Gene

KWMTBOMO08955  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007727

Annotation

PREDICTED:_nicastrin_[Bombyx_mori]

Location

Bomo_Chr15(+):8693378-8703404      View in EpiBrowser

Full name

Nicastrin      

Location in the cell

PlasmaMembrane   Reliability : 4.482

CDS

ATGGCTGTTGTCAGCACATCAAAATTTGGCCTAGTAGAGTTTCTCATAGATCATCCAACAAATATTGCAGGAGTACTTACATATGAAAATGCTTCTGATATCCCCTCATTTTTTACACATGACACAAGATGTCCAAATGAGTTTTCATCAGCAGATGGAAACCAGTGTTCATCTTCAAAGGAAGGTGGTGTTGTGTGGAATGAAAAAGGCACAGGTTTATTAAAGAGAGAAATACCATTTCCAATATTTTTCATACCAGAATCAAGATATGAAGAAATTGAAAAAATCAGTCATTGTTTCGGAAGATTCAATTACGATAAAAACAACCAAAGGGGTCGGTCGCTATGCTCAATACAGTTGAATTCCTTCATGTTTGCTGCAATAAATACCGAAGTTTGCATGAGAAGGTCAGCTACCTCAACGATAGTAACAACAACGAAAGTGTGCGATCCGCTTGGCGATCAAAACGTTTATTATTCCCTTTTCCCTAGAACGAAAGAATCTAAGAAGCAGTCCATCACGTTGGTGACTGCAAGGATCGATTCAGCTTCTTTATTTGATGGGGTGTCTCCGGGTGCTGCTAGTTCTGTCGTCGGCCTAGTCACGCTGATATCAGCAGCCGCCGCATTAGCTCAGCTGATTCCAGTTTCTAAATCGAATCTATACGAGACGAATATATTATGGACGTTATTCAACGGGGAAGCATTTGATTATATTGGTTCACAGCGAGTTGCCTACGACATAAAGCGCGGGGTGTGGCCGCCGAATGCACCGCTGGCACCGACCGATGTAAAACTACACGTTGAAATCGGCCAGATCGGTGGATCCTTATCAGATTATGTGAACGAAAATACATGGCCCTTGAACGCTTTTGTACCTACCCTCGCGCCATCAACAATAAATGACGGTGATAATGATATACAAATCTTCCTGAAACAATTGTCGAATGCATATAACATGACAATACCCGGAATCTTTAATGGCTCTCTGCCACCGTCATCTATACATTCATTCAGAAGAATATTATCCAATGTGACAGAGAGCGGTGAAATGCTTGAAATGTTATTAGTTGATCACAAAGAGACCTTCACGAATGTTTTCTACAACTCTGCTTTGGACGACAGTGACAAAATCGCTTATGTCTATAAAAACATCAGTATGATCAACAATGTTACATTTATATCCACAGCTGAACTCATAGCAGATGGTTTGATGAAAGAAACTGACACTCAAGTAAAGATATCTCGGTTGGCGACGGCTTTAGCTCATGCACTATATCAAAGAGTTGTCGGTGAGGCGTACACTGGTAATATTACAGTGTCCGCACATTTGGTAGATGAAATGCTGTACTGTTTCCTGAAGAACGAGACGTGCAAGTTGTTATCGGCTGCGGAGTTTGGCGGCAACGAGGGGCCGCGGGAGGGTGCAGGGCCGGCGCCGCTGTACGTGGGCGTGACCTCCTGGAACACGGTGGCGCCCGTGTTCGCCGGACACCTGCTGGCCTTGCTTACCGGCACGCAACTCTCGCTCAACAAATCACAGTGCGAAACGAAACCAGAATCGGGATATACAAGGCTCTGGTTAAAAGGATGGAATCACAATGGCGTTTGCATCGAGACCACAATGAACTTTAGTCAAGCACTCAGTCCAGCTTTTATAATATCAGATTATGATTTTAAATCGGGTACGTATTCTACGTGGACCGAGTCAGTTTGGCAAACAATGTGGGCCCGAGTGTTCGTGTCGGCGAGCGGCGGCAGCGCGTGCGTGGCGGCCGCGACCGGTGCCGTGTCAACCCTTATTGCGGCCCTGCTCACGTTTTGGCTACGCAGACACTCATCACTCATATTTGTCGATCCGCCGTCAGCAACCATCGTTGTTGACGATGCTGCTTCCGGAATTTTACGTTCTGTGAACTGTTAG

Protein

MAVVSTSKFGLVEFLIDHPTNIAGVLTYENASDIPSFFTHDTRCPNEFSSADGNQCSSSKEGGVVWNEKGTGLLKREIPFPIFFIPESRYEEIEKISHCFGRFNYDKNNQRGRSLCSIQLNSFMFAAINTEVCMRRSATSTIVTTTKVCDPLGDQNVYYSLFPRTKESKKQSITLVTARIDSASLFDGVSPGAASSVVGLVTLISAAAALAQLIPVSKSNLYETNILWTLFNGEAFDYIGSQRVAYDIKRGVWPPNAPLAPTDVKLHVEIGQIGGSLSDYVNENTWPLNAFVPTLAPSTINDGDNDIQIFLKQLSNAYNMTIPGIFNGSLPPSSIHSFRRILSNVTESGEMLEMLLVDHKETFTNVFYNSALDDSDKIAYVYKNISMINNVTFISTAELIADGLMKETDTQVKISRLATALAHALYQRVVGEAYTGNITVSAHLVDEMLYCFLKNETCKLLSAAEFGGNEGPREGAGPAPLYVGVTSWNTVAPVFAGHLLALLTGTQLSLNKSQCETKPESGYTRLWLKGWNHNGVCIETTMNFSQALSPAFIISDYDFKSGTYSTWTESVWQTMWARVFVSASGGSACVAAATGAVSTLIAALLTFWLRRHSSLIFVDPPSATIVVDDAASGILRSVNC

Description

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

Subunit

Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2.

Similarity

Belongs to the nicastrin family.

Keywords

Complete proteome   Glycoprotein   Membrane   Notch signaling pathway   Reference proteome   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Nicastrin

Uniprot

H9JDY0   A0A2H1WCH3   S4PFY1   A0A2A4JR01   A0A437AWS1   A0A212FGR9   + More
A0A194PQA0   A0A194R7R5   A0A1E1WBR6   B3LV10   A0A1Q3FCX7   A0A3B0JCQ0   A0A1L8DM59   A0A1Y1L8T5   U5EXI1   B0W373   A0A0L7QWU1   A0A154PEW5   D2A5N1   B4QTU0   Q29CG8   A0A1B6JLP8   A0A067QWF2   A0A1B0GHV0   E1JIV8   Q9VC27   Q7KS07   A0A0B4KHG2   B4GN29   B4HHL8   Q17CA6   A0A1W4VR20   A0A1W4W349   A0A1S4F865   A0A182H1V0   A0A182GLG6   B3P6X4   B4PV32   A0A1B6M4G2   A0A1B6KU33   A0A195AUS2   A0A0N0U3I5   E2AJI0   A0A2M4BF61   A0A158NHP2   A0A182SDC3   A0A195E285   A0A1J1J526   B4NFN8   A0A2M4BF39   A0A1Y9HAG1   A0A2M4BFD8   W5JFV8   A0A151XFD1   F4WVP9   A0A182JJR2   A0A1Y9H2V6   A0A240PL32   A0A195FWU1   A0A0C9Q2S0   A0A182Y3U6   A0A195D4A0   A0A182U8L9   E2BHJ1   A0A1I8JSS5   A0A240PKR8   A0A1Y9IVQ9   A0A0M4EHB4   B4K4I5   A0A0Q9WXI5   A0A232F0X7   A0A2M3ZEC1   B4LVZ2   A0A0Q9WP97   A0A1D2MFT3   A0A0A1XBN2   A0A1I8JVR0   A0A1I8JTD9   T1HZX0   A0A182UP50   A0A2M4A8B1   K7ISR9   A0A2M4A852   A0A2M4A7P4   A0A336KLF8   A0A088AD09   A0A1I8JUS5   A0A182MPD3   A0A2A3EKB5   Q7PY38   A0A1S4GCU3   A0A084VZE3   W8C6X3   W8BAG5   A0A1B6EBK1   A0A0K8UPS5   A0A0K8V810   A0A2M3Z3F3   A0A0K8V067   A0A182LA47  

Pubmed

19121390    23622113    22118469    26354079    17994087    28004739    + More
18362917    19820115    15632085    24845553    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    10993067    11781576    11782315    11782316    12660785    17510324    26483478    17550304    20798317    21347285    20920257    23761445    21719571    25244985    28648823    27289101    25830018    20075255    12364791    24438588    24495485    20966253   

EMBL

BABH01002597    BABH01002598    ODYU01007669    SOQ50656.1    GAIX01003847    JAA88713.1    + More
NWSH01000740    PCG74475.1    RSAL01000315    RVE42617.1    AGBW02008599    OWR52935.1    KQ459602    KPI93310.1    KQ460615    KPJ13554.1    GDQN01006669    JAT84385.1    CH902617    EDV42482.1    GFDL01009692    JAV25353.1    OUUW01000005    SPP80154.1    GFDF01006664    JAV07420.1    GEZM01062164    JAV69994.1    GANO01000942    JAB58929.1    DS231831    EDS31216.1    KQ414706    KOC63093.1    KQ434889    KZC10347.1    KQ971345    EFA05049.2    CM000364    EDX14294.1    CM000070    EAL26678.4    GECU01007601    JAT00106.1    KK852869    KDR14663.1    AJWK01005671    AE014297    ACZ95007.1    AF240470    BT003245    AAS65213.2    AGB96312.1    CH479186    EDW39155.1    CH480815    EDW43560.1    CH477310    EAT43969.1    JXUM01023257    KQ560656    KXJ81409.1    JXUM01071934    KQ562693    KXJ75323.1    CH954182    EDV53794.1    CM000160    EDW98881.2    GEBQ01009168    JAT30809.1    GEBQ01025049    JAT14928.1    KQ976737    KYM75926.1    KQ435878    KOX70021.1    GL440027    EFN66375.1    GGFJ01002531    MBW51672.1    ADTU01015830    KQ979763    KYN19253.1    CVRI01000072    CRL07504.1    CH964251    EDW83105.2    GGFJ01002529    MBW51670.1    AXCN02001149    GGFJ01002530    MBW51671.1    ADMH02001345    ETN62941.1    KQ982194    KYQ59045.1    GL888393    EGI61719.1    KQ981208    KYN44896.1    GBYB01008283    JAG78050.1    KQ976870    KYN07730.1    GL448301    EFN84844.1    CP012526    ALC47954.1    CH933806    EDW13937.2    KRG00736.1    NNAY01001330    OXU24334.1    GGFM01006077    MBW26828.1    CH940650    EDW66497.2    KRF82724.1    LJIJ01001406    ODM91835.1    GBXI01005937    JAD08355.1    APCN01000910    ACPB03024513    GGFK01003722    MBW37043.1    AAZX01002902    GGFK01003487    MBW36808.1    GGFK01003505    MBW36826.1    UFQS01000609    UFQT01000609    SSX05329.1    SSX25690.1    AXCM01000028    KZ288220    PBC32167.1    AAAB01008987    EAA01208.4    ATLV01018748    KE525248    KFB43337.1    GAMC01008291    JAB98264.1    GAMC01008290    JAB98265.1    GEDC01001996    JAS35302.1    GDHF01023615    JAI28699.1    GDHF01017436    JAI34878.1    GGFM01002272    MBW23023.1    GDHF01020329    JAI31985.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000053240    + More
UP000007801    UP000268350    UP000002320    UP000053825    UP000076502    UP000007266    UP000000304    UP000001819    UP000027135    UP000092461    UP000000803    UP000008744    UP000001292    UP000008820    UP000192221    UP000069940    UP000249989    UP000008711    UP000002282    UP000078540    UP000053105    UP000000311    UP000005205    UP000075901    UP000078492    UP000183832    UP000007798    UP000075886    UP000000673    UP000075809    UP000007755    UP000075880    UP000075884    UP000075885    UP000078541    UP000076408    UP000078542    UP000075902    UP000008237    UP000069272    UP000075881    UP000075920    UP000092553    UP000009192    UP000215335    UP000008792    UP000094527    UP000076407    UP000075840    UP000015103    UP000075903    UP000002358    UP000005203    UP000075900    UP000075883    UP000242457    UP000007062    UP000030765    UP000075882   

PRIDE

H9JDY0    E1JIV8    Q9VC27    Q7KS07   

Pfam

PF18266   Ncstrn_small        + More
PF05450   Nicastrin
PF15469   Sec5
PF01833   TIG

Interpro

IPR008710   Nicastrin        + More
IPR041084   Ncstrn_small       
IPR029175   EXOC2/Sec5       
IPR039481   EXOC2/Sec5_N_dom       
IPR014756   Ig_E-set       
IPR002909   IPT_dom       
IPR013783   Ig-like_fold       
IPR001810   F-box_dom       

SUPFAM

SSF81296   SSF81296       

Gene 3D

2.60.40.10    

ProteinModelPortal

H9JDY0   A0A2H1WCH3   S4PFY1   A0A2A4JR01   A0A437AWS1   A0A212FGR9   + More
A0A194PQA0   A0A194R7R5   A0A1E1WBR6   B3LV10   A0A1Q3FCX7   A0A3B0JCQ0   A0A1L8DM59   A0A1Y1L8T5   U5EXI1   B0W373   A0A0L7QWU1   A0A154PEW5   D2A5N1   B4QTU0   Q29CG8   A0A1B6JLP8   A0A067QWF2   A0A1B0GHV0   E1JIV8   Q9VC27   Q7KS07   A0A0B4KHG2   B4GN29   B4HHL8   Q17CA6   A0A1W4VR20   A0A1W4W349   A0A1S4F865   A0A182H1V0   A0A182GLG6   B3P6X4   B4PV32   A0A1B6M4G2   A0A1B6KU33   A0A195AUS2   A0A0N0U3I5   E2AJI0   A0A2M4BF61   A0A158NHP2   A0A182SDC3   A0A195E285   A0A1J1J526   B4NFN8   A0A2M4BF39   A0A1Y9HAG1   A0A2M4BFD8   W5JFV8   A0A151XFD1   F4WVP9   A0A182JJR2   A0A1Y9H2V6   A0A240PL32   A0A195FWU1   A0A0C9Q2S0   A0A182Y3U6   A0A195D4A0   A0A182U8L9   E2BHJ1   A0A1I8JSS5   A0A240PKR8   A0A1Y9IVQ9   A0A0M4EHB4   B4K4I5   A0A0Q9WXI5   A0A232F0X7   A0A2M3ZEC1   B4LVZ2   A0A0Q9WP97   A0A1D2MFT3   A0A0A1XBN2   A0A1I8JVR0   A0A1I8JTD9   T1HZX0   A0A182UP50   A0A2M4A8B1   K7ISR9   A0A2M4A852   A0A2M4A7P4   A0A336KLF8   A0A088AD09   A0A1I8JUS5   A0A182MPD3   A0A2A3EKB5   Q7PY38   A0A1S4GCU3   A0A084VZE3   W8C6X3   W8BAG5   A0A1B6EBK1   A0A0K8UPS5   A0A0K8V810   A0A2M3Z3F3   A0A0K8V067   A0A182LA47  

PDB

6IYC     E-value=3.68993e-47,     Score=477

KEGG

101744564    K06171 nicastrin | (RefSeq) nicastrin

PATHWAY

04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0016485   GO:0005887   GO:0007220   GO:0035333   GO:0055037   GO:0045314   GO:0005886   GO:0034205   GO:0006509   GO:0005770   GO:0007219   GO:0046331   GO:0070765   GO:0006893   GO:0000145   GO:0043565   GO:0031012   GO:0005509   GO:0008237   GO:0008270   GO:0016876   GO:0043039  

PANTHER

PTHR21092   PTHR13043  

Subcellular location

Membrane  

Length:

640

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

25.13814

Exp number, first 60 AAs:

0.00728

Total prob of N-in:

0.03565

outside

1  -  640

 

 

Pi

283.940212

Theta

216.891823

Tajima's D

1.091345

CLR

0.067083

CSRT

0.679866006699665

Interpretation

Uncertain