Gene

KWMTBOMO08974

Pre Gene Modal

BGIBMGA007738

Annotation

PREDICTED:_multidrug_resistance-associated_protein_4-like_[Bombyx_mori]

Location

Bomo_Chr15(+):9088293-9114754      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.664

CDS

ATGTTATCGTATTTTGAAAAATGGTTGGAGGAAATAGCTTTGGCAAACAAGATTGGTCGAAAGCCTTCCCTACTCCGCGCGATGACGAAAACCTTCTGGATGAGCTACGCGCCCTCTGGTCTTATGTTTCTAGTACAGGCACTATTATTTAAGCCATTCCAGCCTGTCGTTTTGAGTATGATGCTCGCCTATTGGGAACCAGGGTCCGACATGACATATGAGCAAGCGGTGTACTGCGCCACCACTGTGATACTGATGTCTTTGATAATCGCCTTCCTGAATCACCACGGTTCGTACTCCACACAACAATTTGGAATGAAAGTGCGCATCGCTGCCTGCTCTCTCATTTACAGAAAAGTGATGCGAATGAGTTCCAGTGCTTTGGCTCAAACAACAGCCGGTCAAGTAGTCAATCTACTGTCCAATGATGTGAACAGATTCGACTACGCATTCATCTACACACATTTTATTTGGCTCCTGCCTCTCCAAGTGATAGTGGTCTGCTACCTCATCTACATCAAAATCGGATATGCGGCTGTCGTCGGTGTCATCGGCATCGTGTTGCAAACAATACCCGTTCAATCGTACATGAGTAAACTGGCGGCGAGGCTGCGCATGAAAACAGCATGCAAAACAGATGAACGTGTCAGAATTATGGACGAAATCATTAGTGGTATGCAGGTTATTAAAATGTACGCTTGGGAGAAGCCTTTCGAGCAAGTTGTAGCCCTGGCTCGGAAGAACGAAATCAACTGCATCACGTCAGCGTCTTACCTCCGAGGAGTGTACCTGAGCTTCATGGTGTTCACGGAACGACTCACGCTATATATCACATTACTTTCGCACTCTTTATTCGGTTATCAAGTCACCGCTGATATTGTATTCCCGTTGGCGCAATTCTACAACACACTACAAGGGACTCTGTCGATAATCATGTCTAACGCCGTATCGTTTTTGGCTGAGGCTTTGATCTCGATACAACGCCTCGAAGCGTTCTTGCTGTTTGATGAGAGAGAGGATTTACGTAGTGTCCCTGATGTGGACATTGCTAAGCTAGTACAGAGCATTGACCATCAAAAAAAAAAGAAACTTAGTGAAGTGGAAAAAACTACTAGTACTTTTAAGAAAATCGATGAAGAAGATTATTTCAATCTGGGATTTGAATGCACAGAAAAGGGTTTGACGATAATTTCTCAACCTCCTCGTGATCCCCCCGTAAGTCCTGATATCGGAATCTTAATACAAGACGTGTCTGCCAATTGGACGGAGACTGGCCCTCTCACATTATGTAACGTTAACATCACAGTACCGAAAGGAAAACTCTGCGCTATAATCGGATCTGTGGGCTCTGGGAAGAGTTCCATATTACAGTTACTTTTAAATGAACTACGCCCTATAAGTGGACGTGTTTATCACTCCGGCCCACTGTCATATGCAAGTCAGGAGCCTTGGCTTTTCGTGGCGACGGTCAGACAGAACATTCTATTTGGCCTACCGTACAACCCCAAAAAATACAAAGAGGTTATTAGAGTGTGTGCCCTTCAAAAAGACTTTCAACAGTTTCCACACGGAGATCAAACCTTAGTAGGTGAACGAGGCGCGTCCCTTTCTGGAGGACAAAGGGCTCGTATCAACCTCGCTAGAGCTGTTTATAGACAAGCGGAACTGTATCTCTTGGATGATCCTTTATCGGCGGTGGACGCTCATGTCGGTCGGCAATTGTTCGATGAGTGCATCAGCGGATACCTCCGGCACACAACTCGAGTGCTTGTCACACATCAACTACACTACCTCAAGGCTGCCGATTATATAATCATCATGAATAATGGTACGGTAGACGCTTGTGGAACATACGAAGAACTAATGACTTCCGGTAAAGACTTCGCCAAACTTTTAACCTCTTTGCAAGACGAGAATGAAGATGAACCTAAAAAACTACCTTTGCCAATGTCCAGGCGAACATCAGCCCGGTTATCAACAACACGTCGACCTTCGATGTCGGAGTCAATGACTGGTTGCGAAGGTCCTGCACAAGAGATGGAGGAGGAAGAAAGAGAATCAGGCTCGATGGGCTGGCACGTTTACAAAGCATATCTGACGGCTGGCGGAGGAAGTACTCGGCTGATGTTTACTGTTCTTATACTCGTAATAGGACAACTATCGGCCACGCTTTGTGACTATTGGGTTACATTCTGGACTAACGAAGTTACAAGAATGAAAGAAAAAGAAAGCAATAATACCACAAAGGACTATGAACTAATGCTGACACCGAAAAACAATACCTTTAGTGTTACCAACTACTTCTCCGGAACTGAAGCCCAACCAGATCTAAACATCCACGCATTCATCGGTCCTCTGGATACGGCGCAGTATCTCTACGTTTACACAGCACTGATCATTTGCTGTATCTTCTTCATAACGGCCCGAGCGTTTATGTTCTTCAAAGTTTGCATGACGTCCTCCAGGAACCTCCACAACGACATGTTTCACTCGATGCTTAGAGGCGTAATGCGATTCTTCGATTCCAATTCTTCTGGTCGTATTTTGAATAGGTTTTCAAAAGACATTGGAGCTTTGGACGAGCTCTTGCCGCGTTTCTTGCTGGAGTGCATACAAATATATTTGGTGATGTTCAGCATCCTGGCGTTGAATGCAGCGGCTTTAATATGGACTTTACTGCCCACCACAATCATATTGCTCCTATTTTACACGATACTGCAAATATACCTAAAATCTGCACAGTCTATCAAACGATTGGAAGGCACAACACGAAGCCCGGTGTTTTCTCACATGTCGGCCACTCTCAACGGCATGAGCACAATCCGTTCTGCAGGAGCACAACAAAGATTGATTCAGGAATTTGATAATTTCCAAGATATACACACGTCAACATGGAGCAGCTATTTAGCAAGTGGCGTCACCCTTGGCTTTTGGCTCGATTTAATCTGCGTGCTGTATCTGGCGATCGTCATTATAGCCTTCCTCGTGATAGACAGCAAGACAATATTTTCCGGAAATGTGGGTCTAGCGATTTCGCAAACGCTAATCTTGACAGGAATGTTGCAATTCGGTGTAAGACAAACAGCTGAAGTCATCTCGCAAATGACAAGTGTCGAAAGGATATTGCAGTACACACACATCGAAAGGGAAAGTCAGTGGGAAAAAGGAGAACGCGAAACTCCGAAAGGCTGGCCGTCGAATGGTCGTATTGAGTTCCGTAACTGCTTCATGAAGTACACACCTCAAGACCTGCCCGTACTGAAGAATCTCAATTTAGTCATTGAAAGTGGATGGAAGGTCGGCATCGTGGGTAGAACGGGTGCCGGAAAATCTTCTCTGATATCCTCCTTGTTTCGACTTGCGATAGTTGAAGGAGAGATTCTCATTGATGACATCGAGACCGGATATTTGGCTCTACAGGATCTTCGTTCGAAGATATCGATAATCCCTCAAGAGCCGGTATTGTTCTCGGCCACCGTACGATACAATTTGGATCCCTTCAATAACTACAAGGACGAGGAATTGTGGAAAGCTTTGGAAGCTGTTGATCTAAAGGCCGCTGTTCCTTCTTTAGATTTCAAGGTATCCGAAGGTGGATCTAACTTCTCTCTTGGACAAAGGCAATTGGTTTGTCTCGCGCGTGCTATCTTACGAGGAAATCGTATTCTGGTTCTGGACGAAGCCACCGCTAATGTTGATCCCAAAACTGACGAATTTATTCAAAGAACGATACGGACACGATTTGCTGATTGCACCGTGCTGACTGTAGCGCATCGTCTTAACACCATCATGGACTCCGATAGAGTAATGGTGATGGATGCCGGACGGCTTGTGGAGTTCGATCATCCCTACAAACTGCTCAGTAATCCCGACGGCTATTTCGCGAAAATGGTTAAAGAAACAAATGAAAAAATGTCCCAACAATTATATGAAATAGCGAAAGATACGTACATAAAAAACGGAGGTAGAATTGAGTAA

Protein

MLSYFEKWLEEIALANKIGRKPSLLRAMTKTFWMSYAPSGLMFLVQALLFKPFQPVVLSMMLAYWEPGSDMTYEQAVYCATTVILMSLIIAFLNHHGSYSTQQFGMKVRIAACSLIYRKVMRMSSSALAQTTAGQVVNLLSNDVNRFDYAFIYTHFIWLLPLQVIVVCYLIYIKIGYAAVVGVIGIVLQTIPVQSYMSKLAARLRMKTACKTDERVRIMDEIISGMQVIKMYAWEKPFEQVVALARKNEINCITSASYLRGVYLSFMVFTERLTLYITLLSHSLFGYQVTADIVFPLAQFYNTLQGTLSIIMSNAVSFLAEALISIQRLEAFLLFDEREDLRSVPDVDIAKLVQSIDHQKKKKLSEVEKTTSTFKKIDEEDYFNLGFECTEKGLTIISQPPRDPPVSPDIGILIQDVSANWTETGPLTLCNVNITVPKGKLCAIIGSVGSGKSSILQLLLNELRPISGRVYHSGPLSYASQEPWLFVATVRQNILFGLPYNPKKYKEVIRVCALQKDFQQFPHGDQTLVGERGASLSGGQRARINLARAVYRQAELYLLDDPLSAVDAHVGRQLFDECISGYLRHTTRVLVTHQLHYLKAADYIIIMNNGTVDACGTYEELMTSGKDFAKLLTSLQDENEDEPKKLPLPMSRRTSARLSTTRRPSMSESMTGCEGPAQEMEEEERESGSMGWHVYKAYLTAGGGSTRLMFTVLILVIGQLSATLCDYWVTFWTNEVTRMKEKESNNTTKDYELMLTPKNNTFSVTNYFSGTEAQPDLNIHAFIGPLDTAQYLYVYTALIICCIFFITARAFMFFKVCMTSSRNLHNDMFHSMLRGVMRFFDSNSSGRILNRFSKDIGALDELLPRFLLECIQIYLVMFSILALNAAALIWTLLPTTIILLLFYTILQIYLKSAQSIKRLEGTTRSPVFSHMSATLNGMSTIRSAGAQQRLIQEFDNFQDIHTSTWSSYLASGVTLGFWLDLICVLYLAIVIIAFLVIDSKTIFSGNVGLAISQTLILTGMLQFGVRQTAEVISQMTSVERILQYTHIERESQWEKGERETPKGWPSNGRIEFRNCFMKYTPQDLPVLKNLNLVIESGWKVGIVGRTGAGKSSLISSLFRLAIVEGEILIDDIETGYLALQDLRSKISIIPQEPVLFSATVRYNLDPFNNYKDEELWKALEAVDLKAAVPSLDFKVSEGGSNFSLGQRQLVCLARAILRGNRILVLDEATANVDPKTDEFIQRTIRTRFADCTVLTVAHRLNTIMDSDRVMVMDAGRLVEFDHPYKLLSNPDGYFAKMVKETNEKMSQQLYEIAKDTYIKNGGRIE

Uniprot

A0A3S2TFR5   A0A2H1X0D3   A0A3G1PY98   A0A0E3UUF7   A0A2A4JXS2   A0A194PIS9   + More
A0A194R7E7   A0A223PQG6   A0A212FDE8   A0A194R7E2   A0A088C894   A0A3G1PY80   A0A2A4JLC9   A0A194PJ23   A0A0B4ZTU5   A0A0B4ZWR3   A0A2K9P5C0   A0A060DA23   A0A223PQF2   A0A0F6PPP5   A0A0F6PQI8   A0A060DAW3   A0A0E3ZCM1   A0A3S2PG34   A0A2H4YHR9   A0A1Z2RPL3   G3JWY5   A0A2K9P5A5   A0A0E3ZDK3   A0A2H4YHT5   A0A2H4YHT1   A0A2H4YHT7   A0A2H1WJQ9   A0A097DCY9   A0A2H4YHT2   G3JWY1   D8V116   A0A2A4JM73   A0A060D135   A0A2H4YHR7   G1UHY0   A0A0B4ZS88   A0A2H4YHT4   A0A1N7TA09   A0A2H4YHS1   A0A2H4YHU4   A0A2H4YHV2   D8V119   G3JWY2   A0A1B0RHN5   A0A088C848   A0A1B0RHP5   A0A2L1K5C6   A0A3G1PY78   A0A1Y1MZF9   A0A151WHK6   A0A151IYU4   A0A1Y1MZE9   R9WPG7   A0A0B4ZYY9   F4X6C1   A0A3S2LNC5   A0A139WIK9   A0A151ILB5   K7IU38   D6WKL8   A0A195FX91   A0A182MAA3   E2B3S7   A0A194PIU3   A0A182FEZ4   A0A2J7R104   A0A3L8DIP4   A0A194RCF4   A0A182WC63   A0A437B2W7   A0A182I405   A0A1S4GS60   A0A139WIC1   A0A1I8NAJ3   A0A026X3V7   Q7Q5I0   A0A182Q5F7   T1PE30   A0A182RML1   A0A182NJ65   A0A0R3NZ55   A0A1I8MQY1   A0A1A9VAE6   B4LS94   A0A1B0A228   A0A182KEI1   A0A1A9WJ69   B5DJ61   B4G834   A0A0J7KK65   A0A182PFL5   A0A087ZWE9   A0A1Q3F1A4   A0A151JNS4  

Pubmed

25875245    26354079    22118469    28736301    25662100    21840855    + More
22635270    25154974    29422629    28004739    21719571    18362917    19820115    20075255    20798317    30249741    12364791    25315136    24508170    15632085    17994087    18057021   

EMBL

RSAL01000187    RVE44791.1    ODYU01012016    SOQ58094.1    KY701524    AVV62497.1    + More
KM245560    AKC96179.1    NWSH01000412    PCG76566.1    KQ459602    KPI93326.1    KQ460615    KPJ13572.1    KX710207    ASU47347.1    AGBW02009058    OWR51776.1    KPJ13567.1    KF479232    AHL68987.1    AVV62500.1    NWSH01001057    PCG72885.1    KPI93322.1    KJ930168    AJD79132.1    KJ930170    AJD79133.1    KY646297    AUO38741.1    KF926101    AIB06823.1    KX710208    ASU47346.1    KM232756    AKC34055.1    KM250380    AKC34056.1    KF926102    AIB06824.1    KM245562    AKC96181.1    RSAL01000049    RVE50389.1    MG387043    AUE23766.1    KY489760    ASA45739.1    JN030495    AEI27596.1    KY646296    AUO38740.1    KM245561    AKC96180.1    MG387055    AUE23769.1    MG387056    AUE23770.1    MG387058    AUE23772.1    ODYU01009083    SOQ53247.1    KM103521    AIS93186.1    MG387057    AUE23771.1    JN030490    AEI27592.1    GQ332571    ADH16740.1    PCG72886.1    KF926099    AIB06821.1    MG387051    AUE23768.1    AB621548    BAK86406.1    KJ930171    AJD79136.1    MG387068    AUE23775.1    KM068116    AJY53612.1    MG387050    AUE23767.1    MG387062    AUE23773.1    MG387063    AUE23774.1    GQ332573    ADH16744.1    JN030491    AEI27593.1    KM360184    AKH49600.1    KF479231    AHL68986.1    KM360192    AKH49608.1    MF929077    AVE17269.1    AVV62499.1    GEZM01016941    GEZM01016940    GEZM01016938    JAV91034.1    KQ983115    KYQ47297.1    KQ980745    KYN13667.1    GEZM01016939    JAV91033.1    KC758896    AGO01048.1    KJ930169    AJD79135.1    GL888807    EGI58005.1    RVE50388.1    KQ971342    KYB27685.1    KQ977121    KYN05546.1    AAZX01002657    EFA03011.2    KQ981219    KYN44464.1    AXCM01002561    GL445398    EFN89664.1    KPI93341.1    NEVH01008214    PNF34507.1    QOIP01000007    RLU20304.1    KPJ13586.1    RVE44780.1    APCN01002262    APCN01002263    AAAB01008960    KYB27686.1    KK107019    EZA62671.1    EAA10720.3    AXCN02000455    KA646208    AFP60837.1    CH379060    KRT03846.1    CH940649    EDW63702.2    KRF81256.1    KRF81257.1    KRF81258.1    EDY69930.1    CH479180    EDW28514.1    LBMM01006434    KMQ90611.1    GFDL01013712    JAV21333.1    KQ978837    KYN28011.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    UP000075809    + More
UP000078492    UP000007755    UP000007266    UP000078542    UP000002358    UP000078541    UP000075883    UP000008237    UP000069272    UP000235965    UP000279307    UP000075920    UP000075840    UP000095301    UP000053097    UP000007062    UP000075886    UP000075900    UP000075884    UP000001819    UP000078200    UP000008792    UP000092445    UP000075881    UP000091820    UP000008744    UP000036403    UP000075885    UP000005203   

PRIDE

G1UHY0   

Pfam

PF00005   ABC_tran        + More
PF00664   ABC_membrane
PF17913   FHA_2
PF08645   PNK3P

Interpro

IPR017871   ABC_transporter_CS        + More
IPR003439   ABC_transporter-like       
IPR036640   ABC1_TM_sf       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR003593   AAA+_ATPase       
IPR041388   FHA_2       
IPR013954   PNK3P       
IPR023214   HAD_sf       
IPR006549   HAD-SF_hydro_IIIA       
IPR036412   HAD-like_sf       
IPR006551   Polynucleotide_phosphatase       
IPR006550   PNKP       
IPR008984   SMAD_FHA_dom_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF90123   SSF90123       
SSF49879   SSF49879       
SSF56784   SSF56784       

Gene 3D

1.20.1560.10     3.40.50.1000    

ProteinModelPortal

A0A3S2TFR5   A0A2H1X0D3   A0A3G1PY98   A0A0E3UUF7   A0A2A4JXS2   A0A194PIS9   + More
A0A194R7E7   A0A223PQG6   A0A212FDE8   A0A194R7E2   A0A088C894   A0A3G1PY80   A0A2A4JLC9   A0A194PJ23   A0A0B4ZTU5   A0A0B4ZWR3   A0A2K9P5C0   A0A060DA23   A0A223PQF2   A0A0F6PPP5   A0A0F6PQI8   A0A060DAW3   A0A0E3ZCM1   A0A3S2PG34   A0A2H4YHR9   A0A1Z2RPL3   G3JWY5   A0A2K9P5A5   A0A0E3ZDK3   A0A2H4YHT5   A0A2H4YHT1   A0A2H4YHT7   A0A2H1WJQ9   A0A097DCY9   A0A2H4YHT2   G3JWY1   D8V116   A0A2A4JM73   A0A060D135   A0A2H4YHR7   G1UHY0   A0A0B4ZS88   A0A2H4YHT4   A0A1N7TA09   A0A2H4YHS1   A0A2H4YHU4   A0A2H4YHV2   D8V119   G3JWY2   A0A1B0RHN5   A0A088C848   A0A1B0RHP5   A0A2L1K5C6   A0A3G1PY78   A0A1Y1MZF9   A0A151WHK6   A0A151IYU4   A0A1Y1MZE9   R9WPG7   A0A0B4ZYY9   F4X6C1   A0A3S2LNC5   A0A139WIK9   A0A151ILB5   K7IU38   D6WKL8   A0A195FX91   A0A182MAA3   E2B3S7   A0A194PIU3   A0A182FEZ4   A0A2J7R104   A0A3L8DIP4   A0A194RCF4   A0A182WC63   A0A437B2W7   A0A182I405   A0A1S4GS60   A0A139WIC1   A0A1I8NAJ3   A0A026X3V7   Q7Q5I0   A0A182Q5F7   T1PE30   A0A182RML1   A0A182NJ65   A0A0R3NZ55   A0A1I8MQY1   A0A1A9VAE6   B4LS94   A0A1B0A228   A0A182KEI1   A0A1A9WJ69   B5DJ61   B4G834   A0A0J7KK65   A0A182PFL5   A0A087ZWE9   A0A1Q3F1A4   A0A151JNS4  

PDB

6C3P     E-value=1.6506e-148,     Score=1354

KEGG

101743689    K05673 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 | (RefSeq) multidrug resistance-associ

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0016021   GO:0042626   GO:0055085   GO:0016020   GO:0006810   GO:0016887   GO:0008237   GO:0008270   GO:0043565   GO:0016876   GO:0043039  

Length:

1325

Number of predicted TMHs:

10

Exp number of AAs in TMHs:

228.15642

Exp number, first 60 AAs:

19.76732

Total prob of N-in:

0.40949

POSSIBLE N-term signal

sequence

outside

1  -  42

TMhelix

43  -  65

inside

66  -  76

TMhelix

77  -  99

outside

100  -  150

TMhelix

151  -  173

inside

174  -  174

TMhelix

175  -  197

outside

198  -  709

TMhelix

710  -  732

inside

733  -  790

TMhelix

791  -  813

outside

814  -  861

TMhelix

862  -  881

inside

882  -  887

TMhelix

888  -  910

outside

911  -  973

TMhelix

974  -  996

inside

997  -  1002

TMhelix

1003  -  1025

outside

1026  -  1325

 

 

Pi

243.970279

Theta

170.852394

Tajima's D

0.873467

CLR

0.451209

CSRT

0.621568921553922

Interpretation

Uncertain