Gene

KWMTBOMO08989

Annotation

PREDICTED:_COMM_domain-containing_protein_2-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr15(-):9274553-9278651      View in EpiBrowser

Full name

COMM domain-containing protein 2      

Location in the cell

Extracellular   Reliability : 1.203 Nuclear   Reliability : 1.594

CDS

ATGATAATATTTCTTACAGAATTACAAAAGGATCATCTAAAATTATTACATGAACATTCTGTTCAAGTTTTGATAGACTTCTGCAAATTGGCTGTGGAATACATTAATAAGGGAGCCAACTCAAACAAGTATGGAATCGCTGCTGAAAAACTTAAAGTTCCACTGGCCACAATACGAAATCTTGTCCAAGCACTCGTTTATCTAATATTGGAGGGAAGTAAGCACAATTTATCAGAATCTGATTTTAGATCTTCATTAGCATTGGCAGGTTTTTCAAATGATCAGCAAGATGTTATGAGTAAATTGTATAATACAAAGAAGAAGGAACTATATGAAGCCTTACAACTGTTACAACGTAATGATCCAAAATATATAGATTTTGCTTGGAGGTTTGAAGTGCAGATTGCTTCTAGGAATTCAAATGAAGGAATAAAACCAGTGGTGACAATGGATTTTGTTACAATGAGACCTAAGAGCTTTGCCTTACATGAGAAGGAAACCATTATAAATAGAAAACAAAAGGCTACAAATTATATAGTGGATGCAACTGTACAGGAAGCGAAGGCAGCAATTCAATGTCAAAATAATGTTAATCACACACTTCTTCAGTGTGATATACCAAACCTTATTCATCTCACTAATAAACTGGATCAAGCACTAAAGGAATCAAAGAGTCAACATGTACGTAAAGTACAAAGATCGTTATAA

Protein

MIIFLTELQKDHLKLLHEHSVQVLIDFCKLAVEYINKGANSNKYGIAAEKLKVPLATIRNLVQALVYLILEGSKHNLSESDFRSSLALAGFSNDQQDVMSKLYNTKKKELYEALQLLQRNDPKYIDFAWRFEVQIASRNSNEGIKPVVTMDFVTMRPKSFALHEKETIINRKQKATNYIVDATVQEAKAAIQCQNNVNHTLLQCDIPNLIHLTNKLDQALKESKSQHVRKVQRSL

Description

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Subunit

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.
Interacts (via COMM domain) with COMMD1 (via COMM domain) (PubMed:15799966). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7 (PubMed:28892079, PubMed:15799966, PubMed:21778237, PubMed:23563313, PubMed:23637203, PubMed:25355947).

Similarity

Belongs to the G-protein coupled receptor 1 family.
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Keywords

Complete proteome   Cytoplasm   Direct protein sequencing   Reference proteome   Transcription   Transcription regulation   Ubl conjugation pathway   Alternative splicing   Polymorphism  

Feature

chain  COMM domain-containing protein 2
splice variant  In isoform 2.
sequence variant  In dbSNP:rs9843784.

Uniprot

A0A2H1WXJ9   A0A2A4ITK5   A0A1E1VYW8   I4DLK3   A0A0L7KUS3   A0A194PJ40   + More
A0A194R7G2   A0A212FAM7   S4PB63   A0A437B2P7   D6WKW3   A0A1Y1KIC1   A0A0L7QL01   F4WTF2   A0A195BC43   A0A158NMX2   A0A154PGW3   E2C453   A0A195C5J2   A0A026WL16   A0A0N0BD41   N6ULE7   A0A151WHK3   K7IQZ4   A0A1W4WHM6   A0A088AEZ0   A0A2A3ECK1   A0A2J7R5V2   A0A067RBQ1   A0A195EXT1   E2AHI8   A0A1B6FZV1   A0A1B6H7Z1   A0A210QLV8   A0A1B6D2L1   A0A1B6LWP2   A0A232F760   Q75R54   A0A1X7UEM9   A0A1B6MTC1   H3A4Q5   V4BGG9   A0A2R2MMU2   A8WH05   G1PR05   A0A1L8G4G2   A0A060Y3S9   A0A2C9JJH4   Q6IP66   Q5M7F1   A0A1L8GAQ9   A0A433TDT5   S7MP19   A0A3B4CXP0   A0A369SII3   E3TGB5   E3TD47   G1KGR3   K9IWP9   A0A2P6N5C9   A0A1W5AXQ8   A0A087Y3Y2   A0A3B3UWS8   F1SJN9   A0A3Q2P6N1   H2PBQ6   H2QNK3   A0A1L8DCQ6   A0A0B7BU10   A0A147AIZ9   G3QL53   A0A2R9C244   G1SHZ2   A0A2K5CRR1   F7IIX2   Q172K7   A0A2K6G5F3   F2U5V0   A0A286XCX9   Q497T6   Q8BXC6   A0A2J8WST7   Q5R610   Q86X83   G5BH54   F6T2Y0   A0A2K5R9B2   A0A1S2ZEE4   G3IA75   A0A1A6GE44   A0A402E6K2   A0A0S7M097   A0A0D2X516   A0A3Q0CZ10   A0A3P4M9V6   L5JMH9   A0A3B4F2H0   V9L3H1  

Pubmed

22651552    26227816    26354079    22118469    23622113    18362917    + More
19820115    28004739    21719571    21347285    20798317    24508170    30249741    23537049    20075255    24845553    28812685    28648823    14986137    9215903    23254933    20431018    21993624    27762356    24755649    15562597    30042472    20634964    29378020    16136131    22398555    22722832    25243066    17510324    10349636    11042159    11076861    11217851    12466851    12040188    15489334    16141073    21183079    16141072    15799966    11042152    21778237    23637203    23563313    25355947    25944712    28892079    21993625    17495919    21804562    26319212    23258410    24402279   

EMBL

ODYU01011826    SOQ57790.1    NWSH01007745    PCG62826.1    GDQN01011121    JAT79933.1    + More
AK402171    BAM18793.1    JTDY01005675    KOB66764.1    KQ459602    KPI93342.1    KQ460615    KPJ13587.1    AGBW02009451    OWR50773.1    GAIX01006087    JAA86473.1    RSAL01000187    RVE44776.1    KQ971343    EFA04028.1    GEZM01087723    JAV58517.1    KQ414940    KOC59206.1    GL888334    EGI62544.1    KQ976529    KYM81769.1    ADTU01020830    KQ434902    KZC11101.1    GL452396    EFN77282.1    KQ978231    KYM96117.1    KK107159    QOIP01000001    EZA56725.1    RLU26277.1    KQ435879    KOX69884.1    APGK01028125    KB740686    KB632335    ENN79522.1    ERL92827.1    KQ983115    KYQ47300.1    KZ288287    PBC29420.1    NEVH01006988    PNF36213.1    KK852570    KDR21157.1    KQ981940    KYN32702.1    GL439548    EFN67091.1    GECZ01014055    JAS55714.1    GECU01036900    GECU01025886    JAS70806.1    JAS81820.1    NEDP02002997    OWF49681.1    GEDC01017493    JAS19805.1    GEBQ01011909    JAT28068.1    NNAY01000823    OXU26320.1    AB159147    BAD16595.1    GEBQ01000824    JAT39153.1    AFYH01115616    KB199651    ESP04952.1    AAMC01069271    BC154925    AAI54926.1    AAPE02017728    CM004475    OCT78748.1    FR906320    CDQ84054.1    BC072052    AAH72052.1    BC088679    AAH88679.1    CM004474    OCT80952.1    RQTK01000432    RUS79716.1    KE161952    EPQ06044.1    NOWV01000007    RDD46717.1    GU589401    ADO29351.1    GU588277    ADO28233.1    GABZ01008024    JAA45501.1    MDYQ01000195    PRP79153.1    AYCK01019026    AEMK02000089    ABGA01091369    ABGA01336289    ABGA01336290    AACZ04048258    GABC01010701    GABC01010700    GABF01010805    GABF01010804    GABD01010392    GABD01010391    NBAG03000220    JAA00637.1    JAA11340.1    JAA22708.1    PNI78310.1    GFDF01009833    JAV04251.1    HACG01049573    CEK96438.1    GCES01007783    JAR78540.1    CABD030024776    AJFE02092694    AAGW02015047    GAMT01010051    GAMS01008985    GAMR01007637    GAMQ01004945    GAMP01009284    JAB01810.1    JAB14151.1    JAB26295.1    JAB36906.1    JAB43471.1    CH477435    EAT40957.1    GL832962    EGD82891.1    AAKN02013429    BC100390    BC119316    BC119318    AK143821    CH466530    AAI00391.1    AAI19317.1    BAE25552.1    EDL35318.1    AK047941    AK083784    NDHI03003379    PNJ72844.1    CR860690    AY542158    AF059618    AF125096    BC046131    BC093077    JH170308    GEBF01007033    EHB08615.1    JAN96599.1    JH001671    EGW12270.1    LZPO01097175    OBS64516.1    BDOT01000001    GCF39826.1    GBYX01130023    JAO95173.1    KE346373    KJE97024.1    CYRY02008599    VCW77272.1    KB031157    ELK00550.1    JW873398    AFP05915.1   

Proteomes

UP000218220    UP000037510    UP000053268    UP000053240    UP000007151    UP000283053    + More
UP000007266    UP000053825    UP000007755    UP000078540    UP000005205    UP000076502    UP000008237    UP000078542    UP000053097    UP000279307    UP000053105    UP000019118    UP000030742    UP000075809    UP000002358    UP000192223    UP000005203    UP000242457    UP000235965    UP000027135    UP000078541    UP000000311    UP000242188    UP000215335    UP000007879    UP000008672    UP000030746    UP000085678    UP000008143    UP000001074    UP000186698    UP000193380    UP000076420    UP000271974    UP000261440    UP000253843    UP000221080    UP000001646    UP000241769    UP000192224    UP000028760    UP000261500    UP000008227    UP000265000    UP000001595    UP000002277    UP000001519    UP000240080    UP000001811    UP000233020    UP000008225    UP000008820    UP000233160    UP000007799    UP000005447    UP000000589    UP000005640    UP000006813    UP000002280    UP000233040    UP000079721    UP000001075    UP000092124    UP000288954    UP000008743    UP000189706    UP000010552    UP000261460   

PRIDE

Q8BXC6    Q5R610    Q86X83    G3IA75   

Pfam

PF07258   COMM_domain        + More
PF00001   7tm_1

Interpro

IPR017920   COMM        + More
IPR037354   Commd2       
IPR027430   Retinal_BS       
IPR000276   GPCR_Rhodpsn       
IPR017452   GPCR_Rhodpsn_7TM       
IPR001735   Opsin_RH1/RH2       
IPR001391   Opsin_lateye       
IPR001760   Opsin       

CDD

cd04750  Commd2

ProteinModelPortal

A0A2H1WXJ9   A0A2A4ITK5   A0A1E1VYW8   I4DLK3   A0A0L7KUS3   A0A194PJ40   + More
A0A194R7G2   A0A212FAM7   S4PB63   A0A437B2P7   D6WKW3   A0A1Y1KIC1   A0A0L7QL01   F4WTF2   A0A195BC43   A0A158NMX2   A0A154PGW3   E2C453   A0A195C5J2   A0A026WL16   A0A0N0BD41   N6ULE7   A0A151WHK3   K7IQZ4   A0A1W4WHM6   A0A088AEZ0   A0A2A3ECK1   A0A2J7R5V2   A0A067RBQ1   A0A195EXT1   E2AHI8   A0A1B6FZV1   A0A1B6H7Z1   A0A210QLV8   A0A1B6D2L1   A0A1B6LWP2   A0A232F760   Q75R54   A0A1X7UEM9   A0A1B6MTC1   H3A4Q5   V4BGG9   A0A2R2MMU2   A8WH05   G1PR05   A0A1L8G4G2   A0A060Y3S9   A0A2C9JJH4   Q6IP66   Q5M7F1   A0A1L8GAQ9   A0A433TDT5   S7MP19   A0A3B4CXP0   A0A369SII3   E3TGB5   E3TD47   G1KGR3   K9IWP9   A0A2P6N5C9   A0A1W5AXQ8   A0A087Y3Y2   A0A3B3UWS8   F1SJN9   A0A3Q2P6N1   H2PBQ6   H2QNK3   A0A1L8DCQ6   A0A0B7BU10   A0A147AIZ9   G3QL53   A0A2R9C244   G1SHZ2   A0A2K5CRR1   F7IIX2   Q172K7   A0A2K6G5F3   F2U5V0   A0A286XCX9   Q497T6   Q8BXC6   A0A2J8WST7   Q5R610   Q86X83   G5BH54   F6T2Y0   A0A2K5R9B2   A0A1S2ZEE4   G3IA75   A0A1A6GE44   A0A402E6K2   A0A0S7M097   A0A0D2X516   A0A3Q0CZ10   A0A3P4M9V6   L5JMH9   A0A3B4F2H0   V9L3H1  

KEGG

101744660    K22558 COMM domain containing 2 | (RefSeq) COMM domain-containing protein 2-like

GO

GO:0004930   GO:0018298   GO:0009881   GO:0007602   GO:0016021   GO:0007601   GO:0005737  

PANTHER

PTHR15857  

Subcellular location

Membrane  
Cytoplasm  

Length:

235

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00333

Exp number, first 60 AAs:

0.00165

Total prob of N-in:

0.02925

outside

1  -  235

 

 

Pi

235.353729

Theta

209.652804

Tajima's D

1.286823

CLR

0.108432

CSRT

0.739463026848658

Interpretation

Uncertain