Gene

KWMTBOMO08991  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007783

Annotation

PREDICTED:_succinyl-CoA_ligase_[ADP-forming]_subunit_beta?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr15(-):9310179-9316141      View in EpiBrowser

Full name

Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial       + More
Succinate-CoA ligase subunit beta      

Alternative Name

ATP-specific succinyl-CoA synthetase subunit beta
Succinyl-CoA synthetase beta-A chain

Location in the cell

Mitochondrial   Reliability : 2.165

CDS

ATGGCGATTGTATTACCTCGTTCTCTTGGTTTTGCTGAAACAATATTATTTAGATATGGAAATAAGATATTGACAGCATCTTCAGCCAACAAATTTCCAAGTAAACAACAAGTCCGCCACTTGAATGTACATGAATACATAAGTTATACTCTACTACGGGACCATGGAATTCCTGTACCCAAATTTAATGTGGCCAAAACCAAGGATGAGGCAATTAAGTTTGCCACAGAACTCAATACCAAAGACATCGTTCTAAAAGCACAGGTTCTTGCTGGTGGTCGAGGGAAAGGTACCTTTAAGAATGGACTTAAAGGTGGAGTTCGAATGGTCAACACACCTGAAGTTGCTGGTGATATAGCAGGAAAGATGCTTAAACAACTCCTAGTAACAAAACAAACAGGGGCAGCAGGACGAATTTGCAACATGGTCATGGTCACAGAGAGGAAGTTCCCACGCAGGGAATACTACGTGGCAATTATGATGGAACGCAGTTTCAATGGTCCAGTCATCATTGCTTCATCTCAAGGTGGTGTCAACATTGAAGATGTTGCAGCTGAAAATCCTGATGCAATAACTTATGAACCTATTGATATTGTTTCGGGTATTACTGATGATCAAATTTGCCGTGTTATCGAAAAGATCGGTCTACAAGAATTTGCAACTGAAGCTCATGGTATGATTAAAAAAATGTATGATTTGTTCCTTAAGAAGGATGCCTTATTGATTGAAGTAAATCCGTATGCCGAAGATGCCTTGACAGGACAATTCTTCTGTTTGGATGCCAAGTTTAGATTTGACGATAATGCTGAATTCAGACAAAAAGAGCTATTTAGTTTGAGAGACACTACTCAAGAAGACCCCAAGGAAATTGAAGCAGCTAAATACAACTTAAATTACATTGCTCTCGATGGAAACATTGGGTGTATGGTTAACGGTGCTGGATTAGCTATGGCTACGATGGATATAATCAAACTCTACGGGGGTGACCCCGCTAACTTCTTGGATGTCGGTGGAGGCGCTACTGCCCAGGCTGTCTCTGAGGCGTTCAAAATCATTCTCTCAGACCCGAAGGTGACAGCTATTTTGGTGAACATTTTTGGTGGTATTATGAGGTGCGACGTCATTGCAGAAGGTATCATTAATGCTGCCAAAAATCTGAATATACAGATCCCAGTGATTGTTCGCCTTCAAGGAACGAAGGTTAACGAAGCTAGAAAGTTGGTAGCCGAGTCCGGGCTTCGCATCGTGCCTCGCGACGACCTGGACGAGGCCGCCAAACTCGCCGTGCAACTCTCAGAGATCGTTGCCCTAGCCAGAAAGGCTGGAGTTGAGGTTAAATTTGATATTCCAAGAGTTATGCTTGAAAAGTAA

Protein

MAIVLPRSLGFAETILFRYGNKILTASSANKFPSKQQVRHLNVHEYISYTLLRDHGIPVPKFNVAKTKDEAIKFATELNTKDIVLKAQVLAGGRGKGTFKNGLKGGVRMVNTPEVAGDIAGKMLKQLLVTKQTGAAGRICNMVMVTERKFPRREYYVAIMMERSFNGPVIIASSQGGVNIEDVAAENPDAITYEPIDIVSGITDDQICRVIEKIGLQEFATEAHGMIKKMYDLFLKKDALLIEVNPYAEDALTGQFFCLDAKFRFDDNAEFRQKELFSLRDTTQEDPKEIEAAKYNLNYIALDGNIGCMVNGAGLAMATMDIIKLYGGDPANFLDVGGGATAQAVSEAFKIILSDPKVTAILVNIFGGIMRCDVIAEGIINAAKNLNIQIPVIVRLQGTKVNEARKLVAESGLRIVPRDDLDEAAKLAVQLSEIVALARKAGVEVKFDIPRVMLEK

Description

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Catalytic Activity

ATP + CoA + succinate = ADP + phosphate + succinyl-CoA

Cofactor

Mg(2+)

Subunit

Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
Heterodimer of an alpha and a beta subunit.

Similarity

Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
Belongs to the succinate/malate CoA ligase beta subunit family.

Feature

chain  Succinate-CoA ligase subunit beta

Uniprot

A0A194PKT6   A0A194R7V5   S4NSU9   A0A212F6Q3   A0A2H1WGI7   A0A2A4IVF8   + More
H9JE36   W8BJB4   W8BZS1   A0A034VMK8   A0A2J7QIN4   A0A067R278   A0A0L0CLN1   A0A1I8MEN7   A0A2J7QVC5   D6WNP7   A0A0P4VNG2   A0A0T6AU44   T1PF72   A0A1L8EGZ6   A0A023FCI6   A0A1L8EGY7   A0A1B6FWG5   J3JT86   Q16P82   A0A0V0G4C3   D3TM34   A0A069DUI1   A0A1B0C0H3   A0A1A9YDY8   A0A1A9Z6E2   A0A182HMZ8   A0A023EUP7   A0A1A9VA18   A0A1B6HGI8   A0A182QTV2   K7IUH8   A0A0A9X9V3   A0A182VNQ9   A0A182LI78   Q7PMT2   A0A224XNB4   A0A232F6W6   T1HFZ7   A0A1B6E4X5   A0A084VZT2   Q16P83   A0A182MX75   A0A182JEX9   A0A182NNB2   A0A182R2R2   A0A023ESD2   A0A0R3NJ42   A0A182P605   A0A182WAR1   A0A0R3NPJ5   A0A1W4W933   A0A182WZW1   A0A1A9WH09   B0WFW7   A0A0M5IZT8   N6T7J6   A0A1L8E0M1   B5DYI6   A0A336MYF9   T1DE80   A0A2M3ZFY6   A0A0Q9WFA8   A0A0Q9X7F6   A0A1L8E0U5   A0A3B0KDT3   A0A1Q3FK18   B4GFU8   A0A1Q3FK72   A0A182YI33   A0A0R1E1S6   A0A0Q9WNB3   B4LXK7   A0A126GUR6   A0A1W4W320   B4N817   A0A0C9RA06   Q95U38   B4K9E6   A0A0Q9X0L0   A0A0P8XXK4   B4HKZ0   A0A182FZQ3   A0A0N8P1A9   A0A1J1IZ15   R4WE04   B4JTJ3   A0A2M4AP58   A0A2M4BN71   B4PTX7   A0A195C7K0   B3P1W3   A0A0B4JCW4   A0A2M4A401   A0A1W4VQZ0  

EC Number

6.2.1.5
6.2.1.-

Pubmed

26354079    23622113    22118469    19121390    24495485    25348373    + More
24845553    26108605    25315136    18362917    19820115    27129103    25474469    22516182    23537049    17510324    20353571    26334808    24945155    20075255    25401762    26823975    20966253    12364791    14747013    17210077    28648823    24438588    15632085    17994087    24330624    18057021    25244985    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    23691247   

EMBL

KQ459602    KPI93344.1    KQ460615    KPJ13589.1    GAIX01013902    JAA78658.1    + More
AGBW02009983    OWR49404.1    ODYU01008491    SOQ52137.1    NWSH01006966    PCG63172.1    BABH01002535    BABH01002536    GAMC01007723    JAB98832.1    GAMC01007724    JAB98831.1    GAKP01014381    GAKP01014379    JAC44571.1    NEVH01013583    PNF28442.1    KK852751    KDR17135.1    JRES01000223    KNC33205.1    NEVH01010477    PNF32534.1    KQ971342    EFA03750.1    GDKW01000414    JAI56181.1    LJIG01022813    KRT78584.1    KA647442    AFP62071.1    GFDG01000812    JAV17987.1    GBBI01000214    JAC18498.1    GFDG01000822    JAV17977.1    GECZ01015223    JAS54546.1    BT126442    KB630727    KB632357    AEE61406.1    ERL83818.1    ERL93444.1    CH477792    EAT36152.1    GECL01003227    JAP02897.1    CCAG010009033    EZ422486    ADD18762.1    GBGD01001428    JAC87461.1    JXJN01023622    APCN01008727    GAPW01001414    JAC12184.1    GECU01033862    GECU01013174    JAS73844.1    JAS94532.1    AXCN02001904    AAZX01002659    GBHO01035289    GBHO01029724    GBRD01008202    GBRD01004408    GDHC01010966    JAG08315.1    JAG13880.1    JAG57619.1    JAQ07663.1    AAAB01008968    EAA13239.4    GFTR01006354    JAW10072.1    NNAY01000861    OXU26169.1    ACPB03014676    GEDC01004344    JAS32954.1    ATLV01018955    KE525256    KFB43476.1    EAT36151.1    AXCM01000075    GAPW01001435    JAC12163.1    CM000070    KRT00916.1    KRT00915.1    DS231921    EDS26502.1    CP012526    ALC46361.1    APGK01040619    KB740984    ENN76189.1    GFDF01001833    JAV12251.1    EDY68366.2    UFQS01002857    UFQT01002857    SSX14777.1    SSX34169.1    GALA01001147    JAA93705.1    GGFM01006599    MBW27350.1    CH940650    KRF82930.1    CH933806    KRG01626.1    GFDF01001800    JAV12284.1    OUUW01000008    SPP84429.1    GFDL01007167    JAV27878.1    CH479182    EDW34483.1    GFDL01007152    JAV27893.1    CM000160    KRK03216.1    KRF82929.1    EDW66791.1    AE014297    ALI30546.1    CH964232    EDW81268.2    GBYB01003651    JAG73418.1    AY058331    AAL13560.1    ACZ94855.1    EDW15578.2    KRG01627.1    CH902617    KPU79409.1    CH480815    EDW42954.1    KPU79412.1    CVRI01000064    CRL05523.1    AK418009    BAN21224.1    CH916373    EDV95083.1    GGFK01009232    MBW42553.1    GGFJ01005321    MBW54462.1    EDW96588.1    KQ978231    KYM96128.1    CH954181    EDV49851.1    ADV37289.2    GGFK01002131    MBW35452.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000218220    UP000005204    UP000235965    + More
UP000027135    UP000037069    UP000095301    UP000007266    UP000030742    UP000008820    UP000092444    UP000092460    UP000092443    UP000092445    UP000075840    UP000078200    UP000075886    UP000002358    UP000075903    UP000075882    UP000007062    UP000215335    UP000015103    UP000030765    UP000075883    UP000075880    UP000075884    UP000075900    UP000001819    UP000075885    UP000075920    UP000192223    UP000076407    UP000091820    UP000002320    UP000092553    UP000019118    UP000008792    UP000009192    UP000268350    UP000008744    UP000076408    UP000002282    UP000000803    UP000192221    UP000007798    UP000007801    UP000001292    UP000069272    UP000183832    UP000001070    UP000078542    UP000008711   

PRIDE

H9JE36   

Pfam

PF00549   Ligase_CoA        + More
PF08442   ATP-grasp_2

Interpro

IPR016102   Succinyl-CoA_synth-like        + More
IPR013650   ATP-grasp_succ-CoA_synth-type       
IPR005811   CoA_ligase       
IPR011761   ATP-grasp       
IPR005809   Succ_CoA_synthase_bsu       
IPR017866   Succ-CoA_synthase_bsu_CS       
IPR034723   Succ_CoA_betaA_euk       
IPR013815   ATP_grasp_subdomain_1       

SUPFAM

SSF52210   SSF52210       

Gene 3D

3.30.1490.20     3.40.50.261    

ProteinModelPortal

A0A194PKT6   A0A194R7V5   S4NSU9   A0A212F6Q3   A0A2H1WGI7   A0A2A4IVF8   + More
H9JE36   W8BJB4   W8BZS1   A0A034VMK8   A0A2J7QIN4   A0A067R278   A0A0L0CLN1   A0A1I8MEN7   A0A2J7QVC5   D6WNP7   A0A0P4VNG2   A0A0T6AU44   T1PF72   A0A1L8EGZ6   A0A023FCI6   A0A1L8EGY7   A0A1B6FWG5   J3JT86   Q16P82   A0A0V0G4C3   D3TM34   A0A069DUI1   A0A1B0C0H3   A0A1A9YDY8   A0A1A9Z6E2   A0A182HMZ8   A0A023EUP7   A0A1A9VA18   A0A1B6HGI8   A0A182QTV2   K7IUH8   A0A0A9X9V3   A0A182VNQ9   A0A182LI78   Q7PMT2   A0A224XNB4   A0A232F6W6   T1HFZ7   A0A1B6E4X5   A0A084VZT2   Q16P83   A0A182MX75   A0A182JEX9   A0A182NNB2   A0A182R2R2   A0A023ESD2   A0A0R3NJ42   A0A182P605   A0A182WAR1   A0A0R3NPJ5   A0A1W4W933   A0A182WZW1   A0A1A9WH09   B0WFW7   A0A0M5IZT8   N6T7J6   A0A1L8E0M1   B5DYI6   A0A336MYF9   T1DE80   A0A2M3ZFY6   A0A0Q9WFA8   A0A0Q9X7F6   A0A1L8E0U5   A0A3B0KDT3   A0A1Q3FK18   B4GFU8   A0A1Q3FK72   A0A182YI33   A0A0R1E1S6   A0A0Q9WNB3   B4LXK7   A0A126GUR6   A0A1W4W320   B4N817   A0A0C9RA06   Q95U38   B4K9E6   A0A0Q9X0L0   A0A0P8XXK4   B4HKZ0   A0A182FZQ3   A0A0N8P1A9   A0A1J1IZ15   R4WE04   B4JTJ3   A0A2M4AP58   A0A2M4BN71   B4PTX7   A0A195C7K0   B3P1W3   A0A0B4JCW4   A0A2M4A401   A0A1W4VQZ0  

PDB

6G4Q     E-value=1.06121e-142,     Score=1299

KEGG

101744373    K01900 succinyl-CoA synthetase beta subunit [EC:6.2.1.4 6.2.1.5] | (RefSeq) succinyl-CoA ligase [ADP

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0006099   GO:0004775   GO:0005739   GO:0000287   GO:0016874   GO:0000166   GO:0046872   GO:0042709   GO:0006104   GO:0007291   GO:0031463   GO:0043280   GO:0003824   GO:0009361   GO:0008152   GO:0005794   GO:0008565   GO:0015031   GO:0030123   GO:0016876   GO:0043039  

PANTHER

PTHR11815  

Subcellular location

Mitochondrion  

Length:

456

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.14738

Exp number, first 60 AAs:

0.00113

Total prob of N-in:

0.00196

outside

1  -  456

 

 

Pi

207.373671

Theta

166.124734

Tajima's D

0.763454

CLR

0.338741

CSRT

0.587020648967552

Interpretation

Uncertain