Gene

KWMTBOMO09004

Annotation

PREDICTED:_multiple_C2_and_transmembrane_domain-containing_protein_1-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr15(+):9511726-9537897      View in EpiBrowser

Full name

Multiple C2 and transmembrane domain-containing protein      

Location in the cell

PlasmaMembrane   Reliability : 2.536

CDS

ATGTATCCGATCCGGTACTACAATGAAGTGTCGTTCCCGATCCCGGACGGTTTCGGTATGGATCCGATGGTACCGAACACGCTGGTGGTATCAGCAGACATCATGGACCGGATCGGAAGCGGACTTTCGTTGCTCCGAGATCACGGAAAAAAAGTACAAAAGTACGTGTGGAAAAACAGAAAATTTGACGTACTGAAGAAGCCTACGAAATCTTTAGTAAATATCGTATTAATAGAAGCTAAAGACTTGCCGGATGACCAGACTACAACCTGCAATGGCCTCTACTGCAAGTTCAAGTTAGGCAACGAATCTCACAAATCTAGACAAGTATTGAAAACAAAGCCTGCATGGTGTGAGAGATTCAATATATATTTGTACGAGGAAAACAATTTAGAGGTATCCTTGTGGCATAAAGGAAAACAGAAAAACTTTATGGGAAGATGCGTCATTGACCTTTCTCGACTCGAAAAAGAAAAGACTCACGATATTTGGCAGGAATTGGAATGTGGATACGGTTTTATACATATGTTGATCACGGTCAACGGATCACAGTTAACCAGAGGATTGGCTGTTGACAATATACCGACAAGCAACAACGTTTTACACCCAACACCAAATATTGAAGAATTTTCATGGTATCGCCTAAAGAACAATTGGAATGAAGTGGGTCAGTTGTCAGTGACTGTATACGGCGCCAGAGGGCTAAGTCCACTCGGGATCAGCGGAAAGGCTGATGCATATTGCGTTTTAGTCTTGGATAACTCAAGGATACAGACTCACACAGTCCGTGGCGCGGCAGAGCCGATGTGGAACAAAAGTTATACATTTGCCGTAAACGATATTACGTCAACCCTGGATATCAAAGTTCACGATGAATCGATTATCGGTGAAACTCTCGGTAAAATATCGATACCACTCTTACGAATCATCAACGAAGAGAAAAGATGGTACGCTCTAAAAGATAAAACGAAAAAGTCGAATGCGAAGGGAAACTGCCCCAGGATACTCCTGCAGATGTCCATTGTATGGAATCCGTTAAAAGCTGCGCTACGAACTTTAAGTCCTAAGGAAACGAAATACGATCAGAAGACGCCTAAAAAATTTAGTATTCCCTTAATATATAACAATCTGCTATTCATCAAAGATATATTTAATGTGGTACATACAGGGAACGAATATTTAAAGAATTCATTTGAATGGGAGAACAGAGAGAAGTCGGTGCTAGCGTTATGCGCTTGGCTGGTCTTCTGGTTCTTTTTCCGAATGTGGATGACACCGCTGCTAGTTCTTCTGCCGTTCCTTTACTACTGGACCGGTCACCGCAGCAATAGTACTACTAATTCATTAAGTAACATTTACGGATCCGAGGATGAATTATCCGAAGAGGATCTTGAATCAACGAAGGATGAAAAAACGATTAAAACCCGTCTCTACGGATTACAGGAATTGACGTTTACAATAAAAGACGGCATCGATTACATAGTGTCACTTTTAGAGCGAGTTAAAAATTTATTGAATTTCACTATCCCGTACCTAAGTTATTTAGCGATGGCCGCAATGGTGGGTCTCAGCGTGGCGTTTTATCTAATACCTGCGAACTACATCTTCATGGCATTGGGTATTTATAAATTTACTCGTAAATACTTGAATCCCGATCGAGTTCCGAACAATGATATCTTGGATTTCATATCGAGGGTGCCCGACGATAGGACACTGAAACAATGGCAGGAATTGAAAGTACCCGAACCGAGCTTAAGCAGGACAGGATCAAAGTGCAGAAGATAA

Protein

MYPIRYYNEVSFPIPDGFGMDPMVPNTLVVSADIMDRIGSGLSLLRDHGKKVQKYVWKNRKFDVLKKPTKSLVNIVLIEAKDLPDDQTTTCNGLYCKFKLGNESHKSRQVLKTKPAWCERFNIYLYEENNLEVSLWHKGKQKNFMGRCVIDLSRLEKEKTHDIWQELECGYGFIHMLITVNGSQLTRGLAVDNIPTSNNVLHPTPNIEEFSWYRLKNNWNEVGQLSVTVYGARGLSPLGISGKADAYCVLVLDNSRIQTHTVRGAAEPMWNKSYTFAVNDITSTLDIKVHDESIIGETLGKISIPLLRIINEEKRWYALKDKTKKSNAKGNCPRILLQMSIVWNPLKAALRTLSPKETKYDQKTPKKFSIPLIYNNLLFIKDIFNVVHTGNEYLKNSFEWENREKSVLALCAWLVFWFFFRMWMTPLLVLLPFLYYWTGHRSNSTTNSLSNIYGSEDELSEEDLESTKDEKTIKTRLYGLQELTFTIKDGIDYIVSLLERVKNLLNFTIPYLSYLAMAAMVGLSVAFYLIPANYIFMALGIYKFTRKYLNPDRVPNNDILDFISRVPDDRTLKQWQELKVPEPSLSRTGSKCRR

Description

Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (PubMed:28485711).

Cofactor

Ca(2+)

Keywords

Alternative splicing   Calcium   Complete proteome   Endoplasmic reticulum   Membrane   Reference proteome   Repeat   Transmembrane   Transmembrane helix  

Feature

chain  Multiple C2 and transmembrane domain-containing protein
splice variant  In isoform 2.

Uniprot

A0A2A4J601   A0A2H1V383   A0A2A4J4U8   A0A194R7I2   A0A3S2NMQ7   A0A194PQF0   + More
A0A212F6Q9   A0A2A4J5L1   A0A1E1W180   A0A3S2L1S9   A0A2A4J510   A0A2A4K8X0   A0A194R714   A0A2H1WBS6   H9JW63   A0A2A4K984   A0A2W1BKK6   A0A437BN69   A0A067QZE1   E0VQX2   A0A1Y1M3S5   A0A2J7QM48   A0A1Y1M0D1   U4UKD4   T1I1Y3   A0A0N0P9T6   N6TJP3   A0A232FFH3   A0A1Y1M5V4   Q174I5   A0A1E1X4F5   A0A1I8MDV2   A0A1E1XKP4   A0A1I8PKK1   A0A182GQ57   A0A0P6IW11   A0A1Q3G4S2   A0A1Q3G4S1   A0A1I8MDU5   A0A1S4FEV1   A0A1Q3G4R3   A0A1Q3G4Q9   A0A1E1WBJ9   A0A1I8PKP5   A0A0K8VPT3   A0A034VM56   A0A336MFH5   W8B6U0   A0A3S2M9K5   A0A182X6G0   A0A084VFA7   A0A182UEL5   A0A182VKM5   A0A182I3R3   A0A1S4GVR1   A0A182KRV2   A0A182JQQ1   A0A182RFQ2   A0A182P9V6   A0A0A1XHY1   A0A182J121   A0A182WIT4   A0A182XZH8   A0A182MA45   A0A182Q4S6   A0A182NHJ8   B4QD30   Q7JZN2   E9GTE2   B4HP15   A0A210PMT3   A0A1A9XHA5   B4GA37   Q5TX35   A1ZBD6-3   A1ZBD6   A1ZBD6-2   A0A1B6CV73   A0A341BLU7   A0A0P5PPJ2   B3MI22   A0A341BIY8   A0A0J9RG79   A0A3Q1EAQ1   B3NKB2   A0A341BIZ4   A0A340YBK5   A0A2U4AW94   A0A341BIZ3   A0A341BKF4   A0A1A9WYX3   A0A2U4AWR9   A0A2U4AWA2   A0A384BDH7   A0A341BLU3   A0A384BDZ8   A0A384BCQ7   A0A384BCV7  

Pubmed

26354079    22118469    19121390    28756777    24845553    20566863    + More
28004739    23537049    28648823    17510324    28503490    25315136    29209593    26483478    26999592    25348373    24495485    24438588    12364791    20966253    25830018    25244985    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    21292972    28812685    28485711    22936249   

EMBL

NWSH01002972    PCG67166.1    ODYU01000314    SOQ34832.1    PCG67167.1    KQ460615    + More
KPJ13607.1    RSAL01000237    RVE43708.1    KQ459602    KPI93360.1    AGBW02009983    OWR49417.1    PCG67169.1    GDQN01010306    JAT80748.1    RVE43709.1    PCG67165.1    NWSH01000040    PCG80354.1    KPJ13608.1    ODYU01007596    SOQ50513.1    BABH01025337    BABH01025338    PCG80353.1    KZ150109    PZC73376.1    RSAL01000029    RVE51755.1    KK852859    KDR14857.1    DS235442    EEB15778.1    GEZM01043132    JAV79290.1    NEVH01013215    PNF29689.1    GEZM01043131    JAV79292.1    KB632339    ERL92928.1    ACPB03005944    KQ459166    KPJ03575.1    APGK01034847    APGK01034848    APGK01034849    APGK01034850    KB740923    ENN78073.1    NNAY01000316    OXU29270.1    GEZM01043135    JAV79286.1    CH477410    EAT41473.1    GFAC01005038    JAT94150.1    GFAA01003656    JAT99778.1    JXUM01079729    JXUM01079730    JXUM01079731    JXUM01079732    GDUN01000054    JAN95865.1    GFDL01000252    JAV34793.1    GFDL01000251    JAV34794.1    GFDL01000254    JAV34791.1    GFDL01000258    JAV34787.1    GDQN01006737    JAT84317.1    GDHF01011734    JAI40580.1    GAKP01015775    JAC43177.1    UFQT01001061    SSX28680.1    GAMC01021074    GAMC01021071    JAB85484.1    RSAL01000007    RVE54120.1    ATLV01012371    KE524785    KFB36651.1    APCN01000218    AAAB01008807    GBXI01009905    GBXI01009819    GBXI01003706    JAD04387.1    JAD04473.1    JAD10586.1    AXCM01001910    AXCN02000592    CM000362    EDX07735.1    AE013599    AY071153    AAF57640.2    AAL48775.1    GL732563    EFX77264.1    CH480816    EDW48517.1    NEDP02005580    OWF37787.1    CH479181    EDW31789.1    EAL41731.2    GEDC01020165    GEDC01015264    JAS17133.1    JAS22034.1    GDIQ01131074    JAL20652.1    CH902619    EDV38032.2    CM002911    KMY94937.1    CH954179    EDV55134.2   

Proteomes

UP000218220    UP000053240    UP000283053    UP000053268    UP000007151    UP000005204    + More
UP000027135    UP000009046    UP000235965    UP000030742    UP000015103    UP000019118    UP000215335    UP000008820    UP000095301    UP000095300    UP000069940    UP000076407    UP000030765    UP000075902    UP000075903    UP000075840    UP000075882    UP000075881    UP000075900    UP000075885    UP000075880    UP000075920    UP000076408    UP000075883    UP000075886    UP000075884    UP000000304    UP000000803    UP000000305    UP000001292    UP000242188    UP000092443    UP000008744    UP000007062    UP000252040    UP000007801    UP000257200    UP000008711    UP000265300    UP000245320    UP000091820    UP000261681   

PRIDE

H9JW63    Q7JZN2    A1ZBD6   

Pfam

PF00168   C2        + More
PF08372   PRT_C

Interpro

IPR000008   C2_dom        + More
IPR035892   C2_domain_sf       
IPR013583   PRibTrfase_C       
IPR001565   Synaptotagmin       

Gene 3D

2.60.40.150    

ProteinModelPortal

A0A2A4J601   A0A2H1V383   A0A2A4J4U8   A0A194R7I2   A0A3S2NMQ7   A0A194PQF0   + More
A0A212F6Q9   A0A2A4J5L1   A0A1E1W180   A0A3S2L1S9   A0A2A4J510   A0A2A4K8X0   A0A194R714   A0A2H1WBS6   H9JW63   A0A2A4K984   A0A2W1BKK6   A0A437BN69   A0A067QZE1   E0VQX2   A0A1Y1M3S5   A0A2J7QM48   A0A1Y1M0D1   U4UKD4   T1I1Y3   A0A0N0P9T6   N6TJP3   A0A232FFH3   A0A1Y1M5V4   Q174I5   A0A1E1X4F5   A0A1I8MDV2   A0A1E1XKP4   A0A1I8PKK1   A0A182GQ57   A0A0P6IW11   A0A1Q3G4S2   A0A1Q3G4S1   A0A1I8MDU5   A0A1S4FEV1   A0A1Q3G4R3   A0A1Q3G4Q9   A0A1E1WBJ9   A0A1I8PKP5   A0A0K8VPT3   A0A034VM56   A0A336MFH5   W8B6U0   A0A3S2M9K5   A0A182X6G0   A0A084VFA7   A0A182UEL5   A0A182VKM5   A0A182I3R3   A0A1S4GVR1   A0A182KRV2   A0A182JQQ1   A0A182RFQ2   A0A182P9V6   A0A0A1XHY1   A0A182J121   A0A182WIT4   A0A182XZH8   A0A182MA45   A0A182Q4S6   A0A182NHJ8   B4QD30   Q7JZN2   E9GTE2   B4HP15   A0A210PMT3   A0A1A9XHA5   B4GA37   Q5TX35   A1ZBD6-3   A1ZBD6   A1ZBD6-2   A0A1B6CV73   A0A341BLU7   A0A0P5PPJ2   B3MI22   A0A341BIY8   A0A0J9RG79   A0A3Q1EAQ1   B3NKB2   A0A341BIZ4   A0A340YBK5   A0A2U4AW94   A0A341BIZ3   A0A341BKF4   A0A1A9WYX3   A0A2U4AWR9   A0A2U4AWA2   A0A384BDH7   A0A341BLU3   A0A384BDZ8   A0A384BCQ7   A0A384BCV7  

PDB

2EP6     E-value=8.87462e-17,     Score=214

KEGG

101743125    no KO assigned | (RefSeq) multiple C2 and transmembrane domain-containing protein 1-like

GO

GO:0016021   GO:0005509   GO:0030672   GO:0046928   GO:0048168   GO:0005789   GO:0005515   GO:0005794   GO:0006810   GO:0046872   GO:0008565   GO:0015031   GO:0030123   GO:0016876   GO:0043039  

Subcellular location

Endoplasmic reticulum membrane  

Length:

594

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

49.10471

Exp number, first 60 AAs:

0.04614

Total prob of N-in:

0.42549

inside

1  -  412

TMhelix

413  -  435

outside

436  -  513

TMhelix

514  -  536

inside

537  -  594

 

 

Pi

218.813998

Theta

172.153823

Tajima's D

1.121513

CLR

0

CSRT

0.690415479226039

Interpretation

Uncertain