Gene

KWMTBOMO08930  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007723

Annotation

S-formylglutathione_hydrolase_[Papilio_machaon]

Location

Bomo_Chr15(+):8382374-8384797      View in EpiBrowser

Full name

S-formylglutathione hydrolase      

Alternative Name

Esterase D
Methylumbelliferyl-acetate deacetylase
Esterase 10
Sid 478

Location in the cell

Extracellular   Reliability : 0.789

CDS

ATGGACAGCTTGCAATTAGAATCGTCCAATAAAATTTTTGGTGGTTATCAAAAAGTGTATTCTCATGCATCATCTGAATTAAAATGCAAAATGAATTTTTCTATCTATCTCCCCCCTCAGGCAGAAGGGGGTGATGTGAAATTACCACTTCTATATTATTTGTCTGGTCTAACTTGTAGTGAACAAAACTTCATCACTAAATCTGGTTTCCAGAGGTATGCAGCCGAACATGGTGTAATTGTCGTAGGTCCTGATACTTCGCCACGTGGAGTTAAGATTGATGGAGATGATTCATCATGGGATTTTGGAGTTAGTGCCGGTTTTTATTTAGACGCCACAAATGAACCATGGAATAATAATTACAGAATGGGCAGTTATTTGAATGTTGAATTATATGATTTAATTTTGAAGGCTTTTTGCAATGTGGTAGATCCTAATAGAATTGGTATTATGGGACACAGCATGGGAGGGCATGGTGCTTTAGTTTCTACTCTGAGGAATCCTGGCCAGTACAAGTCAGTAAGCGCTTTTGCTGCTATTTGTAATCCAAGTGCTTGTCCATGGGGAGTGAAGGCTTTTAGTGGATATTTGGGAGAAGATAAGAGTAAATGGGCGGAATGGGATGCCACAGAGCTGGTTAAGAAATACAATGGACCTCCTCTTACACTACTACTAGATCAGGGAAGTGGTGATAAATTTTATTTAGAGAAGCAGTTACTTCCTGAGAATTTGGTGGAGGCATGCCGTTCTGTAGGAGTCCCTGTCATTTTGCAACTACGCGATGGATATGATCACTCCTATTATTACATCTCTACTTACATTGGCGAACACTTCGACTTCCATGCTAAAATACTTAAAGCGTAG

Protein

MDSLQLESSNKIFGGYQKVYSHASSELKCKMNFSIYLPPQAEGGDVKLPLLYYLSGLTCSEQNFITKSGFQRYAAEHGVIVVGPDTSPRGVKIDGDDSSWDFGVSAGFYLDATNEPWNNNYRMGSYLNVELYDLILKAFCNVVDPNRIGIMGHSMGGHGALVSTLRNPGQYKSVSAFAAICNPSACPWGVKAFSGYLGEDKSKWAEWDATELVKKYNGPPLTLLLDQGSGDKFYLEKQLLPENLVEACRSVGVPVILQLRDGYDHSYYYISTYIGEHFDFHAKILKA

Description

Serine hydrolase involved in the detoxification of formaldehyde.

Catalytic Activity

H2O + S-formylglutathione = formate + glutathione + H(+)
4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

Subunit

Homodimer.

Similarity

Belongs to the esterase D family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Cytoplasmic vesicle   Hydrolase   Polymorphism   Reference proteome   Serine esterase   3D-structure   Direct protein sequencing  

Feature

chain  S-formylglutathione hydrolase
sequence variant  In allele ESD*2; dbSNP:rs9778.

Uniprot

H9JDX6   I4DL47   A0A194R8F5   A0A194PIP3   A0A2A4JR73   A0A0L7KSM4   + More
S4PMV1   A0A2H1WY20   A0A212ELI9   A0A3S2NA62   A0A1W4WPE8   U5EZ10   A0A0T6AW79   B0X7U1   D6WL39   A0A1B0CRU8   E9GL94   A0A1Q3FF09   A0A2J7QED9   A0A1L8DB84   A0A067QJI9   A0A2M4AU42   A0A0P4W3N4   A0A2M3Z9F4   A0A1L8DB29   A0A2M4ATD9   A0A2M4AT79   V3ZNB7   Q9GJT2   C3YK61   A0A2M4BW45   A0A2M4CY24   A0A2K6SYU0   A0A2J8VSG6   U3DYQ8   A0A2M4BW05   W5JB48   A0A140VJJ2   P10768   A0A2K5EEI4   G1QRI0   A0A2K5QK41   E2BUY0   A0A2Y9DL81   A0A2J8VSH1   G1M424   G3I3W4   B0BNE5   A0A182FPB8   A0A384DDG9   A0A452RSW4   A0A384DDI0   M3XAF3   A0A2P2HZI9   A0A3B4DIV4   A0A182HSG8   A0A2U3YHW4   A0A2Y9HPJ0   A0A182UIA9   A0A182XAM7   H3A712   A0A250XXK4   A0A3Q7PKX7   A0A164RGX2   A0A2R9ACC7   H2Q7J5   A0A2R7X3K0   A0A182LEH5   A0A2K6Q977   A0A2K5HBG4   A0A341C9V3   A0A2U4BFZ7   E3TGP2   A0A1U7TYK9   A0A0N8A8U2   F6XS05   A0A2U4BFY3   Q7QCH6   A0A2U4BG12   A0A2Y9NCB0   A0A182PI64   A0A0P6J436   A0A182V6N0   A0A3Q7VA79   A0A3Q7WFE0   A0A2D0RVP0   Q9R0P3   V9KJZ9   Q17MG9   A0A084W6L5   H3BKH6   A0A2Y9NMK6   H0WUJ3   A0A182GSL6   F7E7Q0   A0A0Q3PH62   A0A2Y9EJ10   A0A0F8C6Y8   A0A2Y9SWM5   A0A096MM92  

EC Number

3.1.2.12

Pubmed

19121390    22651552    26354079    26227816    23622113    22118469    + More
18362917    19820115    21292972    24845553    23254933    11167536    18563158    25243066    20920257    23761445    11181995    3462698    3164702    10931946    15057823    15489334    3462714    4768551    3770744    19608861    21269460    24275569    25944712    19126594    7907313    12721789    20798317    20010809    21804562    24813606    17975172    9215903    28087693    22722832    16136131    20966253    25362486    20634964    19892987    12364791    14747013    17210077    16141072    21183079    23806337    24402279    17510324    24438588    19468303    26483478    18464734    25835551   

EMBL

BABH01002627    BABH01002628    AK402015    BAM18637.1    KQ460615    KPJ13535.1    + More
KQ459602    KPI93291.1    NWSH01000840    PCG73922.1    JTDY01006326    KOB66105.1    GAIX01003360    JAA89200.1    ODYU01011896    SOQ57902.1    AGBW02014057    OWR42337.1    RSAL01000157    RVE45585.1    GANO01001635    JAB58236.1    LJIG01022714    KRT79093.1    DS232463    EDS42160.1    KQ971343    EFA04060.1    AJWK01025310    GL732550    EFX79817.1    GFDL01008910    JAV26135.1    NEVH01015316    PNF26937.1    GFDF01010500    JAV03584.1    KK853286    KDR08956.1    GGFK01010972    MBW44293.1    GDRN01075082    JAI63121.1    GGFM01004416    MBW25167.1    GFDF01010499    JAV03585.1    GGFK01010661    MBW43982.1    GGFK01010662    MBW43983.1    KB202014    ESO92858.1    AB032555    AB038362    AF254785    GG666520    EEN59518.1    GGFJ01008112    MBW57253.1    GGFL01005987    MBW70165.1    NDHI03003410    PNJ60474.1    GAMS01009976    GAMR01002401    GAMQ01006772    JAB13160.1    JAB31531.1    JAB35079.1    GGFJ01008116    MBW57257.1    ADMH02002014    ETN59989.1    HM005379    CH471075    AEE60979.1    EAX08768.1    M13450    AF112219    BT007059    AL136958    BC001169    AF052509    ADFV01053398    ADFV01053399    GL450772    EFN80517.1    PNJ60475.1    ACTA01193328    JH001215    EGW12863.1    BC158790    AANG04001781    IACF01001493    LAB67191.1    APCN01000278    AFYH01185622    AFYH01185623    AFYH01185624    AFYH01185625    AFYH01185626    AFYH01185627    GFFV01003843    JAV36102.1    LRGB01002190    KZS08642.1    AJFE02035893    AJFE02035894    AACZ04072358    GABF01009821    GABD01005589    NBAG03000497    JAA12324.1    JAA27511.1    PNI19478.1    KK856759    PTY26379.1    GU589528    ADO29478.1    GDIP01171201    JAJ52201.1    AAAB01008859    EAA07649.3    GDIQ01023518    JAN71219.1    AB025408    AK007527    AK010683    AK021209    AK079131    AK088115    BC046766    JW866261    AFO98778.1    CH477206    EAT47869.1    ATLV01020849    KE525308    KFB45859.1    AC154621    AAQR03017648    JXUM01084924    KQ563467    KXJ73792.1    LMAW01002917    KQK75652.1    KQ042663    KKF12264.1    AHZZ02011156   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000037510    UP000007151    + More
UP000283053    UP000192223    UP000002320    UP000007266    UP000092461    UP000000305    UP000235965    UP000027135    UP000030746    UP000008227    UP000001554    UP000233220    UP000008225    UP000000673    UP000005640    UP000233020    UP000001073    UP000233040    UP000008237    UP000248480    UP000008912    UP000001075    UP000002494    UP000069272    UP000261680    UP000291021    UP000291022    UP000011712    UP000261440    UP000075840    UP000245341    UP000248481    UP000075902    UP000076407    UP000008672    UP000286641    UP000076858    UP000240080    UP000002277    UP000075882    UP000233200    UP000233080    UP000252040    UP000245320    UP000221080    UP000189704    UP000002281    UP000007062    UP000248483    UP000075885    UP000075903    UP000286642    UP000000589    UP000008820    UP000030765    UP000005225    UP000069940    UP000249989    UP000002279    UP000051836    UP000248484    UP000028761   

PRIDE

H9JDX6    Q9GJT2    P10768    G3I3W4    B0BNE5    Q9R0P3    + More
H3BKH6   

Pfam

PF00756   Esterase

Interpro

IPR029058   AB_hydrolase        + More
IPR014186   S-formylglutathione_hydrol       
IPR000801   Esterase_put       

SUPFAM

SSF53474   SSF53474       

Gene 3D

3.40.50.1820    

ProteinModelPortal

H9JDX6   I4DL47   A0A194R8F5   A0A194PIP3   A0A2A4JR73   A0A0L7KSM4   + More
S4PMV1   A0A2H1WY20   A0A212ELI9   A0A3S2NA62   A0A1W4WPE8   U5EZ10   A0A0T6AW79   B0X7U1   D6WL39   A0A1B0CRU8   E9GL94   A0A1Q3FF09   A0A2J7QED9   A0A1L8DB84   A0A067QJI9   A0A2M4AU42   A0A0P4W3N4   A0A2M3Z9F4   A0A1L8DB29   A0A2M4ATD9   A0A2M4AT79   V3ZNB7   Q9GJT2   C3YK61   A0A2M4BW45   A0A2M4CY24   A0A2K6SYU0   A0A2J8VSG6   U3DYQ8   A0A2M4BW05   W5JB48   A0A140VJJ2   P10768   A0A2K5EEI4   G1QRI0   A0A2K5QK41   E2BUY0   A0A2Y9DL81   A0A2J8VSH1   G1M424   G3I3W4   B0BNE5   A0A182FPB8   A0A384DDG9   A0A452RSW4   A0A384DDI0   M3XAF3   A0A2P2HZI9   A0A3B4DIV4   A0A182HSG8   A0A2U3YHW4   A0A2Y9HPJ0   A0A182UIA9   A0A182XAM7   H3A712   A0A250XXK4   A0A3Q7PKX7   A0A164RGX2   A0A2R9ACC7   H2Q7J5   A0A2R7X3K0   A0A182LEH5   A0A2K6Q977   A0A2K5HBG4   A0A341C9V3   A0A2U4BFZ7   E3TGP2   A0A1U7TYK9   A0A0N8A8U2   F6XS05   A0A2U4BFY3   Q7QCH6   A0A2U4BG12   A0A2Y9NCB0   A0A182PI64   A0A0P6J436   A0A182V6N0   A0A3Q7VA79   A0A3Q7WFE0   A0A2D0RVP0   Q9R0P3   V9KJZ9   Q17MG9   A0A084W6L5   H3BKH6   A0A2Y9NMK6   H0WUJ3   A0A182GSL6   F7E7Q0   A0A0Q3PH62   A0A2Y9EJ10   A0A0F8C6Y8   A0A2Y9SWM5   A0A096MM92  

PDB

3FCX     E-value=8.63617e-94,     Score=875

KEGG

101737545    K01070 S-formylglutathione hydrolase [EC:3.1.2.12] | (RefSeq) S-formylglutathione hydrolase

PATHWAY

01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0046294   GO:0018738   GO:0052689   GO:0005737   GO:0005829   GO:0042802   GO:0031410   GO:1901687   GO:0047374   GO:0005788   GO:0016788   GO:0070062   GO:0017137   GO:0016813   GO:0016020   GO:0016817   GO:0008270   GO:0043565   GO:0016876   GO:0043039  

PANTHER

PTHR10061  

Subcellular location

Cytoplasm  
Cytoplasmic vesicle  

Length:

287

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00959

Exp number, first 60 AAs:

0.00122

Total prob of N-in:

0.01601

outside

1  -  287

 

 

Pi

341.344431

Theta

233.434704

Tajima's D

1.513207

CLR

0.064078

CSRT

0.789510524473776

Interpretation

Uncertain