Gene

KWMTBOMO08946

Annotation

PREDICTED:_uncharacterized_protein_LOC106138667_[Amyelois_transitella]

Location

Bomo_Chr15(+):8599848-8608553      View in EpiBrowser

Full name

Transcription termination factor 5, mitochondrial      

Alternative Name

Mitochondrial transcription termination factor 5

Location in the cell

Nuclear   Reliability : 3.388

CDS

ATGGATAATTATGGAGAAATTTTAAGAGAATGTCAATTCATCAAAATTATAACCAAACACATTATCAAATATCACACTCTTGTAAGATCCAGGACAATCGCCAAATTAAAAAAGGATGGTTTGATCAAAGCAGATCTAAATCTAGAAAAGGTTTTACAAGACTGTTTTCATGACTGGCCAGAGAGTAATAAAAGATTGCATCATTTTACAGATTCAACCACATCTATTTTACAAGTTCGTATGTGCGTATTGGAAAACTATTTGAAATGGAGATTGTCCATTGAAACTGACGAGTTCCAAAAATACTGTAAAAATTACATGTCTTTCAAACATAAACCAATGTCAGACATTCGAGAAGCTTTAGATATTGCACAAAATGTTATCAAGTTCGATACTGAAGTTATCAGACGCAATGGGTTTATTATCTCATCTGATCCGGTTAATACTAAATTGATACTAGAAAATGTCGAATCGTTAGCTGGCTTTGAAATACAGGACGCTATAAAAATCGAACCTGCCATCTTAAAAAATAACTATAATGCTTTGTTAGAAATGAAGAGTATTTTAGAGGAATACAGAATACCATTGGAGGCTCAAAGACGCTGTTTAAAAATATATTGCATGTGCCCGGAAACAGTACGCGAGCGACTAAAAGAACTAGCCAGTTTAAAAGAATATCAAGTATTATCTACCAACCCTAGAGTATTATCAATGGTCGTTCATAAGAAAAAAATGTTATCACGATTAAGTAAGATACAGGCAGCGAAAAAACAATGTTACAGTCTCAATCATCTCATCTCGTCCAGTAAAGTATTTAACAATTACATAAGCAATTTCGGTAATAAAGTCTGTGGTAGAGATATCGCAATACTAATAAGTTCTTCATTGAATCGGGAGGGATTCGATCATAATAAAGAGATAAGCGAATCCGAGAGGTTGAAGGAGGTGTTACAGCAGTTGAGAAGGCACAAGTTCTGGCTGCACACCGCGTTGGACGTGGTCTGCGACAATTTGCAGTTTCTGAAAAGTCGATTCAACGACAGGGATATTATCAAAAACTGTCAGCTGGTTTTGTATCCTGTAACTGAAATAGAACAATATATAACTAAATTATTAGACATTCGAGACAATAAAGAAATCCATTCACAGGACCGAGGAAATATGTATTACAATAATTTGAATTATGAAAAGCTAACTGGTGAACAGATTCTGAGTTTAGTATTATATGAGATAGAGAAGAAGTATCATTTTAGCGGAGATGGAATATGGGGAATGCAGGACGGTGTTAAAGTGGAATCGCGGGTCTAA

Protein

MDNYGEILRECQFIKIITKHIIKYHTLVRSRTIAKLKKDGLIKADLNLEKVLQDCFHDWPESNKRLHHFTDSTTSILQVRMCVLENYLKWRLSIETDEFQKYCKNYMSFKHKPMSDIREALDIAQNVIKFDTEVIRRNGFIISSDPVNTKLILENVESLAGFEIQDAIKIEPAILKNNYNALLEMKSILEEYRIPLEAQRRCLKIYCMCPETVRERLKELASLKEYQVLSTNPRVLSMVVHKKKMLSRLSKIQAAKKQCYSLNHLISSSKVFNNYISNFGNKVCGRDIAILISSSLNREGFDHNKEISESERLKEVLQQLRRHKFWLHTALDVVCDNLQFLKSRFNDRDIIKNCQLVLYPVTEIEQYITKLLDIRDNKEIHSQDRGNMYYNNLNYEKLTGEQILSLVLYEIEKKYHFSGDGIWGMQDGVKVESRV

Description

Binds promoter DNA and regulates initiation of transcription (PubMed:22784680, PubMed:24068965). Regulates mitochondrial replication and transcription (PubMed:22784680, PubMed:24068965). Required for normal topology and maintenance of mitochondrial DNA (mtDNA) levels (PubMed:22784680, PubMed:24068965). Regulates mtDNA replication by re-activating replication after replication pausing (PubMed:24068965). Likely to regulate replication pausing by coordinating with the mitochondrial termination factor mTTF which promotes replication pausing (PubMed:24068965). Their function in replication pausing prevents unregulated replication that may occur for example by collisions between the machineries of DNA replication and transcription during mtDNA synthesis (PubMed:24068965). This ensures the incorporation of RNA transcripts into replication intermediates at the replication fork and allows for proper fork progression (PubMed:24068965). Possibly functions downstream of Dref which activates genes involved in mtDNA replication and maintenance (PubMed:24068965).

Subunit

Probably binds to the mTTF-DNA complex.

Similarity

Belongs to the mTERF family.

Keywords

Complete proteome   DNA replication   Mitochondrion   Reference proteome   Transcription   Transcription regulation   Transit peptide  

Feature

chain  Transcription termination factor 5, mitochondrial

Uniprot

A0A1E1W3M8   A0A2H1X0K1   A0A2A4JDR3   A0A194PJV2   A0A3S2LR69   A0A0L7LD78   + More
H9JE35   A0A194R8L6   A0A0L7LVA7   A0A212F6P2   Q17F49   A0A1S4F521   B4NG99   A0A1I8Q2P6   A0A1I8N5F7   B4K7H0   A0A3B0JNY9   A0A182JJV1   B4GLN0   Q293T7   B4JI56   W5JR45   B3MTR5   B4M0W8   B4IB88   A0A182H7T3   Q9VEB4   A0A1W4U8U7   B4PL83   A0A1B0CTU3   A0A0L0BX74   A0A1L8D7Q0   B3NZ95   A0A182U5G8   A0A2C9H8J7   A0A182HZA8   Q7QAR2   A0A182MU92   A0A182KXI1   A0A182QNZ0   A0A182RZG6   A0A1B6CTF5   A0A182PS21   W8BXM5   A0A0A1WN33   A0A182VJJ5   A0A1A9UCL3   A0A1B0A628   A0A1A9X8P0   A0A1B0GEC2   A0A336MF22   A0A0K8VK14   A0A1B0BFD1   A0A182K3M2   A0A182Y7D8   A0A182VQ52   A0A1J1HUD3   A0A034WT76   A0A1Q3F2E9   A0A2J7Q1Z9   A0A2J7Q1Z1   B0XD92   A0A067R7T8   A0A2J7Q1Y6   Q17F48   A0A1S4F508   A0A1A9X216   A0A182NLH0   J9JXS7   A0A2S2QG36   A0A226E2A6   A0A1J1IF61   B4QUI0   A0A182FT12   A0A1D2N4P7   A0A293LR41   D6WKL7   A0A0A9WVV1   A0A0C9RB16   A0A1B6KIH5   A0A131YIM6   A0A224Z1C6   L7LUP4   T1HPB6   A0A026VU53   A0A131XAK6   A0A3L8E355  

Pubmed

26354079    26227816    19121390    22118469    17510324    17994087    + More
25315136    15632085    20920257    23761445    26483478    10731132    12537572    12537569    22784680    24068965    17550304    26108605    12364791    14747013    17210077    20966253    24495485    25830018    25244985    25348373    24845553    27289101    18362917    19820115    25401762    26830274    28797301    25576852    24508170    28049606    30249741   

EMBL

GDQN01009484    JAT81570.1    ODYU01012526    SOQ58890.1    NWSH01001761    PCG70225.1    + More
KQ459602    KPI93303.1    RSAL01000370    RVE42143.1    JTDY01001580    KOB73468.1    BABH01002535    KQ460615    KPJ13590.1    JTDY01000017    KOB79397.1    AGBW02009983    OWR49405.1    CH477276    EAT45134.1    CH964251    EDW83316.1    CH933806    EDW15314.1    OUUW01000008    SPP83845.1    CH479185    EDW38454.1    CM000070    EAL29127.2    CH916369    EDV92937.1    ADMH02000418    ETN66596.1    CH902623    EDV30196.1    CH940650    EDW68427.1    CH480827    EDW44646.1    JXUM01116959    KQ566037    KXJ70443.1    AE014297    AY061101    AAL28649.1    CM000160    EDW95865.1    AJWK01027994    JRES01001197    KNC24658.1    GFDF01011591    JAV02493.1    CH954181    EDV48637.1    APCN01005522    AAAB01008888    EAA08774.4    AXCM01001356    AXCN02000136    GEDC01020548    JAS16750.1    GAMC01002498    JAC04058.1    GBXI01014504    JAC99787.1    CCAG010012182    UFQT01001076    SSX28766.1    GDHF01013404    JAI38910.1    JXJN01013371    CVRI01000020    CRK91162.1    GAKP01001103    JAC57849.1    GFDL01013324    JAV21721.1    NEVH01019374    PNF22606.1    PNF22604.1    DS232745    EDS45346.1    KK852880    KDR14429.1    PNF22605.1    EAT45135.1    ABLF02040270    GGMS01007512    MBY76715.1    LNIX01000007    OXA51559.1    CVRI01000047    CRK98188.1    CM000364    EDX12480.1    LJIJ01000247    ODM99915.1    GFWV01006254    MAA30984.1    KQ971342    EFA03014.2    GBHO01033006    GBRD01010143    JAG10598.1    JAG55681.1    GBYB01005510    JAG75277.1    GEBQ01028728    JAT11249.1    GEDV01009423    JAP79134.1    GFPF01008674    MAA19820.1    GACK01009707    JAA55327.1    ACPB03014848    KK107928    EZA47170.1    GEFH01004458    JAP64123.1    QOIP01000001    RLU27134.1   

Proteomes

UP000218220    UP000053268    UP000283053    UP000037510    UP000005204    UP000053240    + More
UP000007151    UP000008820    UP000007798    UP000095300    UP000095301    UP000009192    UP000268350    UP000075880    UP000008744    UP000001819    UP000001070    UP000000673    UP000007801    UP000008792    UP000001292    UP000069940    UP000249989    UP000000803    UP000192221    UP000002282    UP000092461    UP000037069    UP000008711    UP000075902    UP000076407    UP000075840    UP000007062    UP000075883    UP000075882    UP000075886    UP000075900    UP000075885    UP000075903    UP000078200    UP000092445    UP000092443    UP000092444    UP000092460    UP000075881    UP000076408    UP000075920    UP000183832    UP000235965    UP000002320    UP000027135    UP000091820    UP000075884    UP000007819    UP000198287    UP000000304    UP000069272    UP000094527    UP000007266    UP000015103    UP000053097    UP000279307   

PRIDE

H9JE35    Q9VEB4   

Pfam

PF03810   IBN_N        + More
PF08389   Xpo1
PF01399   PCI
PF01425   Amidase
PF02536   mTERF
PF15912   VIR_N

Interpro

IPR003690   MTERF        + More
IPR038538   MTERF_sf       
IPR001494   Importin-beta_N       
IPR016024   ARM-type_fold       
IPR013598   Exportin-1/Importin-b-like       
IPR011989   ARM-like       
IPR036928   AS_sf       
IPR020556   Amidase_CS       
IPR023631   Amidase_dom       
IPR000717   PCI_dom       
IPR036390   WH_DNA-bd_sf       
IPR036388   WH-like_DNA-bd_sf       
IPR026736   Virilizer       
IPR031801   VIR_N       
IPR036187   DNA_mismatch_repair_MutS_sf       

SUPFAM

SSF48371   SSF48371        + More
SSF46785   SSF46785       
SSF75304   SSF75304       
SSF48334   SSF48334       

Gene 3D

1.25.70.10     1.25.10.10     1.10.10.10     3.90.1300.10    

ProteinModelPortal

A0A1E1W3M8   A0A2H1X0K1   A0A2A4JDR3   A0A194PJV2   A0A3S2LR69   A0A0L7LD78   + More
H9JE35   A0A194R8L6   A0A0L7LVA7   A0A212F6P2   Q17F49   A0A1S4F521   B4NG99   A0A1I8Q2P6   A0A1I8N5F7   B4K7H0   A0A3B0JNY9   A0A182JJV1   B4GLN0   Q293T7   B4JI56   W5JR45   B3MTR5   B4M0W8   B4IB88   A0A182H7T3   Q9VEB4   A0A1W4U8U7   B4PL83   A0A1B0CTU3   A0A0L0BX74   A0A1L8D7Q0   B3NZ95   A0A182U5G8   A0A2C9H8J7   A0A182HZA8   Q7QAR2   A0A182MU92   A0A182KXI1   A0A182QNZ0   A0A182RZG6   A0A1B6CTF5   A0A182PS21   W8BXM5   A0A0A1WN33   A0A182VJJ5   A0A1A9UCL3   A0A1B0A628   A0A1A9X8P0   A0A1B0GEC2   A0A336MF22   A0A0K8VK14   A0A1B0BFD1   A0A182K3M2   A0A182Y7D8   A0A182VQ52   A0A1J1HUD3   A0A034WT76   A0A1Q3F2E9   A0A2J7Q1Z9   A0A2J7Q1Z1   B0XD92   A0A067R7T8   A0A2J7Q1Y6   Q17F48   A0A1S4F508   A0A1A9X216   A0A182NLH0   J9JXS7   A0A2S2QG36   A0A226E2A6   A0A1J1IF61   B4QUI0   A0A182FT12   A0A1D2N4P7   A0A293LR41   D6WKL7   A0A0A9WVV1   A0A0C9RB16   A0A1B6KIH5   A0A131YIM6   A0A224Z1C6   L7LUP4   T1HPB6   A0A026VU53   A0A131XAK6   A0A3L8E355  

KEGG

101736537    no KO assigned | (RefSeq) uncharacterized LOC101736537

GO

GO:0006355   GO:0003690   GO:0005739   GO:0006390   GO:0006260   GO:0006393   GO:0006886   GO:0005634   GO:0008536   GO:0016740   GO:0005737  

PANTHER

PTHR23185  

Subcellular location

Mitochondrion  
Nucleus  
Cytoplasm  

Length:

435

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00117

Exp number, first 60 AAs:

0.00095

Total prob of N-in:

0.00509

outside

1  -  435

 

 

Pi

289.200755

Theta

192.84176

Tajima's D

1.56759

CLR

0.006405

CSRT

0.799310034498275

Interpretation

Uncertain