SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08926  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA007720
Annotation
PREDICTED:_serine_protease_inhibitor_2_isoform_X1_[Bombyx_mori]
Location
Bomo_Chr15(+):8293014-8310000      View in EpiBrowser
Full name
Serine protease inhibitor 3/4       + More
Antitrypsin      
Antichymotrypsin-2      
Alaserpin      
Alternative Name
Antichymotrypsin II
Serpin-1
Location in the cell
Cytoplasmic   Reliability : 1.041 Extracellular   Reliability : 1.107
 

Sequence

CDS
ATGATATTTGCCAGAGTTTTGTTAATACTATTTACACTATTGGAAATAAAGAACCCTGTTCTCAGTATGGATTCAAAGGCTTTATCCTCTGCAATCACCAAGTTCTCTGCAAAGTTTTGCAATGAACTGGATAAAAAGAAGAATGTTGTATCATCGCCATTGTCAGCAGAATACTTGCTGGCGTTGATAACTTTGGGAACTACTGATCCTGCACACGAAGAGCTATTGACAAGCCTAGGTATCCCGGATGATGACACGATTCGCTCATCATTCTCGGCTGTGTCGTCAAAATTGAAATCAATAAAAGGTGTTACGTTTAATGTAGCCAACAAAATATACATCAAGGAGGGTGACTATGAGCTCGACCCAAAACTTAAGAAGGACGCTGTCGAGGTATTCGATGCAGATTTTGAAAAAGTTAACTTCGATAACGGAGCCGCAGCCGCCGGCCTAATAAACAAATGGGTTGAAAATAAAACAAATGAACGCATTAAAGATCTCTTGAGTGAAGACAGCCTCGATTCGTTTACGCGTTTGGTTTTGGTCAACGCTCTCTACTTCAAGGGTACATGGCAAAACCAGTTCGACTCTATAAGCACCATGGAGCGACCGTTCTATGTTGACACCGAAACGACAGTTAATATTCCTATGATGTACCAAGAAAATAATTTCAAGTATGGTGAGAGCCACGACCTCAATGCGCAGTTACTCGAAATGGCGTATGAAGGTAACGATGCCAGCATGGTTATCGTGCTGCCGAACGAAATTAATGGCCTGGACGGGATACTGCAGAAGCTGGCCGATGGCTACGACCTAACGGCGGAACTGGACAAAATGTTCTCGACCAAAGTGCGAGTGACGGTGCCGAAATTCAAGATCGAAACTGAGATTGATCTACTTCAAGTTTTGCCCAAGTTGGGTATTCAGGCGATCTTCAACCGCCAGAATTCCGGTCTGACCAAGATCTTGGATAACGACGAGCCGCTGTACGTATCCAAGGCTGTGCAAAAAGCCTTCATTGAAGTCAACGAGGAAGGCGCCGAAGCAGCCGCCGCCACAGCAATGGGCATTGCAAGTTACGCTGCATTCCTTGATGAGCCACCAGTACCTTCCTTCGATGCTGATCGGCCATTTGTAGCCGCAATCTTTGCCCACGGAATCTCTCACTTCTATGCCATATACCGTGGGGAGAATGATGAATAA
Protein
MIFARVLLILFTLLEIKNPVLSMDSKALSSAITKFSAKFCNELDKKKNVVSSPLSAEYLLALITLGTTDPAHEELLTSLGIPDDDTIRSSFSAVSSKLKSIKGVTFNVANKIYIKEGDYELDPKLKKDAVEVFDADFEKVNFDNGAAAAGLINKWVENKTNERIKDLLSEDSLDSFTRLVLVNALYFKGTWQNQFDSISTMERPFYVDTETTVNIPMMYQENNFKYGESHDLNAQLLEMAYEGNDASMVIVLPNEINGLDGILQKLADGYDLTAELDKMFSTKVRVTVPKFKIETEIDLLQVLPKLGIQAIFNRQNSGLTKILDNDEPLYVSKAVQKAFIEVNEEGAEAAAATAMGIASYAAFLDEPPVPSFDADRPFVAAIFAHGISHFYAIYRGENDE

Summary

Miscellaneous
The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).
Similarity
Belongs to the serpin family.
Keywords
Alternative splicing   Direct protein sequencing   Protease inhibitor   Serine protease inhibitor   Signal   Complete proteome   Reference proteome   Secreted   3D-structure   Glycoprotein  
Feature
chain  Serine protease inhibitor 3/4
splice variant  In isoform 2.
Uniprot
A0A0M4JBR8   Q9NGS0   E2GHX4   H9JDX3   A0A2A4JPB5   A0A2A4JQC6   + More
B2X122   A0A2A4JR25   A0A2H1VAC5   A0A2A4JPH1   A0A194PIN8   Q5MGH1   J7HI16   A0A1L7B973   Q5MGH2   A0A2A4JQ63   C0J8H0   A0A1E1WB01   A0A3S2NC81   A0A1E1W229   A0A212EXP2   A0A1L7B974   A0A212ELH5   A0A1E1W071   A0A437BU62   G9F9J6   O02377   A3KEZ8   A0A2H1VE36   C7ASM4   Q5MGH0   C7ASM6   A3KEZ7   Q60FS0   B4XHA1   B4XH99   B4XHA0   F5B4G8   A0A0M4K7J2   A0A1W4XA17   A0A1W4X0N9   C7ASM3   C7ASM7   A0A1W4XB66   C7ASM2   P22922   C7ASM9   P80034   A0A1W4XA13   A0A1W4X0K9   A0A1W4XB61   A0A3S2M7J7   A0A3G1T1E7   A0A1W4X0J8   A0A1W4XBF6   A0A1W4XA23   A0A1L7B975   K4P392   A0A1W4XBF1   A0A1W4XBE6   A0A194R1A3   B4XH98   H9JKA2   Q25496   A0A212FD15   Q5MGH0-2   Q8IS84   Q25501   Q25495   A0A1Y1KQA5   A0A385XRT7   I4DJC8   Q25500   A0A194PZ13   Q25497   D9HQA1   B0FZ62   G9D4T8   C5I795   A0A385XRR7   A0A1Y1KQA4   B0FZ64   A0A1Y1KTQ8   Q25492   B0FZ60   A0A1Y1KVX7   Q8IS86   C5I794   B0FZ63   A0A1Y1KX43   B0FZ65   B0FZ67   P14754   Q25526  
Pubmed
19121390    26354079    16023793    19150649    22118469    11439248    + More
18342903    19524698    21104446    2277028    1368515    1761030    8910411    28004739    30237077    22651552    20375075    21967427    19481148    2463253    8276850    14728663    10368276   
EMBL
KR003725    ALD62503.1    AF242200    AAF61252.1    HM357255    ADN52338.1    + More
BABH01002639    BABH01002640    NWSH01000840    PCG73905.1    PCG73908.1    EF584499    ABU62829.1    PCG73903.1    ODYU01001314    SOQ37342.1    PCG73901.1    KQ459602    KPI93286.1    AY829815    AAV91429.1    JN400442    AFQ01141.1    KY094503    APT69915.1    AY829814    AAV91428.1    PCG73906.1    EU935622    ACG61184.1    GDQN01006900    JAT84154.1    RSAL01000236    RVE43711.1    GDQN01010075    GDQN01007015    JAT80979.1    JAT84039.1    AGBW02011729    OWR46227.1    KY385636    APT69917.1    AGBW02014057    OWR42342.1    GDQN01010691    JAT80363.1    RSAL01000008    RVE53905.1    JN033741    AEW46894.1    U79184    AAB58491.1    AB295499    BAF48335.1    ODYU01002062    SOQ39103.1    FJ613795    ACT36274.1    AY829816    AY829817    AAV91430.1    FJ613797    ACT36278.1    AB295498    BAF48334.1    AB189029    BAD52261.1    EU040210    ABW17158.1    EU040208    ABW17156.1    EU040209    ABW17157.1    HQ615869    ADT63775.1    KR003729    ALD62507.1    FJ613794    FJ613796    ACT36273.1    ACT36275.1    ACT36277.1    ACT36279.1    FJ613793    ACT36272.1    D00738    ACT36276.1    RSAL01000018    RVE52837.1    MG992370    AXY94808.1    KY385635    APT69916.1    JX524148    AFV46312.1    KQ460883    KPJ11294.1    EU040207    ABW17155.1    BABH01041150    U58361    AAC47336.1    AGBW02009121    OWR51607.1    AY148485    AAN71634.1    AAC47339.1    AAC47341.1    GEZM01076851    GEZM01076849    JAV63593.1    MG753798    AYC12555.1    AK401396    BAM18018.1    AAC47335.1    KQ459586    KPI97989.1    AAC47333.1    HM023856    ADJ58589.2    EU368832    ABY68561.1    JF777341    AEU11686.1    FJ763764    ACR56865.1    MG753799    AYC12556.1    GEZM01076850    JAV63592.1    ABY68559.1    GEZM01076852    JAV63590.1    AAC47338.1    ABY68563.1    GEZM01073936    JAV64728.1    AY148483    AAN71632.1    FJ763763    ACR56864.1    ABY68560.1    GEZM01073934    JAV64730.1    ABY68558.1    ABY68556.1    M23438    L20792    L20793    AAA29334.1   
Proteomes
UP000005204    UP000218220    UP000053268    UP000283053    UP000007151    UP000192223    + More
UP000053240   
PRIDE
Q9NGS0    H9JDX3    C0J8H0    C7ASM4    C7ASM6    C7ASM3    + More
C7ASM7    P22922    C7ASM9    P80034    H9JKA2    P14754   
Pfam
PF00079   Serpin
Interpro
IPR036186   Serpin_sf        + More
IPR023796   Serpin_dom       
IPR023795   Serpin_CS       
IPR042178   Serpin_sf_1       
IPR042185   Serpin_sf_2       
IPR000215   Serpin_fam       
SUPFAM
SSF56574   SSF56574       
Gene 3D
2.30.39.10     3.30.497.10    
ProteinModelPortal
A0A0M4JBR8   Q9NGS0   E2GHX4   H9JDX3   A0A2A4JPB5   A0A2A4JQC6   + More
B2X122   A0A2A4JR25   A0A2H1VAC5   A0A2A4JPH1   A0A194PIN8   Q5MGH1   J7HI16   A0A1L7B973   Q5MGH2   A0A2A4JQ63   C0J8H0   A0A1E1WB01   A0A3S2NC81   A0A1E1W229   A0A212EXP2   A0A1L7B974   A0A212ELH5   A0A1E1W071   A0A437BU62   G9F9J6   O02377   A3KEZ8   A0A2H1VE36   C7ASM4   Q5MGH0   C7ASM6   A3KEZ7   Q60FS0   B4XHA1   B4XH99   B4XHA0   F5B4G8   A0A0M4K7J2   A0A1W4XA17   A0A1W4X0N9   C7ASM3   C7ASM7   A0A1W4XB66   C7ASM2   P22922   C7ASM9   P80034   A0A1W4XA13   A0A1W4X0K9   A0A1W4XB61   A0A3S2M7J7   A0A3G1T1E7   A0A1W4X0J8   A0A1W4XBF6   A0A1W4XA23   A0A1L7B975   K4P392   A0A1W4XBF1   A0A1W4XBE6   A0A194R1A3   B4XH98   H9JKA2   Q25496   A0A212FD15   Q5MGH0-2   Q8IS84   Q25501   Q25495   A0A1Y1KQA5   A0A385XRT7   I4DJC8   Q25500   A0A194PZ13   Q25497   D9HQA1   B0FZ62   G9D4T8   C5I795   A0A385XRR7   A0A1Y1KQA4   B0FZ64   A0A1Y1KTQ8   Q25492   B0FZ60   A0A1Y1KVX7   Q8IS86   C5I794   B0FZ63   A0A1Y1KX43   B0FZ65   B0FZ67   P14754   Q25526  
PDB
1SEK     E-value=2.19607e-58,     Score=571

Ontologies

KEGG
692573    no KO assigned | (RefSeq) serpin-2, BmSPN2, SPN2; serine protease inhibitor 2
GO
GO:0005615   GO:0008233   GO:0004867   GO:0016021   GO:0009617  
PANTHER
PTHR11461  

Topology

Subcellular location
Secreted  
  
SignalP
Position:   1 - 22,         Likelihood:  0.939161
 
 
Length:
400
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.28244
Exp number, first 60 AAs:
0.03039
Total prob of N-in:
0.00294
outside
1  -  400
 
 

Population Genetic Test Statistics

Pi
193.738088
Theta
167.608042
Tajima's D
-1.445339
CLR
10.476372
CSRT
0.0689965501724914
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
31250652 WLLEMAYEGNDASMVIVLPNEINGLDGILQKLADGYDLTAELDK 95.56 6e-23
31250652 FCNLLEMAYEGNDASMVIVLPNEINGLDGILQK 100.00 1e-22
31250652 NQIILPSR 100.00 7e-14
28467696 DAVEVFDADFEKVDFDNGAAAAGIINK 96.30 7e-11
28556443 EGDYELDPK 100.00 3e-07
28556443 GTWQNQFDSISTMER 100.00 4e-07
28556443 VNFDNGAAAAGLINK 100.00 4e-07
28556443 MYQENNFK 100.00 1e-05
25044914 GTVTYIAPAGNYK 100.00 2e-05
28556443 GTWQNQFDSISTMER 100.00 2e-05
28556443 FKIETEIDLLQVLPK 100.00 2e-05
28556443 FKIETEIDLLQVLPK 100.00 2e-05
28556443 FKIETEIDLLQVLPK 100.00 2e-05
28556443 VDFDNGAAAAGLINK 100.00 1e-04
28556443 ILDNDEPLYVSKAVQK 100.00 1e-04
28556443 ILDNDEPLYVSK 100.00 3e-04
28556443 FCNELDK 100.00 3e-04
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 VNFDNGAAAAGLINK 100.00 0.002
28556443 LVLVNALYFK 100.00 0.002
28556443 LVLVNALYFK 100.00 0.002
28556443 FKIETEIDLLQVLPK 100.00 0.003
28556443 FCNELDK 100.00 0.003
28556443 FCNELDK 100.00 0.003
28556443 DLLSEDSLDSFTR 100.00 0.003
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IETEIDLLQVLPK 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IKDLLSEDSLDSFTR 100.00 0.006
28556443 IETEIDLLQVLPK 100.00 0.006
28556443 IETEIDLLQVLPK 100.00 0.006
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