Gene

KWMTBOMO08954  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007800

Annotation

PREDICTED:_uncharacterized_protein_LOC106712294_[Papilio_machaon]

Location

Bomo_Chr15(-):8675439-8677547      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase      

Location in the cell

Extracellular   Reliability : 1.801 Nuclear   Reliability : 2.438

CDS

ATGTCGGAGATAGTTGAAAATAAGGTTGACGAATTGCCAGACTTGGATAACTTACTTCAGTGTCCAGTATGTTATGAAATCCCTACAGGTCATATTTTCCAATGCAATGAAGGTCATAATGTATGTGGCAGATGTAAAGTTCGGCTTTCTGTCTGCCCGGTATGCAGGGCACTATTTTTTGGAACCAGGAACTATGCCATGGAAGAGCTCATTGCAAATGTCCGGAAACTAAGAGCTTTTAAATTAGGTGGAAAAGTTACAAGAGGATTATTAGCTTCAGATAGTAGTAGTACACCAGCAAGAGACAGTGGATCTGACAATGCAGAATATTTGGGTGAAGATGAAAATAACGATAATCAAAATTCAGTAGTGGCCCCTAACCCATGTAAAGGACTTTTTCGTTGCCTCTGCTGCAAGAATGGGAATTCCATCAGACTTCCAGCAGCTCGTTTACTTAACCACCTTCGCTACTTTCATTCTCCAGAACTTTTAGAGGTAAGTCTTTTCCCTAATCATTAG

Protein

MSEIVENKVDELPDLDNLLQCPVCYEIPTGHIFQCNEGHNVCGRCKVRLSVCPVCRALFFGTRNYAMEELIANVRKLRAFKLGGKVTRGLLASDSSSTPARDSGSDNAEYLGEDENNDNQNSVVAPNPCKGLFRCLCCKNGNSIRLPAARLLNHLRYFHSPELLEVSLFPNH

Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Similarity

Belongs to the SINA (Seven in absentia) family.

Uniprot

A0A3S2TD66   A0A1E1WRV2   A0A194R6W0   A0A194PKQ1   A0A212FGR7   A0A2A4JRU3   + More
A0A2H1WC39   S4NNX3   A0A195E849   A0A0J7NGI8   A0A158NG43   A0A151I1K8   F4WTP2   A0A151XBE5   A0A1Y1N3R0   A0A195CHZ9   A0A1B6KWV6   A0A232F774   A0A0K8TSM2   K7IQ53   A0A026VSV3   E2AQH4   A0A1B6HBN1   A0A232F017  

EC Number

2.3.2.27

Pubmed

26354079    22118469    23622113    21347285    21719571    28004739    + More
28648823    26369729    20075255    24508170    30249741    20798317   

EMBL

RSAL01000315    RVE42618.1    GDQN01001498    JAT89556.1    KQ460615    KPJ13553.1    + More
KQ459602    KPI93309.1    AGBW02008599    OWR52936.1    NWSH01000740    PCG74476.1    ODYU01007669    SOQ50655.1    GAIX01012099    JAA80461.1    KQ979568    KYN21002.1    LBMM01005283    KMQ91655.1    ADTU01014960    ADTU01014961    KQ976580    KYM79955.1    GL888341    EGI62463.1    KQ982335    KYQ57659.1    GEZM01013542    JAV92494.1    KQ977721    KYN00365.1    GEBQ01024263    JAT15714.1    NNAY01000751    OXU26691.1    GDAI01000485    JAI17118.1    KK108395    QOIP01000006    EZA46720.1    RLU21253.1    GL441764    EFN64322.1    GECU01035638    GECU01009453    JAS72068.1    JAS98253.1    NNAY01001458    OXU23903.1   

Proteomes

UP000283053    UP000053240    UP000053268    UP000007151    UP000218220    UP000078492    + More
UP000036403    UP000005205    UP000078540    UP000007755    UP000075809    UP000078542    UP000215335    UP000002358    UP000053097    UP000279307    UP000000311   

Pfam

PF03145   Sina        + More
PF07714   Pkinase_Tyr

Interpro

IPR013083   Znf_RING/FYVE/PHD        + More
IPR001841   Znf_RING       
IPR004162   SINA-like       
IPR018121   7-in-absentia-prot_TRAF-dom       
IPR008266   Tyr_kinase_AS       
IPR020635   Tyr_kinase_cat_dom       
IPR000719   Prot_kinase_dom       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR011009   Kinase-like_dom_sf       
IPR015919   Cadherin-like_sf       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF56112   SSF56112        + More
SSF49313   SSF49313       

Gene 3D

3.30.40.10    

ProteinModelPortal

A0A3S2TD66   A0A1E1WRV2   A0A194R6W0   A0A194PKQ1   A0A212FGR7   A0A2A4JRU3   + More
A0A2H1WC39   S4NNX3   A0A195E849   A0A0J7NGI8   A0A158NG43   A0A151I1K8   F4WTP2   A0A151XBE5   A0A1Y1N3R0   A0A195CHZ9   A0A1B6KWV6   A0A232F774   A0A0K8TSM2   K7IQ53   A0A026VSV3   E2AQH4   A0A1B6HBN1   A0A232F017  

KEGG

101736145    no KO assigned | (RefSeq) uncharacterized LOC101736145

GO

GO:0006511   GO:0005634   GO:0007275   GO:0016874   GO:0016021   GO:0016567   GO:0046872   GO:0004713   GO:0005524   GO:0005509   GO:0016020   GO:0005515   GO:0008270   GO:0043565   GO:0031012   GO:0008237   GO:0016876   GO:0043039  

PANTHER

PTHR45877  

Length:

172

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00587999999999999

Exp number, first 60 AAs:

0.00359

Total prob of N-in:

0.15938

outside

1  -  172

 

 

Pi

274.377517

Theta

203.022687

Tajima's D

1.254022

CLR

0

CSRT

0.723913804309784

Interpretation

Uncertain