACGTCGGCCTGGCCATAACGCAGGCGATGGGTCTGACCGGCATGTTCCAGTGGGGCATGCGGCAGTCCACTGAACTGGAGAACCAAATGACTAGTGTCGAGAGGATCGACGAATATTCGAACATAGAATCGGAGCCCCCGCTCCAGTCGGAGGGCGACAAGAAGCCTCCCCCCTCGTGGCCGGAGGCGGGCGGCGTGCAGTTCCGCCATGTACATCTGTACTACGCGCCCGGCGAGCCCGCCGTGCTCCGGGACTTGTCCTTCATCATCCTACCCAAAGAGAAGGTCGGCATCGTCGGCAGGACCGGCGCCGGGAAATCTTCTCTTATCAATGCTTTGTTCAGGCTTGCGACAATAGAAGGCGAGATCATAATCGATAATCGAGAGACTTCTTCGATGGGCCTGCATGAGCTCCGTAGTCAGATCTCGATAATTCCTCAAGAGCCAGTTCTGTTTTCGGGCACCATGAGACACAATCTGGATCCCTTCGATGAATATCCCGACCAAGTATTGTGGAGGGCCTTGGAAGAGGTTGAGCTGAAGGAAGTAGTGCAGGAGCTCCCGGCCGGTCTGAACTCTCGCATGTCGGAGGGCGGCGGGAACTTCTCCGTGGGGCAGCGGCAGCTCGTGTGCCTCGCGCGGGCCATCGTCAGGCGCAACCGCCTGCTCGTGCTGGACGAGGCCACCGCCAACGTCGACCCGCAAACCGATGCCCTCATACAAACGACAATTAGAAACAAATTCGCAGAATGCACAGTACTCACGATTGCTCACAGACTTCACACCGTCATGGATTCTGATAAGGTTCTCGTGATGGACGCTGGTCAAATGGTGGAGTTTGATCATCCGCACGTGCTGCTGCAGAAACACGAGGGCGTCCTGCGCGGCATGGTCGAGCAGACCGGCAAGGCCATGGCCGACACGCTTGCGCGGGTCGCGCAACAGGCTTACGAGAAAAAAAATTTAGGGAGTGCGACAGAATGA

Protein

MIILSKAQPIFLGWLVEYYSPDSKMTPSDAYLCAAAVVVCSALNVFVMHPYMMAILHMGMKFRVACCSLIYRKSLRLSKTALGETTIGQVVNLLSNDVNRFDVAVIFIHYLWIGPLVTVIITYFMWLEINWAAVVGVAFMLAFIPLQAYLGKKTSVLRLKTALRTDERVRLMNEILSGIQVIKMYTWEKPFADLVAKARKHEIKQIRATSYIRGVLTSFIMFTTRSCLFCSILAYVLVNNVITAKQVFVITSFYSILRQSMTVFFPQGIAQVAEALISIKRLQSFMLYEDTNKPVPGLAEIQTSTKPKEVTKDSLLPASDELDVKKDDSKLTATGDSSTETKEAKGNGNVNLAPIEASEEDEQELSARVEEDSRGVRLKHATAKWIQSHPENTLTDLSLTIKPGKLIAVIGPVGAGKSSLLHVLLRELPLASGSVHVGGTVSYASQEPWLFAGSVRQNILFGQPMDRPRYNTVVRRCALDRDFALFPHGDKTVVGERGVSLSGGQRARISLARAVYKRADIYLLDDPLSAVDAHVGRHLFESCVVGYLRNSTRILVTHQLQFLRDVDQIIILKNGTIAAAGNFDTLSASGLDFATLLARDQHEEEKPTEAAVLTDTEDNNSVLHGSFRKRQLSIHSVSSVDNLTATAPPEGTREEAEMKSAGAVSGRVYGAYLRACGNAFVITLMLLVAVLAQLLGSASDWWTSFWVKLEEKNYASHTLRTFDDRNETGSLQAADPRVDNAIFSDVGLSRYDCIYIYTGIVAALVAVTLLRSFMFFWIAMRASTRLHNNMFAAITRAPMRFFHVNPSGRILNRFSKDMGAVDEVLPSAVIDVLQIGLSLIGIVVVVAIVNYWLLVPTVAIGVIFYGLRIFYLATSRNIKRLEGVTRSPVFSHLNASLQGITTIRAFGAQEALIREFDNHQDLHSSAWYMFIASSRAFGFWLDLVCVVYIAVVTMSFLVLGNEKYGGDVGLAITQAMGLTGMFQWGMRQSTELENQMTSVERIDEYSNIESEPPLQSEGDKKPPPSWPEAGGVQFRHVHLYYAPGEPAVLRDLSFIILPKEKVGIVGRTGAGKSSLINALFRLATIEGEIIIDNRETSSMGLHELRSQISIIPQEPVLFSGTMRHNLDPFDEYPDQVLWRALEEVELKEVVQELPAGLNSRMSEGGGNFSVGQRQLVCLARAIVRRNRLLVLDEATANVDPQTDALIQTTIRNKFAECTVLTIAHRLHTVMDSDKVLVMDAGQMVEFDHPHVLLQKHEGVLRGMVEQTGKAMADTLARVAQQAYEKKNLGSATE

Uniprot

A0A0F6PRF7   A0A2A4K8A3   A0A3S2PGB0   A0A2H4KAX0   A0A194PK32   A0A212FFZ7   + More
A0A0T6AV52   A0A1Y1MZF9   A0A1Y1MZE9   A0A026X3V7   A0A139WIK9   D6WKL8   A0A3L8DIP4   A0A0C9PVS6   A0A195FX91   E2B3S7   A0A2J7PEN6   F4X6C1   A0A151ILB5   K7IU38   A0A139WIC1   A0A3R5SMP1   A0A232FKB8   A0A158V0F7   A0A1B6BYZ9   A0A067RQX2   A0A0P4W3Q5   A0A0V0G5R1   A0A069DYA9   A0A023F3H7   A0A158NLW9   A0A195BLI3   A0A182FEZ4   A0A0J7KK65   A0A2M4B9G3   A0A2M4B9I8   A0A1S4GS60   Q7Q5I0   W5JPP8   A0A182V3W3   A0A182I405   T1PE30   A0A2A3EMT6   A0A1I8NAJ3   A0A1I8Q3P7   W8BIR1   A0A087ZWE9   E9IHI5   A0A1Q3F1F2   A0A0K8WFC4   A0A0M9AAK9   A0A1Q3F1H9   A0A1Q3F1A4   A0A195BKC7   A0A1Q3F1B6   A0A034V5I7   A0A1B6DRB5   A0A158NLW8   A0A1B0C9L7   A0A1L8DUP6   A0A1L8DV41   B4HYJ3   A0A0J9QZE2   Q9VLN6   A0A182X8X3   B3DN70   B3N748   Q5TQY7   A0A1W4VWU1   A0A1B0A228   A0A1A9VAE6   B4NWW9   A0A0L0CHE8   A0A1A9WJ69   B4LS94   A0A151ILB7   A0A2J7R104   W8C7M0   B4N102   A0A1I8NI62   Q16IR9   A0A0L0CGT9   J9JY34   A0A336K0I7   F4X6C4   A0A1I8Q0X0   B3MNS1   A0A2J7QE18   A0A1I8MQY1   B0XBQ1   A0A0K8VHX2   J9K122   A0A1I8MMA0   F4X6C3   A0A3B0JYQ4   B5DJ61   B4G834   A0A3B0JTG7  

Pubmed

25662100    26354079    22118469    28004739    24508170    18362917    + More
19820115    30249741    20798317    21719571    20075255    28648823    24845553    27129103    26334808    25474469    21347285    12364791    20920257    23761445    25315136    24495485    21282665    25348373    17994087    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    26108605    18057021    17510324    15632085   

EMBL

KM453743    KP335688    AKC34058.1    AKC34900.1    NWSH01000076    PCG79892.1    + More
RSAL01000046    RVE50566.1    KY484779    ASS36021.1    KQ459602    KPI93378.1    AGBW02008743    OWR52650.1    LJIG01022813    KRT78583.1    GEZM01016941    GEZM01016940    GEZM01016938    JAV91034.1    GEZM01016939    JAV91033.1    KK107019    EZA62671.1    KQ971342    KYB27685.1    EFA03011.2    QOIP01000007    RLU20304.1    GBYB01005573    JAG75340.1    KQ981219    KYN44464.1    GL445398    EFN89664.1    NEVH01026090    PNF14801.1    GL888807    EGI58005.1    KQ977121    KYN05546.1    AAZX01002657    KYB27686.1    MH172501    QAA95908.1    NNAY01000107    OXU30908.1    KF828786    AIN44103.1    GEDC01031058    JAS06240.1    KK852521    KDR22129.1    GDKW01000545    JAI56050.1    GECL01002731    JAP03393.1    GBGD01000127    JAC88762.1    GBBI01002866    JAC15846.1    ADTU01019789    ADTU01019790    KQ976450    KYM85726.1    LBMM01006434    KMQ90611.1    GGFJ01000532    MBW49673.1    GGFJ01000531    MBW49672.1    AAAB01008960    EAA10720.3    ADMH02000892    ETN64739.1    APCN01002262    APCN01002263    KA646208    AFP60837.1    KZ288215    PBC32516.1    GAMC01007938    JAB98617.1    GL763279    EFZ19975.1    GFDL01013655    JAV21390.1    GDHF01002527    JAI49787.1    KQ435713    KOX79343.1    GFDL01013644    JAV21401.1    GFDL01013712    JAV21333.1    KYM85725.1    GFDL01013703    JAV21342.1    GAKP01021198    GAKP01021195    JAC37754.1    GEDC01009088    JAS28210.1    ADTU01019786    ADTU01019787    ADTU01019788    AJWK01002463    AJWK01002464    GFDF01003930    JAV10154.1    GFDF01003929    JAV10155.1    CH480818    EDW52123.1    CM002910    KMY89049.1    KMY89050.1    KMY89051.1    AE014134    BT133430    AAF52648.2    AFH03617.1    AFH68354.1    BT032858    ACD81872.1    CH954177    EDV59344.1    EAL40076.2    CM000157    EDW88499.1    JRES01000405    KNC31637.1    CH940649    EDW63702.2    KRF81256.1    KRF81257.1    KRF81258.1    KYN05547.1    NEVH01008214    PNF34507.1    GAMC01007936    GAMC01007935    JAB98619.1    CH963920    EDW78164.1    CH478056    EAT34168.1    KNC31638.1    ABLF02027734    UFQS01000040    UFQT01000040    SSW98269.1    SSX18655.1    EGI58008.1    CH902620    EDV31158.2    NEVH01015354    PNF26826.1    DS232648    EDS44400.1    GDHF01033209    GDHF01033045    GDHF01014300    GDHF01014169    GDHF01011970    GDHF01001646    JAI19105.1    JAI19269.1    JAI38014.1    JAI38145.1    JAI40344.1    JAI50668.1    ABLF02035628    EGI58007.1    OUUW01000010    SPP86203.1    CH379060    EDY69930.1    CH479180    EDW28514.1    OUUW01000008    SPP83702.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000007151    UP000053097    UP000007266    + More
UP000279307    UP000078541    UP000008237    UP000235965    UP000007755    UP000078542    UP000002358    UP000215335    UP000027135    UP000005205    UP000078540    UP000069272    UP000036403    UP000007062    UP000000673    UP000075903    UP000075840    UP000242457    UP000095301    UP000095300    UP000005203    UP000053105    UP000092461    UP000001292    UP000000803    UP000076407    UP000008711    UP000192221    UP000092445    UP000078200    UP000002282    UP000037069    UP000091820    UP000008792    UP000007798    UP000008820    UP000007819    UP000007801    UP000002320    UP000268350    UP000001819    UP000008744   

PRIDE

Q9VLN6    B3DN70   

Pfam

PF00664   ABC_membrane        + More
PF00005   ABC_tran
PF16363   GDP_Man_Dehyd
PF00096   zf-C2H2

Interpro

IPR003439   ABC_transporter-like        + More
IPR017871   ABC_transporter_CS       
IPR003593   AAA+_ATPase       
IPR036640   ABC1_TM_sf       
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR016040   NAD(P)-bd_dom       
IPR036291   NAD(P)-bd_dom_sf       
IPR000788   RNR_lg_C       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF90123   SSF90123        + More
SSF52540   SSF52540       
SSF51735   SSF51735       
SSF57667   SSF57667       

Gene 3D

1.20.1560.10    

ProteinModelPortal

A0A0F6PRF7   A0A2A4K8A3   A0A3S2PGB0   A0A2H4KAX0   A0A194PK32   A0A212FFZ7   + More
A0A0T6AV52   A0A1Y1MZF9   A0A1Y1MZE9   A0A026X3V7   A0A139WIK9   D6WKL8   A0A3L8DIP4   A0A0C9PVS6   A0A195FX91   E2B3S7   A0A2J7PEN6   F4X6C1   A0A151ILB5   K7IU38   A0A139WIC1   A0A3R5SMP1   A0A232FKB8   A0A158V0F7   A0A1B6BYZ9   A0A067RQX2   A0A0P4W3Q5   A0A0V0G5R1   A0A069DYA9   A0A023F3H7   A0A158NLW9   A0A195BLI3   A0A182FEZ4   A0A0J7KK65   A0A2M4B9G3   A0A2M4B9I8   A0A1S4GS60   Q7Q5I0   W5JPP8   A0A182V3W3   A0A182I405   T1PE30   A0A2A3EMT6   A0A1I8NAJ3   A0A1I8Q3P7   W8BIR1   A0A087ZWE9   E9IHI5   A0A1Q3F1F2   A0A0K8WFC4   A0A0M9AAK9   A0A1Q3F1H9   A0A1Q3F1A4   A0A195BKC7   A0A1Q3F1B6   A0A034V5I7   A0A1B6DRB5   A0A158NLW8   A0A1B0C9L7   A0A1L8DUP6   A0A1L8DV41   B4HYJ3   A0A0J9QZE2   Q9VLN6   A0A182X8X3   B3DN70   B3N748   Q5TQY7   A0A1W4VWU1   A0A1B0A228   A0A1A9VAE6   B4NWW9   A0A0L0CHE8   A0A1A9WJ69   B4LS94   A0A151ILB7   A0A2J7R104   W8C7M0   B4N102   A0A1I8NI62   Q16IR9   A0A0L0CGT9   J9JY34   A0A336K0I7   F4X6C4   A0A1I8Q0X0   B3MNS1   A0A2J7QE18   A0A1I8MQY1   B0XBQ1   A0A0K8VHX2   J9K122   A0A1I8MMA0   F4X6C3   A0A3B0JYQ4   B5DJ61   B4G834   A0A3B0JTG7  

PDB

6BHU     E-value=4.09759e-171,     Score=1549

KEGG

101736234    K05673 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 | (RefSeq) probable multidrug resistan

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005524   GO:0042626   GO:0055085   GO:0016020   GO:0006260   GO:0055114   GO:0042060   GO:0005886   GO:0003676   GO:0006810   GO:0016887   GO:0005254   GO:0006811   GO:0016876   GO:0043039  

Length:

1293

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

211.33997

Exp number, first 60 AAs:

22.65886

Total prob of N-in:

0.53128

POSSIBLE N-term signal

sequence

inside

1  -  29

TMhelix

30  -  52

outside

53  -  104

TMhelix

105  -  127

inside

128  -  128

TMhelix

129  -  151

outside

152  -  215

TMhelix

216  -  238

inside

239  -  674

TMhelix

675  -  697

outside

698  -  752

TMhelix

753  -  775

inside

776  -  823

TMhelix

824  -  846

outside

847  -  849

TMhelix

850  -  872

inside

873  -  936

TMhelix

937  -  959

outside

960  -  1293

 

 

Pi

328.058081

Theta

18.968032

Tajima's D

2.333708

CLR

0.286974

CSRT

0.930703464826759

Interpretation

Uncertain