Gene

KWMTBOMO09016

Pre Gene Modal

BGIBMGA007772

Annotation

hypothetical_protein_KGM_19554_[Danaus_plexippus]

Location

Bomo_Chr15(-):9731691-9740795      View in EpiBrowser

Full name

Protein O-mannosyl-transferase TMTC4      

Alternative Name

Transmembrane and TPR repeat-containing protein 4

Location in the cell

PlasmaMembrane   Reliability : 4.854

CDS

ATGAGTGGTGAAAGGTTGATAGCCATTCATTTTAAGATCACAAACTTAATATGCCACATATGGGGATGTATTGTTTTATGGATATTTTTGAGAACTGTTTTAAATATTCAAAATGAAGGATTTTATGAAACCTCATTTTTGACAACATTATTGTTTGCTGTACACCCCATACATGTAGAAGCAGTAAGTGGCATAGTAGGACGAGCTGATGTCATGGCTTCAAATATTTTTCTTCTTGCATTTCTTGTGTATCATTTCTCACAATCAAAATCTAAATCAATTTGGAAACACTTAATTCTGTTGACAACAATAATCCTCTCAGGAATATCTATGCTGTTTAAAGAAAATGGGATTACTGTTTTGGGATTTTGTTTGGTGTATGAAATTATGAATAAGATGAAATTTATGAAATTAAAAAAATCAACAACTGGTAATTTTGTCATAAATAACAGATTTGTAAATCTGGAATTAGATTCAATACTTAGAATACTTATTATCCTAAGTGGAGCAATTTTACTATTATCGGGAAGGTGGCTTATAATGGGAGGATCTTATCCAGAATTCAAACCAGTTGATAACCCTGCAGCTTTTGTTGAAAATTATTACACAAGGGTAAAAACATATAATTATATTTATTTCTTGAATATCTTGCTGCTGATCTGGCCCCAGTGGTTATGCTATGACTGGTCTATGGGCTGCATTCCTTTACTTGAAAATAATATGGACTTTAGGACCATATTCATATTCATTATGTACATTTATGGAGGACTGTTAATTAAAAGTTTGTTCAATAACAAAAATCATAGTACAACAAAAAGATCATTGATTATTGGTGTATCTCTAATGATATTGCCTTTTCTGCCAGCAGCAAATATTGTACGCCCAGTTGGTTTTGTTATTGCTGAGAGAATTCTCTACATATCTTCATCCGGATATTGTTTACTTATTGTTATTGGATATAAAAAAATCTGTAAAAAGGTGAACAGTGTAAAATGTAAGGTGTTATCTGCAATGTTTTTATTTCTGCTAATAATTTATGGAATGAGAAGTTTCCAAAGGTCAGGTGACTGGCAGAATGAATATAAACTATTTACGAGTGGGCTTTCGGTGTGTCCTCTGAATGCTAAAATACACTATAATGTCGCCAAAGTGGCTGATAGTGAGCAACATGTAGAATGGGCTCTAATGGAATACAAAGAATCAATCAGATTGAATCCTACGTACTACCAGGCGATGAATAATCTAGGGAATCTACTAAAGACTTTAAAACGGTTCGACGAAGCAGAATATTACCTACGAGAAGCAATTAAACAGAAGAATGACTACCCGGCAACGTGGATGAATCTAGGAATTGTATTAGCTAATAAAAAACAATACCGCGAATCGGAGATAGCCTACAAAACCGCTATACAACACCGAAGAAAATATCCGGACTGTTATTATAACCTGGGAAACTTGTATTTAGAGCTGAACGATACGAATGCTGCGTCTGAATGTTGGTTACAGGCCATAAATTTAAACTCTAAGCACAATTTGGCTTGGACTAATTTACTTGCGCTACTTGATAATACAGGACAAACTGACAAGGCTCTAAAAATCATTCCGCGTGCACTCAACGAATTACCGGATTCGGCATCAGTAAATTTCGCTGTTGCAAATATTTACGGAAAAATTGAACTTTATGTGCAAGCTGAAAAGTATTTCAAAATCGCAATTAAATTGTTCGGCAAAAGAGTCCAAGCTCTTCATTTCTCAAATCTAGGTGTTTTGTACCACCGATGGAAGAAATATAGTTTAGCCAAAGAAATGTATAGTAAAGCTATCGAATTAGATCCATTATTTACAAGCGCACAGAAAAATCTGAAGACTCTAAAGAGACTAAACTAA

Protein

MSGERLIAIHFKITNLICHIWGCIVLWIFLRTVLNIQNEGFYETSFLTTLLFAVHPIHVEAVSGIVGRADVMASNIFLLAFLVYHFSQSKSKSIWKHLILLTTIILSGISMLFKENGITVLGFCLVYEIMNKMKFMKLKKSTTGNFVINNRFVNLELDSILRILIILSGAILLLSGRWLIMGGSYPEFKPVDNPAAFVENYYTRVKTYNYIYFLNILLLIWPQWLCYDWSMGCIPLLENNMDFRTIFIFIMYIYGGLLIKSLFNNKNHSTTKRSLIIGVSLMILPFLPAANIVRPVGFVIAERILYISSSGYCLLIVIGYKKICKKVNSVKCKVLSAMFLFLLIIYGMRSFQRSGDWQNEYKLFTSGLSVCPLNAKIHYNVAKVADSEQHVEWALMEYKESIRLNPTYYQAMNNLGNLLKTLKRFDEAEYYLREAIKQKNDYPATWMNLGIVLANKKQYRESEIAYKTAIQHRRKYPDCYYNLGNLYLELNDTNAASECWLQAINLNSKHNLAWTNLLALLDNTGQTDKALKIIPRALNELPDSASVNFAVANIYGKIELYVQAEKYFKIAIKLFGKRVQALHFSNLGVLYHRWKKYSLAKEMYSKAIELDPLFTSAQKNLKTLKRLN

Description

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.

Catalytic Activity

dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)
dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)

Similarity

Belongs to the TMTC family.

Keywords

Alternative splicing   Complete proteome   Endoplasmic reticulum   Membrane   Reference proteome   Repeat   TPR repeat   Transferase   Transmembrane   Transmembrane helix   Polymorphism  

Feature

chain  Protein O-mannosyl-transferase TMTC4
splice variant  In isoform 3.
sequence variant  In dbSNP:rs3809371.

Uniprot

A0A2A4K6I1   A0A212FFY2   A0A2A4K7I8   A0A194R8P6   A0A194PQG0   A0A2H1VBH6   + More
A0A437BJE0   A0A0L7L9Z8   A0A0M9A5U5   A0A2A3EDI1   A0A232FD09   A0A1B6I8D4   A0A164Y413   A0A0P5QVL4   A0A0P6DYF7   D6WKI5   A0A1B6KLG0   T1HCD0   A0A224XJH2   A0A2J7QL63   A0A158NSY2   A0A0L7RIM8   A0A069DWL5   E9HNB4   A0A0P6I3B5   E2CA07   A0A195C3D0   L5KVV2   F7D9L4   A0A0P5X6G4   A0A154P854   A0A452RYB6   A0A2U3W9J5   A0A287B0H9   A0A3Q2H906   D2H0A6   A0A0P4WHF3   A0A2Y9JL06   A0A3Q1LKM2   E0VLB8   A0A224YV62   A0A2J8X8C6   A0A3Q7SUN2   G3HGS4   F1MXG4   A0A2J8X8D6   A0A3Q7PA36   A0A443RK51   A0A091IK05   F1PL94   A0A2Y9JBZ5   A0A091E7G0   A0A131XZU2   A0A091PEE8   Q8BG19   A0A2Y9JFV4   A0A2Y9JBX8   A0A3Q1M4B4   R0LWH4   U3I4T0   A0A091G394   A0A2I0UA52   A0A093S391   U6DKU8   A0A0A0A0Z3   A0A091UMF7   X1WSG6   A0A093QTD3   A0A0Q3TZX8   A0A091IPX9   A0A093FQ10   F1RP11   A0A2H8U132   A0A384BLQ6   A0A3Q7W3U9   A0A3R7M9H9   M3W7C8   A0A452VFB8   A0A2P8ZHJ3   A0A091CZQ7   A0A452VFD8   A0A151NSG8   H0ZKX3   A0A401PDF0   A0A1U7QI59   A0A0L8I9F3   A0A1W4X688   A0A2D4HQJ0   A0A1U7SRN8   A0A3Q0DKK9   A0A401SDS8   Q5T4D3   Q5T4D3-3   G3R9Z8   A0A3Q7VJW7   A0A452ENZ9   A0A337S813   A0A2I2YD76   W5P387   A0A452VF85  

EC Number

2.4.1.109

Pubmed

22118469    26354079    26227816    28648823    18362917    19820115    + More
21347285    26334808    21292972    20798317    23258410    19892987    20010809    19393038    20566863    28797301    21804562    16341006    16141072    15489334    23749191    17975172    24813606    29403074    22293439    20360741    30297745    14702039    17974005    15057823    28973932    16959974    22398555    20809919   

EMBL

NWSH01000076    PCG79875.1    AGBW02008743    OWR52645.1    PCG79874.1    KQ460615    + More
KPJ13620.1    KQ459602    KPI93370.1    ODYU01001646    SOQ38161.1    RSAL01000046    RVE50574.1    JTDY01002115    KOB72076.1    KQ435727    KOX77837.1    KZ288282    PBC29544.1    NNAY01000442    OXU28349.1    GECU01024556    JAS83150.1    LRGB01000944    KZS14859.1    GDIQ01118436    JAL33290.1    GDIQ01070397    JAN24340.1    KQ971342    EFA04002.2    GEBQ01027704    JAT12273.1    ACPB03002116    GFTR01007816    JAW08610.1    NEVH01013250    PNF29325.1    ADTU01002481    ADTU01002482    ADTU01002483    ADTU01002484    KQ414584    KOC70586.1    GBGD01000658    JAC88231.1    GL732695    EFX66778.1    GDIQ01011118    JAN83619.1    GL453916    EFN75244.1    KQ978350    KYM94696.1    KB030555    ELK14918.1    GDIP01076731    JAM26984.1    KQ434825    KZC07388.1    AEMK02000079    ACTA01017390    GL192404    EFB25973.1    GDRN01088834    JAI60767.1    DS235271    EEB14174.1    GFPF01010350    MAA21496.1    NDHI03003370    PNJ78279.1    JH000360    EGW09368.1    PNJ78281.1    NCKU01000399    NCKU01000396    RWS15638.1    RWS15645.1    KL217898    KFO99980.1    AAEX03013345    AAEX03013346    KK717783    KFO52572.1    GEFM01004550    JAP71246.1    KK657220    KFQ05721.1    AK015064    AK017580    AK028333    AK033947    AK039093    AK043293    AK044391    AK045271    AK049748    AK082526    BC031368    KB742744    EOB04833.1    ADON01040036    ADON01040037    KL447766    KFO76995.1    KZ505950    PKU42891.1    KL414475    KFW77444.1    HAAF01011372    CCP83196.1    KL870166    KGL87053.1    KL409734    KFQ91557.1    ABLF02018964    KL672873    KFW87187.1    LMAW01000359    KQL59326.1    KK500610    KFP09435.1    KK394317    KFV56414.1    GFXV01007313    MBW19118.1    QCYY01001624    ROT76660.1    AANG04001781    PYGN01000056    PSN55969.1    KN123763    KFO23420.1    AKHW03002195    KYO39415.1    ABQF01013266    BFAA01000333    GCB71148.1    KQ416274    KOF97630.1    IACK01048561    LAA74213.1    BEZZ01000209    GCC28503.1    AK056409    AK027530    AK299859    BX647956    AL359085    BC018707    CABD030090626    CABD030090627    CABD030090628    CABD030090629    CABD030090630    CABD030090631    CABD030090632    LWLT01000013    AMGL01016174    AMGL01016175    AMGL01016176   

Proteomes

UP000218220    UP000007151    UP000053240    UP000053268    UP000283053    UP000037510    + More
UP000053105    UP000242457    UP000215335    UP000076858    UP000007266    UP000015103    UP000235965    UP000005205    UP000053825    UP000000305    UP000008237    UP000078542    UP000010552    UP000002281    UP000076502    UP000291022    UP000245340    UP000008227    UP000008912    UP000248482    UP000009136    UP000009046    UP000286640    UP000001075    UP000286641    UP000285301    UP000054308    UP000002254    UP000052976    UP000000589    UP000016666    UP000053760    UP000053858    UP000053283    UP000007819    UP000053258    UP000051836    UP000053119    UP000261680    UP000286642    UP000283509    UP000011712    UP000291021    UP000245037    UP000028990    UP000050525    UP000007754    UP000288216    UP000189706    UP000053454    UP000192223    UP000189704    UP000287033    UP000005640    UP000001519    UP000291000    UP000002356   

PRIDE

G3HGS4    Q8BG19    F1RP11    Q5T4D3   

Pfam

PF00515   TPR_1        + More
PF08409   DUF1736
PF13181   TPR_8
PF13519   VWA_2
PF07719   TPR_2

Interpro

IPR001440   TPR_1        + More
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       
IPR013618   DUF1736       
IPR002035   VWF_A       
IPR036465   vWFA_dom_sf       
IPR013105   TPR_2       
IPR006597   Sel1-like       

SUPFAM

SSF48452   SSF48452        + More
SSF53300   SSF53300       

Gene 3D

1.25.40.10     3.40.50.410    

ProteinModelPortal

A0A2A4K6I1   A0A212FFY2   A0A2A4K7I8   A0A194R8P6   A0A194PQG0   A0A2H1VBH6   + More
A0A437BJE0   A0A0L7L9Z8   A0A0M9A5U5   A0A2A3EDI1   A0A232FD09   A0A1B6I8D4   A0A164Y413   A0A0P5QVL4   A0A0P6DYF7   D6WKI5   A0A1B6KLG0   T1HCD0   A0A224XJH2   A0A2J7QL63   A0A158NSY2   A0A0L7RIM8   A0A069DWL5   E9HNB4   A0A0P6I3B5   E2CA07   A0A195C3D0   L5KVV2   F7D9L4   A0A0P5X6G4   A0A154P854   A0A452RYB6   A0A2U3W9J5   A0A287B0H9   A0A3Q2H906   D2H0A6   A0A0P4WHF3   A0A2Y9JL06   A0A3Q1LKM2   E0VLB8   A0A224YV62   A0A2J8X8C6   A0A3Q7SUN2   G3HGS4   F1MXG4   A0A2J8X8D6   A0A3Q7PA36   A0A443RK51   A0A091IK05   F1PL94   A0A2Y9JBZ5   A0A091E7G0   A0A131XZU2   A0A091PEE8   Q8BG19   A0A2Y9JFV4   A0A2Y9JBX8   A0A3Q1M4B4   R0LWH4   U3I4T0   A0A091G394   A0A2I0UA52   A0A093S391   U6DKU8   A0A0A0A0Z3   A0A091UMF7   X1WSG6   A0A093QTD3   A0A0Q3TZX8   A0A091IPX9   A0A093FQ10   F1RP11   A0A2H8U132   A0A384BLQ6   A0A3Q7W3U9   A0A3R7M9H9   M3W7C8   A0A452VFB8   A0A2P8ZHJ3   A0A091CZQ7   A0A452VFD8   A0A151NSG8   H0ZKX3   A0A401PDF0   A0A1U7QI59   A0A0L8I9F3   A0A1W4X688   A0A2D4HQJ0   A0A1U7SRN8   A0A3Q0DKK9   A0A401SDS8   Q5T4D3   Q5T4D3-3   G3R9Z8   A0A3Q7VJW7   A0A452ENZ9   A0A337S813   A0A2I2YD76   W5P387   A0A452VF85  

PDB

1W3B     E-value=9.3541e-14,     Score=189

KEGG

101741634    K23424 protein O-mannosyl-transferase [EC:2.4.1.-] | (RefSeq) transmembrane and TPR repeat-containin

GO

GO:0016021   GO:0016740   GO:0000030   GO:0035269   GO:0004169   GO:0005783   GO:0005515   GO:0005634   GO:0008270   GO:0046872   GO:0005794   GO:0008565   GO:0015031   GO:0030123   GO:0016876   GO:0043039  

Subcellular location

Membrane  
Endoplasmic reticulum  

Length:

628

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

190.83663

Exp number, first 60 AAs:

26.69918

Total prob of N-in:

0.87592

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  64

TMhelix

65  -  87

inside

88  -  93

TMhelix

94  -  113

outside

114  -  158

TMhelix

159  -  181

inside

182  -  207

TMhelix

208  -  225

outside

226  -  244

TMhelix

245  -  263

inside

264  -  274

TMhelix

275  -  293

outside

294  -  297

TMhelix

298  -  320

inside

321  -  326

TMhelix

327  -  346

outside

347  -  628

 

 

Pi

276.150307

Theta

188.522306

Tajima's D

2.039102

CLR

0.135744

CSRT

0.892405379731013

Interpretation

Uncertain