Gene

KWMTBOMO08962

Pre Gene Modal

BGIBMGA007732

Annotation

protein_tyrosine_phosphatase_[Bombyx_mori]

Location

Bomo_Chr15(+):8882133-8889059      View in EpiBrowser

Full name

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase       + More
Kinesin-like protein      

Location in the cell

PlasmaMembrane   Reliability : 4.896

CDS

ATGTCCAACAAGGCAATGAAAAGCAACACCTCTGGACTTTCGATTGGAAAGATTTATCTTCTTGTCTATAACGCCGCTCAAACTCTTGGATGGTCTTACATGCTATGGCAGTCATTAGTACATTTTTTGAACCGTGGTACTTTGGATGCTTTTTGGAGTGAGATCAAGTGGACTGTCATTATATTTCAAAATGCTGCTGTATTAGAGATTTTACACGCTGCTGTAGGCTTAGTTCCATCTAGTGTATTTGTAGTTCTTATGCAAGTGTATTCAAGAGTGTTTCTGGTATGTGGAGCTTTACTGGCAACACAAGGAGCGACTACAAGTCCAGGGTTGCCTCTGTGTATACTCGCCTGGTCGATAACTGAAATCATAAGATATGCCTACTACGCTCTCAATCTGGTCGATATTGTACCCTCATCGCTGACGTTTTTGAGGTATTCCACGTTTCTCGTGATGTATCCCCTCGGTATTACTGGAGAGCTGCTCTGCATGTACCACTCATTGGATGAAATCTTCGAGAAAAAACTTTTCACCATCTCAATGCCGAATGCTTGGAATTTCGCGTTTAACTATTACTATTTTCTAATTTTCTACATGTTCTTGTATATCCCATTGTTCCCAGTACTGTTTGGTCATATGTTATCGCAGAGAAGAAAAATGCTCGGTAAAGAACAGAAAAAATCGAAATCGAATTAA

Protein

MSNKAMKSNTSGLSIGKIYLLVYNAAQTLGWSYMLWQSLVHFLNRGTLDAFWSEIKWTVIIFQNAAVLEILHAAVGLVPSSVFVVLMQVYSRVFLVCGALLATQGATTSPGLPLCILAWSITEIIRYAYYALNLVDIVPSSLTFLRYSTFLVMYPLGITGELLCMYHSLDEIFEKKLFTISMPNAWNFAFNYYYFLIFYMFLYIPLFPVLFGHMLSQRRKMLGKEQKKSKSN

Description

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Catalytic Activity

a very-long-chain (3R)-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O

Similarity

Belongs to the very long-chain fatty acids dehydratase HACD family.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Feature

chain  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Uniprot

H9JDY5   Q1HQ17   A0A1E1WLL3   A0A2A4IV79   A0A212EY85   I4DPT3   + More
S4PYF7   A0A194PJW8   I4DR60   A0A3S2NDM6   A0A1L8DY34   W5JQ23   A0A2M4AW82   Q17AR5   A0A182GG80   A0A1L8DYI0   A0A1B6FPQ3   A0A2M3ZB80   A0A023EJU9   B0WVQ0   A0A1B6HX92   A0A182QH14   A0A453YNM2   A0A1Q3FM53   A0A1W4WSE6   A0A182LXL1   A0A2C9GS19   A0A1Q3FND4   A0A182TEM5   A0A1Y9J0B8   Q7QFV7   A0A1J1IGP3   A0A182UW19   A0A1Q3FMI8   A0A084VC08   A0A182F9F3   A0A240PPN7   A0A336MWV4   A0A182VXT6   A0A182XXC5   E0VBY6   A0A195B2K4   A0A158NLD2   A0A182LAP2   A0A1B6L6H3   U5EVL1   A0A182SSN4   A0A182JPF1   A0A026WIL7   A0A3L8D8B0   A0A195E7G7   A0A195F1B2   T1E3U2   D6WKW4   E2ATA0   A0A151XC98   A0A0N7ZBS9   K7J6J7   N6UFW3   A0A182NFW0   A0A0K8TQP1   B4P1W5   B3N3Z2   A0A336MAZ4   F4X6L7   A0A0M9A7T9   A0A336MB45   A0A224XWW1   A0A3Q0IKJ3   A0A1W4VAL5   B3MLH8   A0A182ITA0   B4Q3C5   A0A0V0G809   Q9VKD2   B4IE44   E9IZ70   A0A154P6G0   A0A195CYE2   A0A1A9WME6   A0A226E3T9   A0A1I8MGJ0   T1PDB6   Q29L90   B4GQH9   B4JQY1   R4G3M4   A0A0P4VR67   A0A1A9VPE9   A0A034VY35   A0A0A9W0J4   A0A0C9PYJ3   A0A369SLL3   B3S149   A0A1B0EZS1   A0A0A1WIS8   A0A146LUT9   A0A0A9VPF4  

EC Number

4.2.1.134

Pubmed

19121390    22118469    22651552    23622113    26354079    20920257    + More
23761445    17519023    17510324    26483478    24945155    12364791    14747013    17210077    24438588    25244985    20566863    21347285    20966253    24508170    30249741    24330624    18362917    19820115    20798317    20075255    23537049    26369729    17994087    17550304    21719571    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    21282665    25315136    15632085    27129103    25348373    25401762    30042472    18719581    25830018    26823975   

EMBL

BABH01002590    DQ443235    ABF51324.1    GDQN01005080    GDQN01003141    JAT85974.1    + More
JAT87913.1    NWSH01007229    PCG63033.1    AGBW02011580    OWR46456.1    AK403771    BAM19923.1    GAIX01003368    JAA89192.1    KQ459602    KPI93318.1    AK404958    BAM20400.1    RSAL01000187    RVE44788.1    GFDF01002758    JAV11326.1    ADMH02000438    ETN66497.1    GGFK01011732    MBW45053.1    EF173369    CH477331    CH477325    ABM68591.1    EAT43320.1    EAT43480.1    JXUM01062250    KQ562191    KXJ76450.1    GFDF01002759    JAV11325.1    GECZ01017638    GECZ01016956    GECZ01005793    JAS52131.1    JAS52813.1    JAS63976.1    GGFM01005012    MBW25763.1    GAPW01004237    JAC09361.1    DS232130    EDS35657.1    GECU01028407    JAS79299.1    AXCN02000249    GFDL01006479    JAV28566.1    AXCM01001575    APCN01003108    GFDL01005940    JAV29105.1    AAAB01008844    EAA05966.4    CVRI01000048    CRK98938.1    GFDL01006254    JAV28791.1    ATLV01009969    KE524560    KFB35502.1    UFQT01003476    SSX35034.1    DS235044    EEB10892.1    KQ976662    KYM78434.1    ADTU01019320    GEBQ01020654    JAT19323.1    GANO01003357    JAB56514.1    KK107185    EZA55818.1    QOIP01000012    RLU16158.1    KQ979568    KYN20779.1    KQ981864    KYN34360.1    GALA01000060    JAA94792.1    KQ971343    EFA03551.1    GL442545    EFN63345.1    KQ982314    KYQ58016.1    GDRN01078907    JAI62496.1    AAZX01001318    APGK01028125    KB740686    KB632335    ENN79521.1    ERL92826.1    GDAI01001130    JAI16473.1    CM000157    EDW88136.1    CH954177    EDV58844.1    UFQT01000835    SSX27504.1    GL888818    EGI57799.1    KQ435726    KOX78236.1    SSX27505.1    GFTR01003907    JAW12519.1    CH902620    EDV31727.1    CM000361    CM002910    EDX04756.1    KMY89854.1    GECL01001976    JAP04148.1    AE014134    AY069058    AAF53144.1    AAL39203.1    CH480831    EDW45871.1    GL767119    EFZ14117.1    KQ434826    KZC07431.1    KQ977115    KYN05602.1    LNIX01000007    OXA52099.1    KA646679    AFP61308.1    CH379060    EAL34155.2    CH479187    EDW39851.1    CH916372    EDV99311.1    ACPB03009213    GAHY01001546    JAA75964.1    GDKW01001693    JAI54902.1    GAKP01012182    JAC46770.1    GBHO01045214    GBHO01045213    JAF98389.1    JAF98390.1    GBYB01006598    JAG76365.1    NOWV01000001    RDD47778.1    DS985247    EDV23504.1    AJVK01064228    GBXI01015711    JAC98580.1    GDHC01008323    GDHC01008182    JAQ10306.1    JAQ10447.1    GBHO01045212    JAF98391.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000283053    UP000000673    + More
UP000008820    UP000069940    UP000249989    UP000002320    UP000075886    UP000075900    UP000192223    UP000075883    UP000075840    UP000075902    UP000076407    UP000007062    UP000183832    UP000075903    UP000030765    UP000069272    UP000075885    UP000075920    UP000076408    UP000009046    UP000078540    UP000005205    UP000075882    UP000075901    UP000075881    UP000053097    UP000279307    UP000078492    UP000078541    UP000007266    UP000000311    UP000075809    UP000002358    UP000019118    UP000030742    UP000075884    UP000002282    UP000008711    UP000007755    UP000053105    UP000079169    UP000192221    UP000007801    UP000075880    UP000000304    UP000000803    UP000001292    UP000076502    UP000078542    UP000091820    UP000198287    UP000095301    UP000001819    UP000008744    UP000001070    UP000015103    UP000078200    UP000253843    UP000009022    UP000092462   

PRIDE

H9JDY5    Q1HQ17    Q9VKD2   

Pfam

PF04387   PTPLA        + More
PF00225   Kinesin

Interpro

IPR007482   Tyr_Pase-like_PTPLA        + More
IPR001005   SANT/Myb       
IPR036961   Kinesin_motor_dom_sf       
IPR027640   Kinesin-like_fam       
IPR001752   Kinesin_motor_dom       
IPR027417   P-loop_NTPase       
IPR019821   Kinesin_motor_CS       

SUPFAM

SSF52540   SSF52540       

Gene 3D

3.40.850.10    

CDD

cd00167  SANT

ProteinModelPortal

H9JDY5   Q1HQ17   A0A1E1WLL3   A0A2A4IV79   A0A212EY85   I4DPT3   + More
S4PYF7   A0A194PJW8   I4DR60   A0A3S2NDM6   A0A1L8DY34   W5JQ23   A0A2M4AW82   Q17AR5   A0A182GG80   A0A1L8DYI0   A0A1B6FPQ3   A0A2M3ZB80   A0A023EJU9   B0WVQ0   A0A1B6HX92   A0A182QH14   A0A453YNM2   A0A1Q3FM53   A0A1W4WSE6   A0A182LXL1   A0A2C9GS19   A0A1Q3FND4   A0A182TEM5   A0A1Y9J0B8   Q7QFV7   A0A1J1IGP3   A0A182UW19   A0A1Q3FMI8   A0A084VC08   A0A182F9F3   A0A240PPN7   A0A336MWV4   A0A182VXT6   A0A182XXC5   E0VBY6   A0A195B2K4   A0A158NLD2   A0A182LAP2   A0A1B6L6H3   U5EVL1   A0A182SSN4   A0A182JPF1   A0A026WIL7   A0A3L8D8B0   A0A195E7G7   A0A195F1B2   T1E3U2   D6WKW4   E2ATA0   A0A151XC98   A0A0N7ZBS9   K7J6J7   N6UFW3   A0A182NFW0   A0A0K8TQP1   B4P1W5   B3N3Z2   A0A336MAZ4   F4X6L7   A0A0M9A7T9   A0A336MB45   A0A224XWW1   A0A3Q0IKJ3   A0A1W4VAL5   B3MLH8   A0A182ITA0   B4Q3C5   A0A0V0G809   Q9VKD2   B4IE44   E9IZ70   A0A154P6G0   A0A195CYE2   A0A1A9WME6   A0A226E3T9   A0A1I8MGJ0   T1PDB6   Q29L90   B4GQH9   B4JQY1   R4G3M4   A0A0P4VR67   A0A1A9VPE9   A0A034VY35   A0A0A9W0J4   A0A0C9PYJ3   A0A369SLL3   B3S149   A0A1B0EZS1   A0A0A1WIS8   A0A146LUT9   A0A0A9VPF4  

KEGG

732939    K10703 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134] | (RefSeq) protein tyrosine

PATHWAY

00062    Fatty acid elongation - Bombyx mori (domestic silkworm)
01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0102344   GO:0006633   GO:0102343   GO:0102345   GO:0016021   GO:0005789   GO:0102158   GO:0030497   GO:0018812   GO:0030148   GO:0042761   GO:0007018   GO:0005874   GO:0008017   GO:0005524   GO:0003777   GO:0005783   GO:0019899  

PANTHER

PTHR11035   PTHR24115  

Subcellular location

Endoplasmic reticulum membrane  

Length:

232

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

110.99138

Exp number, first 60 AAs:

20.94759

Total prob of N-in:

0.96441

POSSIBLE N-term signal

sequence

inside

1  -  12

TMhelix

13  -  35

outside

36  -  64

TMhelix

65  -  87

inside

88  -  146

TMhelix

147  -  169

outside

170  -  188

TMhelix

189  -  211

inside

212  -  232

 

 

Pi

212.441624

Theta

163.953542

Tajima's D

1.511785

CLR

0.032777

CSRT

0.791610419479026

Interpretation

Uncertain