Gene

KWMTBOMO08943

Annotation

PREDICTED:_beta-galactoside_alpha-2?6-sialyltransferase_2_[Bombyx_mori]

Location

Bomo_Chr15(-):8575238-8593447      View in EpiBrowser

Full name

Beta-galactoside alpha-2,6-sialyltransferase 2      

Alternative Name

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Sialyltransferase 2

Location in the cell

Extracellular   Reliability : 1.061

CDS

ATGGGAGAGAGTAAAGTATTTCGATCGGGTTTGGATATGCACAATACTTACGATGTAAAATACAAAAGTGGCCCCAAGAATGCGTTATCAAAACACGACGTGATGTGTGCGTTAAAGCGCATAAAAGTGAATACGGTGACCAAGAGAGATGAACCTTTTGCACGCTACGATTTTCAAATTCCTGAGGGTCCCCTTCAAGACGGTACATTTTATAATACTTGCGCTGTCGTCAGCAGTGCAGGAGCTCTGCTTGGATCAAGATTGGGTGATTTCATAGATTCACATGATATGGTGTTAAGATTTAACAATGCTCCGACTGATAATTATACAGACGACGTCGGATCAAAGACAACATTCCGTATCTTAAATTCTCAGGTTGTATCGAAACCTGAATATAAATTTCTAGAAGATCCATTATATAAAGGCGTTTCCATAATAATCTGGGATCCGGCGAACTATTCGTCTACGCTAGAAGAGTGGTATAATCATCCTGATTTCCCGTTGTTTCCTGTTTATAAGAAATTTCTTGAGGAGACGCCAAATGCGGATGCGCATTTATTAAATCCGCAGGTATTATGGTCCCTATGGGCGGTCCTTCAAAACGTATCGCCTTATCGCTTACGAAGAAATCCACCATCTTCAGGTTTTATTGGTTTGTGGTTTTCCCTGAATCGTTGTCGCAGAGTTCGCGTTTTCGAATATGTACCGTCAACACGTGCGAGTCGCCGGTGTCATTACTATGCACATCGCGATGACGTCGCGTGTACATTCGGGGCCTGGCATCCTTTGGCGCAAGAGAAGGCTTTGGCTGAAACCCTAAGGGATAATTCGGATATCGACACCTTTCAACGAGGTTTCATTGACATTACCGGACTAGCTACAATACAATGTTGA

Protein

MGESKVFRSGLDMHNTYDVKYKSGPKNALSKHDVMCALKRIKVNTVTKRDEPFARYDFQIPEGPLQDGTFYNTCAVVSSAGALLGSRLGDFIDSHDMVLRFNNAPTDNYTDDVGSKTTFRILNSQVVSKPEYKFLEDPLYKGVSIIIWDPANYSSTLEEWYNHPDFPLFPVYKKFLEETPNADAHLLNPQVLWSLWAVLQNVSPYRLRRNPPSSGFIGLWFSLNRCRRVRVFEYVPSTRASRRCHYYAHRDDVACTFGAWHPLAQEKALAETLRDNSDIDTFQRGFIDITGLATIQC

Description

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.

Catalytic Activity

a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)

Similarity

Belongs to the glycosyltransferase 29 family.

Keywords

Complete proteome   Disulfide bond   Glycoprotein   Glycosyltransferase   Golgi apparatus   Membrane   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Beta-galactoside alpha-2,6-sialyltransferase 2

Uniprot

A0A2A4JFM1   A0A194R8G5   A0A437AVI3   A0A2H1W2Q3   A0A0A9ZAF5   A0A2L2YLX3   + More
D6WKX7   A0A067R712   A0A1B6DNN9   A0A1Y1KDX4   A0A1B6KAB9   A0A0N7ZCA1   A0A1J1I408   N6TUS0   A0A1B6HHR2   A0A2S2P2A9   A0A1B6G8S5   A0A2H8TUS2   J9JVH7   E4ZFH6   F7EBM7   A0A2S2QG28   Q179D1   A0A3B3SET8   D2U4T9   A0A182FEG5   Q1XAA7   A0A2J7QTG4   A0A182PIM0   Q16FF7   A0A1L8G4R6   W5JS32   A0A1L8GBG2   A0A182H0G1   H3A499   A0A182V509   A0A182RJH7   A0A182U5M6   A0A182LY01   A0A336N5K6   A0A182L3R0   A0A2D0S5K2   Q683N9   A0A336MV60   Q7QIJ3   E0W2H2   A0A084WKS2   V8PIS9   A0A182WBF3   A0A182XA28   A0A1W7R8I7   A0A093LUF5   A0A182K1K1   A0A1L8H8L4   A0A091PM56   R0M1I5   A0A182WWF4   A0A2I0MSQ8   A0A2U3WTD5   A0A3B4BWL9   A0A091RW52   G1M416   A0A2I2V3C2   A0A091J530   A0A094KWH8   A0A060XHJ0   A0A091HA19   A0A091R6N8   A0A182Q4F9   A0A091MHA6   A0A091SV25   A0A093EG45   K7FZ65   A0A1L8HGN6   A0A091VSG5   A0A093G9T4   E1BZW3   A0A091P1H6   A0A093H1Q8   G1NPP5   A0A402E7B1   Q0E5A5   A0A093P8U1   A0A2Y9KEE3   Q701R1   A0A182Y806   M3YHC7   A0A2Y9GAF5   A0A087QVZ8   A0A0A0AC68   A0A3P4PKL9   A0A3Q7XB83   A0A1S3MWJ9   A0A3Q7Q8Q5   A0A093S9F9   A0A091IT66   A8KBE9   A0A0M3QV91  

EC Number

2.4.99.1

Pubmed

26354079    25401762    26561354    18362917    19820115    24845553    + More
28004739    23537049    20431018    17510324    29240929    23594743    27762356    20920257    23761445    26483478    9215903    20966253    15843597    12364791    14747013    17210077    20566863    24438588    24297900    23371554    20010809    17975172    24755649    17381049    15592404    20838655    25244985   

EMBL

NWSH01001761    PCG70223.1    KQ460615    KPJ13545.1    RSAL01000370    RVE42141.1    + More
ODYU01005917    SOQ47303.1    GBHO01003266    JAG40338.1    IAAA01039218    LAA09113.1    KQ971343    EFA04036.1    KK852901    KDR14086.1    GEDC01010016    JAS27282.1    GEZM01086307    GEZM01086306    JAV59564.1    GEBQ01031597    JAT08380.1    GDRN01070497    JAI63872.1    CVRI01000040    CRK95040.1    APGK01051418    KB741190    ENN73020.1    GECU01033494    JAS74212.1    GGMR01010936    MBY23555.1    GECZ01010932    JAS58837.1    GFXV01006171    MBW17976.1    ABLF02017448    FN996984    CBQ74109.1    AAMC01022236    GGMS01007438    MBY76641.1    CH477354    EAT42839.1    CR956630    FN550105    CBE70255.1    AY955495    AAY26387.1    NEVH01011194    PNF31879.1    CH478449    EAT32971.1    CM004475    OCT78833.1    ADMH02000525    ETN66113.1    CM004474    OCT81066.1    JXUM01101305    KQ564638    KXJ71976.1    AFYH01089477    AFYH01089478    AFYH01089479    AFYH01089480    AFYH01089481    AFYH01089482    AXCM01003390    UFQT01002625    SSX33788.1    AJ821850    CAH25390.1    UFQT01002409    SSX33401.1    AAAB01008807    EAA04038.4    DS235878    EEB19828.1    ATLV01024134    KE525349    KFB50816.1    AZIM01000026    ETE73871.1    GEHC01000174    JAV47471.1    KK611145    KFW12281.1    CM004469    OCT92444.1    KK675271    KFQ08373.1    KB742598    EOB06553.1    AKCR02000003    PKK32712.1    KK935124    KFQ46805.1    ACTA01010598    AANG04002548    KK501560    KFP16094.1    KL265532    KFZ61622.1    FR905405    CDQ79083.1    KL530840    KFO92716.1    KK810062    KFQ34897.1    AXCN02000560    KK504789    KFP60975.1    KK487957    KFQ62567.1    KL243841    KFV13496.1    AGCU01029545    CM004468    OCT95239.1    KL411326    KFR05690.1    KL215166    KFV63632.1    AC147973    JX035873    AFN40453.1    KK648104    KFQ00162.1    KK381527    KFV48643.1    BDOT01000002    GCF40060.1    AM398838    CAL44596.1    KL225186    KFW68657.1    AJ627628    AEYP01061193    AEYP01061194    AEYP01061195    AEYP01061196    KL225954    KFM05402.1    KL871279    KGL91711.1    CYRY02034308    VCX10692.1    KL670503    KFW79499.1    KL218156    KFP02831.1    AAMC01072475    AAMC01072476    AAMC01072477    AAMC01072478    AAMC01072479    AAMC01072480    AAMC01072481    BC154086    AAI54087.1    CP012524    ALC42009.1   

Proteomes

UP000218220    UP000053240    UP000283053    UP000007266    UP000027135    UP000183832    + More
UP000019118    UP000007819    UP000008143    UP000008820    UP000261540    UP000000437    UP000069272    UP000235965    UP000075885    UP000186698    UP000000673    UP000069940    UP000249989    UP000008672    UP000075903    UP000075900    UP000075902    UP000075883    UP000075882    UP000221080    UP000007062    UP000009046    UP000030765    UP000075920    UP000076407    UP000075881    UP000053872    UP000245340    UP000261440    UP000008912    UP000011712    UP000053119    UP000193380    UP000075886    UP000007267    UP000053283    UP000053875    UP000000539    UP000001645    UP000288954    UP000054081    UP000248482    UP000076408    UP000000715    UP000248481    UP000053286    UP000053858    UP000286642    UP000087266    UP000286641    UP000053258    UP000054308    UP000092553   

PRIDE

Q701R1   

Pfam

PF00777   Glyco_transf_29

Interpro

IPR001675   Glyco_trans_29        + More
IPR038578   GT29-like_sf       
IPR012163   Sialyl_trans       
IPR011330   Glyco_hydro/deAcase_b/a-brl       

SUPFAM

SSF88713   SSF88713       

Gene 3D

3.90.1480.20    

ProteinModelPortal

A0A2A4JFM1   A0A194R8G5   A0A437AVI3   A0A2H1W2Q3   A0A0A9ZAF5   A0A2L2YLX3   + More
D6WKX7   A0A067R712   A0A1B6DNN9   A0A1Y1KDX4   A0A1B6KAB9   A0A0N7ZCA1   A0A1J1I408   N6TUS0   A0A1B6HHR2   A0A2S2P2A9   A0A1B6G8S5   A0A2H8TUS2   J9JVH7   E4ZFH6   F7EBM7   A0A2S2QG28   Q179D1   A0A3B3SET8   D2U4T9   A0A182FEG5   Q1XAA7   A0A2J7QTG4   A0A182PIM0   Q16FF7   A0A1L8G4R6   W5JS32   A0A1L8GBG2   A0A182H0G1   H3A499   A0A182V509   A0A182RJH7   A0A182U5M6   A0A182LY01   A0A336N5K6   A0A182L3R0   A0A2D0S5K2   Q683N9   A0A336MV60   Q7QIJ3   E0W2H2   A0A084WKS2   V8PIS9   A0A182WBF3   A0A182XA28   A0A1W7R8I7   A0A093LUF5   A0A182K1K1   A0A1L8H8L4   A0A091PM56   R0M1I5   A0A182WWF4   A0A2I0MSQ8   A0A2U3WTD5   A0A3B4BWL9   A0A091RW52   G1M416   A0A2I2V3C2   A0A091J530   A0A094KWH8   A0A060XHJ0   A0A091HA19   A0A091R6N8   A0A182Q4F9   A0A091MHA6   A0A091SV25   A0A093EG45   K7FZ65   A0A1L8HGN6   A0A091VSG5   A0A093G9T4   E1BZW3   A0A091P1H6   A0A093H1Q8   G1NPP5   A0A402E7B1   Q0E5A5   A0A093P8U1   A0A2Y9KEE3   Q701R1   A0A182Y806   M3YHC7   A0A2Y9GAF5   A0A087QVZ8   A0A0A0AC68   A0A3P4PKL9   A0A3Q7XB83   A0A1S3MWJ9   A0A3Q7Q8Q5   A0A093S9F9   A0A091IT66   A8KBE9   A0A0M3QV91  

PDB

4JS2     E-value=3.91658e-59,     Score=576

KEGG

101744994    no KO assigned | (RefSeq) beta-galactoside alpha-2,6-sialyltransferase 2

GO

GO:0006486   GO:0005794   GO:0008373   GO:0016021   GO:0003835   GO:0009311   GO:0005975   GO:0032580   GO:0016757   GO:0008270   GO:0031012   GO:0005509   GO:0008237   GO:0043565   GO:0016876   GO:0043039  

Subcellular location

  

Length:

297

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01859

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01840

outside

1  -  297

 

 

Pi

207.196005

Theta

161.83806

Tajima's D

0.665877

CLR

0.619392

CSRT

0.567721613919304

Interpretation

Uncertain