Gene

KWMTBOMO08934  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007806

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_integrator_complex_subunit_8_[Bombyx_mori]

Location

Bomo_Chr15(-):8414513-8419613      View in EpiBrowser

Full name

Mothers against decapentaplegic homolog       + More
Integrator complex subunit 8      

Alternative Name

SMAD family member

Location in the cell

Cytoplasmic   Reliability : 1.449

CDS

ATGGATGTAGATCTGTTAAGACCCGGCACTGTGCCCATTTCACCTGACACTATATTATGGTTCGAGTTTCTCTTACATCCAGAACTGCTAAAGAATCATCTCAGCAAACCTAACCCAGAGCCATCAGCATGTGAACTTATAGAGGAATTTTTGTCAGTTGACTCCAAGGGTGCAAACTCGAAGCCTACTAGTGAACGAATACCAGATACTGATGCTCCACCCACCCCACCATCGGCGATTTCATCTCCCATACAGTTTACTCGAAAACAACTGGCTTTGAAAATCCTTGGACTGAAAGTGGCAGCATCATTACATTGGAACCTAGATACTTTGGAATTGAATCTAGCACCTCAAATACAGCACCAACTCATGCAAGACCTTGTTTACATGGCCACAGATGCAGGTTTTGCTGTACCGCCACAGGAAATACCAGCAGAGTTAATGCAAAAGCCACAAGTTATATTTGCATTAACTCTATACCACAGATGGACATTGAGATTCCCTGTGAAGGCGGCTTTGTATGCTAAATCATCAAAAATATACATGCACATGCCTGGAATGCAGACAGATGGTGGCTACCCTCCATTGAACCAAAATTTCGAAAAAATATTACGTATGTGTGAAGGAAATCGTACACATAGTATAAAATTTCTCGAAGAAGTTTTGTCCATGTACGAACTCACGTCAAATTCTAGCCGTAGAGAAACTAAAAAAATTAAAGTTCCGCCAATGGAGGCATTTATTCATCTCACTGAAGATTCTGATGAAGTAATACATAACTGGGATGCTGGAGACATTCTAATTACACAATTTGAATTAGCGATGCAAATACACTTTGATCTTTGTTACAATTATTTTTTCTATGGACAACATGATTTAGCAAAAAAACATATACTTGGATGCAGAGAAAATTCTAACCTTTTAGAAAGAGAAGTGTCTATCTATGGTTATGGTCCACACAAAGTTGTTCCTTGGGGTGAATTTTATTATGCTAGTATGACTAAAGATGATATTATTGGTTATATCAGAGCCCTCAACTTAGGTCAAGAAGTTTTAAATGAAGAAGCATCGTTATTGCAAAAACTTCAAGAATCTATAGCTAATCATTATACGGGCATCATTGCAGTTTTACAGGCTGATAATTTAGCTCGTGAAATTCCGATGATTCACAGACAAGTCGTCGAGTTGGATATACAAGGATCAGCGTCAAGTGGTGCATTCACAGTAGCCAGAGATCTCCTTAATCGGGTATCGGCTCTGAATGCAGTTAGATATGCTCTCGAAGGAGGCATACCCTCTACACATCCAGATTTCTTGAATAAATTCAAAACAGTTGGCATAAAGTTTTTCGATCTCCTCTTTTGGGCTCTTGGACCAGTATTACTATCGGATCTTTCTTTAGAAGACTGGCAACACTTACGAATGTTTTTCTTACATTTGATAACCTCTCAATGCAGACTTCCAATCGATAGAATAGATGAGTATATGAAAAAACATATTGGTGAAGCAGCAGGAAATATAAGAAAAAAACTGATTACCGATGAGCAACTTAGCATAATTCTGAACGATCCAATTAACAACGACGATGAAAACATGGAAATTCCTCGGGAACTACTCACCGACGACTGGGAAACGCCTGATTTTGATTTCAAAACTGTCCCTGAATTGGACATGGGCAGATTAAAGAAACGTCTCATCGAAGCTTCGACGGCTGATGACGTGCGCATGTGTCTAGTGAAACTAGCAATGATGTCTCCTTCGTTGCCTTTGTGGAAGTTAAGCCCGTCGTGGAAACCGGCAGGTGTATTGGGAAATGCTTTGATGTCGCTTAACAGAGGATTTTTGCAAGATTTTGGCTATGTAGTCTCGGGCGCAGCCCGTGCTCGTGCCGAATCGGGATCTGCACGAACTGCGTTGTCTCTCTTGTCGGTGCTTGAAGGAGAAGCTCGTAGTCAACTAGGCGGTGGCACTGATCCAGTGCTGTATCGACTGTGCCGACAGTTATCGTGGGAAGTACTGCTGCTGCAAGTCAACGTGATGCTCTCCGAGTGGCCTCACCATAGACTCAACCTTACTGCACTGGCAAATAAATGCAAAGCTTGCATTGCAGCGGCTAATTCTGGTGACGGTATCATACCACGACCACAGGTTTTAGAAGCGTGCTGGAGTTGTTTGGTTAATTCTTGCGAATGGGAAGGTCTGGGTGTCACCACAGGCCCTGGAGAATTAGCTTCCGCTCTTTGTGCGGCATGCTTTGAACTACAACGCGGTAAAGGCTCTAGAAAATTTCCAAGACCTCTATGGGACTACGCGTTATCGGTGTACAGTAACGGCCCAAATATTTCAATGAAACGTAGCGCGGGAGGGATGTCCCATGCGCGTGAAATGATGAACGCGGCGGCTGAGTCGCGCAACGCGTTCAACGGCTTCCTGGCAACCCTGCGCGAGCCACTCGCGATCAGCATCATGATGTCGCTCTTGGCTAGAATACACAACCTGCTGATCGACGACAACTCGCTCGAACTCAACACCGAATACACGAGTTTGTGGCCTTCTAGCGTTTCGAACATAAACAATTACAACATAAAATTCGTGTTAGAATCTCTAACCGATATGTTAGAAAGGAGTCTCAAATTATACCCCTACAATACTTCGTGGTGA

Protein

MDVDLLRPGTVPISPDTILWFEFLLHPELLKNHLSKPNPEPSACELIEEFLSVDSKGANSKPTSERIPDTDAPPTPPSAISSPIQFTRKQLALKILGLKVAASLHWNLDTLELNLAPQIQHQLMQDLVYMATDAGFAVPPQEIPAELMQKPQVIFALTLYHRWTLRFPVKAALYAKSSKIYMHMPGMQTDGGYPPLNQNFEKILRMCEGNRTHSIKFLEEVLSMYELTSNSSRRETKKIKVPPMEAFIHLTEDSDEVIHNWDAGDILITQFELAMQIHFDLCYNYFFYGQHDLAKKHILGCRENSNLLEREVSIYGYGPHKVVPWGEFYYASMTKDDIIGYIRALNLGQEVLNEEASLLQKLQESIANHYTGIIAVLQADNLAREIPMIHRQVVELDIQGSASSGAFTVARDLLNRVSALNAVRYALEGGIPSTHPDFLNKFKTVGIKFFDLLFWALGPVLLSDLSLEDWQHLRMFFLHLITSQCRLPIDRIDEYMKKHIGEAAGNIRKKLITDEQLSIILNDPINNDDENMEIPRELLTDDWETPDFDFKTVPELDMGRLKKRLIEASTADDVRMCLVKLAMMSPSLPLWKLSPSWKPAGVLGNALMSLNRGFLQDFGYVVSGAARARAESGSARTALSLLSVLEGEARSQLGGGTDPVLYRLCRQLSWEVLLLQVNVMLSEWPHHRLNLTALANKCKACIAAANSGDGIIPRPQVLEACWSCLVNSCEWEGLGVTTGPGELASALCAACFELQRGKGSRKFPRPLWDYALSVYSNGPNISMKRSAGGMSHAREMMNAAAESRNAFNGFLATLREPLAISIMMSLLARIHNLLIDDNSLELNTEYTSLWPSSVSNINNYNIKFVLESLTDMLERSLKLYPYNTSW

Description

Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424).

Subunit

Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.

Similarity

Belongs to the dwarfin/SMAD family.
Belongs to the Integrator subunit 8 family.

Keywords

Complete proteome   Nucleus   Reference proteome  

Feature

chain  Integrator complex subunit 8

Uniprot

H9JE59   A0A437B537   A0A2A4JR35   A0A212F005   A0A2H1W3B4   A0A194PKN4   + More
A0A194R7P8   A0A0L7KT01   A0A0L7RH99   A0A195B7C7   A0A158NGY0   A0A195DWH2   E2AIH7   F4X124   A0A151XD29   A0A195FQ30   E2BWB0   A0A026X0Q8   A0A087ZZ34   A0A0M9A3Y3   A0A2J7PL41   A0A154PB00   A0A2A3EF35   A0A151ILM0   K7J228   A0A067RNU6   A0A182GK56   A0A232F5G6   A0A310SJD7   Q178M0   A0A1S4FC20   A0A0C9QTU2   A0A1Q3G202   W5JPK3   A0A182YDD3   A0A182XCB1   A0A1S4H7K5   A0A182TSX6   A0A182LPJ5   A0A182QPP1   A0A182P9D6   A0A182UYZ3   A0A2P8XUV1   A0A182WF50   A0A182MP25   A0A1A9WIS6   Q7Q324   A0A1Y1MIF8   D6WSC4   A0A182RFB3   E0VUJ0   A0A182JBU6   A0A1I8PH80   A0A0L0CQW0   A0A1B0B7E5   A0A1A9ZGI3   A0A1A9XP18   A0A0P5NCZ6   A0A0P5WNF3   A0A0P5SPL8   A0A1I8MH08   A0A182K240   A0A034VK54   B4QIG5   A0A1B0GI48   A1ZAK1   B4HTA0   B3NP62   A0A0A1WDZ2   A0A1Y1MIK6   A0A1W4UL65   A0A0P4XDT3   A0A084WBF4   W8BRV2   A0A182MXX2   B4P5V0   A0A0P5FX38   A0A1B6FX52   A0A182FTC9   A0A182HNL2   A0A3B0JU79   A0A0N7ZPS8   B4LM91   A0A1B0GNW5   B3MDA4   B4GIM2   B5DUR9   A0A1B6JHI1   B4MR83   B4KNM0   A0A0P5X4E1   A0A146LFG5   A0A0K8TK26   A0A0A9YL24   A0A0P5HG84   A0A0A9YMJ4  

Pubmed

19121390    22118469    26354079    26227816    21347285    20798317    + More
21719571    24508170    30249741    20075255    24845553    26483478    28648823    17510324    20920257    23761445    25244985    12364791    20966253    29403074    28004739    18362917    19820115    20566863    26108605    25315136    25348373    17994087    22936249    10731132    12537572    10731137    12537569    21078872    23097424    25830018    24438588    24495485    17550304    15632085    26823975    25401762   

EMBL

BABH01002625    BABH01002626    RSAL01000157    RVE45592.1    NWSH01000840    PCG73913.1    + More
AGBW02011197    OWR47070.1    ODYU01005917    SOQ47312.1    KQ459602    KPI93294.1    KQ460615    KPJ13539.1    JTDY01006242    KOB66176.1    KQ414596    KOC70096.1    KQ976574    KYM80157.1    ADTU01015319    KQ980204    KYN17238.1    GL439791    EFN66767.1    GL888525    EGI59835.1    KQ982294    KYQ58284.1    KQ981387    KYN42029.1    GL451103    EFN80014.1    KK107063    QOIP01000005    EZA60979.1    RLU22451.1    KQ435765    KOX75369.1    NEVH01024527    PNF17053.1    KQ434864    KZC09011.1    KZ288269    PBC29892.1    KQ977104    KYN05764.1    KK852513    KDR22280.1    JXUM01069301    KQ562544    KXJ75658.1    NNAY01000882    OXU26076.1    KQ759820    OAD62741.1    CH477362    EAT42622.1    GBYB01007159    JAG76926.1    GFDL01001198    JAV33847.1    ADMH02000540    ETN66056.1    AAAB01008966    AXCN02002114    PYGN01001311    PSN35787.1    AXCM01000772    EAA13028.4    GEZM01030562    JAV85494.1    KQ971352    EFA06620.1    DS235786    EEB17046.1    JRES01000049    KNC34577.1    JXJN01009571    GDIQ01147168    JAL04558.1    GDIP01083880    LRGB01003024    JAM19835.1    KZS05013.1    GDIP01140484    JAL63230.1    GAKP01016083    JAC42869.1    CM000362    CM002911    EDX07412.1    KMY94376.1    AJWK01011291    AE013599    BT044437    AL031863    AY058406    AAL13635.1    ACH92502.1    CAA21313.1    CH480816    EDW48201.1    CH954179    EDV55701.1    GBXI01017406    JAC96885.1    GEZM01030565    JAV85493.1    GDIP01244556    JAI78845.1    ATLV01022351    KE525331    KFB47548.1    GAMC01010574    JAB95981.1    CM000158    EDW91866.1    GDIQ01256268    JAJ95456.1    GECZ01014993    JAS54776.1    APCN01001942    APCN01001943    OUUW01000001    SPP74628.1    GDIP01224513    JAI98888.1    CH940648    EDW60969.1    AJVK01031073    AJVK01031074    AJVK01031075    CH902619    EDV37437.1    CH479183    EDW36342.1    CH674335    EDY71638.1    GECU01009353    JAS98353.1    CH963849    EDW74622.1    CH933808    EDW10005.1    GDIP01078026    JAM25689.1    GDHC01011616    JAQ07013.1    GBRD01000101    JAG65720.1    GBHO01011283    JAG32321.1    GDIQ01227273    JAK24452.1    GBHO01011281    JAG32323.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007151    UP000053268    UP000053240    + More
UP000037510    UP000053825    UP000078540    UP000005205    UP000078492    UP000000311    UP000007755    UP000075809    UP000078541    UP000008237    UP000053097    UP000279307    UP000005203    UP000053105    UP000235965    UP000076502    UP000242457    UP000078542    UP000002358    UP000027135    UP000069940    UP000249989    UP000215335    UP000008820    UP000000673    UP000076408    UP000076407    UP000075902    UP000075882    UP000075886    UP000075885    UP000075903    UP000245037    UP000075920    UP000075883    UP000091820    UP000007062    UP000007266    UP000075900    UP000009046    UP000075880    UP000095300    UP000037069    UP000092460    UP000092445    UP000092443    UP000076858    UP000095301    UP000075881    UP000000304    UP000092461    UP000000803    UP000001292    UP000008711    UP000192221    UP000030765    UP000075884    UP000002282    UP000069272    UP000075840    UP000268350    UP000008792    UP000092462    UP000007801    UP000008744    UP000001819    UP000007798    UP000009192   

PRIDE

H9JE59    A1ZAK1   

Pfam

PF03165   MH1        + More
PF03166   MH2
PF03712   Cu2_monoox_C
PF01082   Cu2_monooxygen
PF03351   DOMON
PF00270   DEAD

Interpro

IPR038751   Int8        + More
IPR011990   TPR-like_helical_dom_sf       
IPR019734   TPR_repeat       
IPR003619   MAD_homology1_Dwarfin-type       
IPR036578   SMAD_MH1_sf       
IPR008984   SMAD_FHA_dom_sf       
IPR013790   Dwarfin       
IPR017855   SMAD-like_dom_sf       
IPR001132   SMAD_dom_Dwarfin-type       
IPR013019   MAD_homology_MH1       
IPR014784   Cu2_ascorb_mOase-like_C       
IPR005018   DOMON_domain       
IPR036939   Cu2_ascorb_mOase_N_sf       
IPR008977   PHM/PNGase_F_dom_sf       
IPR024548   Cu2_monoox_C       
IPR028460   Tbh/DBH       
IPR020611   Cu2_ascorb_mOase_CS-1       
IPR000323   Cu2_ascorb_mOase_N       
IPR027417   P-loop_NTPase       
IPR000629   RNA-helicase_DEAD-box_CS       
IPR014001   Helicase_ATP-bd       
IPR014014   RNA_helicase_DEAD_Q_motif       
IPR011545   DEAD/DEAH_box_helicase_dom       

SUPFAM

SSF48452   SSF48452        + More
SSF49879   SSF49879       
SSF56366   SSF56366       
SSF49742   SSF49742       
SSF52540   SSF52540       

Gene 3D

1.25.40.10     2.60.200.10     3.90.520.10     2.60.120.230     2.60.120.310    

ProteinModelPortal

H9JE59   A0A437B537   A0A2A4JR35   A0A212F005   A0A2H1W3B4   A0A194PKN4   + More
A0A194R7P8   A0A0L7KT01   A0A0L7RH99   A0A195B7C7   A0A158NGY0   A0A195DWH2   E2AIH7   F4X124   A0A151XD29   A0A195FQ30   E2BWB0   A0A026X0Q8   A0A087ZZ34   A0A0M9A3Y3   A0A2J7PL41   A0A154PB00   A0A2A3EF35   A0A151ILM0   K7J228   A0A067RNU6   A0A182GK56   A0A232F5G6   A0A310SJD7   Q178M0   A0A1S4FC20   A0A0C9QTU2   A0A1Q3G202   W5JPK3   A0A182YDD3   A0A182XCB1   A0A1S4H7K5   A0A182TSX6   A0A182LPJ5   A0A182QPP1   A0A182P9D6   A0A182UYZ3   A0A2P8XUV1   A0A182WF50   A0A182MP25   A0A1A9WIS6   Q7Q324   A0A1Y1MIF8   D6WSC4   A0A182RFB3   E0VUJ0   A0A182JBU6   A0A1I8PH80   A0A0L0CQW0   A0A1B0B7E5   A0A1A9ZGI3   A0A1A9XP18   A0A0P5NCZ6   A0A0P5WNF3   A0A0P5SPL8   A0A1I8MH08   A0A182K240   A0A034VK54   B4QIG5   A0A1B0GI48   A1ZAK1   B4HTA0   B3NP62   A0A0A1WDZ2   A0A1Y1MIK6   A0A1W4UL65   A0A0P4XDT3   A0A084WBF4   W8BRV2   A0A182MXX2   B4P5V0   A0A0P5FX38   A0A1B6FX52   A0A182FTC9   A0A182HNL2   A0A3B0JU79   A0A0N7ZPS8   B4LM91   A0A1B0GNW5   B3MDA4   B4GIM2   B5DUR9   A0A1B6JHI1   B4MR83   B4KNM0   A0A0P5X4E1   A0A146LFG5   A0A0K8TK26   A0A0A9YL24   A0A0P5HG84   A0A0A9YMJ4  

KEGG

101745290    K13145 integrator complex subunit 8 | (RefSeq) integrator complex subunit 8

GO

GO:0034472   GO:0005667   GO:0003700   GO:0005634   GO:0005737   GO:0007179   GO:0003677   GO:0016715   GO:0005507   GO:0005524   GO:0003676   GO:0032039   GO:0016180  

PANTHER

PTHR13350   PTHR13703  

Subcellular location

Cytoplasm  
Nucleus  

Length:

886

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06668

Exp number, first 60 AAs:

0.00544

Total prob of N-in:

0.00056

outside

1  -  886

 

 

Pi

233.82538

Theta

191.674114

Tajima's D

0.991235

CLR

0.001161

CSRT

0.653717314134293

Interpretation

Uncertain