Gene

KWMTBOMO08998

Annotation

PREDICTED:_pseudouridine-metabolizing_bifunctional_protein_C1861.05_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr15(-):9435888-9453621      View in EpiBrowser

Full name

Pseudouridine-5'-phosphate glycosidase      

Location in the cell

Mitochondrial   Reliability : 2.046

CDS

ATGGCGTACCGACTAAATGGCATACCGAAACTTGTTCAGCGTAATTTGGGTTTTCTTAGAAATTATAGCGAGTCTCGTCATCCCTTCGTTTATTCCAAGGAAGTTTCTCGGGCGAAGTCAGAAAATATGCCAATAGTAGCCCTCGAATCAACTATTATTACACACGGAATGCCTTACCCACAGAACTTGGAAACGGCTCTGGAAGTGGAGAATATAATTAGGCAACGGGGTGCCGTTCCAGCGACTGTGGCAATTCTTAAAGGGCAATTGACCGTTGGTCTGACGGAAGATCAACTTCGATACCTTGCTCAGGCCAAAGGTGTAATTAAAGCATCGAGACGTGATCTTGCTTATATAGCTGCGGCTAAGCTTGACGGTGCCACAACCGTCGCTGGGACAATTATTGCTTCAGAATTAGCTGACATACCAGTCTTCGTGACCGGTGGAATTGGGGGCGTCCATCGTGAAGGTGAAAGTACACTAGACATCTCAGCAGATCTGAATGAACTCGGGCGAAGCAAAACACTCGTTGTTTGCAGCGGAATCAAATCAATACTCGACATTGGAAGAACTCTCGAATATTTGGAAACGCAAGGCGTCTGTGTGTGTTCGTTTGGCGAGTCTAACGAGTTTCCAGCATTTTACACGGTCCGTTCCGGTCACCGGGCTCCGTATAGCGTTGCCGACGCGAAGCACGCCGCTCGGATTCTTCACGAATCACACAGATTCCACCTCAATTCCGGCGTCGTCATCGCTGTTCCTGTGCCGCGACGTGACGCTATGGACGAAAAAGTAATTGAAGAGGCTATCAATAGTGCCCTGACGGATGCCAAAAGAAAAGGTATTCGCGGTAAAGAAGTTACTCCTTACATTTTATCGAACGTCAGTGAAGCGACCAGCGGCACGTCACTTGAAACCAATATCGCATTGATAAAGAACAATGCGCGCGTCGGCGCCGATATAGCCGTCGAATTTAAAAAACTCAAGAACGCCGACAATGTAAACGATTCTAATATTGGATTCCGCAAGGGCGCCGAGAATATCTCGAATTTCACGAGGACATTTCACACTTCGTCTAATACGAGGAGCGGGGCGGAGAATTGCGGAGATGATACGCCTATGCTCGCTTTAGATATGAAGGCGGACGGAGACGTGCTCGTGATCGGAGGGGCCAACGTTGACAGAACCTACAGAGTATCAGAAGATACCATTCAGCACAATTATGTTCGCGTGTCCGAGCGAGACAGCGAGATATTGCTTCTTCACACCAACTCGCACTGTTGA

Protein

MAYRLNGIPKLVQRNLGFLRNYSESRHPFVYSKEVSRAKSENMPIVALESTIITHGMPYPQNLETALEVENIIRQRGAVPATVAILKGQLTVGLTEDQLRYLAQAKGVIKASRRDLAYIAAAKLDGATTVAGTIIASELADIPVFVTGGIGGVHREGESTLDISADLNELGRSKTLVVCSGIKSILDIGRTLEYLETQGVCVCSFGESNEFPAFYTVRSGHRAPYSVADAKHAARILHESHRFHLNSGVVIAVPVPRRDAMDEKVIEEAINSALTDAKRKGIRGKEVTPYILSNVSEATSGTSLETNIALIKNNARVGADIAVEFKKLKNADNVNDSNIGFRKGAENISNFTRTFHTSSNTRSGAENCGDDTPMLALDMKADGDVLVIGGANVDRTYRVSEDTIQHNYVRVSERDSEILLLHTNSHC

Description

Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.

Catalytic Activity

D-ribose 5-phosphate + uracil = H2O + psi-UMP

Cofactor

Mn(2+)

Subunit

Homotrimer.

Similarity

Belongs to the pseudouridine-5'-phosphate glycosidase family.
Belongs to the carbohydrate kinase PfkB family.

Uniprot

H9JE33   A0A2H1WUY8   A0A2A4JUW0   A0A194PK04   A0A194R704   A0A212F6P5   + More
A0A452HRQ7   A0A1B6J3W4   A0A1B6K1A6   A0A084VBP9   H0ZN49   A0A1I6RYZ6   A0A182INK8   A0A3L8SGV1   A0A218V0X4   A0A182VIA2   A0A3Q3T1L6   A0A0P6GLY1   A0A1L8GW64   A0A1W4W8Z3   A0A285CS70   A0A0C7B735   A0A367J1X1   A0A0P5KGR8   A0A1J1IF73   A0A1X0RM47   A0A164XRG1   A0A182F9G3   A0A231RY48   A0A0P5DBB6   A0A1U6HKE9   A0A0P5QIH9   A0A0P5KM36   A0A0P6DCF7   A0A0N8BDK1   A0A0P5SHL0   A0A0P5LFI6   A0A0P5M4C4   A0A1J6WRK1   A0A0P4ZRU7   A0A0P5NMP2   A0A0P6WVQ5   A0A0P5GDW0   A0A0P5NZJ3   A0A0P5DKZ8   A0A0N8CFC0   A0A0P5J066   A0A0P5D6K7   A0A1B6BE42   A0A0P5LIS2   A0A0C1R7J9   A0A0P5LDJ7   A0A0P5W0Y9   A0A0P5JWV2   A0A0P6DWD4   A0A1A8CU46   A0A0P5ITJ9   A0A0P5WWE3   A0A0P5D2R0   A0A182XXD4   A0A0P5A5C8   A0A367JCP8   E9HD67   A0A1M5S1Q6   A0A068RTJ3   A0A3B4XWJ6   A0A0P4ZBZ9   A0A2D0RHN7   A0A2G4T858   A0A1X0RFX8   A0A0N8ARS7  

EC Number

4.2.1.70

Pubmed

19121390    26354079    22118469    28562605    24438588    20360741    + More
30282656    27762356    29674435    27956601    25489752    25244985    21292972   

EMBL

BABH01002526    ODYU01011263    SOQ56889.1    NWSH01000600    PCG75414.1    KQ459602    + More
KPI93353.1    KQ460615    KPJ13598.1    AGBW02009983    OWR49412.1    GECU01037450    GECU01013842    JAS70256.1    JAS93864.1    GECU01002470    JAT05237.1    ATLV01008987    KE524494    KFB35393.1    ABQF01016418    ABQF01016419    FPAA01000006    SFS69896.1    QUSF01000021    RLW01861.1    MUZQ01000075    OWK59576.1    GDIQ01043501    JAN51236.1    CM004470    OCT88087.1    OAOP01000004    SNX70407.1    CCYT01000006    CEG66759.1    PJQL01002543    RCH83829.1    GDIQ01191140    JAK60585.1    CVRI01000048    CRK98919.1    KV921571    ORE13077.1    LRGB01000944    KZS14499.1    MWSH01000001    OXS64367.1    GDIP01174734    JAJ48668.1    PVYY01000001    FVZH01000001    PRX79505.1    SLJ96284.1    GDIQ01113682    JAL38044.1    GDIQ01189598    JAK62127.1    GDIQ01079247    JAN15490.1    GDIQ01188251    JAK63474.1    GDIP01139644    JAL64070.1    GDIQ01170362    JAK81363.1    GDIQ01169566    JAK82159.1    MINN01000106    OIU70535.1    GDIP01208812    JAJ14590.1    GDIQ01144233    JAL07493.1    LIXZ01000003    KPL60501.1    GDIQ01243940    JAK07785.1    GDIQ01145626    JAL06100.1    GDIP01155791    JAJ67611.1    GDIP01137287    JAL66427.1    GDIQ01208209    JAK43516.1    GDIP01160484    JAJ62918.1    BDHH01000010    GAU77991.1    GDIQ01173007    JAK78718.1    AYSO01000017    KIE46491.1    GDIQ01173006    JAK78719.1    GDIP01093286    JAM10429.1    GDIQ01197854    JAK53871.1    GDIQ01071285    JAN23452.1    HADZ01018280    SBP82221.1    GDIQ01208210    JAK43515.1    GDIP01080638    JAM23077.1    GDIP01162075    JAJ61327.1    GDIP01203829    JAJ19573.1    PJQL01001603    RCH87718.1    GL732622    EFX70313.1    FQXH01000016    SHH32379.1    CBTN010000017    CDH53349.1    GDIP01215380    JAJ08022.1    KZ303842    PHZ16856.1    KV921861    ORE10945.1    GDIQ01249243    JAK02482.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000291020    + More
UP000030765    UP000007754    UP000198660    UP000075880    UP000276834    UP000197619    UP000075903    UP000261640    UP000186698    UP000192223    UP000219546    UP000054919    UP000252139    UP000183832    UP000242381    UP000076858    UP000069272    UP000214946    UP000189895    UP000237918    UP000182062    UP000050398    UP000095197    UP000031366    UP000076408    UP000000305    UP000242520    UP000027586    UP000261360    UP000221080    UP000242254    UP000242414   

PRIDE

H9JE33   

Pfam

PF04227   Indigoidine_A        + More
PF00294   PfkB

Interpro

IPR022830   Indigdn_synthA-like        + More
IPR007342   PsuG       
IPR029056   Ribokinase-like       
IPR011611   PfkB_dom       
IPR002173   Carboh/pur_kinase_PfkB_CS       
IPR002139   Ribo/fructo_kinase       

SUPFAM

SSF110581   SSF110581        + More
SSF53613   SSF53613       

Gene 3D

3.40.1790.10     3.40.1190.20    

ProteinModelPortal

H9JE33   A0A2H1WUY8   A0A2A4JUW0   A0A194PK04   A0A194R704   A0A212F6P5   + More
A0A452HRQ7   A0A1B6J3W4   A0A1B6K1A6   A0A084VBP9   H0ZN49   A0A1I6RYZ6   A0A182INK8   A0A3L8SGV1   A0A218V0X4   A0A182VIA2   A0A3Q3T1L6   A0A0P6GLY1   A0A1L8GW64   A0A1W4W8Z3   A0A285CS70   A0A0C7B735   A0A367J1X1   A0A0P5KGR8   A0A1J1IF73   A0A1X0RM47   A0A164XRG1   A0A182F9G3   A0A231RY48   A0A0P5DBB6   A0A1U6HKE9   A0A0P5QIH9   A0A0P5KM36   A0A0P6DCF7   A0A0N8BDK1   A0A0P5SHL0   A0A0P5LFI6   A0A0P5M4C4   A0A1J6WRK1   A0A0P4ZRU7   A0A0P5NMP2   A0A0P6WVQ5   A0A0P5GDW0   A0A0P5NZJ3   A0A0P5DKZ8   A0A0N8CFC0   A0A0P5J066   A0A0P5D6K7   A0A1B6BE42   A0A0P5LIS2   A0A0C1R7J9   A0A0P5LDJ7   A0A0P5W0Y9   A0A0P5JWV2   A0A0P6DWD4   A0A1A8CU46   A0A0P5ITJ9   A0A0P5WWE3   A0A0P5D2R0   A0A182XXD4   A0A0P5A5C8   A0A367JCP8   E9HD67   A0A1M5S1Q6   A0A068RTJ3   A0A3B4XWJ6   A0A0P4ZBZ9   A0A2D0RHN7   A0A2G4T858   A0A1X0RFX8   A0A0N8ARS7  

PDB

4GIL     E-value=2.40761e-70,     Score=675

KEGG

101743270    K16330 pseudouridylate synthase / pseudouridine kinase [EC:4.2.1.70 2.7.1.83] | (RefSeq) pseudouridi

PATHWAY

00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016798   GO:0008152   GO:0004730   GO:0046872   GO:0046113   GO:0016301   GO:0016773   GO:0004674   GO:0005524   GO:0005794   GO:0008565   GO:0015031   GO:0030123   GO:0016876   GO:0043039  

PANTHER

PTHR42909  

Length:

427

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.12511

Exp number, first 60 AAs:

0.00072

Total prob of N-in:

0.01216

outside

1  -  427

 

 

Pi

249.111036

Theta

161.278586

Tajima's D

1.67282

CLR

0.273276

CSRT

0.822858857057147

Interpretation

Uncertain