Silkworm Genome Informatics Database

Gene

KWMTBOMO08990 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007745

Annotation

PREDICTED:_AP-3_complex_subunit_delta_[Bombyx_mori]

Location

Bomo_Chr15(+):9284452-9305576 View in EpiBrowser

Full name

AP-3 complex subunit delta + More
Cystathionine beta-synthase

Alternative Name

Delta adaptin subunit of AP-3
Garnet protein

Location in the cell

Nuclear Reliability : 3.121

CDS

ATGGCTTTAAAAAAAGTCAAAGGCAACTTCGAGAGGATGTTTGATAAAAACCTCACGGATTTGGTTCGAGGTATCCGAAATAATAAAGATAATGAGGCCAAGTACATTGCCCAATGTATGGAAGAAATAAAAATTGAACTACGACAGGATAACATTGCTGTTAAAGCAAATGCTGTTGCAAAATTGACATATCTGCAGATGCTGGGATATGATATATCATGGGCTATATTTAACATAATTGAAGTAATGAGCTCAAACAAGTTCACATGTAAACGTGTTGGATACTTAGCAGCAAGTCAGTCCTTCCATGCTGACTCTGAGCTGCTCATGTTAACCACTAATATGATTCGTAAAGATTTGAATGCTCAAAATCAATATGAAGCTGGGTTAGCTCTTAGTGGATTGAGTTGCTTCATTTCCCATGACTTAGCTAGAGATTTAGCAAATGACATCATGACATTGATGAGTTCCACAAAACCTTATTTAAGAATGAAGGCTGTGTTAATGATGTATAAAGTTTTTCTAAGGTATCCTGAAGCACTTAGACCTGCATTTCCTAAATTAAAAGAAAAGCTGGAAGATCCGGATCCAGGTGTACAATCGGCAGCAGTGAATGTTGTTTGTGAACTAGCGAGAAAAAACCCTAAAAATTATTTATCCTTAGCTCCAATTTTCTTCAAATTGATGACTACTTCCACTAACAATTGGATGCTGATAAAAATTATCAAATTGTTCGGTGCCTTAACCCCATTAGAGCCTCGGCTTGGCAAGAAACTGATAGAACCATTAACTAATTTAATTCATAGCACATCTGCAATGTCATTACTTTACGAGTGCATCAACACTGTAATAGCGGTGTTGATCAGTATAAGCAGCGGGATGCCGGGACACGCAGCCTCGGTACAGCTATGCGTACAGAAACTAAGAATATTAATTGAAGATAGCGATCAGAACCTAAAATACTTGGGCTTGCTGGCAATGTCAAGAATACTCAAGTCACACCCGAAGTCCGTTCAAGCTCACAAAGACCTCGTATCGGCGTGTCTTGACGACAAAGACGAGTCGATTCGACTGAGGGCACTCGGCCTTCTCTACGGAATGGTGTCCAAGAAAAATTTAATGGAAATAGTGAAGAAGTTGATGTCGCACATGGAACGTGCCGAGGGGACGTTATACCGGGACGAACTGCTGACCCGGATGATCGAGATCTGTTCTCAAAACAACTACCAGCACGTTGTGGATTTCGAGTGGTACATCACGGTACTGGCAGAGCTTACCGAAATGGAAACCAGTGCTAAACATGGGTGTATAATAGCGGCGCAGCTGACGGAGGTGGGCGCGCGCGTGGCGGACGTGCGACCGTTCGCGGCGCGGGAGTGCGGCGCGCTGTGTGCGCGGGTGGCCGCCGCGCCGCCCGGCCCCGCCTCCCGCGAGGTGCTCTACGCCGCCGCCTACGTGCTGTCCGAGTACTGCGAGGAAGAGGAAGTGATGCTGAACGCCGTGTCCCCGCTGCTGGCGTGCGCGGGCGTGGGCGGCGGCTACATGCGGGCGCGCGCCGTGTGCGTGCACGCCGCGCTCAAGCTGTGCGCACGTTTGCTGCGGGCGCGGCGCGACCGAAACATGCGCGACCAGGACATCGAGCTCATACGTGAATGTCTGGCGGGTTTGCGACCGCTGCTCTGCAGCGAGGATATGGAGGTACAAGAACGCGCCCATAACGCCACCGCGCTGCTGACGCTGGTCCTCCGCGAGCTCAGCCCCGGGGACGCGGTACTGCCCGCGGAGGAGCCGCCCTCAGCGACGGGACTGCTCGTTGAACACGAACAGAGTAACGGCTTAGAGAACGCGGACGACGAGGAAACGCTTAATCAGAATGCCAAGGAGGATTTGATCGAAGAATTAGCTCAATTGTTTGATGGGGAACTAAAGCCGGTTGCGCCTAAAGCCCAGAAGAAAGTGCCCATGCCGCCAGACTTGAACCTGGATCAGTGGTTGTCGCGCGACCGCTGGTCTTCGGAGAGCTCGAGCTCGGAGGGGGAGGGCGAGGGCGAAGAGGGGGGCCCTATGTTCCCGGCTCCGCACGACGCGCGACCCACGGCGCAGTTCACTCCCGAAGAACTTGACATGTTACGTGAAGCGCGGCGTCAAGAACAAGCCAACAACCCGCACTACCTCAAAGACGACTCGCCGCGCTCCTACCAACAAGACGACATTCCAATAGCAGAGATCGCACTCGAAGTCCCGCTGCAAATACACACTAAACGATCAGATAAGTACTTAATGTCTCGAGAGAGCTCGAGTAAAAAGAAGAAGGAGAAGCGGACGACAAAAAAGCGAAAGGCAAAGAAGCAAGACAAACATTCCACTGACTCTGAGAGCGAAGAGTGGGAGCGGCGGCCGGCGGTGTGCGCGGGCGGGGAGCTGCCCGAGGGCGCGGCGCCGTCCGACGACGAACCGCCGCCGCCGCACGACGACCCGCACCACGCGCTCGACCTCGACCTCGACAGGCCATTACGCGAAGACGAGCTTCTTACGTCACGTCTCCAACAATATCCGTCCCCCGGCGTCGGTTTGCTAGACAAAAAGAAAGATAAACCGGCAAAAAAATCCAAAAACGCAGAAAACGACACGCCTGATAAACCTGTTAAGAAAAAGAAGGACAAGAAATCAAAGCAACGCAAGCAAAGTGCGACAGAATCGATAAAAAATGAGAAAACTGAAGATATTTTACTCATCGATGGAGTTTTTAAAAGCAACGGCGAGCAACTGAAAGAAGATGTCGTTGAAAATACTGAATTAACTGTCGACGAGGGAAAGACATTAAAGACTGAGAAACACAAGAAAAAGAAAGAGTCGAAAAACAAAGATCAGACCATTTCATCGAAGAAACGAAAGTCTACGAAAAAAGATAAGCATGAATCCAAAACGGGCTACGAAGAAGCTTTAGGTATCTCGACACCTAGCAAAGAAGTCGTATAG

Protein

MALKKVKGNFERMFDKNLTDLVRGIRNNKDNEAKYIAQCMEEIKIELRQDNIAVKANAVAKLTYLQMLGYDISWAIFNIIEVMSSNKFTCKRVGYLAASQSFHADSELLMLTTNMIRKDLNAQNQYEAGLALSGLSCFISHDLARDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAVNVVCELARKNPKNYLSLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPGHAASVQLCVQKLRILIEDSDQNLKYLGLLAMSRILKSHPKSVQAHKDLVSACLDDKDESIRLRALGLLYGMVSKKNLMEIVKKLMSHMERAEGTLYRDELLTRMIEICSQNNYQHVVDFEWYITVLAELTEMETSAKHGCIIAAQLTEVGARVADVRPFAARECGALCARVAAAPPGPASREVLYAAAYVLSEYCEEEEVMLNAVSPLLACAGVGGGYMRARAVCVHAALKLCARLLRARRDRNMRDQDIELIRECLAGLRPLLCSEDMEVQERAHNATALLTLVLRELSPGDAVLPAEEPPSATGLLVEHEQSNGLENADDEETLNQNAKEDLIEELAQLFDGELKPVAPKAQKKVPMPPDLNLDQWLSRDRWSSESSSSEGEGEGEEGGPMFPAPHDARPTAQFTPEELDMLREARRQEQANNPHYLKDDSPRSYQQDDIPIAEIALEVPLQIHTKRSDKYLMSRESSSKKKKEKRTTKKRKAKKQDKHSTDSESEEWERRPAVCAGGELPEGAAPSDDEPPPPHDDPHHALDLDLDRPLREDELLTSRLQQYPSPGVGLLDKKKDKPAKKSKNAENDTPDKPVKKKKDKKSKQRKQSATESIKNEKTEDILLIDGVFKSNGEQLKEDVVENTELTVDEGKTLKTEKHKKKKESKNKDQTISSKKRKSTKKDKHESKTGYEEALGISTPSKEVV

Description

Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity).

Catalytic Activity

L-homocysteine + L-serine = H2O + L,L-cystathionine

Cofactor

pyridoxal 5'-phosphate

Subunit

Adaptor protein complex 3 (AP-3) is a heterotetramer.
Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large chains (delta and beta3), a medium chain (mu3) and a small chain (sigma3).

Similarity

Belongs to the adaptor complexes large subunit family.
Belongs to the cysteine synthase/cystathionine beta-synthase family.

Keywords

Complete proteome Cytoplasmic vesicle Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Repeat Transport

Feature

chain AP-3 complex subunit delta

Uniprot

A0A194PJZ4 A0A194R6Z5 A0A212FAK4 A0A1Q3F9I4 A0A1Q3F930 Q16YQ5 + More
U5EX37 A0A182MZL2 A0A0A1XCL2 A0A1A9UEI3 W8ALE4 A0A1L8DVZ0 A0A182W523 A0A182HIE3 A0A1I8NA53 A0A182R7K9 A0A034V786 A0A2M4BBA4 A0A182GTM7 A0A2M3Z2Q3 A0A2M3ZGK4 A0A2M4AE53 A0A2M4BB74 A0A2M4BB85 A0A0K8U4X3 W5JT16 A0A1I8PN69 A0A182YQT9 A0A182PI08 A0A182Q5E6 A0A182KBD6 A0A1A9W8N9 Q7QEU9 B4JLL4 A0A182JLU7 A0A088A8Z7 A0A1S4G852 B4NC97 B4L8M3 A0A182VE07 A0A1Y1LRF6 A0A182X970 B4M1W3 A0A154PPP9 P54362 A0A1W4VVP2 B4Q2F3 B3NVZ8 U4UPP7 Q6NNU5 A0A0C9RN01 B3MW07 A0A139WGC0 Q29HV6 A0A232F8S9 A0A3B0JZD9 A0A220QMD6 A0A146M8N8 A0A2P8YR48 A0A0P4VV50 A0A224X5M8 A0A1B6EHK0 A0A069DXV2 A0A0Q9XGA5 A0A0M8ZZD0 E2BM89 E9J3Z3 A0A3L8DFW6 A0A195BR35 A0A026VX14 A0A195DI06 F4WKB7 E0VFE0 M9PHJ5 A0A158NQJ0 A0A1W4VU42 A0A195D3T8 A0A1B6HG59 A0A2H1WGQ5 A0A151XAU0 A0A0R3NZG9 A0A2L2YBF4 A0A023GDD7 A0A1D2MXU0 A0A2S2PK04 A0A1B6DPB2 A0A0P5LDH1 A0A2S2QNY4 E9H0U3 A0A0P5J9H4 A0A0P5IIQ3 A0A0P5ITG8 A0A0P5RQ59 A0A0P5RXC8

EC Number

4.2.1.22

Pubmed

26354079 22118469 17510324 25830018 24495485 25315136 + More
25348373 26483478 20920257 23761445 25244985 12364791 17994087 28004739 9303295 10659786 10731132 12537572 17372656 18327897 17550304 23537049 18362917 19820115 15632085 23185243 28648823 28657684 26823975 29403074 27129103 26334808 20798317 21282665 30249741 24508170 21719571 20566863 12537568 12537573 12537574 16110336 17569856 17569867 21347285 26561354 27289101 21292972

EMBL

KQ459602 KPI93343.1 KQ460615 KPJ13588.1 AGBW02009451 OWR50772.1 + More
GFDL01010866 JAV24179.1 GFDL01011018 JAV24027.1 CH477512 EAT39753.1 GANO01000257 JAB59614.1 GBXI01016699 GBXI01005611 JAC97592.1 JAD08681.1 GAMC01019833 GAMC01019828 JAB86727.1 GFDF01003480 JAV10604.1 APCN01003930 GAKP01021544 JAC37408.1 GGFJ01001151 MBW50292.1 JXUM01087500 JXUM01087501 JXUM01087502 JXUM01087503 JXUM01087504 KQ563637 KXJ73568.1 GGFM01002045 MBW22796.1 GGFM01006898 MBW27649.1 GGFK01005738 MBW39059.1 GGFJ01001163 MBW50304.1 GGFJ01001162 MBW50303.1 GDHF01030703 JAI21611.1 ADMH02000167 ETN67522.1 AXCN02001298 AAAB01008846 EAA06496.5 CH916370 EDW00467.1 AXCP01007159 CH964239 EDW82456.1 CH933815 EDW07998.1 GEZM01054499 JAV73607.1 CH940651 EDW65667.1 KQ434996 KZC13228.1 AF002164 AF044287 U31351 AE014298 CM000162 EDX01614.1 CH954180 EDV47163.1 KB632310 ERL92126.1 BT011188 AAR88549.1 GBYB01014812 JAG84579.1 CH902625 EDV35152.1 KQ971345 KYB27048.1 CH379064 EAL31651.2 NNAY01000707 OXU26869.1 OUUW01000003 SPP78091.1 KY769577 ASK06162.1 GDHC01003493 JAQ15136.1 PYGN01000418 PSN46726.1 GDKW01000138 JAI56457.1 GFTR01008650 JAW07776.1 GECZ01032353 JAS37416.1 GBGD01000174 JAC88715.1 KRG07536.1 KQ435813 KOX72703.1 GL449158 EFN83215.1 GL768069 EFZ12443.1 QOIP01000008 RLU19347.1 KQ976419 KYM89316.1 KK107648 EZA48333.1 KQ980824 KYN12476.1 GL888199 EGI65341.1 DS235111 EEB12096.1 AGB95370.1 ADTU01023340 ADTU01023341 KQ976885 KYN07557.1 GECU01034043 JAS73663.1 ODYU01008491 SOQ52136.1 KQ982335 KYQ57501.1 KRT06430.1 IAAA01010293 LAA05474.1 GBBM01003549 JAC31869.1 LJIJ01000436 ODM97515.1 GGMR01017108 MBY29727.1 GEDC01009780 GEDC01001379 JAS27518.1 JAS35919.1 GDIQ01173042 JAK78683.1 GGMS01010228 MBY79431.1 GL732582 EFX74641.1 GDIQ01208237 GDIQ01206932 GDIQ01205086 JAK46639.1 GDIQ01214185 JAK37540.1 GDIQ01208238 GDIQ01206933 GDIQ01205085 GDIQ01203391 JAK43487.1 GDIQ01106477 JAL45249.1 GDIQ01095025 JAL56701.1

Proteomes

UP000053268 UP000053240 UP000007151 UP000008820 UP000075884 UP000078200 + More
UP000075920 UP000075840 UP000095301 UP000075900 UP000069940 UP000249989 UP000000673 UP000095300 UP000076408 UP000075885 UP000075886 UP000075881 UP000091820 UP000007062 UP000001070 UP000075880 UP000005203 UP000007798 UP000009192 UP000075903 UP000076407 UP000008792 UP000076502 UP000000803 UP000192221 UP000002282 UP000008711 UP000030742 UP000007801 UP000007266 UP000001819 UP000215335 UP000268350 UP000245037 UP000053105 UP000008237 UP000279307 UP000078540 UP000053097 UP000078492 UP000007755 UP000009046 UP000005205 UP000078542 UP000075809 UP000094527 UP000000305

PRIDE

P54362 Q6NNU5

Pfam

PF01602   Adaptin_N        + More
PF00291   PALP
PF00571   CBS

Interpro

IPR016024   ARM-type_fold        + More
IPR017105   AP3_complex_dsu
IPR002553   Clathrin/coatomer_adapt-like_N
IPR011989   ARM-like
IPR036052   Trypto_synt_PLP_dependent
IPR001926   PLP-dep
IPR000644   CBS_dom
IPR005857   Cysta_beta_synth
IPR001216   P-phosphate_BS

SUPFAM

SSF48371 SSF48371 + More
SSF53686 SSF53686

Gene 3D

1.25.10.10

ProteinModelPortal

A0A194PJZ4 A0A194R6Z5 A0A212FAK4 A0A1Q3F9I4 A0A1Q3F930 Q16YQ5 + More
U5EX37 A0A182MZL2 A0A0A1XCL2 A0A1A9UEI3 W8ALE4 A0A1L8DVZ0 A0A182W523 A0A182HIE3 A0A1I8NA53 A0A182R7K9 A0A034V786 A0A2M4BBA4 A0A182GTM7 A0A2M3Z2Q3 A0A2M3ZGK4 A0A2M4AE53 A0A2M4BB74 A0A2M4BB85 A0A0K8U4X3 W5JT16 A0A1I8PN69 A0A182YQT9 A0A182PI08 A0A182Q5E6 A0A182KBD6 A0A1A9W8N9 Q7QEU9 B4JLL4 A0A182JLU7 A0A088A8Z7 A0A1S4G852 B4NC97 B4L8M3 A0A182VE07 A0A1Y1LRF6 A0A182X970 B4M1W3 A0A154PPP9 P54362 A0A1W4VVP2 B4Q2F3 B3NVZ8 U4UPP7 Q6NNU5 A0A0C9RN01 B3MW07 A0A139WGC0 Q29HV6 A0A232F8S9 A0A3B0JZD9 A0A220QMD6 A0A146M8N8 A0A2P8YR48 A0A0P4VV50 A0A224X5M8 A0A1B6EHK0 A0A069DXV2 A0A0Q9XGA5 A0A0M8ZZD0 E2BM89 E9J3Z3 A0A3L8DFW6 A0A195BR35 A0A026VX14 A0A195DI06 F4WKB7 E0VFE0 M9PHJ5 A0A158NQJ0 A0A1W4VU42 A0A195D3T8 A0A1B6HG59 A0A2H1WGQ5 A0A151XAU0 A0A0R3NZG9 A0A2L2YBF4 A0A023GDD7 A0A1D2MXU0 A0A2S2PK04 A0A1B6DPB2 A0A0P5LDH1 A0A2S2QNY4 E9H0U3 A0A0P5J9H4 A0A0P5IIQ3 A0A0P5ITG8 A0A0P5RQ59 A0A0P5RXC8

PDB

6DFF E-value=2.03827e-34, Score=369

KEGG

101743409 K12396 AP-3 complex subunit delta | (RefSeq) AP-3 complex subunit delta

PATHWAY

04142 Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0030123 GO:0006886 GO:0016192 GO:0005794 GO:0004122 GO:0006535 GO:0019343 GO:0043195 GO:1904115 GO:0098830 GO:0006896 GO:0098943 GO:0048499 GO:0048490 GO:0005886 GO:0006623 GO:0010008 GO:0016182 GO:0008565 GO:0048072 GO:0005783 GO:0007220 GO:0005798 GO:0060967 GO:0005770 GO:0006895 GO:0008340 GO:0005795 GO:0006727 GO:0007040 GO:0008057 GO:0005829 GO:0008055 GO:0046907 GO:0030665 GO:0006887 GO:0007041 GO:0006726 GO:0006897 GO:0015031 GO:0016020 GO:0030117 GO:0005488 GO:0016876 GO:0043039

PANTHER

PTHR22781

Subcellular location

Golgi apparatus
Cytoplasmic vesicle   Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.   With evidence from 1 publications.
Clathrin-coated vesicle membrane   Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.   With evidence from 1 publications.

Length:

992

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.30039

Exp number, first 60 AAs:

0.04668

Total prob of N-in:

0.04934

outside

1 - 992

Pi

232.015162

Theta

170.741189

Tajima's D

1.182338

CLR

0.504461

CSRT

0.705464726763662

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics