Gene

KWMTBOMO08968  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007735

Annotation

PREDICTED:_probable_multidrug_resistance-associated_protein_lethal(2)03659_[Bombyx_mori]

Location

Bomo_Chr15(+):8977053-9010926      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.771

CDS

ATGGGTGTTGGAAGTGAAAAAGTTGATGAGAAGAAAAAGAAAAAACAATTGCCTACGATGAAAGAGCCTCCCGGAGCGTTTTCTCGTTCGTTATTCTGTTGGATGTTTCCGTTGTTTTATAGAGGGAACTACAGGGATTTAGAAGAAGAAGACTTAGTTCCGCCTAAAAATCAATACAATTCGAAACTAGTCGGAGATCAGCTAGAAAGGGCATGGTTATTGGAGGAGCATAATGCACGAGCAGCCGGTAGAGACCCATCACTTATTAAAGTATTGTTCAAAACATTCGGATGGTCTTTTTTGCCTGGCGGTATTTTGCAATTCGGTTTTGCGATTTTACGTATTATAACACCTCTGTTATTTGGAGAGCTGCTCACGTATTGGACAGTGGATCCGCCTATTACGCAAATGGAAGCGGTATACTACGCACTCAGTATGATAATCATTAACTGGATTGCAGCCTATCTGAACCATCACGGCAATTTATTTTGCTCCCAATTCGGAATGAAACTTAGAATTGCTACAAGCTCTTTGATGTTCAGGAAGGTAATGCGCATGAACAATGGTGCTTTAGGAGACACGACGGCCGGGAAAGTAGTCAATATACTTTCAAACGACCTGCAAAGATACGACAATGCCTTTATATTCTTGCATTTCGTTTGGATCATACCCATACAGTTGGTTGCTGTCTGCTATCTGGGCTACCTTCAAGCTGGTGTTGCAGCTCTCATTGGCTTAGCTTCCCTTGTTGTCATAGCACTCCCTATTCAAGGTGTGCTCGGAAACATTGTGGGAAAAGTTCGCGCCCGGAATGCTGTAAAAACCGATGAGAGGATCAAATTAATGAGCGAAGTCATTAGCGGCATTCAGGTGATCAAAATGTACGCATGGGAAGTACCGTTCCAAAAATCGGTGGCTGAGAAACGTAGCGACGAGCTAAAAGAAGTCCGTACAGCGACTATACTGAGAACCATATTCCTTGGCTTCATGATATTCACAGAGAGGGCTGCACTTTTCATAACAATACTTACTTTTATATTATTGGGTAATGCATTAAGTGCCACTGTGATTTATCCCTTACAACAATTCATGAACGCTGCACAACTCAATATCACATTGATTCTACCTCTCATTCTGACTTTCACTGCCGAATTAATGGTGTCTCTTCGACGAGTTCAGGAGTTTCTCGTCGCAGAGGATCGGCCAGATTTAGTGAAGCGAGATTCATTGATGCCTGCTGGTTCGAACATATTCCGTAATGTAACTGGAAGTTTCCGTAAATCTGAGCCAACTGTTAGACCGCTATCGTACAGCCAGAAAACCGAAATATTACCTACCGACTTCAACTCTAGCAACAATCTGGTAAAACGTAACAATTCAAGACTCTTAAGACGCATGTCTCATCTGGACGACACGGCCGTGGTGTTACACGATGTCTCCGCTAGCTGGACAGGCGACCCAAATTTCTTAGCTATCAAGAATATCTCAATGAAACTCCGCAAAGGGAAACTATGCGTTATCATTGGCGCCGTCGGGTCTGGGAAGTCTTCAATTCTGCAACTGCTTCTAAAGGAATTGCCTCCGGCCACTGGCACAGTTTCAATCTATGGAAAGGTTTCGTACGCCAGCCAAGAGGCGTGGCTTTTCCCTAGTACCGTCCGGGAAAACATACTTTTCGGTTTACCGTTTGAGCCGGAAAAATATAAGATGGTTTGCAAAGCATGTGCATTGGAAAAGGACTTTAAACAATTCCCATACGGAGACCAGACGTTGGTGGGAGAGAGAGGGGTGTCACTATCGGGAGGACAGCGGGCCAGAATCAATTTAGCTCGTTCTGTCTACAGAGAGGCCGACATCTACTTACTGGACGACCCGCTATCTGCAGTTGACGCGAATGTGGGGAGACAGCTTTTTGAAGGCTGCATAAATGGATACCTTCGACAACGCACGAGGATACTTGTCACGCATCAGATACACTTCCTCAAAGCTGCTGACTACATTGTCGTCATGAACGAGGGCCGCATCGAGAACATGGGAACATTCGATGAGCTCACCGCCGCAGGCAAGGCATTCTCCTTGATGTTATCTTCGCTACAAGAAAACAAAGAAAAAGACACCGAAAGTTTGGGATCACGGGGCAAAGAAGAAAAAGAAAATCCGGTTTTATTTAAAAATCAATTGTCTATAATTGAGACTGATGATTTAGAGCAATTTGAAGCTCAGAAGATGGCCGACGAAGAGCGCCAGTCCGGTAATCTAAAGTGGTCAGTGATCGCGGCATACTTCCGAGCCGGAGGAAACATCTGTTTTTTGTTGTTCACCTTTTTGCTGATCATCCTGACAGCGGCTTCCTCGGCTGGCGCTGACTACTGGATCAGTTACTGGACGAATGCAATGGCAGCGTATGACGAAGAGTTAGCAGGTGCTGAAGTGGATACAGGCCTAGATGTTCAAGTGGGACTGTTCACGACCGGCCAATATCTCATGATTCACGGAGCCATAGTATTAGTTACGATTTTCATAACCAATATAAGAGTTATTCCTTTCGCGGAGTTGTGCGTCACCGCTTCGAGTAGACTCCACAACAGCATGTTCTCCACAATGATCAAAGGCATCATGAGGTTTTTCGATACGAGCTCTTCAGGGCGTATTCTCAATCGTTTCACTAAGGACATGGGAGCTTTGGACGAGATATTGCCGAGGACTCTGTTGGACGTGCTTCAAATCTACGCCACTCTTGGAGCTATTCTCGTTTTGAACGCAATCGCACTGTATTGGACATTGATTCCTTCTGTTATACTTCTGACTTTGTTCTACTTCTTTGTCAAAGTCTATCTTAAAACCGCACAAAGCATTAAAAGATTGGAGGGAACAACAAAAAGCCCGGTGTTTGGCATGGTGACGTCATCGCTAAACGGTATAGCTACAATCAGGTCTTCGGGAGCGGAGGACCGATTAATCAGCAACTTCGATGTACTTCAGGACTTACATTCATCCGCCTGGAACGGTTACTTGGGCGGAGGCACCACTTTTGGTTTTTATTTGGACACGATGTGCCTCTTATATCTCACTACCGTTATTTTAGTGTTCATCTTTATAGACTTTGGTAACGTCATTGCCGTGGGAAGTGTCGGTCTGGCAGTAACACAGAGTAACACGCTGACGGCCATGTTGCAACACGGAGCTCGGATGCTGGTAGAGTTCCTCGCCCAGCTTACCAGCGTCGAGAGAGTACTAGAGTATACTAAAATTGAATCGGAGAAGAATCTTTTTGAAGGACAAAAACCGATGCCCCCAACTTGGCCGGCGCATGGAAGAATTATTATGGACAATGTCAGCTTACAGTACGCTCCCGAAGAAGAAGCAGTGCTGAAAAACCTCAACATCGTTATTGAAAGTGGATGGAAGGTCGGTATAGTCGGCAGGACTGGAGCAGGAAAATCCTCACTGATATCCGCCTTGTTCAGATTCGCGTATATCGATGGCTCTATAACTATCGACGGGCTCGACACTTCTGTTATATCGAAACAGGGACTCCGATCAAAAATCTCGATAATTCCGCAAGAACCGGTATTATTCTCTGCGACTATCAGATACAACTTAGATCCGTTCAGCGTGTACAGTGACGACGAGCTTTGGAGGGCGTTAGAACAGGTGGACATGAAAGCGGCCGTTCCTTCGTTGGATTTCAAAGTGACAGAAGGTGGATCTAACTTCTCCGTGGGCCAAAGACAGCTGATGTGCTTGGCACGAGCCATACTCAGATCCAATAAAATTTTAATTATGGACGAGGCCACAGCCAACGTTGATCCTCAAACGGATAATTTCATTCAGCAGACTATACGGCGTGCTTTTGCTTCATGTACCGTATTGACTATTGCACATCGCTTGAACACGATCATGGATTCGGACCGAGTTCTGGTAATGAGTACCGGAGAGGTGGCAGAATTCGATCATCCATACATTCTTATGTCCGATCCCAATAGTCACCTTTCTAGTATGGTACGAGAAACGGGCGAGAAGAATAGCTTAAAGTTATTTGAAGTTGCCAAAGATGCGTATTTCCAAAGTAATCTGAAAGAAAACATGAGATGA

Protein

MGVGSEKVDEKKKKKQLPTMKEPPGAFSRSLFCWMFPLFYRGNYRDLEEEDLVPPKNQYNSKLVGDQLERAWLLEEHNARAAGRDPSLIKVLFKTFGWSFLPGGILQFGFAILRIITPLLFGELLTYWTVDPPITQMEAVYYALSMIIINWIAAYLNHHGNLFCSQFGMKLRIATSSLMFRKVMRMNNGALGDTTAGKVVNILSNDLQRYDNAFIFLHFVWIIPIQLVAVCYLGYLQAGVAALIGLASLVVIALPIQGVLGNIVGKVRARNAVKTDERIKLMSEVISGIQVIKMYAWEVPFQKSVAEKRSDELKEVRTATILRTIFLGFMIFTERAALFITILTFILLGNALSATVIYPLQQFMNAAQLNITLILPLILTFTAELMVSLRRVQEFLVAEDRPDLVKRDSLMPAGSNIFRNVTGSFRKSEPTVRPLSYSQKTEILPTDFNSSNNLVKRNNSRLLRRMSHLDDTAVVLHDVSASWTGDPNFLAIKNISMKLRKGKLCVIIGAVGSGKSSILQLLLKELPPATGTVSIYGKVSYASQEAWLFPSTVRENILFGLPFEPEKYKMVCKACALEKDFKQFPYGDQTLVGERGVSLSGGQRARINLARSVYREADIYLLDDPLSAVDANVGRQLFEGCINGYLRQRTRILVTHQIHFLKAADYIVVMNEGRIENMGTFDELTAAGKAFSLMLSSLQENKEKDTESLGSRGKEEKENPVLFKNQLSIIETDDLEQFEAQKMADEERQSGNLKWSVIAAYFRAGGNICFLLFTFLLIILTAASSAGADYWISYWTNAMAAYDEELAGAEVDTGLDVQVGLFTTGQYLMIHGAIVLVTIFITNIRVIPFAELCVTASSRLHNSMFSTMIKGIMRFFDTSSSGRILNRFTKDMGALDEILPRTLLDVLQIYATLGAILVLNAIALYWTLIPSVILLTLFYFFVKVYLKTAQSIKRLEGTTKSPVFGMVTSSLNGIATIRSSGAEDRLISNFDVLQDLHSSAWNGYLGGGTTFGFYLDTMCLLYLTTVILVFIFIDFGNVIAVGSVGLAVTQSNTLTAMLQHGARMLVEFLAQLTSVERVLEYTKIESEKNLFEGQKPMPPTWPAHGRIIMDNVSLQYAPEEEAVLKNLNIVIESGWKVGIVGRTGAGKSSLISALFRFAYIDGSITIDGLDTSVISKQGLRSKISIIPQEPVLFSATIRYNLDPFSVYSDDELWRALEQVDMKAAVPSLDFKVTEGGSNFSVGQRQLMCLARAILRSNKILIMDEATANVDPQTDNFIQQTIRRAFASCTVLTIAHRLNTIMDSDRVLVMSTGEVAEFDHPYILMSDPNSHLSSMVRETGEKNSLKLFEVAKDAYFQSNLKENMR

Uniprot

G1UHY0   A0A2K9P5C0   A0A0F6PPP5   A0A0F6PQI8   A0A060DAW3   A0A060DA23   + More
A0A088C894   A0A2A4JLC9   A0A3G1PY80   A0A212FDE8   A0A194R7E2   A0A194PJ23   A0A0B4ZWR3   A0A0B4ZTU5   A0A3S2PG34   A0A223PQF2   A0A0E3ZCM1   D8V118   A0A2H1WJI9   A0A0B4ZX17   A0A0E3ZDK3   G3JWY5   A0A097DCY9   A0A194PJX3   A0A2H1WJQ9   A0A2K9P5A5   A0A2H4YHR9   G3JWY1   A0A1Z2RPL3   A0A2H4YHT5   A0A2H4YHT1   D8V116   A0A2A4JM73   G3JWY2   A0A2H4YHT2   A0A2H4YHT7   A0A2H4YHR7   A0A060D135   D8V119   A0A1N7TA09   A0A2H4YHT4   A0A2H4YHS1   A0A088C848   A0A2L1K5C6   A0A2H4YHV2   A0A2H4YHU4   A0A1B0RHN5   A0A1B0RHP5   A0A223PQG6   A0A3G1PY78   I1VH51   G1UHW7   A0A0B4ZS88   G1UHW8   R9WPG7   A0A212FDD7   A0A0K1SB04   A0A0K1SB50   A0A3G1PY98   A0A3S2TFR5   A0A0E3UUF7   A0A3S2LNC5   A0A0B4ZYY9   A0A2H1X0D3   A0A060D4Q3   A0A2A4JXS2   A0A2H4KAX0   A0A3R5SMP1   E2B3S7   A0A3L8DIZ7   A0A2A4K8A3   A0A0C9PVS6   A0A0L0CKR5   A0A3L8DIP4   A0A151ILB5   J9JY34   A0A2A3EMT6   A0A3S2PGB0   F4X6C1   J9KIT1   A0A182FEZ4   A0A087ZWE9   A0A1L8DV41   A0A336MEW6   W5JPP8   A0A1L8DUP6   A0A1B0AFP6   A0A182I405   A0A182V3W3   A0A182Q5F7   A0A1B6DRB5   A0A2H8TLL8   Q16IR9   A0A194PK32   A0A1S4GS60   B3MNS1   A0A026X3V7  

Pubmed

22635270    28736301    25662100    22118469    26354079    25875245    + More
21840855    25154974    29422629    20798317    30249741    26108605    21719571    20920257    23761445    17510324    12364791    17994087    24508170   

EMBL

AB621548    BAK86406.1    KY646297    AUO38741.1    KM232756    AKC34055.1    + More
KM250380    AKC34056.1    KF926102    AIB06824.1    KF926101    AIB06823.1    KF479232    AHL68987.1    NWSH01001057    PCG72885.1    KY701524    AVV62500.1    AGBW02009058    OWR51776.1    KQ460615    KPJ13567.1    KQ459602    KPI93322.1    KJ930170    AJD79133.1    KJ930168    AJD79132.1    RSAL01000049    RVE50389.1    KX710208    ASU47346.1    KM245562    AKC96181.1    GQ332573    ADH16743.1    ODYU01009083    SOQ53245.1    KJ930167    AJD79134.1    KM245561    AKC96180.1    JN030495    AEI27596.1    KM103521    AIS93186.1    KPI93323.1    SOQ53247.1    KY646296    AUO38740.1    MG387043    AUE23766.1    JN030490    AEI27592.1    KY489760    ASA45739.1    MG387055    AUE23769.1    MG387056    AUE23770.1    GQ332571    ADH16740.1    PCG72886.1    JN030491    AEI27593.1    MG387057    AUE23771.1    MG387058    AUE23772.1    MG387051    AUE23768.1    KF926099    AIB06821.1    ADH16744.1    KM068116    AJY53612.1    MG387068    AUE23775.1    MG387050    AUE23767.1    KF479231    AHL68986.1    MF929077    AVE17269.1    MG387063    AUE23774.1    MG387062    AUE23773.1    KM360184    AKH49600.1    KM360192    AKH49608.1    KX710207    ASU47347.1    AVV62499.1    JQ774504    AFI44049.1    AB620074    BAK82126.1    KJ930171    AJD79136.1    AB620075    BAK82127.1    KC758896    AGO01048.1    OWR51775.1    KP400523    AKV71230.1    KP400524    AKV71231.1    AVV62497.1    RSAL01000187    RVE44791.1    KM245560    AKC96179.1    RVE50388.1    KJ930169    AJD79135.1    ODYU01012016    SOQ58094.1    KF926100    AIB06822.1    NWSH01000412    PCG76566.1    KY484779    ASS36021.1    MH172501    QAA95908.1    GL445398    EFN89664.1    QOIP01000007    RLU20387.1    NWSH01000076    PCG79892.1    GBYB01005573    JAG75340.1    JRES01000264    KNC32832.1    RLU20304.1    KQ977121    KYN05546.1    ABLF02027734    KZ288215    PBC32516.1    RSAL01000046    RVE50566.1    GL888807    EGI58005.1    ABLF02035624    GFDF01003929    JAV10155.1    UFQT01000742    SSX26867.1    ADMH02000892    ETN64739.1    GFDF01003930    JAV10154.1    APCN01002262    APCN01002263    AXCN02000455    GEDC01009088    JAS28210.1    GFXV01002383    MBW14188.1    CH478056    EAT34168.1    KPI93378.1    AAAB01008960    CH902620    EDV31158.2    KK107019    EZA62671.1   

Proteomes

UP000218220    UP000007151    UP000053240    UP000053268    UP000283053    UP000008237    + More
UP000279307    UP000037069    UP000078542    UP000007819    UP000242457    UP000007755    UP000069272    UP000005203    UP000000673    UP000092445    UP000075840    UP000075903    UP000075886    UP000008820    UP000007801    UP000053097   

PRIDE

G1UHY0    I1VH51    G1UHW7    G1UHW8   

Pfam

PF00005   ABC_tran        + More
PF00664   ABC_membrane
PF16363   GDP_Man_Dehyd

Interpro

IPR003593   AAA+_ATPase        + More
IPR036640   ABC1_TM_sf       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR017871   ABC_transporter_CS       
IPR003439   ABC_transporter-like       
IPR016040   NAD(P)-bd_dom       
IPR036291   NAD(P)-bd_dom_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF90123   SSF90123       
SSF51735   SSF51735       

Gene 3D

1.20.1560.10    

ProteinModelPortal

G1UHY0   A0A2K9P5C0   A0A0F6PPP5   A0A0F6PQI8   A0A060DAW3   A0A060DA23   + More
A0A088C894   A0A2A4JLC9   A0A3G1PY80   A0A212FDE8   A0A194R7E2   A0A194PJ23   A0A0B4ZWR3   A0A0B4ZTU5   A0A3S2PG34   A0A223PQF2   A0A0E3ZCM1   D8V118   A0A2H1WJI9   A0A0B4ZX17   A0A0E3ZDK3   G3JWY5   A0A097DCY9   A0A194PJX3   A0A2H1WJQ9   A0A2K9P5A5   A0A2H4YHR9   G3JWY1   A0A1Z2RPL3   A0A2H4YHT5   A0A2H4YHT1   D8V116   A0A2A4JM73   G3JWY2   A0A2H4YHT2   A0A2H4YHT7   A0A2H4YHR7   A0A060D135   D8V119   A0A1N7TA09   A0A2H4YHT4   A0A2H4YHS1   A0A088C848   A0A2L1K5C6   A0A2H4YHV2   A0A2H4YHU4   A0A1B0RHN5   A0A1B0RHP5   A0A223PQG6   A0A3G1PY78   I1VH51   G1UHW7   A0A0B4ZS88   G1UHW8   R9WPG7   A0A212FDD7   A0A0K1SB04   A0A0K1SB50   A0A3G1PY98   A0A3S2TFR5   A0A0E3UUF7   A0A3S2LNC5   A0A0B4ZYY9   A0A2H1X0D3   A0A060D4Q3   A0A2A4JXS2   A0A2H4KAX0   A0A3R5SMP1   E2B3S7   A0A3L8DIZ7   A0A2A4K8A3   A0A0C9PVS6   A0A0L0CKR5   A0A3L8DIP4   A0A151ILB5   J9JY34   A0A2A3EMT6   A0A3S2PGB0   F4X6C1   J9KIT1   A0A182FEZ4   A0A087ZWE9   A0A1L8DV41   A0A336MEW6   W5JPP8   A0A1L8DUP6   A0A1B0AFP6   A0A182I405   A0A182V3W3   A0A182Q5F7   A0A1B6DRB5   A0A2H8TLL8   Q16IR9   A0A194PK32   A0A1S4GS60   B3MNS1   A0A026X3V7  

PDB

5UJA     E-value=6.10575e-178,     Score=1608

KEGG

100736431    K05673 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 | (RefSeq) ABC transporter

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005524   GO:0042626   GO:0042060   GO:0006810   GO:0016887   GO:0008237   GO:0008270   GO:0043565   GO:0016876   GO:0043039   GO:0055085  

Length:

1364

Number of predicted TMHs:

11

Exp number of AAs in TMHs:

248.99929

Exp number, first 60 AAs:

0.81462

Total prob of N-in:

0.94078

inside

1  -  97

TMhelix

98  -  120

outside

121  -  139

TMhelix

140  -  162

inside

163  -  213

TMhelix

214  -  236

outside

237  -  240

TMhelix

241  -  263

inside

264  -  324

TMhelix

325  -  347

outside

348  -  366

TMhelix

367  -  389

inside

390  -  769

TMhelix

770  -  792

outside

793  -  826

TMhelix

827  -  849

inside

850  -  896

TMhelix

897  -  919

outside

920  -  923

TMhelix

924  -  946

inside

947  -  1018

TMhelix

1019  -  1041

outside

1042  -  1364

 

 

Pi

218.878525

Theta

168.926046

Tajima's D

0.539932

CLR

1.358225

CSRT

0.524673766311684

Interpretation

Possibly Positive selection